Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	29066
Gene name	Zinc finger CCCH-type containing 7A
Gene symbol	ZC3H7A
Synonyms (NCBI Gene)	HSPC055ZC3H7ZC3HDC7
Chromosome	16
Chromosome location	16p13.13

125

Show/Hide all (125)

miRTarBase ID	miRNA	Experiments	Reference
MIRT048747	hsa-miR-93-5p	CLASH	23622248
MIRT1506172	hsa-miR-101	CLIP-seq
MIRT1506173	hsa-miR-1305	CLIP-seq
MIRT1506174	hsa-miR-3120-3p	CLIP-seq
MIRT1506175	hsa-miR-362-5p	CLIP-seq
MIRT1506176	hsa-miR-4275	CLIP-seq
MIRT1506177	hsa-miR-4282	CLIP-seq
MIRT1506178	hsa-miR-4698	CLIP-seq
MIRT1506179	hsa-miR-4709-5p	CLIP-seq
MIRT1506180	hsa-miR-4729	CLIP-seq
MIRT1506181	hsa-miR-494	CLIP-seq
MIRT1506182	hsa-miR-500b	CLIP-seq
MIRT1506183	hsa-miR-501-5p	CLIP-seq
MIRT1506184	hsa-miR-513c	CLIP-seq
MIRT1506185	hsa-miR-514b-5p	CLIP-seq
MIRT1506186	hsa-miR-545	CLIP-seq
MIRT1506187	hsa-miR-548p	CLIP-seq
MIRT1506188	hsa-miR-552	CLIP-seq
MIRT1506189	hsa-miR-607	CLIP-seq
MIRT1506190	hsa-miR-627	CLIP-seq
MIRT1506191	hsa-miR-944	CLIP-seq
MIRT2152394	hsa-miR-133a	CLIP-seq
MIRT2152395	hsa-miR-133b	CLIP-seq
MIRT2152396	hsa-miR-2682	CLIP-seq
MIRT2152397	hsa-miR-3194-3p	CLIP-seq
MIRT2152398	hsa-miR-3663-5p	CLIP-seq
MIRT2152399	hsa-miR-3920	CLIP-seq
MIRT2152400	hsa-miR-4438	CLIP-seq
MIRT2152401	hsa-miR-449c	CLIP-seq
MIRT2152402	hsa-miR-4514	CLIP-seq
MIRT2152403	hsa-miR-4692	CLIP-seq
MIRT2152404	hsa-miR-5095	CLIP-seq
MIRT2152397	hsa-miR-3194-3p	CLIP-seq
MIRT2372789	hsa-miR-331-5p	CLIP-seq
MIRT2152398	hsa-miR-3663-5p	CLIP-seq
MIRT2152399	hsa-miR-3920	CLIP-seq
MIRT2372790	hsa-miR-4678	CLIP-seq
MIRT2372791	hsa-miR-4704-5p	CLIP-seq
MIRT1506179	hsa-miR-4709-5p	CLIP-seq
MIRT2372792	hsa-miR-487a	CLIP-seq
MIRT1506172	hsa-miR-101	CLIP-seq
MIRT2665598	hsa-miR-1184	CLIP-seq
MIRT2665599	hsa-miR-1205	CLIP-seq
MIRT2665600	hsa-miR-1252	CLIP-seq
MIRT2665601	hsa-miR-1301	CLIP-seq
MIRT2665602	hsa-miR-2355-3p	CLIP-seq
MIRT1506174	hsa-miR-3120-3p	CLIP-seq
MIRT2665603	hsa-miR-3158-5p	CLIP-seq
MIRT2665604	hsa-miR-3163	CLIP-seq
MIRT2665605	hsa-miR-3200-5p	CLIP-seq
MIRT2665606	hsa-miR-3653	CLIP-seq
MIRT2665607	hsa-miR-3658	CLIP-seq
MIRT2665608	hsa-miR-3664-3p	CLIP-seq
MIRT2665609	hsa-miR-3685	CLIP-seq
MIRT2665610	hsa-miR-384	CLIP-seq
MIRT2665611	hsa-miR-3923	CLIP-seq
MIRT2665612	hsa-miR-3928	CLIP-seq
MIRT2665613	hsa-miR-3940-5p	CLIP-seq
MIRT2665614	hsa-miR-4255	CLIP-seq
MIRT2665615	hsa-miR-4268	CLIP-seq
MIRT1506177	hsa-miR-4282	CLIP-seq
MIRT2665616	hsa-miR-4318	CLIP-seq
MIRT2665617	hsa-miR-4424	CLIP-seq
MIRT2665618	hsa-miR-4433	CLIP-seq
MIRT2665619	hsa-miR-4459	CLIP-seq
MIRT2665620	hsa-miR-4507	CLIP-seq
