ABR (ABR activator of RhoGEF and GTPase)

Gene

• Entrez ID: 29
• Gene name: ABR activator of RhoGEF and GTPase
• Gene symbol: ABR
• Synonyms (NCBI Gene): MDB
• Chromosome: 17
• Chromosome location: 17p13.3
• Summary: This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT050728	hsa-miR-18a-5p	CLASH	23622248
MIRT040702	hsa-miR-92b-3p	CLASH	23622248
MIRT038901	hsa-miR-93-3p	CLASH	23622248
MIRT037178	hsa-miR-877-3p	CLASH	23622248
MIRT733077	hsa-miR-762	Luciferase reporter assay, Western blotting, qRT-PCR	31823748
MIRT761001	hsa-miR-1324	CLIP-seq
MIRT761002	hsa-miR-199a-5p	CLIP-seq
MIRT761003	hsa-miR-199b-5p	CLIP-seq
MIRT761004	hsa-miR-202	CLIP-seq
MIRT761005	hsa-miR-214	CLIP-seq
MIRT761006	hsa-miR-3121-3p	CLIP-seq
MIRT761007	hsa-miR-3202	CLIP-seq
MIRT761008	hsa-miR-3616-3p	CLIP-seq
MIRT761009	hsa-miR-3619-5p	CLIP-seq
MIRT761010	hsa-miR-3689d	CLIP-seq
MIRT761011	hsa-miR-3713	CLIP-seq
MIRT761012	hsa-miR-4436b-3p	CLIP-seq
MIRT761013	hsa-miR-4459	CLIP-seq
MIRT761014	hsa-miR-4471	CLIP-seq
MIRT761015	hsa-miR-4654	CLIP-seq
MIRT761016	hsa-miR-4711-5p	CLIP-seq
MIRT761017	hsa-miR-4722-5p	CLIP-seq
MIRT761018	hsa-miR-4747-5p	CLIP-seq
MIRT761019	hsa-miR-4769-5p	CLIP-seq
MIRT761020	hsa-miR-4773	CLIP-seq
MIRT761021	hsa-miR-4802-5p	CLIP-seq
MIRT761022	hsa-miR-761	CLIP-seq
MIRT761023	hsa-miR-1270	CLIP-seq
MIRT761024	hsa-miR-1281	CLIP-seq
MIRT761025	hsa-miR-1285	CLIP-seq
MIRT761026	hsa-miR-139-3p	CLIP-seq
MIRT761027	hsa-miR-18a	CLIP-seq
MIRT761028	hsa-miR-18b	CLIP-seq
MIRT761029	hsa-miR-191	CLIP-seq
MIRT761030	hsa-miR-3180-5p	CLIP-seq
MIRT761031	hsa-miR-3187-5p	CLIP-seq
MIRT761032	hsa-miR-361-3p	CLIP-seq
MIRT761033	hsa-miR-3647-3p	CLIP-seq
MIRT761034	hsa-miR-378g	CLIP-seq
MIRT761035	hsa-miR-4486	CLIP-seq
MIRT761036	hsa-miR-4683	CLIP-seq
MIRT761037	hsa-miR-4735-3p	CLIP-seq
MIRT761038	hsa-miR-4761-5p	CLIP-seq
MIRT761039	hsa-miR-4795-5p	CLIP-seq
MIRT761040	hsa-miR-520a-5p	CLIP-seq
MIRT761041	hsa-miR-525-5p	CLIP-seq
MIRT761042	hsa-miR-612	CLIP-seq
MIRT761043	hsa-miR-620	CLIP-seq
MIRT761044	hsa-miR-622	CLIP-seq
MIRT761045	hsa-miR-624	CLIP-seq
MIRT761024	hsa-miR-1281	CLIP-seq
MIRT761046	hsa-miR-299-5p	CLIP-seq
MIRT761032	hsa-miR-361-3p	CLIP-seq
MIRT761047	hsa-miR-369-3p	CLIP-seq
MIRT761048	hsa-miR-374a	CLIP-seq
MIRT761049	hsa-miR-374b	CLIP-seq
MIRT761050	hsa-miR-433	CLIP-seq
MIRT761051	hsa-miR-4477a	CLIP-seq
MIRT761052	hsa-miR-499-3p	CLIP-seq
MIRT761053	hsa-miR-499a-3p	CLIP-seq
MIRT761054	hsa-miR-664	CLIP-seq
