NKAIN3 (sodium/potassium transporting ATPase interacting 3)

Gene

• Entrez ID: 286183
• Gene name: Sodium/potassium transporting ATPase interacting 3
• Gene symbol: NKAIN3
• Synonyms (NCBI Gene): FAM77D, NKAIN3-IT1, UG0898H09
• Chromosome: 8
• Chromosome location: 8q12.3
• Summary: NKAIN3 is a member of a family of mammalian proteins (see NKAIN1; MIM 612871) with similarity to Drosophila Nkain (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1186046	hsa-miR-3591-5p	CLIP-seq
MIRT1186047	hsa-miR-3681	CLIP-seq
MIRT1186048	hsa-miR-4426	CLIP-seq
MIRT1186049	hsa-miR-4460	CLIP-seq
MIRT1186050	hsa-miR-4476	CLIP-seq
MIRT1186051	hsa-miR-4528	CLIP-seq
MIRT1186052	hsa-miR-4647	CLIP-seq
MIRT1186053	hsa-miR-4662b	CLIP-seq
MIRT1186054	hsa-miR-4667-5p	CLIP-seq
MIRT1186055	hsa-miR-4700-5p	CLIP-seq
MIRT1186056	hsa-miR-4727-3p	CLIP-seq
MIRT1186057	hsa-miR-520a-5p	CLIP-seq
MIRT1186058	hsa-miR-525-5p	CLIP-seq
MIRT1186059	hsa-miR-637	CLIP-seq
MIRT1186060	hsa-miR-653	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002028	Process	Regulation of sodium ion transport	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: 612872
• HGNC: 26829
• e!Ensembl: ENSG00000185942

Protein

• UniProt ID: Q8N8D7
• Protein name: Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 (Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3) (Protein FAM77D)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05640	NKAIN	1 → 183	Na,K-Atpase Interacting protein	Family

• Sequence:

  MGCCTGRCSLICLCALQLVSALERQIFDFLGFQWAPILGNFLHIIVVILGLFGTIQYRPR
  YIMVYTVWTALWVTWNVFIICFYLEVGGLSKDTDLMTFNISVHRSWWREHGPGCVRRVLP
  PSAHGMMDDYTYVSVTGCIVDFQYLEVIHSAVQILLSLVGFVYACYVISISMEEEDTYSC
  DLQVCKHLFIQMLQIIE

• Sequence length: 197

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BULIMIA NERVOSA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIODONTITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEASONAL ALLERGIC RHINITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UPPER AERODIGESTIVE TRACT NEOPLASM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Allergic rhinitis (disorder)	Allergic rhinitis	GWASCAT_DG	25085501		★☆☆☆☆ Found in Text Mining only
Alzheimer`s Disease	Alzheimer disease	GWASCAT_DG	26830138		★☆☆☆☆ Found in Text Mining only
Bulimia Nervosa	Bulimia	GWASDB_DG	23568457		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bulimia Nervosa	Bulimia	GWASCAT_DG	23568457		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Dyslexia	Dyslexia	Pubtator	30741946	Associate	★☆☆☆☆ Found in Text Mining only
Narcolepsy	Narcolepsy	GWASDB_DG	19629137		★☆☆☆☆ Found in Text Mining only