Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID	28951
Gene name	Tribbles pseudokinase 2
Gene symbol	TRIB2
Synonyms (NCBI Gene)	C5FWGS3955TRB2
Chromosome	2
Chromosome location	2p24.3
Summary	This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles protein

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miRTarBase ID	miRNA	Experiments	Reference
MIRT007037	hsa-miR-511-5p	GFP reporter assay	23071539
MIRT007038	hsa-miR-1297	GFP reporter assay	23071539
MIRT044275	hsa-miR-106b-5p	CLASH	23622248
MIRT438664	hsa-let-7c-5p	FlowGFP reporter assayqRT-PCRWestern blot	23850892
MIRT298003	hsa-miR-99a-5p	Luciferase reporter assay	24191888
MIRT298003	hsa-miR-99a-5p	Luciferase reporter assay	24191888
MIRT438664	hsa-let-7c-5p	FlowGFP reporter assayqRT-PCRWestern blot	23850892
MIRT298003	hsa-miR-99a-5p	Luciferase reporter assay	24191888
MIRT298003	hsa-miR-99a-5p	Luciferase reporter assay	24191888
MIRT612340	hsa-miR-548ac	HITS-CLIP	23824327
MIRT612339	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT612338	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT612337	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT612336	hsa-miR-548z	HITS-CLIP	23824327
MIRT612335	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT612334	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT612333	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT621484	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT621483	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT612332	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT612331	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT612330	hsa-miR-6880-3p	HITS-CLIP	23824327
MIRT612329	hsa-miR-6886-3p	HITS-CLIP	23824327
MIRT612340	hsa-miR-548ac	HITS-CLIP	23824327
MIRT612339	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT612338	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT612337	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT612336	hsa-miR-548z	HITS-CLIP	23824327
MIRT612334	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT612333	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT621484	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT621483	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT612332	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT612331	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT612330	hsa-miR-6880-3p	HITS-CLIP	23824327
MIRT612329	hsa-miR-6886-3p	HITS-CLIP	23824327
MIRT612340	hsa-miR-548ac	HITS-CLIP	23824327
MIRT612339	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT612338	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT612337	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT612336	hsa-miR-548z	HITS-CLIP	23824327
MIRT612335	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT612334	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT612333	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT612332	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT612331	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT612330	hsa-miR-6880-3p	HITS-CLIP	23824327