MIRT1924324	hsa-miR-106a	CLIP-seq
MIRT1924325	hsa-miR-106b	CLIP-seq
MIRT1924326	hsa-miR-1207-5p	CLIP-seq
MIRT1924327	hsa-miR-1238	CLIP-seq
MIRT1924328	hsa-miR-1245b-5p	CLIP-seq
MIRT1924329	hsa-miR-125a-5p	CLIP-seq
MIRT1924330	hsa-miR-125b	CLIP-seq
MIRT761025	hsa-miR-1285	CLIP-seq
MIRT1924331	hsa-miR-1287	CLIP-seq
MIRT1924332	hsa-miR-1587	CLIP-seq
MIRT1924333	hsa-miR-17	CLIP-seq
MIRT1924334	hsa-miR-1913	CLIP-seq
MIRT1924335	hsa-miR-1915	CLIP-seq
MIRT761004	hsa-miR-202	CLIP-seq
MIRT1924336	hsa-miR-20a	CLIP-seq
MIRT1924337	hsa-miR-20b	CLIP-seq
MIRT1924338	hsa-miR-219-1-3p	CLIP-seq
MIRT1924339	hsa-miR-302a	CLIP-seq
MIRT1924340	hsa-miR-302b	CLIP-seq
MIRT1924341	hsa-miR-302c	CLIP-seq
MIRT1924342	hsa-miR-302d	CLIP-seq
MIRT1924343	hsa-miR-302e	CLIP-seq
MIRT1924344	hsa-miR-3064-5p	CLIP-seq
MIRT1924345	hsa-miR-3135b	CLIP-seq
MIRT1924346	hsa-miR-3142	CLIP-seq
MIRT761031	hsa-miR-3187-5p	CLIP-seq
MIRT1924347	hsa-miR-3189-3p	CLIP-seq
MIRT761007	hsa-miR-3202	CLIP-seq
MIRT1924348	hsa-miR-324-3p	CLIP-seq
MIRT1924349	hsa-miR-326	CLIP-seq
MIRT1924350	hsa-miR-330-5p	CLIP-seq
MIRT1924351	hsa-miR-340	CLIP-seq
MIRT1924352	hsa-miR-3614-3p	CLIP-seq
MIRT761008	hsa-miR-3616-3p	CLIP-seq
MIRT1924353	hsa-miR-3622a-3p	CLIP-seq
MIRT1924354	hsa-miR-3622b-3p	CLIP-seq
MIRT1924355	hsa-miR-3649	CLIP-seq
MIRT1924356	hsa-miR-3652	CLIP-seq
MIRT1924357	hsa-miR-372	CLIP-seq
MIRT1924358	hsa-miR-373	CLIP-seq
MIRT1924359	hsa-miR-378	CLIP-seq
MIRT1924360	hsa-miR-378b	CLIP-seq
MIRT1924361	hsa-miR-378c	CLIP-seq
MIRT1924362	hsa-miR-378d	CLIP-seq
MIRT1924363	hsa-miR-378e	CLIP-seq
MIRT1924364	hsa-miR-378f	CLIP-seq
MIRT1924365	hsa-miR-378h	CLIP-seq
MIRT1924366	hsa-miR-378i	CLIP-seq
MIRT1924367	hsa-miR-3918	CLIP-seq
MIRT1924368	hsa-miR-3922-5p	CLIP-seq
MIRT1924369	hsa-miR-3937	CLIP-seq
MIRT1924370	hsa-miR-422a	CLIP-seq
MIRT1924371	hsa-miR-4286	CLIP-seq
MIRT1924372	hsa-miR-4293	CLIP-seq
MIRT1924373	hsa-miR-4319	CLIP-seq
MIRT1924374	hsa-miR-4430	CLIP-seq
MIRT761012	hsa-miR-4436b-3p	CLIP-seq
MIRT761013	hsa-miR-4459	CLIP-seq
MIRT1924375	hsa-miR-4476	CLIP-seq
MIRT761051	hsa-miR-4477a	CLIP-seq
MIRT1924376	hsa-miR-4492	CLIP-seq
MIRT1924377	hsa-miR-4498	CLIP-seq
MIRT1924378	hsa-miR-4505	CLIP-seq
MIRT1924379	hsa-miR-4512	CLIP-seq
MIRT1924380	hsa-miR-4514	CLIP-seq
MIRT1924381	hsa-miR-4517	CLIP-seq
MIRT1924382	hsa-miR-4533	CLIP-seq
MIRT1924383	hsa-miR-4535	CLIP-seq
MIRT1924384	hsa-miR-4639-3p	CLIP-seq
MIRT1924385	hsa-miR-4640-5p	CLIP-seq
