Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	28973
Gene name	Mitochondrial ribosomal protein S18B
Gene symbol	MRPS18B
Synonyms (NCBI Gene)	C6orf14HSPC183HumanS18aMRP-S18-2MRPS18-2PTD017S18amtmS40
Chromosome	6
Chromosome location	6p21.33
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot

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Show/Hide all (230)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029306	hsa-miR-26b-5p	Microarray	19088304
MIRT041787	hsa-miR-484	CLASH	23622248
MIRT040153	hsa-miR-615-3p	CLASH	23622248
MIRT317415	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT317412	hsa-miR-320a	PAR-CLIP	20371350
MIRT317413	hsa-miR-320b	PAR-CLIP	20371350
MIRT317414	hsa-miR-320c	PAR-CLIP	20371350
MIRT317416	hsa-miR-320d	PAR-CLIP	20371350
MIRT317417	hsa-miR-4429	PAR-CLIP	20371350
MIRT100247	hsa-miR-4445-3p	PAR-CLIP	20371350
MIRT100248	hsa-miR-548al	PAR-CLIP	20371350
MIRT100250	hsa-miR-4682	PAR-CLIP	20371350
MIRT564376	hsa-miR-219a-1-3p	PAR-CLIP	20371350
MIRT100244	hsa-miR-571	PAR-CLIP	20371350
MIRT317420	hsa-miR-8077	PAR-CLIP	20371350
MIRT100249	hsa-miR-4650-3p	PAR-CLIP	20371350
MIRT564375	hsa-miR-3529-5p	PAR-CLIP	20371350
MIRT564374	hsa-miR-379-5p	PAR-CLIP	20371350
MIRT564373	hsa-miR-4451	PAR-CLIP	20371350
MIRT317415	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT317412	hsa-miR-320a	PAR-CLIP	20371350
MIRT317413	hsa-miR-320b	PAR-CLIP	20371350
MIRT317414	hsa-miR-320c	PAR-CLIP	20371350
MIRT317416	hsa-miR-320d	PAR-CLIP	20371350
MIRT317417	hsa-miR-4429	PAR-CLIP	20371350
MIRT100247	hsa-miR-4445-3p	PAR-CLIP	20371350
MIRT100248	hsa-miR-548al	PAR-CLIP	20371350
MIRT100250	hsa-miR-4682	PAR-CLIP	20371350
MIRT564376	hsa-miR-219a-1-3p	PAR-CLIP	20371350
MIRT100244	hsa-miR-571	PAR-CLIP	20371350
MIRT317420	hsa-miR-8077	PAR-CLIP	20371350
MIRT100249	hsa-miR-4650-3p	PAR-CLIP	20371350
MIRT564375	hsa-miR-3529-5p	PAR-CLIP	20371350
MIRT564374	hsa-miR-379-5p	PAR-CLIP	20371350
MIRT564373	hsa-miR-4451	PAR-CLIP	20371350
MIRT1159892	hsa-miR-122	CLIP-seq
MIRT1159893	hsa-miR-1224-3p	CLIP-seq
MIRT1159894	hsa-miR-1245	CLIP-seq
MIRT1159895	hsa-miR-1281	CLIP-seq
MIRT1159896	hsa-miR-1290	CLIP-seq
MIRT1159897	hsa-miR-129-5p	CLIP-seq
MIRT1159898	hsa-miR-134	CLIP-seq
MIRT1159899	hsa-miR-1343	CLIP-seq
MIRT1159900	hsa-miR-181a	CLIP-seq
MIRT1159901	hsa-miR-181b	CLIP-seq
MIRT1159902	hsa-miR-181c	CLIP-seq
MIRT1159903	hsa-miR-181d	CLIP-seq
MIRT1159904	hsa-miR-1909	CLIP-seq
MIRT1159905	hsa-miR-193a-3p	CLIP-seq
