GRM2 (glutamate metabotropic receptor 2)

Gene

• Entrez ID: 2912
• Gene name: Glutamate metabotropic receptor 2
• Gene symbol: GRM2
• Synonyms (NCBI Gene): GLUR2, GPRC1B, MGLUR2, mGlu2
• Chromosome: 3
• Chromosome location: 3p21.2
• Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbe

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2239413	hsa-miR-4436b-3p	CLIP-seq
MIRT2239414	hsa-miR-4685-5p	CLIP-seq
MIRT2239415	hsa-miR-759	CLIP-seq
MIRT2388783	hsa-miR-140-3p	CLIP-seq
MIRT2388784	hsa-miR-3944-5p	CLIP-seq
MIRT2388785	hsa-miR-4318	CLIP-seq
MIRT2388786	hsa-miR-4436a	CLIP-seq
MIRT2388787	hsa-miR-4693-5p	CLIP-seq
MIRT2388788	hsa-miR-4700-3p	CLIP-seq
MIRT2388789	hsa-miR-606	CLIP-seq
MIRT2388790	hsa-miR-892a	CLIP-seq
MIRT2239413	hsa-miR-4436b-3p	CLIP-seq
MIRT2239414	hsa-miR-4685-5p	CLIP-seq
MIRT2239415	hsa-miR-759	CLIP-seq
MIRT2682094	hsa-miR-3926	CLIP-seq
MIRT2239413	hsa-miR-4436b-3p	CLIP-seq
MIRT2239414	hsa-miR-4685-5p	CLIP-seq
MIRT2682095	hsa-miR-548s	CLIP-seq
MIRT2682096	hsa-miR-617	CLIP-seq
MIRT2239415	hsa-miR-759	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
HDAC2	Unknown	22864611

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001641	Function	Group II metabotropic glutamate receptor activity	IBA
GO:0001641	Function	Group II metabotropic glutamate receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	7620613
GO:0005246	Function	Calcium channel regulator activity	IEA
GO:0005515	Function	Protein binding	IPI	18297054, 25416956, 32296183, 34903715
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	12011465
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	7620613
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA	34239069
GO:0007194	Process	Negative regulation of adenylate cyclase activity	TAS	7620613
GO:0007196	Process	Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA
GO:0007215	Process	Glutamate receptor signaling pathway	IEA
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IBA
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IDA	37286794
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IDA	37286794
GO:0007268	Process	Chemical synaptic transmission	TAS	7620613
GO:0008066	Function	Glutamate receptor activity	IDA	37286794
GO:0008066	Function	Glutamate receptor activity	IEA
GO:0008066	Function	Glutamate receptor activity	TAS	7620613
GO:0010467	Process	Gene expression	IEA
GO:0014047	Process	Glutamate secretion	IEA
GO:0014048	Process	Regulation of glutamate secretion	IEA
GO:0014059	Process	Regulation of dopamine secretion	IEA
GO:0016020	Component	Membrane	IEA
GO:0030424	Component	Axon	IEA
GO:0030424	Component	Axon	ISS
GO:0030425	Component	Dendrite	IEA
GO:0033554	Process	Cellular response to stress	IEA
GO:0035095	Process	Behavioral response to nicotine	IEA
GO:0042220	Process	Response to cocaine	IEA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS
GO:0051966	Process	Regulation of synaptic transmission, glutamatergic	IBA
GO:0060292	Process	Long-term synaptic depression	IEA
GO:0090461	Process	Intracellular glutamate homeostasis	IEA
GO:0097110	Function	Scaffold protein binding	IEA
GO:0097110	Function	Scaffold protein binding	ISS
GO:0097449	Component	Astrocyte projection	IEA
GO:0097449	Component	Astrocyte projection	ISS
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099171	Process	Presynaptic modulation of chemical synaptic transmission	IEA
GO:2001023	Process	Regulation of response to drug	IEA

Other IDs

• MIM: 604099
• HGNC: 4594
• e!Ensembl: ENSG00000164082

Protein

• UniProt ID: Q14416
• Protein name: Metabotropic glutamate receptor 2 (mGluR2)
• Protein function: Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate (PubMed:37286794). Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits pr
• PDB: 4XAQ, 4XAS, 5CNI, 5CNJ, 5KZN, 5KZQ, 7E9G, 7EPA, 7EPB, 7EPD, 7MTQ, 7MTR, 7MTS, 8JCU, 8JCV, 8JCW, 8JCX, 8JCY, 8JCZ, 8JD0, 8JD1, 8JD2, 8JD3, 8JD4, 8JD5, 8WG9, 8WGB, 8WGC, 8WGD
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01094	ANF_receptor	60 → 462	Receptor family ligand binding region	Family
  PF07562	NCD3G	496 → 546	Nine Cysteines Domain of family 3 GPCR	Family
  PF00003	7tm_3	579 → 816	7 transmembrane sweet-taste receptor of 3 GCPR	Family

• Tissue specificity: TISSUE SPECIFICITY: Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain. {ECO:0000269|PubMed:18297054}.
• Sequence:

  MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
  RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
  CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
  FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
  VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
  ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
  DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
  DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
  DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
  GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
  SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
  FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
  CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
  YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
  RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL

• Sequence length: 872

Pathways

KEGG:

Phospholipase D signaling pathway
Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction

Reactome:

