Gene Gene information from NCBI Gene database.
Entrez ID 2886
Gene name Growth factor receptor bound protein 7
Gene symbol GRB7
Synonyms (NCBI Gene)
-
Chromosome 17
Chromosome location 17q12
Summary The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal
miRNA miRNA information provided by mirtarbase database.
126
miRTarBase ID miRNA Experiments Reference
MIRT016993 hsa-miR-335-5p Microarray 18185580
MIRT028909 hsa-miR-26b-5p Microarray 19088304
MIRT1033299 hsa-miR-1193 CLIP-seq
MIRT1033300 hsa-miR-1243 CLIP-seq
MIRT1033301 hsa-miR-1293 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding IEA
GO:0005515 Function Protein binding IPI 8940081, 9079677, 9516479, 10377264, 10664463, 12061724, 12223469, 12852788, 12975581, 15806159, 16273093, 20665473, 24189400, 24728074, 25416956, 25814554, 31515488, 32296183
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol IDA 10893408, 12021278
GO:0005829 Component Cytosol TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601522 4567 ENSG00000141738
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14451
Protein name Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)
Protein function Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HR
PDB 1MW4 , 1WGR , 2L4K , 2QMS , 3PQZ , 4WWQ , 4X6S , 5D0J , 5EEL , 5EEQ , 5TYI , 5U06 , 5U1Q , 7MP3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00788 RA 100 186 Ras association (RalGDS/AF-6) domain Domain
PF00169 PH 230 338 PH domain Domain
PF08947 BPS 365 412 BPS (Between PH and SH2) Domain
PF00017 SH2 431 512 SH2 domain Domain
Sequence
Sequence length 532
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    GRB7 events in ERBB2 signaling
Signaling by SCF-KIT
Downstream signal transduction
Tie2 Signaling
RET signaling
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
15
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASTHMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, RENAL CELL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CERVICAL CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma CTD_human_DG 21552421
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma, Basal Cell Adenocarcinoma CTD_human_DG 21552421
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma, Oxyphilic Adenocarcinoma CTD_human_DG 21552421
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma, Tubular Adenocarcinoma CTD_human_DG 21552421
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 16778393 Associate
★☆☆☆☆
Found in Text Mining only
Barrett Esophagus Barrett esophagus BEFREE 15386389
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 12866037, 15010812, 16322295, 20126311, 20622016, 20635137, 21788678, 24464577, 25182704, 26400847, 29083893, 30604896, 31627265, 7907978, 8988034
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma CTD_human_DG 17426702, 19075277
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 10664463, 16475676, 18853468, 19717535, 21288332, 22253820, 23714731, 24194916, 26975656, 28295715, 31017268, 31627265, 33191115, 38036593 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Neoplasms Breast neoplasm Pubtator 16849266 Stimulate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations