Gene Gene information from NCBI Gene database.
Entrez ID 29015
Gene name Solute carrier family 43 member 3
Gene symbol SLC43A3
Synonyms (NCBI Gene)
EEG1ENBT1FOAP-13PRO1659SEEEG-1
Chromosome 11
Chromosome location 11q12.1
miRNA miRNA information provided by mirtarbase database.
342
miRTarBase ID miRNA Experiments Reference
MIRT022191 hsa-miR-124-3p Microarray 18668037
MIRT691680 hsa-miR-548a-5p HITS-CLIP 23313552
MIRT691679 hsa-miR-548ab HITS-CLIP 23313552
MIRT691678 hsa-miR-548ad-5p HITS-CLIP 23313552
MIRT691677 hsa-miR-548ae-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32814053
GO:0005886 Component Plasma membrane IEA
GO:0006869 Process Lipid transport IEA
GO:0015207 Function Adenine transmembrane transporter activity IDA 26455426, 30910793, 32339528
GO:0015208 Function Guanine transmembrane transporter activity IDA 26455426
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
618034 17466 ENSG00000134802
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NBI5
Protein name Equilibrative nucleobase transporter 1 (Protein FOAP-13) (Solute carrier family 43 member 3)
Protein function Sodium-independent purine-selective nucleobase transporter which mediates the equilibrative transport of extracellular purine nucleobases such as adenine, guanine and hypoxanthine (PubMed:26455426, PubMed:32339528). May regulate fatty acid (FA)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07690 MFS_1 12 441 Major Facilitator Superfamily Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed with highest levels in the liver and lung, followed by the pancreas (PubMed:26455426). Highly expressed in macrophages (Ref.1). {ECO:0000269|PubMed:26455426, ECO:0000269|Ref.1}.
Sequence
Sequence length 491
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
15
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Acute myeloid leukemia Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cervical cancer Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Colorectal cancer Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Atherosclerosis Atherosclerosis Pubtator 21827714 Associate
★☆☆☆☆
Found in Text Mining only
Hemangiosarcoma Hemangiosarcoma BEFREE 26527604
★☆☆☆☆
Found in Text Mining only
IGA Glomerulonephritis Glomerulonephritis CTD_human_DG 25133636
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Malignant Neoplasms Malignant Neoplasm BEFREE 27807008
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 26527604
★☆☆☆☆
Found in Text Mining only