ZCCHC4 (zinc finger CCHC-type containing 4)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 29063 |
| Gene name | Zinc finger CCHC-type containing 4 |
| Gene symbol | ZCCHC4 |
| Synonyms (NCBI Gene) |
HSPC052ZGRF4
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| Chromosome | 4 |
| Chromosome location | 4p15.2 |
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miRNA
miRNA information provided by mirtarbase database.
286
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9H5U6 | |||||||||||||||
| Protein name | rRNA N(6)-adenosine-methyltransferase ZCCHC4 (EC 2.1.1.-) (Zinc finger CCHC domain-containing protein 4) | |||||||||||||||
| Protein function | rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA (PubMed:30531910, PubMed:31328227, PubMed:31695039, PubMed:31799605). N6-methylation of adenine(4220) in 28S rRNA is required for translation (PubMed | |||||||||||||||
| PDB | 6UCA | |||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 513 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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