Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	29097
Gene name	Cornichon family member 4
Gene symbol	CNIH4
Synonyms (NCBI Gene)	CNIH-4HSPC163
Chromosome	1
Chromosome location	1q42.11

Show/Hide all (75)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021630	hsa-miR-142-3p	Microarray	17612493
MIRT023924	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT029902	hsa-miR-26b-5p	Microarray	19088304
MIRT042444	hsa-miR-424-5p	CLASH	23622248
MIRT041742	hsa-miR-484	CLASH	23622248
MIRT036705	hsa-miR-301b-3p	CLASH	23622248
MIRT444525	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT444524	hsa-miR-4468	PAR-CLIP	22100165
MIRT444525	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT444524	hsa-miR-4468	PAR-CLIP	22100165
MIRT444525	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT444524	hsa-miR-4468	PAR-CLIP	22100165
MIRT444525	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT444524	hsa-miR-4468	PAR-CLIP	22100165
MIRT899715	hsa-miR-1183	CLIP-seq
MIRT899716	hsa-miR-149	CLIP-seq
MIRT899717	hsa-miR-3064-5p	CLIP-seq
MIRT899718	hsa-miR-3120-3p	CLIP-seq
MIRT899719	hsa-miR-3125	CLIP-seq
MIRT899720	hsa-miR-326	CLIP-seq
MIRT899721	hsa-miR-330-5p	CLIP-seq
MIRT899722	hsa-miR-3653	CLIP-seq
MIRT899723	hsa-miR-3658	CLIP-seq
MIRT899724	hsa-miR-375	CLIP-seq
MIRT899725	hsa-miR-3916	CLIP-seq
MIRT899726	hsa-miR-3929	CLIP-seq
MIRT899727	hsa-miR-4263	CLIP-seq
MIRT899728	hsa-miR-4268	CLIP-seq
MIRT899729	hsa-miR-4280	CLIP-seq
MIRT899730	hsa-miR-4419b	CLIP-seq
MIRT899731	hsa-miR-4478	CLIP-seq
MIRT899732	hsa-miR-4521	CLIP-seq
MIRT899733	hsa-miR-4794	CLIP-seq
MIRT899734	hsa-miR-548c-3p	CLIP-seq
MIRT899735	hsa-miR-593	CLIP-seq
MIRT899736	hsa-miR-617	CLIP-seq
MIRT1966893	hsa-miR-129-5p	CLIP-seq
MIRT899716	hsa-miR-149	CLIP-seq
MIRT899717	hsa-miR-3064-5p	CLIP-seq
MIRT899719	hsa-miR-3125	CLIP-seq
MIRT899720	hsa-miR-326	CLIP-seq
MIRT899721	hsa-miR-330-5p	CLIP-seq
MIRT899722	hsa-miR-3653	CLIP-seq
MIRT899723	hsa-miR-3658	CLIP-seq
MIRT899724	hsa-miR-375	CLIP-seq
MIRT899725	hsa-miR-3916	CLIP-seq
MIRT899727	hsa-miR-4263	CLIP-seq
MIRT899728	hsa-miR-4268	CLIP-seq
MIRT899732	hsa-miR-4521	CLIP-seq
MIRT899733	hsa-miR-4794	CLIP-seq
MIRT899735	hsa-miR-593	CLIP-seq
MIRT899715	hsa-miR-1183	CLIP-seq
MIRT1966893	hsa-miR-129-5p	CLIP-seq
MIRT899716	hsa-miR-149	CLIP-seq
MIRT899717	hsa-miR-3064-5p	CLIP-seq
MIRT899719	hsa-miR-3125	CLIP-seq
MIRT899720	hsa-miR-326	CLIP-seq
MIRT899721	hsa-miR-330-5p	CLIP-seq
MIRT899722	hsa-miR-3653	CLIP-seq
MIRT899723	hsa-miR-3658	CLIP-seq
MIRT899724	hsa-miR-375	CLIP-seq
MIRT899725	hsa-miR-3916	CLIP-seq
MIRT899727	hsa-miR-4263	CLIP-seq
MIRT899728	hsa-miR-4268	CLIP-seq
MIRT899729	hsa-miR-4280	CLIP-seq
MIRT899732	hsa-miR-4521	CLIP-seq
MIRT899733	hsa-miR-4794	CLIP-seq
MIRT899735	hsa-miR-593	CLIP-seq
MIRT899716	hsa-miR-149	CLIP-seq
MIRT899717	hsa-miR-3064-5p	CLIP-seq
MIRT899720	hsa-miR-326	CLIP-seq
MIRT899721	hsa-miR-330-5p	CLIP-seq
MIRT899728	hsa-miR-4268	CLIP-seq
MIRT899733	hsa-miR-4794	CLIP-seq
MIRT899735	hsa-miR-593	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005102	Function	Signaling receptor binding	IBA
GO:0005515	Function	Protein binding	IPI	24405750, 32296183
GO:0005783	Component	Endoplasmic reticulum	IDA	24405750
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005793	Component	Endoplasmic reticulum-Golgi intermediate compartment	IDA	24405750
GO:0005793	Component	Endoplasmic reticulum-Golgi intermediate compartment	IEA
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IBA
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IMP	24405750
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0030134	Component	COPII-coated ER to Golgi transport vesicle	IBA
GO:0031730	Function	CCR5 chemokine receptor binding	IPI	24405750

MIM	HGNC	e!Ensembl
617483	25013	ENSG00000143771

Q9P003

Protein name

Protein cornichon homolog 4 (CNIH-4) (Cornichon family AMPA receptor auxiliary protein 4)

Protein function

Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery (PubMed:24405750)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03311	Cornichon	3 → 130	Cornichon protein	Family

Sequence

MEAVVFVFSLLDCCALIFLSVYFIITLSDLECDYINARSCCSKLNKWVIPELIGHTIVTV
LLLMSLHWFIFLLNLPVATWNIYRYIMVPSGNMGVFDPTEIHNRGQLKSHMKEAMIKLGF
HLLCFFMYLYSMILALIND

Sequence length

139

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	38092781	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	33934539	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	31253868		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	31253868	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	25646370		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	37062068	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	31253868		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	36404537	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CNIH4 (cornichon family member 4)