MIRT1159906	hsa-miR-193b	CLIP-seq
MIRT1159907	hsa-miR-197	CLIP-seq
MIRT1159908	hsa-miR-3074-5p	CLIP-seq
MIRT1159909	hsa-miR-3118	CLIP-seq
MIRT1159910	hsa-miR-3127-5p	CLIP-seq
MIRT1159911	hsa-miR-3135b	CLIP-seq
MIRT1159912	hsa-miR-3164	CLIP-seq
MIRT1159913	hsa-miR-3167	CLIP-seq
MIRT1159914	hsa-miR-3652	CLIP-seq
MIRT1159915	hsa-miR-3663-5p	CLIP-seq
MIRT1159916	hsa-miR-3672	CLIP-seq
MIRT1159917	hsa-miR-3680	CLIP-seq
MIRT1159918	hsa-miR-3689a-5p	CLIP-seq
MIRT1159919	hsa-miR-3689b	CLIP-seq
MIRT1159920	hsa-miR-3689e	CLIP-seq
MIRT1159921	hsa-miR-3689f	CLIP-seq
MIRT1159922	hsa-miR-3690	CLIP-seq
MIRT1159923	hsa-miR-383	CLIP-seq
MIRT1159924	hsa-miR-3934	CLIP-seq
MIRT1159925	hsa-miR-4254	CLIP-seq
MIRT1159926	hsa-miR-4262	CLIP-seq
MIRT1159927	hsa-miR-4430	CLIP-seq
MIRT1159928	hsa-miR-4455	CLIP-seq
MIRT1159929	hsa-miR-450b-3p	CLIP-seq
MIRT1159930	hsa-miR-4690-3p	CLIP-seq
MIRT1159931	hsa-miR-4701-5p	CLIP-seq
MIRT1159932	hsa-miR-4713-3p	CLIP-seq
MIRT1159933	hsa-miR-4733-5p	CLIP-seq
MIRT1159934	hsa-miR-4772-3p	CLIP-seq
MIRT1159935	hsa-miR-4772-5p	CLIP-seq
MIRT1159936	hsa-miR-5096	CLIP-seq
MIRT1159937	hsa-miR-543	CLIP-seq
MIRT1159938	hsa-miR-545	CLIP-seq
MIRT1159939	hsa-miR-548u	CLIP-seq
MIRT1159940	hsa-miR-552	CLIP-seq
MIRT1159941	hsa-miR-579	CLIP-seq
MIRT1159942	hsa-miR-588	CLIP-seq
MIRT1159943	hsa-miR-638	CLIP-seq
MIRT1159944	hsa-miR-664	CLIP-seq
MIRT1159945	hsa-miR-668	CLIP-seq
MIRT1159946	hsa-miR-767-5p	CLIP-seq
MIRT1159947	hsa-miR-769-3p	CLIP-seq
MIRT1159948	hsa-miR-876-5p	CLIP-seq
MIRT1159949	hsa-miR-891b	CLIP-seq
MIRT1159892	hsa-miR-122	CLIP-seq
MIRT1159898	hsa-miR-134	CLIP-seq
MIRT1159899	hsa-miR-1343	CLIP-seq
MIRT1159904	hsa-miR-1909	CLIP-seq
MIRT1159905	hsa-miR-193a-3p	CLIP-seq
MIRT1159906	hsa-miR-193b	CLIP-seq
MIRT1159909	hsa-miR-3118	CLIP-seq
MIRT1159910	hsa-miR-3127-5p	CLIP-seq
MIRT1159911	hsa-miR-3135b	CLIP-seq
MIRT1159912	hsa-miR-3164	CLIP-seq
MIRT1159914	hsa-miR-3652	CLIP-seq
MIRT1159915	hsa-miR-3663-5p	CLIP-seq
MIRT1159918	hsa-miR-3689a-5p	CLIP-seq
MIRT1159919	hsa-miR-3689b	CLIP-seq
MIRT1159920	hsa-miR-3689e	CLIP-seq
MIRT1159921	hsa-miR-3689f	CLIP-seq
MIRT2045931	hsa-miR-371-5p	CLIP-seq
MIRT2045932	hsa-miR-371b-5p	CLIP-seq
MIRT1159927	hsa-miR-4430	CLIP-seq
MIRT1159928	hsa-miR-4455	CLIP-seq
MIRT1159929	hsa-miR-450b-3p	CLIP-seq
MIRT2045933	hsa-miR-4643	CLIP-seq
MIRT2045934	hsa-miR-466	CLIP-seq
MIRT1159931	hsa-miR-4701-5p	CLIP-seq
MIRT1159932	hsa-miR-4713-3p	CLIP-seq
MIRT1159933	hsa-miR-4733-5p	CLIP-seq