MIRT612329	hsa-miR-6886-3p	HITS-CLIP	23824327
MIRT612340	hsa-miR-548ac	HITS-CLIP	23824327
MIRT612339	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT612338	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT612337	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT612336	hsa-miR-548z	HITS-CLIP	23824327
MIRT612335	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT612334	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT612333	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT621484	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT621483	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT612332	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT612331	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT612330	hsa-miR-6880-3p	HITS-CLIP	23824327
MIRT612329	hsa-miR-6886-3p	HITS-CLIP	23824327
MIRT612340	hsa-miR-548ac	HITS-CLIP	23824327
MIRT612339	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT612338	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT612337	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT612336	hsa-miR-548z	HITS-CLIP	23824327
MIRT612335	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT612334	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT612333	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT612332	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT612331	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT612330	hsa-miR-6880-3p	HITS-CLIP	23824327
MIRT612329	hsa-miR-6886-3p	HITS-CLIP	23824327
MIRT612340	hsa-miR-548ac	HITS-CLIP	23824327
MIRT612339	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT612338	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT612337	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT612336	hsa-miR-548z	HITS-CLIP	23824327
MIRT612335	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT612334	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT612333	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT612332	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT612331	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT612330	hsa-miR-6880-3p	HITS-CLIP	23824327
MIRT612329	hsa-miR-6886-3p	HITS-CLIP	23824327
MIRT612340	hsa-miR-548ac	HITS-CLIP	23824327
MIRT612339	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT612338	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT612337	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT612336	hsa-miR-548z	HITS-CLIP	23824327
MIRT612335	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT612334	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT612333	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT621484	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT621483	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT612332	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT612331	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT612330	hsa-miR-6880-3p	HITS-CLIP	23824327
MIRT612329	hsa-miR-6886-3p	HITS-CLIP	23824327