MIRT2665621	hsa-miR-4660	CLIP-seq
MIRT2665622	hsa-miR-4668-3p	CLIP-seq
MIRT2665623	hsa-miR-4682	CLIP-seq
MIRT2665624	hsa-miR-4690-3p	CLIP-seq
MIRT2665625	hsa-miR-4693-5p	CLIP-seq
MIRT2665626	hsa-miR-4694-3p	CLIP-seq
MIRT1506178	hsa-miR-4698	CLIP-seq
MIRT1506179	hsa-miR-4709-5p	CLIP-seq
MIRT2665627	hsa-miR-4714-3p	CLIP-seq
MIRT1506180	hsa-miR-4729	CLIP-seq
MIRT2665628	hsa-miR-4766-3p	CLIP-seq
MIRT2665629	hsa-miR-4768-3p	CLIP-seq
MIRT1506181	hsa-miR-494	CLIP-seq
MIRT2665630	hsa-miR-495	CLIP-seq
MIRT2665631	hsa-miR-500a	CLIP-seq
MIRT1506183	hsa-miR-501-5p	CLIP-seq
MIRT2665632	hsa-miR-5047	CLIP-seq
MIRT2665633	hsa-miR-522	CLIP-seq
MIRT1506186	hsa-miR-545	CLIP-seq
MIRT1506187	hsa-miR-548p	CLIP-seq
MIRT1506188	hsa-miR-552	CLIP-seq
MIRT2665634	hsa-miR-562	CLIP-seq
MIRT1506189	hsa-miR-607	CLIP-seq
MIRT2665635	hsa-miR-676	CLIP-seq
MIRT2665636	hsa-miR-767-3p	CLIP-seq
MIRT2665637	hsa-miR-888	CLIP-seq
MIRT2665638	hsa-miR-892a	CLIP-seq
MIRT1506172	hsa-miR-101	CLIP-seq
MIRT2665600	hsa-miR-1252	CLIP-seq
MIRT2665602	hsa-miR-2355-3p	CLIP-seq
MIRT1506174	hsa-miR-3120-3p	CLIP-seq
MIRT2695520	hsa-miR-323b-3p	CLIP-seq
MIRT2665608	hsa-miR-3664-3p	CLIP-seq
MIRT2665609	hsa-miR-3685	CLIP-seq
MIRT2665610	hsa-miR-384	CLIP-seq
MIRT2665612	hsa-miR-3928	CLIP-seq
MIRT2665613	hsa-miR-3940-5p	CLIP-seq
MIRT2665616	hsa-miR-4318	CLIP-seq
MIRT2665618	hsa-miR-4433	CLIP-seq
MIRT2665619	hsa-miR-4459	CLIP-seq
MIRT2665620	hsa-miR-4507	CLIP-seq
MIRT2665622	hsa-miR-4668-3p	CLIP-seq
MIRT2665624	hsa-miR-4690-3p	CLIP-seq
MIRT2665625	hsa-miR-4693-5p	CLIP-seq
MIRT1506178	hsa-miR-4698	CLIP-seq
MIRT1506179	hsa-miR-4709-5p	CLIP-seq
MIRT2665627	hsa-miR-4714-3p	CLIP-seq
MIRT1506180	hsa-miR-4729	CLIP-seq
MIRT2665629	hsa-miR-4768-3p	CLIP-seq
MIRT1506181	hsa-miR-494	CLIP-seq
MIRT1506186	hsa-miR-545	CLIP-seq
MIRT1506187	hsa-miR-548p	CLIP-seq
MIRT1506188	hsa-miR-552	CLIP-seq
MIRT2665634	hsa-miR-562	CLIP-seq
MIRT1506189	hsa-miR-607	CLIP-seq
MIRT2665635	hsa-miR-676	CLIP-seq
MIRT2665636	hsa-miR-767-3p	CLIP-seq
MIRT2665637	hsa-miR-888	CLIP-seq
MIRT2665638	hsa-miR-892a	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010608	Process	Post-transcriptional regulation of gene expression	IEA
GO:0010608	Process	Post-transcriptional regulation of gene expression	IMP	28431233
GO:0035196	Process	MiRNA processing	IBA
GO:0035196	Process	MiRNA processing	IEA
GO:0035196	Process	MiRNA processing	IMP	28431233
GO:0035198	Function	MiRNA binding	IBA
GO:0035198	Function	MiRNA binding	IDA	28431233
GO:0035198	Function	MiRNA binding	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
619819	30959	ENSG00000122299