MIRT2045935	hsa-miR-4789-3p	CLIP-seq
MIRT2045936	hsa-miR-554	CLIP-seq
MIRT1159942	hsa-miR-588	CLIP-seq
MIRT1159943	hsa-miR-638	CLIP-seq
MIRT1159945	hsa-miR-668	CLIP-seq
MIRT1159947	hsa-miR-769-3p	CLIP-seq
MIRT2274975	hsa-miR-106a	CLIP-seq
MIRT2274976	hsa-miR-106b	CLIP-seq
MIRT1159893	hsa-miR-1224-3p	CLIP-seq
MIRT1159895	hsa-miR-1281	CLIP-seq
MIRT1159896	hsa-miR-1290	CLIP-seq
MIRT1159898	hsa-miR-134	CLIP-seq
MIRT1159899	hsa-miR-1343	CLIP-seq
MIRT2274977	hsa-miR-17	CLIP-seq
MIRT1159900	hsa-miR-181a	CLIP-seq
MIRT1159901	hsa-miR-181b	CLIP-seq
MIRT1159902	hsa-miR-181c	CLIP-seq
MIRT1159903	hsa-miR-181d	CLIP-seq
MIRT1159905	hsa-miR-193a-3p	CLIP-seq
MIRT1159906	hsa-miR-193b	CLIP-seq
MIRT1159907	hsa-miR-197	CLIP-seq
MIRT2274978	hsa-miR-20a	CLIP-seq
MIRT2274979	hsa-miR-20b	CLIP-seq
MIRT2274980	hsa-miR-302a	CLIP-seq
MIRT2274981	hsa-miR-302b	CLIP-seq
MIRT2274982	hsa-miR-302c	CLIP-seq
MIRT2274983	hsa-miR-302d	CLIP-seq
MIRT2274984	hsa-miR-302e	CLIP-seq
MIRT1159908	hsa-miR-3074-5p	CLIP-seq
MIRT1159909	hsa-miR-3118	CLIP-seq
MIRT1159910	hsa-miR-3127-5p	CLIP-seq
MIRT1159912	hsa-miR-3164	CLIP-seq
MIRT1159913	hsa-miR-3167	CLIP-seq
MIRT1159915	hsa-miR-3663-5p	CLIP-seq
MIRT1159918	hsa-miR-3689a-5p	CLIP-seq
MIRT1159919	hsa-miR-3689b	CLIP-seq
MIRT1159920	hsa-miR-3689e	CLIP-seq
MIRT1159921	hsa-miR-3689f	CLIP-seq
MIRT1159922	hsa-miR-3690	CLIP-seq
MIRT2045931	hsa-miR-371-5p	CLIP-seq
MIRT2045932	hsa-miR-371b-5p	CLIP-seq
MIRT2274985	hsa-miR-372	CLIP-seq
MIRT2274986	hsa-miR-373	CLIP-seq
MIRT1159925	hsa-miR-4254	CLIP-seq
MIRT1159926	hsa-miR-4262	CLIP-seq
MIRT2274987	hsa-miR-4433	CLIP-seq
MIRT2045933	hsa-miR-4643	CLIP-seq
MIRT2274988	hsa-miR-4645-3p	CLIP-seq
MIRT2045934	hsa-miR-466	CLIP-seq
MIRT1159930	hsa-miR-4690-3p	CLIP-seq
MIRT2274989	hsa-miR-4700-3p	CLIP-seq
MIRT1159931	hsa-miR-4701-5p	CLIP-seq
MIRT2274990	hsa-miR-4731-5p	CLIP-seq
MIRT2274991	hsa-miR-4732-5p	CLIP-seq
MIRT1159933	hsa-miR-4733-5p	CLIP-seq
MIRT1159934	hsa-miR-4772-3p	CLIP-seq
MIRT2045935	hsa-miR-4789-3p	CLIP-seq
MIRT2274992	hsa-miR-5095	CLIP-seq
MIRT1159936	hsa-miR-5096	CLIP-seq
MIRT2274993	hsa-miR-512-3p	CLIP-seq
MIRT2274994	hsa-miR-519d	CLIP-seq
MIRT2274995	hsa-miR-520a-3p	CLIP-seq
MIRT2274996	hsa-miR-520b	CLIP-seq
MIRT2274997	hsa-miR-520c-3p	CLIP-seq
MIRT2274998	hsa-miR-520d-3p	CLIP-seq
MIRT2274999	hsa-miR-520e	CLIP-seq
MIRT2275000	hsa-miR-520g	CLIP-seq
MIRT2275001	hsa-miR-520h	CLIP-seq
MIRT1159937	hsa-miR-543	CLIP-seq
MIRT1159938	hsa-miR-545	CLIP-seq
