Gene Gene information from NCBI Gene database.
Entrez ID 2887
Gene name Growth factor receptor bound protein 10
Gene symbol GRB10
Synonyms (NCBI Gene)
GRB-IRGrb-10IRBPMEG1RSS
Chromosome 7
Chromosome location 7p12.1
Summary The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin re
miRNA miRNA information provided by mirtarbase database.
460
miRTarBase ID miRNA Experiments Reference
MIRT019136 hsa-miR-335-5p Microarray 18185580
MIRT020299 hsa-miR-130b-3p Sequencing 20371350
MIRT046714 hsa-miR-222-3p CLASH 23622248
MIRT037307 hsa-miR-877-5p CLASH 23622248
MIRT054627 hsa-miR-199b-5p ChIP-seqFlowqRT-PCRWestern blot 24608802
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
33
GO ID Ontology Definition Evidence Reference
GO:0005158 Function Insulin receptor binding IBA
GO:0005158 Function Insulin receptor binding IEA
GO:0005158 Function Insulin receptor binding ISS 15664450
GO:0005515 Function Protein binding IPI 8798570, 9506989, 15060076, 15722337, 20670374, 20878056, 23246379, 24658140, 25814554, 31980649, 32296183, 32814053, 35271311, 36931259
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601523 4564 ENSG00000106070
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q13322
Protein name Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
Protein function Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like grow
PDB 1NRV , 3HK0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00788 RA 166 250 Ras association (RalGDS/AF-6) domain Domain
PF00169 PH 291 399 PH domain Domain
PF08947 BPS 425 471 BPS (Between PH and SH2) Domain
PF00017 SH2 493 574 SH2 domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung, kidney, skeletal muscle, heart, spleen, skin and brain. {ECO:0000269|PubMed:11527390}.
Sequence
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMN
ASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAV
RRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK
VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASE
SKFLFRKNYA
KYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVK
ELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH
GLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKY
GMLLYQNYRIPQQRKALLSPF
STPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHP
STLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIK
NFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFY
QLNKGVLPCKLKHHCIRVAL
Sequence length 594
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  mTOR signaling pathway   Signaling by SCF-KIT
IRS activation
Signal attenuation
Insulin receptor signalling cascade
RET signaling
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
23
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATRIAL FIBRILLATION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTOIMMUNE DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHROMOSOMAL DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Achondroplasia Achondroplasia BEFREE 27370225
★☆☆☆☆
Found in Text Mining only
Achondroplasia Achondroplasia Pubtator 27370225 Associate
★☆☆☆☆
Found in Text Mining only
Alopecia Alopecia BEFREE 21481762
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 25391383 Associate
★☆☆☆☆
Found in Text Mining only
Amaurosis congenita of Leber, type 1 Leber congenital amaurosis BEFREE 29721936
★☆☆☆☆
Found in Text Mining only
Beckwith-Wiedemann Syndrome Beckwith-Wiedemann Syndrome BEFREE 12510981, 20933618
★☆☆☆☆
Found in Text Mining only
Brain Injuries Traumatic Brain injuries Pubtator 35571247 Associate
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 25560175 Associate
★☆☆☆☆
Found in Text Mining only
Bronchopulmonary Dysplasia Bronchopulmonary dysplasia Pubtator 39988826 Stimulate
★☆☆☆☆
Found in Text Mining only
Carcinoma Ovarian Epithelial Epithelial ovarian carcinoma Pubtator 24190013 Associate
★☆☆☆☆
Found in Text Mining only