MIRT1924386	hsa-miR-4645-5p	CLIP-seq
MIRT1924387	hsa-miR-4646-5p	CLIP-seq
MIRT1924388	hsa-miR-4651	CLIP-seq
MIRT761015	hsa-miR-4654	CLIP-seq
MIRT1924389	hsa-miR-4656	CLIP-seq
MIRT1924390	hsa-miR-4667-5p	CLIP-seq
MIRT1924391	hsa-miR-4673	CLIP-seq
MIRT1924392	hsa-miR-4674	CLIP-seq
MIRT1924393	hsa-miR-4675	CLIP-seq
MIRT1924394	hsa-miR-4677-3p	CLIP-seq
MIRT1924395	hsa-miR-4682	CLIP-seq
MIRT1924396	hsa-miR-4685-5p	CLIP-seq
MIRT1924397	hsa-miR-4690-3p	CLIP-seq
MIRT1924398	hsa-miR-4692	CLIP-seq
MIRT1924399	hsa-miR-4700-5p	CLIP-seq
MIRT1924400	hsa-miR-4717-5p	CLIP-seq
MIRT761017	hsa-miR-4722-5p	CLIP-seq
MIRT1924401	hsa-miR-4725-5p	CLIP-seq
MIRT1924402	hsa-miR-4726-5p	CLIP-seq
MIRT1924403	hsa-miR-4731-5p	CLIP-seq
MIRT1924404	hsa-miR-4741	CLIP-seq
MIRT761018	hsa-miR-4747-5p	CLIP-seq
MIRT1924405	hsa-miR-4753-5p	CLIP-seq
MIRT1924406	hsa-miR-4757-5p	CLIP-seq
MIRT1924407	hsa-miR-4763-3p	CLIP-seq
MIRT761019	hsa-miR-4769-5p	CLIP-seq
MIRT761020	hsa-miR-4773	CLIP-seq
MIRT1924408	hsa-miR-4776-5p	CLIP-seq
MIRT761021	hsa-miR-4802-5p	CLIP-seq
MIRT1924409	hsa-miR-498	CLIP-seq
MIRT1924410	hsa-miR-504	CLIP-seq
MIRT1924411	hsa-miR-510	CLIP-seq
MIRT1924412	hsa-miR-512-3p	CLIP-seq
MIRT1924413	hsa-miR-513a-5p	CLIP-seq
MIRT1924414	hsa-miR-519d	CLIP-seq
MIRT1924415	hsa-miR-520a-3p	CLIP-seq
MIRT1924416	hsa-miR-520b	CLIP-seq
MIRT1924417	hsa-miR-520c-3p	CLIP-seq
MIRT1924418	hsa-miR-520d-3p	CLIP-seq
MIRT1924419	hsa-miR-520e	CLIP-seq
MIRT1924420	hsa-miR-571	CLIP-seq
MIRT1924421	hsa-miR-608	CLIP-seq
MIRT761042	hsa-miR-612	CLIP-seq
MIRT1924422	hsa-miR-635	CLIP-seq
MIRT1924423	hsa-miR-637	CLIP-seq
MIRT1924424	hsa-miR-711	CLIP-seq
MIRT1924425	hsa-miR-765	CLIP-seq
MIRT1924426	hsa-miR-93	CLIP-seq
MIRT1924427	hsa-miR-940	CLIP-seq
MIRT1924334	hsa-miR-1913	CLIP-seq
MIRT1924338	hsa-miR-219-1-3p	CLIP-seq
MIRT1924345	hsa-miR-3135b	CLIP-seq
MIRT1924348	hsa-miR-324-3p	CLIP-seq
MIRT2165644	hsa-miR-346	CLIP-seq
MIRT2165645	hsa-miR-3659	CLIP-seq
MIRT1924371	hsa-miR-4286	CLIP-seq
MIRT2165646	hsa-miR-4288	CLIP-seq
MIRT1924380	hsa-miR-4514	CLIP-seq
MIRT2165647	hsa-miR-4658	CLIP-seq
MIRT1924395	hsa-miR-4682	CLIP-seq
MIRT1924398	hsa-miR-4692	CLIP-seq
MIRT2165648	hsa-miR-4711-3p	CLIP-seq
MIRT1924403	hsa-miR-4731-5p	CLIP-seq
MIRT2165649	hsa-miR-485-5p	CLIP-seq
MIRT1924420	hsa-miR-571	CLIP-seq
MIRT2165650	hsa-miR-574-5p	CLIP-seq
MIRT2165651	hsa-miR-632	CLIP-seq
MIRT2383789	hsa-miR-4691-3p	CLIP-seq
MIRT2441917	hsa-miR-370	CLIP-seq
MIRT2468097	hsa-miR-103b	CLIP-seq