MIRT1159941	hsa-miR-579	CLIP-seq
MIRT1159942	hsa-miR-588	CLIP-seq
MIRT1159944	hsa-miR-664	CLIP-seq
MIRT1159945	hsa-miR-668	CLIP-seq
MIRT1159948	hsa-miR-876-5p	CLIP-seq
MIRT2275002	hsa-miR-93	CLIP-seq
MIRT2275003	hsa-miR-936	CLIP-seq
MIRT2391075	hsa-miR-1236	CLIP-seq
MIRT1159894	hsa-miR-1245	CLIP-seq
MIRT1159895	hsa-miR-1281	CLIP-seq
MIRT1159897	hsa-miR-129-5p	CLIP-seq
MIRT1159899	hsa-miR-1343	CLIP-seq
MIRT2573975	hsa-miR-3149	CLIP-seq
MIRT2573976	hsa-miR-3170	CLIP-seq
MIRT2573977	hsa-miR-338-5p	CLIP-seq
MIRT1159916	hsa-miR-3672	CLIP-seq
MIRT1159924	hsa-miR-3934	CLIP-seq
MIRT1159929	hsa-miR-450b-3p	CLIP-seq
MIRT1159930	hsa-miR-4690-3p	CLIP-seq
MIRT2573978	hsa-miR-4699-3p	CLIP-seq
MIRT1159932	hsa-miR-4713-3p	CLIP-seq
MIRT2573979	hsa-miR-4735-5p	CLIP-seq
MIRT2573980	hsa-miR-4775	CLIP-seq
MIRT1159939	hsa-miR-548u	CLIP-seq
MIRT1159940	hsa-miR-552	CLIP-seq
MIRT2573981	hsa-miR-590-3p	CLIP-seq
MIRT1159943	hsa-miR-638	CLIP-seq
MIRT1159946	hsa-miR-767-5p	CLIP-seq
MIRT1159947	hsa-miR-769-3p	CLIP-seq
MIRT1159897	hsa-miR-129-5p	CLIP-seq
MIRT2573975	hsa-miR-3149	CLIP-seq
MIRT2573977	hsa-miR-338-5p	CLIP-seq
MIRT1159916	hsa-miR-3672	CLIP-seq
MIRT1159924	hsa-miR-3934	CLIP-seq
MIRT1159930	hsa-miR-4690-3p	CLIP-seq
MIRT2573978	hsa-miR-4699-3p	CLIP-seq
MIRT2573979	hsa-miR-4735-5p	CLIP-seq
MIRT2573980	hsa-miR-4775	CLIP-seq
MIRT1159940	hsa-miR-552	CLIP-seq
MIRT2573981	hsa-miR-590-3p	CLIP-seq
MIRT1159946	hsa-miR-767-5p	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	ISS	11402041
GO:0003735	Function	Structural constituent of ribosome	NAS	11279123
GO:0005515	Function	Protein binding	IPI	18391203, 22003127, 28514442, 30021884, 32296183, 33961781
GO:0005654	Component	Nucleoplasm	IDA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	27023846
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005763	Component	Mitochondrial small ribosomal subunit	IDA	25838379
GO:0005763	Component	Mitochondrial small ribosomal subunit	IEA
GO:0005763	Component	Mitochondrial small ribosomal subunit	ISS	11402041
GO:0005763	Component	Mitochondrial small ribosomal subunit	NAS	11279123, 25838379
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	11279123
GO:0030054	Component	Cell junction	IDA
GO:0032543	Process	Mitochondrial translation	IEA
GO:0032543	Process	Mitochondrial translation	ISS	11402041
GO:0032543	Process	Mitochondrial translation	NAS	27023846
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
611982	14516	ENSG00000204568