MIRT612340	hsa-miR-548ac	HITS-CLIP	23824327
MIRT612339	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT612338	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT612337	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT612336	hsa-miR-548z	HITS-CLIP	23824327
MIRT612334	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT612333	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT621484	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT621483	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT612332	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT612331	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT612330	hsa-miR-6880-3p	HITS-CLIP	23824327
MIRT612329	hsa-miR-6886-3p	HITS-CLIP	23824327
MIRT612340	hsa-miR-548ac	HITS-CLIP	23824327
MIRT612339	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT612338	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT612337	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT612336	hsa-miR-548z	HITS-CLIP	23824327
MIRT612335	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT612334	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT612333	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT612332	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT612331	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT612330	hsa-miR-6880-3p	HITS-CLIP	23824327
MIRT612329	hsa-miR-6886-3p	HITS-CLIP	23824327
MIRT612340	hsa-miR-548ac	HITS-CLIP	23824327
MIRT612339	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT612338	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT612337	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT612336	hsa-miR-548z	HITS-CLIP	23824327
MIRT612335	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT612334	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT612333	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT621484	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT621483	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT612332	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT612331	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT612330	hsa-miR-6880-3p	HITS-CLIP	23824327
MIRT612329	hsa-miR-6886-3p	HITS-CLIP	23824327
MIRT612340	hsa-miR-548ac	HITS-CLIP	23824327
MIRT612339	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT612338	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT612337	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT612336	hsa-miR-548z	HITS-CLIP	23824327
MIRT612335	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT612334	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT612333	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT612332	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT612331	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT612330	hsa-miR-6880-3p	HITS-CLIP	23824327
MIRT612329	hsa-miR-6886-3p	HITS-CLIP	23824327
MIRT612340	hsa-miR-548ac	HITS-CLIP	23824327