MIRT1924326	hsa-miR-1207-5p	CLIP-seq
MIRT2468098	hsa-miR-1225-3p	CLIP-seq
MIRT2468099	hsa-miR-1227	CLIP-seq
MIRT2468100	hsa-miR-1229	CLIP-seq
MIRT2468101	hsa-miR-1237	CLIP-seq
MIRT2468102	hsa-miR-128	CLIP-seq
MIRT761025	hsa-miR-1285	CLIP-seq
MIRT2468103	hsa-miR-1301	CLIP-seq
MIRT2468104	hsa-miR-134	CLIP-seq
MIRT2468105	hsa-miR-149	CLIP-seq
MIRT2468106	hsa-miR-1538	CLIP-seq
MIRT1924334	hsa-miR-1913	CLIP-seq
MIRT2468107	hsa-miR-1976	CLIP-seq
MIRT2468108	hsa-miR-2114	CLIP-seq
MIRT2468109	hsa-miR-2117	CLIP-seq
MIRT761005	hsa-miR-214	CLIP-seq
MIRT2468110	hsa-miR-3064-3p	CLIP-seq
MIRT1924344	hsa-miR-3064-5p	CLIP-seq
MIRT2468111	hsa-miR-3118	CLIP-seq
MIRT761006	hsa-miR-3121-3p	CLIP-seq
MIRT2468112	hsa-miR-3121-5p	CLIP-seq
MIRT2468113	hsa-miR-3122	CLIP-seq
MIRT2468114	hsa-miR-3127-3p	CLIP-seq
MIRT2468115	hsa-miR-3152-5p	CLIP-seq
MIRT2468116	hsa-miR-3181	CLIP-seq
MIRT2468117	hsa-miR-3182	CLIP-seq
MIRT761031	hsa-miR-3187-5p	CLIP-seq
MIRT1924347	hsa-miR-3189-3p	CLIP-seq
MIRT761007	hsa-miR-3202	CLIP-seq
MIRT1924348	hsa-miR-324-3p	CLIP-seq
MIRT1924349	hsa-miR-326	CLIP-seq
MIRT2468118	hsa-miR-329	CLIP-seq
MIRT1924350	hsa-miR-330-5p	CLIP-seq
MIRT2468119	hsa-miR-331-3p	CLIP-seq
MIRT2468120	hsa-miR-33a	CLIP-seq
MIRT2468121	hsa-miR-33b	CLIP-seq
MIRT1924351	hsa-miR-340	CLIP-seq
MIRT2468122	hsa-miR-345	CLIP-seq
MIRT1924352	hsa-miR-3614-3p	CLIP-seq
MIRT761009	hsa-miR-3619-5p	CLIP-seq
MIRT2468123	hsa-miR-3620	CLIP-seq
MIRT1924353	hsa-miR-3622a-3p	CLIP-seq
MIRT1924354	hsa-miR-3622b-3p	CLIP-seq
MIRT2468124	hsa-miR-362-3p	CLIP-seq
MIRT1924355	hsa-miR-3649	CLIP-seq
MIRT2468125	hsa-miR-3667-3p	CLIP-seq
MIRT2468126	hsa-miR-3689a-3p	CLIP-seq
MIRT2468127	hsa-miR-3689c	CLIP-seq
MIRT761010	hsa-miR-3689d	CLIP-seq
MIRT2441917	hsa-miR-370	CLIP-seq
MIRT2468128	hsa-miR-3913-5p	CLIP-seq
MIRT2468129	hsa-miR-3929	CLIP-seq
MIRT2468130	hsa-miR-3944-3p	CLIP-seq
MIRT2468131	hsa-miR-4254	CLIP-seq
MIRT2468132	hsa-miR-4260	CLIP-seq
MIRT2468133	hsa-miR-4269	CLIP-seq
MIRT2468134	hsa-miR-4273	CLIP-seq
MIRT2468135	hsa-miR-4281	CLIP-seq
MIRT2468136	hsa-miR-4283	CLIP-seq
MIRT2468137	hsa-miR-4284	CLIP-seq
MIRT1924371	hsa-miR-4286	CLIP-seq
MIRT2468138	hsa-miR-4292	CLIP-seq
MIRT1924372	hsa-miR-4293	CLIP-seq
MIRT2468139	hsa-miR-4297	CLIP-seq
MIRT2468140	hsa-miR-4300	CLIP-seq
MIRT2468141	hsa-miR-4308	CLIP-seq
MIRT2468142	hsa-miR-4419b	CLIP-seq
MIRT2468143	hsa-miR-4421	CLIP-seq
MIRT2468144	hsa-miR-4423-5p	CLIP-seq
MIRT2468145	hsa-miR-4453	CLIP-seq
