Gene Gene information from NCBI Gene database.
Entrez ID 29063
Gene name Zinc finger CCHC-type containing 4
Gene symbol ZCCHC4
Synonyms (NCBI Gene)
HSPC052ZGRF4
Chromosome 4
Chromosome location 4p15.2
miRNA miRNA information provided by mirtarbase database.
286
miRTarBase ID miRNA Experiments Reference
MIRT1507329 hsa-miR-1227 CLIP-seq
MIRT1507330 hsa-miR-124 CLIP-seq
MIRT1507331 hsa-miR-1304 CLIP-seq
MIRT1507332 hsa-miR-24 CLIP-seq
MIRT1507333 hsa-miR-25 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
GO ID Ontology Definition Evidence Reference
GO:0003676 Function Nucleic acid binding IEA
GO:0005634 Component Nucleus IEA
GO:0005730 Component Nucleolus IBA
GO:0005730 Component Nucleolus IDA 30531910, 31799605
GO:0005730 Component Nucleolus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611792 22917 ENSG00000168228
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9H5U6
Protein name rRNA N(6)-adenosine-methyltransferase ZCCHC4 (EC 2.1.1.-) (Zinc finger CCHC domain-containing protein 4)
Protein function rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA (PubMed:30531910, PubMed:31328227, PubMed:31695039, PubMed:31799605). N6-methylation of adenine(4220) in 28S rRNA is required for translation (PubMed
PDB 6UCA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06839 zf-GRF 38 82 GRF zinc finger Domain
PF10237 N6-adenineMlase 166 345 Probable N6-adenine methyltransferase Family
Sequence
MAASRNGFEAVEAEGSAGCRGSSGMEVVLPLDPAVPAPLCPHGPTLLFVKVTQGKEETRR
FYACSACRDRKDCNFFQWEDEK
LSGARLAAREAHNRRCQPPLSRTQCVERYLKFIELPLT
QRKFCQTCQQLLLPDDWGQHSEHQVLGNVSITQLRRPSQLLYPLENKKTNAQYLFADRSC
QFLVDLLSALGFRRVLCVGTPRLHELIKLTASGDKKSNIKSLLLDIDFRYSQFYMEDSFC
HYNMFNHHFFDGKTALEVCRAFLQEDKGEGIIMVTDPPFGGLVEPLAITFKKLIAMWKEG
QSQDDSHKELPIFWIFPYFFESRICQFFPSFQMLDYQVDYDNHAL
YKHGKTGRKQSPVRI
FTNIPPNKIILPTEEGYRFCSPCQRYVSLENQHCELCNSCTSKDGRKWNHCFLCKKCVKP
SWIHCSICNHCAVPDHSCEGPKHGCFICGELDHKRSTCPNIATSKRANKAVRKQKQRKSN
KMKMETTKGQSMNHTSATRRKKRRERAHQYLGS
Sequence length 513
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Cervical cancer Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INSOMNIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Lung cancer Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Sarcoma Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Attention Deficit Disorder with Hyperactivity Attention deficit hyperactivity disorder Pubtator 27754487 Associate
★☆☆☆☆
Found in Text Mining only
Attention deficit hyperactivity disorder Attention Deficit Hyperactivity Disorder BEFREE 27754487
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 35853866 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 35853866 Associate
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma BEFREE 30531910
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 30531910
★☆☆☆☆
Found in Text Mining only
Pancreatic Neoplasms Pancreatic neoplasm Pubtator 35853866 Associate
★☆☆☆☆
Found in Text Mining only