Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	28978
Gene name	Transmembrane protein 14A
Gene symbol	TMEM14A
Synonyms (NCBI Gene)	C6orf73PTD011
Chromosome	6
Chromosome location	6p12.2

138

Show/Hide all (138)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002540	hsa-miR-373-3p	Microarray	15685193
MIRT019430	hsa-miR-148b-3p	Microarray	17612493
MIRT002540	hsa-miR-373-3p	Microarray;Other	15685193
MIRT025139	hsa-miR-181a-5p	Microarray	17612493
MIRT025971	hsa-miR-148a-3p	Sequencing	20371350
MIRT439437	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439437	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1431369	hsa-miR-181a	CLIP-seq
MIRT1431370	hsa-miR-181b	CLIP-seq
MIRT1431371	hsa-miR-181c	CLIP-seq
MIRT1431372	hsa-miR-181d	CLIP-seq
MIRT1431373	hsa-miR-200b	CLIP-seq
MIRT1431374	hsa-miR-200c	CLIP-seq
MIRT1431375	hsa-miR-3647-3p	CLIP-seq
MIRT1431376	hsa-miR-4262	CLIP-seq
MIRT1431377	hsa-miR-429	CLIP-seq
MIRT1431378	hsa-miR-4427	CLIP-seq
MIRT1431379	hsa-miR-4724-5p	CLIP-seq
MIRT1431380	hsa-miR-664	CLIP-seq
MIRT2129295	hsa-miR-4282	CLIP-seq
MIRT2129296	hsa-miR-570	CLIP-seq
MIRT2350846	hsa-miR-3672	CLIP-seq
MIRT2644438	hsa-miR-1179	CLIP-seq
MIRT2644439	hsa-miR-1206	CLIP-seq
MIRT2644440	hsa-miR-1279	CLIP-seq
MIRT2644441	hsa-miR-129-5p	CLIP-seq
MIRT2644442	hsa-miR-1305	CLIP-seq
MIRT2644443	hsa-miR-208a	CLIP-seq
MIRT2644444	hsa-miR-208b	CLIP-seq
MIRT2644445	hsa-miR-3121-3p	CLIP-seq
MIRT2644446	hsa-miR-3129-3p	CLIP-seq
MIRT2644447	hsa-miR-3148	CLIP-seq
MIRT2644448	hsa-miR-3163	CLIP-seq
MIRT2644449	hsa-miR-3194-3p	CLIP-seq
MIRT2644450	hsa-miR-323-3p	CLIP-seq
MIRT2644451	hsa-miR-3613-3p	CLIP-seq
MIRT2644452	hsa-miR-3616-5p	CLIP-seq
MIRT2644453	hsa-miR-3647-5p	CLIP-seq
MIRT2644454	hsa-miR-3662	CLIP-seq
MIRT2644455	hsa-miR-3671	CLIP-seq
MIRT2350846	hsa-miR-3672	CLIP-seq
MIRT2644456	hsa-miR-3673	CLIP-seq
MIRT2644457	hsa-miR-3688-3p	CLIP-seq
MIRT2644458	hsa-miR-371-5p	CLIP-seq
MIRT2644459	hsa-miR-382	CLIP-seq
MIRT2644460	hsa-miR-3942-5p	CLIP-seq
MIRT2644461	hsa-miR-409-3p	CLIP-seq
MIRT2644462	hsa-miR-410	CLIP-seq
MIRT2644463	hsa-miR-4263	CLIP-seq
MIRT2129295	hsa-miR-4282	CLIP-seq
MIRT2644464	hsa-miR-4422	CLIP-seq
MIRT2644465	hsa-miR-4432	CLIP-seq
MIRT2644466	hsa-miR-4436b-5p	CLIP-seq
MIRT2644467	hsa-miR-4503	CLIP-seq
MIRT2644468	hsa-miR-4645-3p	CLIP-seq
MIRT2644469	hsa-miR-4666-3p	CLIP-seq
MIRT2644470	hsa-miR-4670-3p	CLIP-seq
MIRT2644471	hsa-miR-4677-3p	CLIP-seq
MIRT2644472	hsa-miR-4679	CLIP-seq
MIRT2644473	hsa-miR-4680-5p	CLIP-seq
MIRT2644474	hsa-miR-4694-3p	CLIP-seq
MIRT2644475	hsa-miR-4703-3p	CLIP-seq
MIRT2644476	hsa-miR-4703-5p	CLIP-seq
MIRT2644477	hsa-miR-4777-3p	CLIP-seq
MIRT2644478	hsa-miR-4778-5p	CLIP-seq
MIRT2644479	hsa-miR-496	CLIP-seq
MIRT2644480	hsa-miR-499-5p	CLIP-seq
MIRT2644481	hsa-miR-542-3p	CLIP-seq
MIRT2644482	hsa-miR-548ae	CLIP-seq
MIRT2644483	hsa-miR-548aj	CLIP-seq
MIRT2644484	hsa-miR-548am	CLIP-seq
MIRT2644485	hsa-miR-548x	CLIP-seq
MIRT2129296	hsa-miR-570	CLIP-seq
MIRT2644486	hsa-miR-573	CLIP-seq
MIRT2644487	hsa-miR-576-5p	CLIP-seq
MIRT2644488	hsa-miR-587	CLIP-seq
MIRT2644489	hsa-miR-599	CLIP-seq
MIRT2644490	hsa-miR-607	CLIP-seq
MIRT2644491	hsa-miR-617	CLIP-seq
MIRT2644492	hsa-miR-877	CLIP-seq
MIRT2644493	hsa-miR-885-3p	CLIP-seq
MIRT2644438	hsa-miR-1179	CLIP-seq
MIRT2644439	hsa-miR-1206	CLIP-seq
MIRT2644440	hsa-miR-1279	CLIP-seq
MIRT2644441	hsa-miR-129-5p	CLIP-seq
MIRT2644442	hsa-miR-1305	CLIP-seq
MIRT2644443	hsa-miR-208a	CLIP-seq
MIRT2644444	hsa-miR-208b	CLIP-seq
MIRT2644445	hsa-miR-3121-3p	CLIP-seq
MIRT2644446	hsa-miR-3129-3p	CLIP-seq
MIRT2644447	hsa-miR-3148	CLIP-seq
MIRT2644448	hsa-miR-3163	CLIP-seq