MIRT612339	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT612338	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT612337	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT612336	hsa-miR-548z	HITS-CLIP	23824327
MIRT612335	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT612334	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT612333	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT612332	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT612331	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT612330	hsa-miR-6880-3p	HITS-CLIP	23824327
MIRT612329	hsa-miR-6886-3p	HITS-CLIP	23824327
MIRT1452746	hsa-let-7a	CLIP-seq
MIRT1452747	hsa-let-7b	CLIP-seq
MIRT1452748	hsa-let-7c	CLIP-seq
MIRT1452749	hsa-let-7d	CLIP-seq
MIRT1452750	hsa-let-7e	CLIP-seq
MIRT1452751	hsa-let-7f	CLIP-seq
MIRT1452752	hsa-let-7g	CLIP-seq
MIRT1452753	hsa-let-7i	CLIP-seq
MIRT1452754	hsa-miR-100	CLIP-seq
MIRT1452755	hsa-miR-125a-5p	CLIP-seq
MIRT1452756	hsa-miR-125b	CLIP-seq
MIRT1452757	hsa-miR-1278	CLIP-seq
MIRT1452758	hsa-miR-1290	CLIP-seq
MIRT1452759	hsa-miR-1292	CLIP-seq
MIRT1452760	hsa-miR-1294	CLIP-seq
MIRT1452761	hsa-miR-132	CLIP-seq
MIRT1452762	hsa-miR-146b-3p	CLIP-seq
MIRT1452763	hsa-miR-193a-3p	CLIP-seq
MIRT1452764	hsa-miR-193b	CLIP-seq
MIRT1452765	hsa-miR-202	CLIP-seq
MIRT1452766	hsa-miR-2054	CLIP-seq
MIRT1452767	hsa-miR-212	CLIP-seq
MIRT1452768	hsa-miR-22	CLIP-seq
MIRT1452769	hsa-miR-2682	CLIP-seq
MIRT1452770	hsa-miR-3120-3p	CLIP-seq
MIRT1452771	hsa-miR-3121-3p	CLIP-seq
MIRT1452772	hsa-miR-3140-5p	CLIP-seq
MIRT1452773	hsa-miR-3167	CLIP-seq
MIRT1452774	hsa-miR-3173-5p	CLIP-seq
MIRT1452775	hsa-miR-340	CLIP-seq
MIRT1452776	hsa-miR-3616-5p	CLIP-seq
MIRT1452777	hsa-miR-3619-3p	CLIP-seq
MIRT1452778	hsa-miR-3647-5p	CLIP-seq
MIRT1452779	hsa-miR-3667-3p	CLIP-seq
MIRT1452780	hsa-miR-3691-3p	CLIP-seq
MIRT1452781	hsa-miR-377	CLIP-seq
MIRT1452782	hsa-miR-380	CLIP-seq
MIRT1452783	hsa-miR-4319	CLIP-seq
MIRT1452784	hsa-miR-4326	CLIP-seq
MIRT1452785	hsa-miR-4458	CLIP-seq
MIRT1452786	hsa-miR-4471	CLIP-seq
MIRT1452787	hsa-miR-449c	CLIP-seq
MIRT1452788	hsa-miR-4500	CLIP-seq
MIRT1452789	hsa-miR-4517	CLIP-seq
MIRT1452790	hsa-miR-4646-5p	CLIP-seq
MIRT1452791	hsa-miR-4659a-3p	CLIP-seq
MIRT1452792	hsa-miR-4659b-3p	CLIP-seq
MIRT1452793	hsa-miR-4670-3p	CLIP-seq
MIRT1452794	hsa-miR-4700-3p	CLIP-seq
MIRT1452795	hsa-miR-4719	CLIP-seq
MIRT1452796	hsa-miR-4732-3p	CLIP-seq
MIRT1452797	hsa-miR-4733-5p	CLIP-seq
MIRT1452798	hsa-miR-4742-3p	CLIP-seq
MIRT1452799	hsa-miR-4753-3p	CLIP-seq
MIRT1452800	hsa-miR-4762-5p	CLIP-seq
MIRT1452801	hsa-miR-4778-3p	CLIP-seq
MIRT1452802	hsa-miR-4789-5p	CLIP-seq
MIRT1452803	hsa-miR-513b	CLIP-seq
MIRT1452804	hsa-miR-573	CLIP-seq
MIRT1452805	hsa-miR-606	CLIP-seq
MIRT1452806	hsa-miR-670	CLIP-seq
MIRT1452807	hsa-miR-874	CLIP-seq
MIRT1452808	hsa-miR-876-5p	CLIP-seq
MIRT1452809	hsa-miR-892b	CLIP-seq
MIRT1452810	hsa-miR-98	CLIP-seq
MIRT1452811	hsa-miR-99a	CLIP-seq
MIRT1452812	hsa-miR-99b	CLIP-seq
MIRT2135609	hsa-miR-1229	CLIP-seq
MIRT1452757	hsa-miR-1278	CLIP-seq
MIRT2135610	hsa-miR-4422	CLIP-seq
MIRT2135611	hsa-miR-4738-5p	CLIP-seq