MIRT2468146	hsa-miR-4455	CLIP-seq
MIRT761014	hsa-miR-4471	CLIP-seq
MIRT1924375	hsa-miR-4476	CLIP-seq
MIRT2468147	hsa-miR-4478	CLIP-seq
MIRT2468148	hsa-miR-4489	CLIP-seq
MIRT1924380	hsa-miR-4514	CLIP-seq
MIRT1924381	hsa-miR-4517	CLIP-seq
MIRT2468149	hsa-miR-4538	CLIP-seq
MIRT2468150	hsa-miR-4633-3p	CLIP-seq
MIRT1924384	hsa-miR-4639-3p	CLIP-seq
MIRT1924385	hsa-miR-4640-5p	CLIP-seq
MIRT1924386	hsa-miR-4645-5p	CLIP-seq
MIRT1924388	hsa-miR-4651	CLIP-seq
MIRT761015	hsa-miR-4654	CLIP-seq
MIRT2468151	hsa-miR-4660	CLIP-seq
MIRT1924390	hsa-miR-4667-5p	CLIP-seq
MIRT1924391	hsa-miR-4673	CLIP-seq
MIRT1924394	hsa-miR-4677-3p	CLIP-seq
MIRT2468152	hsa-miR-4686	CLIP-seq
MIRT1924397	hsa-miR-4690-3p	CLIP-seq
MIRT2468153	hsa-miR-4690-5p	CLIP-seq
MIRT1924398	hsa-miR-4692	CLIP-seq
MIRT1924399	hsa-miR-4700-5p	CLIP-seq
MIRT2468154	hsa-miR-4707-5p	CLIP-seq
MIRT2468155	hsa-miR-4722-3p	CLIP-seq
MIRT761017	hsa-miR-4722-5p	CLIP-seq
MIRT1924401	hsa-miR-4725-5p	CLIP-seq
MIRT1924402	hsa-miR-4726-5p	CLIP-seq
MIRT1924403	hsa-miR-4731-5p	CLIP-seq
MIRT2468156	hsa-miR-4745-3p	CLIP-seq
MIRT761018	hsa-miR-4747-5p	CLIP-seq
MIRT2468157	hsa-miR-4749-3p	CLIP-seq
MIRT2468158	hsa-miR-4750	CLIP-seq
MIRT2468159	hsa-miR-4755-3p	CLIP-seq
MIRT1924407	hsa-miR-4763-3p	CLIP-seq
MIRT2468160	hsa-miR-4768-3p	CLIP-seq
MIRT761019	hsa-miR-4769-5p	CLIP-seq
MIRT761020	hsa-miR-4773	CLIP-seq
MIRT2468161	hsa-miR-4794	CLIP-seq
MIRT2165649	hsa-miR-485-5p	CLIP-seq
MIRT2468162	hsa-miR-502-5p	CLIP-seq
MIRT1924410	hsa-miR-504	CLIP-seq
MIRT2468163	hsa-miR-5047	CLIP-seq
MIRT1924413	hsa-miR-513a-5p	CLIP-seq
MIRT2468164	hsa-miR-556-5p	CLIP-seq
MIRT2468165	hsa-miR-558	CLIP-seq
MIRT2468166	hsa-miR-582-3p	CLIP-seq
MIRT2468167	hsa-miR-596	CLIP-seq
MIRT1924421	hsa-miR-608	CLIP-seq
MIRT2468168	hsa-miR-609	CLIP-seq
MIRT761042	hsa-miR-612	CLIP-seq
MIRT2468169	hsa-miR-627	CLIP-seq
MIRT2468170	hsa-miR-629	CLIP-seq
MIRT1924423	hsa-miR-637	CLIP-seq
MIRT2468171	hsa-miR-645	CLIP-seq
MIRT2468172	hsa-miR-671-5p	CLIP-seq
MIRT761022	hsa-miR-761	CLIP-seq
MIRT2468173	hsa-miR-767-3p	CLIP-seq
MIRT2468174	hsa-miR-885-3p	CLIP-seq
MIRT2468175	hsa-miR-888	CLIP-seq
MIRT2468176	hsa-miR-892b	CLIP-seq
MIRT2468177	hsa-miR-920	CLIP-seq
MIRT2468178	hsa-miR-924	CLIP-seq
MIRT2468179	hsa-miR-936	CLIP-seq
MIRT2468180	hsa-miR-939	CLIP-seq
MIRT1924427	hsa-miR-940	CLIP-seq
MIRT2441917	hsa-miR-370	CLIP-seq
MIRT1924401	hsa-miR-4725-5p	CLIP-seq
MIRT1924410	hsa-miR-504	CLIP-seq
MIRT2441917	hsa-miR-370	CLIP-seq
