DCPS (decapping enzyme, scavenger)

Gene Gene information from NCBI Gene database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 28960
Gene name Decapping enzyme, scavenger
Gene symbol DCPS
Synonyms (NCBI Gene)
ARSDCS1HINT-5HINT5HSL1HSPC015
Chromosome 11
Chromosome location 11q24.2
Summary This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosom
SNPs SNP information provided by dbSNP.
5
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (5)
SNP ID Visualize variation Clinical significance Consequence
rs138737928 C>T Pathogenic Coding sequence variant, missense variant
rs147935593 G>T Conflicting-interpretations-of-pathogenicity Missense variant, coding sequence variant
rs556401323 C>T Likely-pathogenic Missense variant, coding sequence variant
rs770528538 G>A,T Pathogenic Splice donor variant
rs1057519083 T>C Pathogenic Missense variant, coding sequence variant, splice donor variant
miRNA miRNA information provided by mirtarbase database.
190
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (190)
miRTarBase ID miRNA Experiments Reference
MIRT041500 hsa-miR-193b-3p CLASH 23622248
MIRT461052 hsa-miR-4695-5p HITS-CLIP 23706177
MIRT461051 hsa-miR-1910-3p HITS-CLIP 23706177
MIRT461050 hsa-miR-6511a-5p HITS-CLIP 23706177
MIRT461049 hsa-miR-3174 HITS-CLIP 23706177
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
28
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (28)
GO ID Ontology Definition Evidence Reference
GO:0000288 Process Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
GO:0000288 Process Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS 12198172, 15383679, 22985415
GO:0000290 Process Deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
GO:0000290 Process Deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
GO:0000340 Function RNA 7-methylguanosine cap binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
610534 29812 ENSG00000110063
Protein Protein information from UniProt database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96C86
Protein name m7GpppX diphosphatase (EC 3.6.1.59) (DCS-1) (Decapping scavenger enzyme) (Hint-related 7meGMP-directed hydrolase) (Histidine triad nucleotide-binding protein 5) (Histidine triad protein member 5) (HINT-5) (Scavenger mRNA-decapping enzyme DcpS)
Protein function Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosph
PDB 1ST0 , 1ST4 , 1XML , 1XMM , 3BL7 , 3BL9 , 3BLA , 4QDE , 4QDV , 4QEB , 5OSY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05652 DcpS 43 → 146 Scavenger mRNA decapping enzyme (DcpS) N-terminal Family
PF11969 DcpS_C 174 → 294 Family
Tissue specificity TISSUE SPECIFICITY: Detected in liver, brain, kidney, testis and prostate. {ECO:0000269|PubMed:12871939}.
Sequence
Sequence length 337
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  RNA degradation   mRNA decay by 3' to 5' exoribonuclease
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Causal Diseases (1)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Al-Raqad syndrome Likely pathogenic; Pathogenic rs904572688, rs768872827, rs2497258001, rs1057519083, rs770528538, rs138737928 RCV001806794
RCV003155876
RCV004018049
RCV000412501
RCV000412559
View all (1 more)
★★★★★
★★★★★
ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (2)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
AUTOSOMAL RECESSIVE NON-SYNDROMIC INTELLECTUAL DISABILITY — Disgenet, Orphanet
Disgenet, Orphanet
Disgenet, Orphanet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DCPS-related disorder Likely benign; Benign ClinVar
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (66)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Absence of septum pellucidum Absence Of Septum Pellucidum HPO_DG
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult type dermatomyositis Dermatomyositis BEFREE 25903820, 31779485
★★★★★
★☆☆☆☆
Found in Text Mining only
AL-RAQAD SYNDROME AL-Raqad Syndrome UNIPROT_DG 25701870, 25712129
★★★★★
★★★★★
ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
AL-RAQAD SYNDROME AL-Raqad Syndrome GENOMICS_ENGLAND_DG 25712129
★★★★★
★★★★★
ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
AL-RAQAD SYNDROME AL-Raqad Syndrome BEFREE 30289615
★★★★★
★★★★★
ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
AL-RAQAD SYNDROME AL-Raqad Syndrome CLINVAR_DG
★★★★★
★★★★★
ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
AL-RAQAD SYNDROME AL-Raqad Syndrome CTD_human_DG
★★★★★
★★★★★
ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Aniridia Aniridia BEFREE 27929720
★★★★★
★☆☆☆☆
Found in Text Mining only
Antisynthetase syndrome Antithrombin deficiency Pubtator 28586844 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Autistic behavior Autism HPO_DG
★★★★★
★☆☆☆☆
Found in Text Mining only