MIRT2135612	hsa-miR-4755-3p	CLIP-seq
MIRT2135613	hsa-miR-766	CLIP-seq
MIRT1452746	hsa-let-7a	CLIP-seq
MIRT1452747	hsa-let-7b	CLIP-seq
MIRT1452748	hsa-let-7c	CLIP-seq
MIRT1452749	hsa-let-7d	CLIP-seq
MIRT1452750	hsa-let-7e	CLIP-seq
MIRT1452751	hsa-let-7f	CLIP-seq
MIRT1452752	hsa-let-7g	CLIP-seq
MIRT1452753	hsa-let-7i	CLIP-seq
MIRT1452754	hsa-miR-100	CLIP-seq
MIRT2356739	hsa-miR-103b	CLIP-seq
MIRT2356740	hsa-miR-1237	CLIP-seq
MIRT2356741	hsa-miR-1248	CLIP-seq
MIRT1452757	hsa-miR-1278	CLIP-seq
MIRT1452760	hsa-miR-1294	CLIP-seq
MIRT1452763	hsa-miR-193a-3p	CLIP-seq
MIRT1452764	hsa-miR-193b	CLIP-seq
MIRT1452765	hsa-miR-202	CLIP-seq
MIRT2356742	hsa-miR-3074-3p	CLIP-seq
MIRT1452776	hsa-miR-3616-5p	CLIP-seq
MIRT1452778	hsa-miR-3647-5p	CLIP-seq
MIRT1452780	hsa-miR-3691-3p	CLIP-seq
MIRT2356743	hsa-miR-371-5p	CLIP-seq
MIRT2356744	hsa-miR-374c	CLIP-seq
MIRT1452785	hsa-miR-4458	CLIP-seq
MIRT1452788	hsa-miR-4500	CLIP-seq
MIRT1452797	hsa-miR-4733-5p	CLIP-seq
MIRT1452800	hsa-miR-4762-5p	CLIP-seq
MIRT2356745	hsa-miR-514	CLIP-seq
MIRT2356746	hsa-miR-514b-3p	CLIP-seq
MIRT2356747	hsa-miR-526b	CLIP-seq
MIRT2356748	hsa-miR-571	CLIP-seq
MIRT1452804	hsa-miR-573	CLIP-seq
MIRT2356749	hsa-miR-642b	CLIP-seq
MIRT2356750	hsa-miR-655	CLIP-seq
MIRT2356751	hsa-miR-888	CLIP-seq
MIRT1452809	hsa-miR-892b	CLIP-seq
MIRT1452810	hsa-miR-98	CLIP-seq
MIRT1452811	hsa-miR-99a	CLIP-seq
MIRT1452812	hsa-miR-99b	CLIP-seq
MIRT2356740	hsa-miR-1237	CLIP-seq
MIRT2356741	hsa-miR-1248	CLIP-seq
MIRT1452757	hsa-miR-1278	CLIP-seq
MIRT2396335	hsa-miR-29a	CLIP-seq
MIRT2396336	hsa-miR-29b	CLIP-seq
MIRT2396337	hsa-miR-29c	CLIP-seq
MIRT2396338	hsa-miR-3065-3p	CLIP-seq
MIRT2396339	hsa-miR-3074-5p	CLIP-seq
MIRT2356745	hsa-miR-514	CLIP-seq
MIRT2356746	hsa-miR-514b-3p	CLIP-seq
MIRT2356747	hsa-miR-526b	CLIP-seq
MIRT2356749	hsa-miR-642b	CLIP-seq
MIRT1452771	hsa-miR-3121-3p	CLIP-seq
MIRT1452754	hsa-miR-100	CLIP-seq
MIRT2356739	hsa-miR-103b	CLIP-seq
MIRT2650205	hsa-miR-1200	CLIP-seq
MIRT1452758	hsa-miR-1290	CLIP-seq
MIRT2650206	hsa-miR-186	CLIP-seq
MIRT2650207	hsa-miR-18a	CLIP-seq
MIRT2650208	hsa-miR-18b	CLIP-seq
MIRT2650209	hsa-miR-204	CLIP-seq
MIRT2650210	hsa-miR-2053	CLIP-seq
MIRT1452766	hsa-miR-2054	CLIP-seq
MIRT2650211	hsa-miR-211	CLIP-seq
MIRT2396335	hsa-miR-29a	CLIP-seq
MIRT2396336	hsa-miR-29b	CLIP-seq
MIRT2396337	hsa-miR-29c	CLIP-seq
MIRT2396338	hsa-miR-3065-3p	CLIP-seq
MIRT2356742	hsa-miR-3074-3p	CLIP-seq
MIRT2396339	hsa-miR-3074-5p	CLIP-seq
MIRT1452770	hsa-miR-3120-3p	CLIP-seq
MIRT1452771	hsa-miR-3121-3p	CLIP-seq
MIRT2650212	hsa-miR-3124-3p	CLIP-seq
MIRT2650213	hsa-miR-3127-3p	CLIP-seq
MIRT2650214	hsa-miR-3127-5p	CLIP-seq
MIRT2650215	hsa-miR-3143	CLIP-seq
MIRT2650216	hsa-miR-3148	CLIP-seq
MIRT1452773	hsa-miR-3167	CLIP-seq
MIRT2650217	hsa-miR-3175	CLIP-seq
MIRT2650218	hsa-miR-330-3p	CLIP-seq
MIRT1452775	hsa-miR-340	CLIP-seq
MIRT1452776	hsa-miR-3616-5p	CLIP-seq
MIRT1452777	hsa-miR-3619-3p	CLIP-seq
MIRT2650219	hsa-miR-3647-3p	CLIP-seq
MIRT1452778	hsa-miR-3647-5p	CLIP-seq
MIRT2650220	hsa-miR-3679-3p	CLIP-seq
