Gene Gene information from NCBI Gene database.
Entrez ID 29035
Gene name HUWE1 associated protein modifying stress responses
Gene symbol HAPSTR1
Synonyms (NCBI Gene)
C16orf72PRO0149TAPR1
Chromosome 16
Chromosome location 16p13.2
miRNA miRNA information provided by mirtarbase database.
1116
miRTarBase ID miRNA Experiments Reference
MIRT027223 hsa-miR-103a-3p Sequencing 20371350
MIRT032066 hsa-miR-16-5p Sequencing 20371350
MIRT075894 hsa-miR-107 HITS-CLIP 21572407
MIRT027223 hsa-miR-103a-3p HITS-CLIP 21572407
MIRT075895 hsa-miR-15b-5p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 24722188, 25416956, 31515488, 32296183, 36631436
GO:0005634 Component Nucleus IDA 35776542
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IDA 35776542
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14CZ0
Protein name HUWE1-associated protein modifying stress responses 1 (Telomere attrition and p53 response 1 protein)
Protein function Acts as a central player within a network of stress response pathways promoting cellular adaptability. The E3 ligase HUWE1 assists HAPSTR1 in controlling stress signaling and in turn, HUWE1 feeds back to promote the degradation of HAPSTR1. HAPST
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15251 DUF4588 25 273 Domain of unknown function (DUF4588) Family
Sequence
Sequence length 275
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANDROGENETIC ALOPECIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIABETIC MACULOPATHY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INSOMNIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Schizophrenia Schizophrenia Pubtator 21285140 Associate
★☆☆☆☆
Found in Text Mining only