Q8IWR0

Protein name

Zinc finger CCCH domain-containing protein 7A

Protein function

May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop.

PDB

2D9M

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00642	zf-CCCH	903 → 927	Zinc finger C-x8-C-x5-C-x3-H type (and similar)	Family

Sequence

MSNVSEERRKRQQNIKEGLQFIQSPLSYPGTQEQYAVYLRALVRNLFNEGNDVYREHDWN
NSISQYTEALNIADYAKSEEILIPKEIIEKLYINRIACYSNMGFHDKVLEDCNIVLSLNA
SNCKALYRKSKALSDLGRYKKAYDAVAKCSLAVPQDEHVIKLTQELAQKLGFKIRKAYVR
AELSLKSVPGDGATKALNHSVEDIEPDLLTPRQEAVPVVSLPAPSFSHEVGSELASVPVM
PLTSILPLQVEESALPSAVLANGGKMPFTMPEAFLDDGDMVLGDELDDLLDSAPETNETV
MPSALVRGPLQTASVSPSMPFSASLLGTLPIGARYAPPPSFSEFYPPLTSSLEDFCSSLN
SFSMSESKRDLSTSTSREGTPLNNSNSSLLLMNGPGSLFASENFLGISSQPRNDFGNFFG
SAVTKPSSSVTPRHPLEGTHELRQACQICFVKSGPKLMDFTYHANIDHKCKKDILIGRIK
NVEDKSWKKIRPRPTKTNYEGPYYICKDVAAEEECRYSGHCTFAYCQEEIDVWTLERKGA
FSREAFFGGNGKINLTVFKLLQEHLGEFIFLCEKCFDHKPRMISKRNKDNSTACSHPVTK
HEFEDNKCLVHILRETTVKYSKIRSFHGQCQLDLCRHEVRYGCLREDECFYAHSLVELKV
WIMQNETGISHDAIAQESKRYWQNLEANVPGAQVLGNQIMPGFLNMKIKFVCAQCLRNGQ
VIEPDKNRKYCSAKARHSWTKDRRAMRVMSIERKKWMNIRPLPTKKQMPLQFDLCNHIAS
GKKCQYVGNCSFAHSPEEREVWTYMKENGIQDMEQFYELWLKSQKNEKSEDIASQSNKEN
GKQIHMPTDYAEVTVDFHCWMCGKNCNSEKQWQGHISSEKHKEKVFHTEDDQYCWQHRFP
TGYFSICDRYMNGTCPEGNSCKFAHGNAELHEWEERRDALKMKLNKARKDHLIGPNDNDF
GKYSFLFKDLN

Sequence length

971

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GILLES DE LA TOURETTE SYNDROME	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	22797009	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Stromal Sarcoma	Endometrial Stromal Sarcoma	BEFREE	23580382, 24530230		★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	27219024		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23580382		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	22797009	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ZC3H7A (zinc finger CCCH-type containing 7A)