MIRT1452780	hsa-miR-3691-3p	CLIP-seq
MIRT1452781	hsa-miR-377	CLIP-seq
MIRT1452782	hsa-miR-380	CLIP-seq
MIRT2650221	hsa-miR-3976	CLIP-seq
MIRT2650222	hsa-miR-4270	CLIP-seq
MIRT2650223	hsa-miR-4274	CLIP-seq
MIRT2650224	hsa-miR-4279	CLIP-seq
MIRT2650225	hsa-miR-4289	CLIP-seq
MIRT2135610	hsa-miR-4422	CLIP-seq
MIRT2650226	hsa-miR-4441	CLIP-seq
MIRT2650227	hsa-miR-4446-5p	CLIP-seq
MIRT2650228	hsa-miR-4453	CLIP-seq
MIRT2650229	hsa-miR-450b-3p	CLIP-seq
MIRT1452789	hsa-miR-4517	CLIP-seq
MIRT2650230	hsa-miR-4519	CLIP-seq
MIRT2650231	hsa-miR-4538	CLIP-seq
MIRT2650232	hsa-miR-4635	CLIP-seq
MIRT1452791	hsa-miR-4659a-3p	CLIP-seq
MIRT1452792	hsa-miR-4659b-3p	CLIP-seq
MIRT2650233	hsa-miR-4662a-3p	CLIP-seq
MIRT2650234	hsa-miR-4668-5p	CLIP-seq
MIRT2650235	hsa-miR-4691-5p	CLIP-seq
MIRT1452794	hsa-miR-4700-3p	CLIP-seq
MIRT1452795	hsa-miR-4719	CLIP-seq
MIRT1452797	hsa-miR-4733-5p	CLIP-seq
MIRT2650236	hsa-miR-4735-3p	CLIP-seq
MIRT1452799	hsa-miR-4753-3p	CLIP-seq
MIRT2650237	hsa-miR-4755-5p	CLIP-seq
MIRT1452801	hsa-miR-4778-3p	CLIP-seq
MIRT1452803	hsa-miR-513b	CLIP-seq
MIRT2650238	hsa-miR-520d-5p	CLIP-seq
MIRT2650239	hsa-miR-524-5p	CLIP-seq
MIRT2356747	hsa-miR-526b	CLIP-seq
MIRT2650240	hsa-miR-548p	CLIP-seq
MIRT2356748	hsa-miR-571	CLIP-seq
MIRT1452804	hsa-miR-573	CLIP-seq
MIRT1452805	hsa-miR-606	CLIP-seq
MIRT2650241	hsa-miR-616	CLIP-seq
MIRT2650242	hsa-miR-623	CLIP-seq
MIRT2356749	hsa-miR-642b	CLIP-seq
MIRT2650243	hsa-miR-767-5p	CLIP-seq
MIRT2650244	hsa-miR-769-3p	CLIP-seq
MIRT1452808	hsa-miR-876-5p	CLIP-seq
MIRT1452811	hsa-miR-99a	CLIP-seq
MIRT1452812	hsa-miR-99b	CLIP-seq
MIRT2650205	hsa-miR-1200	CLIP-seq
MIRT1452758	hsa-miR-1290	CLIP-seq
MIRT2650207	hsa-miR-18a	CLIP-seq
MIRT2650208	hsa-miR-18b	CLIP-seq
MIRT2650210	hsa-miR-2053	CLIP-seq
MIRT2396339	hsa-miR-3074-5p	CLIP-seq
MIRT1452771	hsa-miR-3121-3p	CLIP-seq
MIRT2650213	hsa-miR-3127-3p	CLIP-seq
MIRT2650214	hsa-miR-3127-5p	CLIP-seq
MIRT2650215	hsa-miR-3143	CLIP-seq
MIRT1452773	hsa-miR-3167	CLIP-seq
MIRT2650218	hsa-miR-330-3p	CLIP-seq
MIRT2650219	hsa-miR-3647-3p	CLIP-seq
MIRT2650220	hsa-miR-3679-3p	CLIP-seq
MIRT1452781	hsa-miR-377	CLIP-seq
MIRT2650221	hsa-miR-3976	CLIP-seq
MIRT2650222	hsa-miR-4270	CLIP-seq
MIRT2650224	hsa-miR-4279	CLIP-seq
MIRT2650225	hsa-miR-4289	CLIP-seq
MIRT2135610	hsa-miR-4422	CLIP-seq
MIRT2650226	hsa-miR-4441	CLIP-seq
MIRT2650227	hsa-miR-4446-5p	CLIP-seq
MIRT2650228	hsa-miR-4453	CLIP-seq
MIRT2650229	hsa-miR-450b-3p	CLIP-seq
MIRT2650231	hsa-miR-4538	CLIP-seq
MIRT2650232	hsa-miR-4635	CLIP-seq
MIRT2650235	hsa-miR-4691-5p	CLIP-seq
MIRT2650236	hsa-miR-4735-3p	CLIP-seq
MIRT1452799	hsa-miR-4753-3p	CLIP-seq
MIRT2650238	hsa-miR-520d-5p	CLIP-seq
MIRT2650239	hsa-miR-524-5p	CLIP-seq
MIRT2356747	hsa-miR-526b	CLIP-seq
MIRT2650240	hsa-miR-548p	CLIP-seq
MIRT2356748	hsa-miR-571	CLIP-seq
MIRT2650241	hsa-miR-616	CLIP-seq
MIRT2356749	hsa-miR-642b	CLIP-seq
MIRT2650244	hsa-miR-769-3p	CLIP-seq
MIRT1452808	hsa-miR-876-5p	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
PITX1	Repression	21425961

