Gene Gene information from NCBI Gene database.
Entrez ID 28987
Gene name NIN1 (RPN12) binding protein 1 homolog
Gene symbol NOB1
Synonyms (NCBI Gene)
ART-4MST158MSTP158NOB1PPSMD8BP1
Chromosome 16
Chromosome location 16q22.1
Summary In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, a
miRNA miRNA information provided by mirtarbase database.
215
miRTarBase ID miRNA Experiments Reference
MIRT005263 hsa-miR-16-5p pSILAC 18668040
MIRT020518 hsa-miR-155-5p Proteomics 18668040
MIRT024702 hsa-miR-215-5p Microarray 19074876
MIRT026103 hsa-miR-192-5p Microarray 19074876
MIRT005263 hsa-miR-16-5p Proteomics;Other 18668040
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
GO ID Ontology Definition Evidence Reference
GO:0004518 Function Nuclease activity IEA
GO:0004519 Function Endonuclease activity IEA
GO:0004521 Function RNA endonuclease activity EXP 23439679, 23482395
GO:0004521 Function RNA endonuclease activity IBA
GO:0004521 Function RNA endonuclease activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613586 29540 ENSG00000141101
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9ULX3
Protein name RNA-binding protein NOB1 (EC 3.1.-.-) (Phosphorylation regulatory protein HP-10) (Protein ART-4)
Protein function May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity).
PDB 6G18 , 6G4S , 6G51 , 6G53 , 6G5I , 6ZUO , 6ZXD , 6ZXE , 6ZXF , 7WTW , 7WTX , 7WTZ , 7WU0 , 8ZDC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF17146 PIN_6 7 93 PIN domain of ribonuclease Domain
PF15017 WRNPLPNID 152 212 Putative WW-binding domain and destruction box Disordered
PF08772 NOB1_Zn_bind 260 332 Nin one binding (NOB1) Zn-ribbon like Domain
Tissue specificity TISSUE SPECIFICITY: Detected in liver, lung, placenta, endothelial cells and spleen. {ECO:0000269|PubMed:16172919, ECO:0000269|PubMed:1791827}.
Sequence
MAPVEHVVADAGAFLRHAALQDIGKNIYTIREVVTEIRDKATRRRLAVLPYELRFKEPLP
EYVRLVTEFSKKTGDYPSLSATDIQVLALTYQL
EAEFVGVSHLKQEPQKVKVSSSIQHPE
TPLHISGFHLPYKPKPPQETEKGHSACEPENLEFSSFMFWRNPLPNIDHELQELLIDRGE
DVPSEEEEEEENGFEDRKDDSDDDGGGWITPS
NIKQIQQELEQCDVPEDVRVGCLTTDFA
MQNVLLQMGLHVLAVNGMLIREARSYILRCHGCFKTTSDMSRVFCSHCGNKTLKKVSVTV
SDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGG
KYAINPHLTEDQRFPQLRLSQKARQKTN
VFAPDYIAGVSPFVENDISSRSATLQVRDSTLGAGRRRLNPNASRKKFVKKR
Sequence length 412
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Ribosome biogenesis in eukaryotes   Major pathway of rRNA processing in the nucleolus and cytosol
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Acute myeloid leukemia Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Gastric cancer Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Blast Crisis Blast crisis Pubtator 19654405 Associate
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 22901129
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 35150481 Associate
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 24228091 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Carcinoma BEFREE 24133592, 24228091
★☆☆☆☆
Found in Text Mining only
Carcinoma, Ovarian Epithelial Ovarian Epithelial carcinoma BEFREE 21287298, 26617713, 28337275, 29254193
★☆☆☆☆
Found in Text Mining only
Clear-cell metastatic renal cell carcinoma Renal Carcinoma BEFREE 25010867
★☆☆☆☆
Found in Text Mining only
Colon Carcinoma Colon Carcinoma BEFREE 24824907
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 25624720, 25760058, 29391877
★☆☆☆☆
Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma Renal Carcinoma BEFREE 25010867
★☆☆☆☆
Found in Text Mining only