MIRT1924401	hsa-miR-4725-5p	CLIP-seq
MIRT1924410	hsa-miR-504	CLIP-seq
MIRT1924326	hsa-miR-1207-5p	CLIP-seq
MIRT2468098	hsa-miR-1225-3p	CLIP-seq
MIRT2468099	hsa-miR-1227	CLIP-seq
MIRT2468101	hsa-miR-1237	CLIP-seq
MIRT2468102	hsa-miR-128	CLIP-seq
MIRT761025	hsa-miR-1285	CLIP-seq
MIRT2468104	hsa-miR-134	CLIP-seq
MIRT2468105	hsa-miR-149	CLIP-seq
MIRT2468106	hsa-miR-1538	CLIP-seq
MIRT1924334	hsa-miR-1913	CLIP-seq
MIRT2468107	hsa-miR-1976	CLIP-seq
MIRT2468108	hsa-miR-2114	CLIP-seq
MIRT2468110	hsa-miR-3064-3p	CLIP-seq
MIRT2468111	hsa-miR-3118	CLIP-seq
MIRT2468112	hsa-miR-3121-5p	CLIP-seq
MIRT2468114	hsa-miR-3127-3p	CLIP-seq
MIRT2468116	hsa-miR-3181	CLIP-seq
MIRT2468117	hsa-miR-3182	CLIP-seq
MIRT761031	hsa-miR-3187-5p	CLIP-seq
MIRT1924347	hsa-miR-3189-3p	CLIP-seq
MIRT1924348	hsa-miR-324-3p	CLIP-seq
MIRT1924349	hsa-miR-326	CLIP-seq
MIRT2468118	hsa-miR-329	CLIP-seq
MIRT1924350	hsa-miR-330-5p	CLIP-seq
MIRT2468119	hsa-miR-331-3p	CLIP-seq
MIRT2468120	hsa-miR-33a	CLIP-seq
MIRT2468121	hsa-miR-33b	CLIP-seq
MIRT1924351	hsa-miR-340	CLIP-seq
MIRT1924352	hsa-miR-3614-3p	CLIP-seq
MIRT2468123	hsa-miR-3620	CLIP-seq
MIRT2468124	hsa-miR-362-3p	CLIP-seq
MIRT1924355	hsa-miR-3649	CLIP-seq
MIRT2468125	hsa-miR-3667-3p	CLIP-seq
MIRT761010	hsa-miR-3689d	CLIP-seq
MIRT2441917	hsa-miR-370	CLIP-seq
MIRT2468129	hsa-miR-3929	CLIP-seq
MIRT2468130	hsa-miR-3944-3p	CLIP-seq
MIRT2468131	hsa-miR-4254	CLIP-seq
MIRT2468135	hsa-miR-4281	CLIP-seq
MIRT2468137	hsa-miR-4284	CLIP-seq
MIRT1924371	hsa-miR-4286	CLIP-seq
MIRT2468138	hsa-miR-4292	CLIP-seq
MIRT2468140	hsa-miR-4300	CLIP-seq
MIRT2468141	hsa-miR-4308	CLIP-seq
MIRT2468142	hsa-miR-4419b	CLIP-seq
MIRT2468143	hsa-miR-4421	CLIP-seq
MIRT2468146	hsa-miR-4455	CLIP-seq
MIRT2468147	hsa-miR-4478	CLIP-seq
MIRT1924380	hsa-miR-4514	CLIP-seq
MIRT1924381	hsa-miR-4517	CLIP-seq
MIRT2468150	hsa-miR-4633-3p	CLIP-seq
MIRT1924384	hsa-miR-4639-3p	CLIP-seq
MIRT1924386	hsa-miR-4645-5p	CLIP-seq
MIRT1924388	hsa-miR-4651	CLIP-seq
MIRT761015	hsa-miR-4654	CLIP-seq
MIRT1924390	hsa-miR-4667-5p	CLIP-seq
MIRT1924391	hsa-miR-4673	CLIP-seq
MIRT2468152	hsa-miR-4686	CLIP-seq
MIRT1924397	hsa-miR-4690-3p	CLIP-seq
MIRT1924398	hsa-miR-4692	CLIP-seq
MIRT1924399	hsa-miR-4700-5p	CLIP-seq
MIRT2468154	hsa-miR-4707-5p	CLIP-seq
MIRT2468155	hsa-miR-4722-3p	CLIP-seq
MIRT761017	hsa-miR-4722-5p	CLIP-seq
MIRT1924401	hsa-miR-4725-5p	CLIP-seq
MIRT1924403	hsa-miR-4731-5p	CLIP-seq
MIRT2468156	hsa-miR-4745-3p	CLIP-seq
