Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2868
Gene name	G protein-coupled receptor kinase 4
Gene symbol	GRK4
Synonyms (NCBI Gene)	GPRK2LGPRK4GRK4aIT11
Chromosome	4
Chromosome location	4p16.3
Summary	This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deac

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miRTarBase ID	miRNA	Experiments	Reference
MIRT437523	hsa-miR-19b-3p	Immunoprecipitaion	22382630
MIRT633348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT679705	hsa-miR-6823-5p	HITS-CLIP	23824327
MIRT679704	hsa-miR-7113-5p	HITS-CLIP	23824327
MIRT679703	hsa-miR-4685-5p	HITS-CLIP	23824327
MIRT679702	hsa-miR-6837-5p	HITS-CLIP	23824327
MIRT633347	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT633346	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT633345	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT633344	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT633343	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT633342	hsa-miR-1976	HITS-CLIP	23824327
MIRT633341	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT633340	hsa-miR-4279	HITS-CLIP	23824327
MIRT633335	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT633334	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT633333	hsa-miR-7977	HITS-CLIP	23824327
MIRT633332	hsa-miR-6776-5p	HITS-CLIP	23824327
MIRT633348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT633347	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT633346	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT633345	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT633344	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT633341	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT633340	hsa-miR-4279	HITS-CLIP	23824327
MIRT633339	hsa-miR-5693	HITS-CLIP	23824327
MIRT633338	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT633337	hsa-miR-4284	HITS-CLIP	23824327
MIRT633336	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT633335	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT633334	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT633333	hsa-miR-7977	HITS-CLIP	23824327
MIRT633332	hsa-miR-6776-5p	HITS-CLIP	23824327
MIRT633348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT633347	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT633346	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT633345	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT633344	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT633343	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT633342	hsa-miR-1976	HITS-CLIP	23824327
MIRT633341	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT633340	hsa-miR-4279	HITS-CLIP	23824327
MIRT633339	hsa-miR-5693	HITS-CLIP	23824327
MIRT633338	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT633337	hsa-miR-4284	HITS-CLIP	23824327
MIRT633336	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT633335	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT633334	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT633333	hsa-miR-7977	HITS-CLIP	23824327
MIRT633332	hsa-miR-6776-5p	HITS-CLIP	23824327
MIRT617543	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT617542	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT617541	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT617540	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT617539	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT617538	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT617543	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT617542	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT617541	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT617540	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT617539	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT617538	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT633348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT679705	hsa-miR-6823-5p	HITS-CLIP	23824327
MIRT679704	hsa-miR-7113-5p	HITS-CLIP	23824327
MIRT679703	hsa-miR-4685-5p	HITS-CLIP	23824327
MIRT679702	hsa-miR-6837-5p	HITS-CLIP	23824327
MIRT633347	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT633346	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT633345	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT633344	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT633343	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT633342	hsa-miR-1976	HITS-CLIP	23824327
MIRT633341	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT633340	hsa-miR-4279	HITS-CLIP	23824327
MIRT633335	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT633334	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT633333	hsa-miR-7977	HITS-CLIP	23824327
MIRT633332	hsa-miR-6776-5p	HITS-CLIP	23824327
MIRT633348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT633347	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT633346	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT633345	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT633344	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT633341	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT633340	hsa-miR-4279	HITS-CLIP	23824327
MIRT633339	hsa-miR-5693	HITS-CLIP	23824327
MIRT633338	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT633337	hsa-miR-4284	HITS-CLIP	23824327
MIRT633336	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT633335	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT633334	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT633333	hsa-miR-7977	HITS-CLIP	23824327
MIRT633332	hsa-miR-6776-5p	HITS-CLIP	23824327
MIRT633348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT633347	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT633346	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT633345	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT633344	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT633343	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT633342	hsa-miR-1976	HITS-CLIP	23824327
MIRT633341	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT633340	hsa-miR-4279	HITS-CLIP	23824327
MIRT633339	hsa-miR-5693	HITS-CLIP	23824327
MIRT633338	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT633337	hsa-miR-4284	HITS-CLIP	23824327
MIRT633336	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT633335	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT633334	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT633333	hsa-miR-7977	HITS-CLIP	23824327
MIRT633332	hsa-miR-6776-5p	HITS-CLIP	23824327
MIRT617543	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT617542	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT617541	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT617540	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT617539	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT617538	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT617543	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT617542	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT617541	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT617540	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT617539	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT617538	hsa-miR-5582-3p	HITS-CLIP	23824327

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IBA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004703	Function	G protein-coupled receptor kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	32707033, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0005938	Component	Cell cortex	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	IEA
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	TAS	1338872
GO:0009966	Process	Regulation of signal transduction	IBA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0022400	Process	Regulation of opsin-mediated signaling pathway	TAS
GO:0031623	Process	Receptor internalization	IDA	20074556
GO:0050254	Function	Rhodopsin kinase activity	TAS
GO:0097381	Component	Photoreceptor disc membrane	TAS

MIM	HGNC	e!Ensembl
137026	4543	ENSG00000125388

P32298

Protein name

G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1)

Protein function

Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with

PDB

4YHJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00615	RGS	52 → 171	Regulator of G protein signaling domain	Domain
PF00069	Pkinase	187 → 449	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in myometrium. {ECO:0000269|PubMed:16636192, ECO:0000269|PubMed:8626439}.

Sequence

MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ
PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE
IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ
PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE
KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL
EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN
EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI
CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD
IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK
NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC

Sequence length

578

Interactions

View interactions

	KEGG		Reactome
	Chemokine signaling pathway Endocytosis Morphine addiction		Inactivation, recovery and regulation of the phototransduction cascade

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ESSENTIAL HYPERTENSION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (24)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	18767025		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	35769816	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Arteriosclerosis	Coronary Arteriosclerosis	BEFREE	22949529		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	22949529		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	22949529	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	BEFREE	22949529		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	23133444	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Essential Hypertension	Hypertension	BEFREE	11904438, 12589180, 15548830, 16636198, 17044852, 20153824, 22407378, 25732908, 25775155		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Essential Hypertension	Hypertension	Pubtator	25732908, 34297769	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Huntington Disease	Huntington Disease	GWASDB_DG	22387017		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	22949529, 23133444, 23509080, 25732908, 26134571, 33899625, 34297769	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	12589180, 15548830, 16439609, 16441255, 18370232, 20153824, 20448640, 21544086, 22407378, 22639547, 22949529, 25150869, 25775155, 26134571, 26730182, 28052878, 29307864, 30698033 View all (3 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	LHGDN	15097232, 17044852		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	30115642	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	18767025		★★★★★ ★☆☆☆☆ Found in Text Mining only
Maternal hypertension	Maternal hypertension	BEFREE	30698033		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	22949529		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial infarction	Pubtator	22949529	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephrosclerosis	Nephrosclerosis	Pubtator	19119263	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	25768006		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	25768006	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stroke	Stroke	Pubtator	22949529	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Testicular Germ Cell Tumor	Testicular germ cell tumor	Pubtator	34621245	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Testicular Neoplasms	Testicular neoplasm	Pubtator	30115642	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

GRK4 (G protein-coupled receptor kinase 4)