MIRT2644450	hsa-miR-323-3p	CLIP-seq
MIRT2644451	hsa-miR-3613-3p	CLIP-seq
MIRT2644452	hsa-miR-3616-5p	CLIP-seq
MIRT2644453	hsa-miR-3647-5p	CLIP-seq
MIRT2644454	hsa-miR-3662	CLIP-seq
MIRT2350846	hsa-miR-3672	CLIP-seq
MIRT2644456	hsa-miR-3673	CLIP-seq
MIRT2644457	hsa-miR-3688-3p	CLIP-seq
MIRT2644458	hsa-miR-371-5p	CLIP-seq
MIRT2644459	hsa-miR-382	CLIP-seq
MIRT2644460	hsa-miR-3942-5p	CLIP-seq
MIRT2644461	hsa-miR-409-3p	CLIP-seq
MIRT2644462	hsa-miR-410	CLIP-seq
MIRT2129295	hsa-miR-4282	CLIP-seq
MIRT2644464	hsa-miR-4422	CLIP-seq
MIRT2644465	hsa-miR-4432	CLIP-seq
MIRT2644466	hsa-miR-4436b-5p	CLIP-seq
MIRT2693410	hsa-miR-4501	CLIP-seq
MIRT2644467	hsa-miR-4503	CLIP-seq
MIRT2693411	hsa-miR-4504	CLIP-seq
MIRT2644468	hsa-miR-4645-3p	CLIP-seq
MIRT2644469	hsa-miR-4666-3p	CLIP-seq
MIRT2644470	hsa-miR-4670-3p	CLIP-seq
MIRT2644471	hsa-miR-4677-3p	CLIP-seq
MIRT2644472	hsa-miR-4679	CLIP-seq
MIRT2644473	hsa-miR-4680-5p	CLIP-seq
MIRT2644474	hsa-miR-4694-3p	CLIP-seq
MIRT2644475	hsa-miR-4703-3p	CLIP-seq
MIRT2644476	hsa-miR-4703-5p	CLIP-seq
MIRT2644477	hsa-miR-4777-3p	CLIP-seq
MIRT2644478	hsa-miR-4778-5p	CLIP-seq
MIRT2644479	hsa-miR-496	CLIP-seq
MIRT2644480	hsa-miR-499-5p	CLIP-seq
MIRT2644481	hsa-miR-542-3p	CLIP-seq
MIRT2644482	hsa-miR-548ae	CLIP-seq
MIRT2644483	hsa-miR-548aj	CLIP-seq
MIRT2644484	hsa-miR-548am	CLIP-seq
MIRT2644485	hsa-miR-548x	CLIP-seq
MIRT2129296	hsa-miR-570	CLIP-seq
MIRT2644486	hsa-miR-573	CLIP-seq
MIRT2644488	hsa-miR-587	CLIP-seq
MIRT2644489	hsa-miR-599	CLIP-seq
MIRT2644490	hsa-miR-607	CLIP-seq
MIRT2644491	hsa-miR-617	CLIP-seq
MIRT2644492	hsa-miR-877	CLIP-seq
MIRT2644493	hsa-miR-885-3p	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005739	Component	Mitochondrion	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	21723035
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0031966	Component	Mitochondrial membrane	IBA
GO:0031966	Component	Mitochondrial membrane	IDA	21723035
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IMP	21723035
GO:1901029	Process	Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IMP	21723035

MIM	HGNC	e!Ensembl
616870	21076	ENSG00000096092

Q9Y6G1

Protein name

Transmembrane protein 14A

Protein function

Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.

PDB

2LOO , 2LOP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03647	Tmemb_14	3 → 94	Transmembrane proteins 14C	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed at significantly higher levels in ovarian cancer tissues than in normal tissues (at protein level). {ECO:0000269|PubMed:26896463}.

Sequence

MDLIGFGYAALVTFGSIFGYKRRGGVPSLIAGLFVGCLAGYGAYRVSNDKRDVKVSLFTA
FFLATIMGVRFKRSKKIMPAGLVAGLSLMMILRLVLLLL

Sequence length

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (11)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	25148458	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	26896463	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	26896463		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	26896463		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	30853176		★★★★★ ★☆☆☆☆ Found in Text Mining only
Oestrogen receptor positive breast cancer	Oestrogen Receptor Positive Breast Cancer	BEFREE	25148458		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	Pubtator	25148458	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	26896463		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	26896463	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Serous cystadenocarcinoma ovary	Ovarian Serous Cystadenocarcinoma	BEFREE	26896463		★★★★★ ★☆☆☆☆ Found in Text Mining only

TMEM14A (transmembrane protein 14A)