MIRT2468157	hsa-miR-4749-3p	CLIP-seq
MIRT2468158	hsa-miR-4750	CLIP-seq
MIRT2468159	hsa-miR-4755-3p	CLIP-seq
MIRT1924407	hsa-miR-4763-3p	CLIP-seq
MIRT2468160	hsa-miR-4768-3p	CLIP-seq
MIRT761019	hsa-miR-4769-5p	CLIP-seq
MIRT2468161	hsa-miR-4794	CLIP-seq
MIRT2165649	hsa-miR-485-5p	CLIP-seq
MIRT2468162	hsa-miR-502-5p	CLIP-seq
MIRT1924410	hsa-miR-504	CLIP-seq
MIRT1924413	hsa-miR-513a-5p	CLIP-seq
MIRT2468164	hsa-miR-556-5p	CLIP-seq
MIRT2468165	hsa-miR-558	CLIP-seq
MIRT2468166	hsa-miR-582-3p	CLIP-seq
MIRT1924421	hsa-miR-608	CLIP-seq
MIRT2468168	hsa-miR-609	CLIP-seq
MIRT761042	hsa-miR-612	CLIP-seq
MIRT1924423	hsa-miR-637	CLIP-seq
MIRT2468171	hsa-miR-645	CLIP-seq
MIRT2468172	hsa-miR-671-5p	CLIP-seq
MIRT2468173	hsa-miR-767-3p	CLIP-seq
MIRT2468174	hsa-miR-885-3p	CLIP-seq
MIRT2468175	hsa-miR-888	CLIP-seq
MIRT2468176	hsa-miR-892b	CLIP-seq
MIRT2468177	hsa-miR-920	CLIP-seq
MIRT2468180	hsa-miR-939	CLIP-seq
MIRT1924427	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	7479768
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005096	Function	GTPase activator activity	IDA	7479768
GO:0005096	Function	GTPase activator activity	IEA
GO:0005096	Function	GTPase activator activity	TAS	8262969
GO:0005515	Function	Protein binding	IPI	20962234
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007264	Process	Small GTPase-mediated signal transduction	IEA
GO:0007264	Process	Small GTPase-mediated signal transduction	TAS	8262969
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA
GO:0030424	Component	Axon	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043197	Component	Dendritic spine	IEA
GO:0045202	Component	Synapse	IEA
GO:0050804	Process	Modulation of chemical synaptic transmission	ISS
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0090630	Process	Activation of GTPase activity	IDA	7479768
GO:0098685	Component	Schaffer collateral - CA1 synapse	ISS
GO:0098978	Component	Glutamatergic synapse	ISS

Other IDs

• MIM: 600365
• HGNC: 81
• e!Ensembl: ENSG00000159842

Protein

• UniProt ID: Q12979
• Protein name: Active breakpoint cluster region-related protein
• Protein function: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00621	RhoGEF	95 → 282	RhoGEF domain	Domain
  PF00169	PH	302 → 459	PH domain	Domain
  PF00168	C2	504 → 610	C2 domain	Domain
  PF00620	RhoGAP	661 → 813	RhoGAP domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly enriched in the brain. Much weaker expression in heart, lung and muscle.