G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AMPHETAMINE OR RELATED ACTING SYMPATHOMIMETIC ABUSE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AMPHETAMINE-RELATED DISORDERS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EPILEPSY, TEMPORAL LOBE	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHOSES, SUBSTANCE-INDUCED	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Amnesia	Amnesia	BEFREE	28285415		★☆☆☆☆ Found in Text Mining only
Amyloidosis	Amyloidosis	BEFREE	20875805		★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	10589532, 12694394, 14985749, 15294873, 16225946, 20372915, 20409611, 20424386		★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	LHGDN	15330338		★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis, Sporadic	Lateral Sclerosis	BEFREE	16225946, 20372915, 20424386		★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	BEFREE	30453142		★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorders	Autism Spectrum Disorder	BEFREE	31133774		★☆☆☆☆ Found in Text Mining only
Brain Ischemia	Cerebral Ischemia	BEFREE	28821279		★☆☆☆☆ Found in Text Mining only
Bulbo-Spinal Atrophy, X-Linked	Bulbospinal Atrophy, X-Linked	BEFREE	16225946		★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	16215279, 23112146		★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognitive disorder	BEFREE	28108498, 28213064, 30240581		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	9330603		★☆☆☆☆ Found in Text Mining only
Cone-Rod Dystrophy 2	Cone-rod dystrophy	BEFREE	18971481		★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	BEFREE	22091727, 28138040		★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	18258217		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	18258217		★☆☆☆☆ Found in Text Mining only
Encephalitis	Encephalitis	BEFREE	31195997		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	11119696, 14985442, 15006707, 20188170, 28214985, 9347614		★☆☆☆☆ Found in Text Mining only
Epilepsy, Benign Psychomotor, Childhood	Epilepsy	CTD_human_DG	18804094		★☆☆☆☆ Found in Text Mining only
Epilepsy, Lateral Temporal	Epilepsy	CTD_human_DG	18804094		★☆☆☆☆ Found in Text Mining only
Epilepsy, Temporal Lobe	Epilepsy	BEFREE	11442354		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Epilepsy, Temporal Lobe	Epilepsy	CTD_human_DG	18804094		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Fibroid Tumor	Leiomyoma	BEFREE	14630051		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	12172541		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	12172541		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	12614329	Associate	★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington Disease	BEFREE	20082658		★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	21419184, 28108498, 28213064, 30240581		★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	BEFREE	16215279		★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	BEFREE	19386277, 30326345		★☆☆☆☆ Found in Text Mining only
Manic	Manic Disorder	BEFREE	27890550		★☆☆☆☆ Found in Text Mining only
Memory dysfunction	Memory Disorders	BEFREE	30009679		★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	BEFREE	22091727, 28138040		★☆☆☆☆ Found in Text Mining only
Mental disorders	Mental Disorders	BEFREE	26658273, 28167616, 30005976, 30964565		★☆☆☆☆ Found in Text Mining only
Mixed anxiety and depressive disorder	Mixed Anxiety And Depressive Disorder	BEFREE	29301614		★☆☆☆☆ Found in Text Mining only
Mood Disorders	Mood Disorder	BEFREE	19386277, 30326345		★☆☆☆☆ Found in Text Mining only
Motor Neuron Disease	Motor Neuron Disease	BEFREE	20424386		★☆☆☆☆ Found in Text Mining only
Movement Disorders	Movement Disorders	BEFREE	30176255		★☆☆☆☆ Found in Text Mining only
Myasthenia Gravis	Myasthenia Gravis	BEFREE	31195997		★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	26987983, 27650988		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	8915893		★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	29753867		★☆☆☆☆ Found in Text Mining only
Neurodevelopmental Disorders	Neurodevelopmental Disorders	BEFREE	30564095		★☆☆☆☆ Found in Text Mining only
Neuropathy	Neuropathy	BEFREE	29296613		★☆☆☆☆ Found in Text Mining only
Nonorganic psychosis	Nonorganic Psychosis	BEFREE	18297054, 30038413, 30209534, 30240581		★☆☆☆☆ Found in Text Mining only
Olivopontocerebellar Atrophies	Olivopontocerebellar Atrophies	BEFREE	12083339		★☆☆☆☆ Found in Text Mining only
Optic Atrophy, Hereditary, Leber	Hereditary Leber Optic Atrophy	BEFREE	31234430		★☆☆☆☆ Found in Text Mining only
Panic Disorder	Panic Disorder	BEFREE	30108314, 30905115		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	30176255, 31499061, 31632264		★☆☆☆☆ Found in Text Mining only
Post-Traumatic Stress Disorder	Stress Disorder	BEFREE	30108314		★☆☆☆☆ Found in Text Mining only
Psychotic Disorders	Psychosis	BEFREE	18297054, 30038413, 30209534, 30240581		★☆☆☆☆ Found in Text Mining only
Pulmonary Arterial Hypertension	Pulmonary arterial hypertension	Pubtator	35960497	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	11317221, 17531207, 17982252, 18297054, 18759551, 18853337, 19707855, 20211215, 21173788, 23149219, 26758213, 27995279, 28213064, 28265857, 29793154, 30038413, 30209534, 30240581, 30301879, 30326345, 30564095, 30807107, 30890967, 31228641, 31242055, 7609609, 9099808		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	LHGDN	18853337		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	CTD_human_DG	18923069		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Shared Paranoid Disorder	Shared Paranoid Disorder	BEFREE	20211215		★☆☆☆☆ Found in Text Mining only
Uncinate Epilepsy	Epilepsy	CTD_human_DG	18804094		★☆☆☆☆ Found in Text Mining only
Uterine Fibroids	Uterine Fibroids	BEFREE	14630051		★☆☆☆☆ Found in Text Mining only