Q9Y676

Protein name

Small ribosomal subunit protein mS40 (28S ribosomal protein S18-2, mitochondrial) (MRP-S18-2) (28S ribosomal protein S18b, mitochondrial) (MRP-S18-b) (Mrps18-b) (S18mt-b) (Small ribosomal subunit protein bS18b)

PDB

3J9M , 6NU2 , 6NU3 , 6RW4 , 6RW5 , 6VLZ , 6VMI , 6ZM5 , 6ZM6 , 6ZS9 , 6ZSA , 6ZSB , 6ZSC , 6ZSD , 6ZSE , 6ZSG , 7A5F , 7A5G , 7A5I , 7A5K , 7L08 , 7OG4 , 7P2E , 7PNX , 7PNY , 7PNZ , 7PO0 , 7PO1 , 7PO2 , 7PO3 , 7QI4 , 7QI5 , 7QI6 , 8ANY , 8CSP , 8CSQ , 8CSR , 8CSS , 8CST , 8CSU , 8K2A , 8OIR , 8OIS , 8QRK , 8QRL , 8QRM , 8QRN , 8RRI , 8XT0 , 8XT2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01084	Ribosomal_S18	111 → 163	Ribosomal protein S18	Family

Sequence

MAASVLNTVLRRLPMLSLFRGSHRVQVPLQTLCTKAPSEEDSLSSVPISPYKDEPWKYLE
SEEYQERYGSRPVWADYRRNHKGGVPPQRTRKTCIRRNKVVGNPCPICRDHKLHVDFRNV
KLLEQFVCAHTGIIFYAPYTGVCVKQHKRLTQAIQKARDHGLLIYHIPQVEPRDLDFSTS
HGAVSATPPAPTLVSGDPWYPWYNWKQPPERELSRLRRLYQGHLQEESGPPPESMPKMPP
RTPAEASSTGQTGPQSAL

Sequence length

258

Interactions

View interactions

	KEGG		Reactome
	Viral carcinogenesis		Mitochondrial translation elongation Mitochondrial translation termination

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
NEUROBLASTOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIATIC ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STOMACH NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (10)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Arthritis, Psoriatic	Psoriatic Arthritis	GWASCAT_DG	30552173		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Carcinoma	Endometrial carcinoma	BEFREE	29396484		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Diffuse Gastric Cancer	Gastric Cancer	CTD_human_DG	21364753		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	29104783		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of endometrium	Endometrial Cancer	BEFREE	29396484		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	CTD_human_DG	21364753		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	32599975	Stimulate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pleural Diseases	Pleural diseases	Pubtator	32365959	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	29396484		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach Neoplasms	CTD_human_DG	21364753		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

MRPS18B (mitochondrial ribosomal protein S18B)