• Sequence:

  MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQL
  SARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPL
  KATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ
  LGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPI
  DRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETR
  QLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSP
  EESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLL
  NSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCF
  KLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKT
  RVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDP
  QTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKV
  PYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGT
  LKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLK
  RVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQH
  PPISFAELKRNTLYFSTDV

• Sequence length: 859

Pathways

Reactome:

NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ABR-related disorder	Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VITILIGO	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acoustic Neuroma	Acoustic Neuroma	BEFREE	28945052, 29334639		★☆☆☆☆ Found in Text Mining only
Adrenoleukodystrophy	Adrenoleukodystrophy	BEFREE	3127785		★☆☆☆☆ Found in Text Mining only
Adult Medulloblastoma	Medulloblastoma	BEFREE	7829075		★☆☆☆☆ Found in Text Mining only
Anaplastic astrocytoma	Anaplastic Astrocytoma	BEFREE	7536455		★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	23497784		★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	23497784		★☆☆☆☆ Found in Text Mining only
Auditory Perceptual Disorders	Auditory processing disorder	BEFREE	30682902		★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	21388612		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	28703710		★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	BEFREE	30773991		★☆☆☆☆ Found in Text Mining only
Childhood Medulloblastoma	Medulloblastoma	BEFREE	7829075		★☆☆☆☆ Found in Text Mining only
Classical Lissencephalies and Subcortical Band Heterotopias	Lissencephaly	Pubtator	8262969	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	24966994	Associate	★☆☆☆☆ Found in Text Mining only
Conductive hearing loss	Hearing Loss	BEFREE	21982076		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	31071640		★☆☆☆☆ Found in Text Mining only
Hemophilia A	Hemophilia	BEFREE	30091822, 31711245		★☆☆☆☆ Found in Text Mining only
Hemophilia, NOS	Hemophilia	BEFREE	30091822, 31711245		★☆☆☆☆ Found in Text Mining only
Juvenile Pilocytic Astrocytoma	Astrocytoma	BEFREE	7536455		★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	29262589		★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	29262589		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	28703710		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	CTD_human_DG	24763052		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	29966326		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	7898918		★☆☆☆☆ Found in Text Mining only
Medulloblastoma	Medulloblastoma	BEFREE	7829075		★☆☆☆☆ Found in Text Mining only
Miller Dieker syndrome	Miller Dieker Syndrome	BEFREE	8262969		★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	29262589		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28903971, 29262589		★☆☆☆☆ Found in Text Mining only
Neuroectodermal Tumor, Primitive	Neuroectodermal Tumors	BEFREE	8988035		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	29966326		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	20470445		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Prostatic Neoplasms	CTD_human_DG	24763052		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	37650285	Associate	★☆☆☆☆ Found in Text Mining only
Rett Syndrome	Rett Syndrome	BEFREE	3434729		★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	16948864	Associate	★☆☆☆☆ Found in Text Mining only
Sensorineural Hearing Loss (disorder)	Hearing Loss	BEFREE	21982076		★☆☆☆☆ Found in Text Mining only
Skin Erosion	Skin Erosion	BEFREE	30629465		★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	37324256	Associate	★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	37854594	Associate	★☆☆☆☆ Found in Text Mining only
Vitiligo	Vitiligo	BEFREE	28197707		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)	Vitiligo-associated SYSTEMIC LUPUS ERYTHEMATOSUS	BEFREE	28197707		★☆☆☆☆ Found in Text Mining only