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	ISS
GO:0004672	Function	Protein kinase activity	ISS
GO:0004860	Function	Protein kinase inhibitor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005856	Component	Cytoskeleton	IEA
GO:0006468	Process	Protein phosphorylation	ISS
GO:0031434	Function	Mitogen-activated protein kinase kinase binding	IBA
GO:0031625	Function	Ubiquitin protein ligase binding	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	ISS	20410507
GO:0032436	Process	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA
GO:0032436	Process	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA
GO:0032436	Process	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS	20410507
GO:0032693	Process	Negative regulation of interleukin-10 production	IMP	18643775
GO:0043405	Process	Regulation of MAP kinase activity	ISS
GO:0045599	Process	Negative regulation of fat cell differentiation	IEA
GO:0045599	Process	Negative regulation of fat cell differentiation	ISS	17576771
GO:0055106	Function	Ubiquitin-protein transferase regulator activity	IEA
GO:0055106	Function	Ubiquitin-protein transferase regulator activity	ISS	20410507
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IEA
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	ISS	17576771

MIM	HGNC	e!Ensembl
609462	30809	ENSG00000071575

Q92519

Protein name

Tribbles homolog 2 (TRB-2)

Protein function

Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).

PDB

7UPM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	72 → 308	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in peripheral blood leukocytes. {ECO:0000269|PubMed:15299019}.

Sequence

MNIHRSTPITIARYGRSRNKTQDFEELSSIRSAEPSQSFSPNLGSPSPPETPNLSHCVSC
IGKYLLLEPLEGDHVFRAVHLHSGEELVCKVFDISCYQESLAPCFCLSAHSNINQITEII
LGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRK
FIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSL
GVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQ
EILDHPWFSTDFSVSNSAYGAKEVSDQLVPDVNMEENLDPFFN

Sequence length

343

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (15)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CATARACT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DENTAL CARIES	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC RETINOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DUPUYTREN CONTRACTURE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GESTATIONAL DIABETES	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESTLESS LEGS SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (67)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute Erythroblastic Leukemia	Erythroblastic Leukemia	LHGDN	17545167		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	30031847		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute monocytic leukemia	Monocytic Leukemia	BEFREE	24516045, 30254057		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma	Adenocarcinoma	BEFREE	23071539		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	24402374, 28005074		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia, Macrocytic	Anemia	BEFREE	27550848		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	27550848		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	34326276, 35044082	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	24089522, 25311538	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	29670085		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	34326276	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	34870494	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	28670762		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cataplexy	Cataplexy	BEFREE	20160349		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cataplexy	Cataplexy	Pubtator	20614846	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	Pubtator	36710479	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Chromosomal Instability	Chromosomal instability	Pubtator	38254916	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	22775572		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	30541550		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30541550	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Epithelial ovarian cancer	Ovarian cancer	BEFREE	28670762		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	31318172		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	31318172	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	35044082	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	31318172		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	31318172		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	31318172, 35044082	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic Neoplasms	BEFREE	30254057		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic neoplasm	Pubtator	30254057	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	22271508		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Failure Chronic	Kidney failure	Pubtator	38254916	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	20410507, 21338441, 22775572, 26517929, 26996668, 27550848, 29670085		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	17097562, 17910043, 20005259, 20410507, 24516045, 26996668, 30031847, 30254057		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	23769673		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	21399661		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	23769673, 24089522, 24211582, 26517929, 29670085		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	21399661, 29670085		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	15311059		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	23769673, 24089522, 25586991, 26517929, 28276427, 29312632, 29670085, 30541550, 31318172		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	20208562, 25586991		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metastatic melanoma	Metastatic Melanoma	BEFREE	25586991		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	20944657		★★★★★ ★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	BEFREE	22775572, 30031847		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Myelodysplastic syndrome	Pubtator	22775572	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Myelodysplastic syndrome	Pubtator	36629404	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia	Myeloid Leukemia	BEFREE	20410507, 29670085		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	22775572, 29436678		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myopia	Myopia	Pubtator	36710479	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Narcolepsy	Narcolepsy	BEFREE	20160349, 20403960, 24485154		★★★★★ ★☆☆☆☆ Found in Text Mining only
Narcolepsy	Narcolepsy	Pubtator	20614846	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Narcolepsy 1	Narcolepsy	Pubtator	31328572	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Narcolepsy type 1	Narcolepsy	BEFREE	31328572		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	20208562, 28670762, 29599919, 29670085		★★★★★ ★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	31328572		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	28212671	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	22355351	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	BEFREE	30031847		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	15311059		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	15311059		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	22355351, 34973338	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	35494527	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Small cell carcinoma of lung	Lung carcinoma	BEFREE	29312632		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	38254916	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Hormone Resistance Syndrome	Thyroid hormone resistance	Pubtator	21622532	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveitis	Uveitis	LHGDN	15950723		★★★★★ ★☆☆☆☆ Found in Text Mining only
Vascular Diseases	Vascular Diseases	BEFREE	18952906		★★★★★ ★☆☆☆☆ Found in Text Mining only
Vascular Diseases	Vascular disease	Pubtator	18952906	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

TRIB2 (tribbles pseudokinase 2)