XKR6 (XK related 6)

Gene

• Entrez ID: 286046
• Gene name: XK related 6
• Gene symbol: XKR6
• Synonyms (NCBI Gene): C8orf21, C8orf5, C8orf7, XRG6
• Chromosome: 8
• Chromosome location: 8p23.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017113	hsa-miR-335-5p	Microarray	18185580
MIRT707490	hsa-miR-6074	HITS-CLIP	21572407
MIRT707489	hsa-miR-3924	HITS-CLIP	21572407
MIRT518127	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT518126	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT518125	hsa-miR-4795-3p	HITS-CLIP	21572407
MIRT518123	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT518127	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT518126	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT518125	hsa-miR-4795-3p	HITS-CLIP	23313552
MIRT518123	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT518127	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT518126	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT518125	hsa-miR-4795-3p	HITS-CLIP	23313552
MIRT518124	hsa-miR-6083	HITS-CLIP	23313552
MIRT518123	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT620492	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT620491	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT620490	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT620489	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT620488	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT620487	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT620486	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT620484	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT620485	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT620483	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT620482	hsa-miR-3198	HITS-CLIP	23824327
MIRT620481	hsa-miR-4309	HITS-CLIP	23824327
MIRT620480	hsa-miR-7850-5p	HITS-CLIP	23824327
MIRT518127	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518126	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT518125	hsa-miR-4795-3p	HITS-CLIP	23824327
MIRT518124	hsa-miR-6083	HITS-CLIP	23824327
MIRT518123	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT651439	hsa-miR-4455	HITS-CLIP	23824327
MIRT620492	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT620491	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT620490	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT620489	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT620488	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT620487	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT620486	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT620484	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT620485	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT620483	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT620482	hsa-miR-3198	HITS-CLIP	23824327
MIRT620481	hsa-miR-4309	HITS-CLIP	23824327
MIRT620480	hsa-miR-7850-5p	HITS-CLIP	23824327
MIRT620492	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT620491	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT620490	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT620489	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT620488	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT620487	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT620486	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT620484	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT620485	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT620483	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT620482	hsa-miR-3198	HITS-CLIP	23824327
MIRT620481	hsa-miR-4309	HITS-CLIP	23824327
MIRT620480	hsa-miR-7850-5p	HITS-CLIP	23824327
MIRT518127	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518126	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT518125	hsa-miR-4795-3p	HITS-CLIP	23824327
MIRT518124	hsa-miR-6083	HITS-CLIP	23824327
MIRT518123	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT518127	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT518126	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT518125	hsa-miR-4795-3p	PAR-CLIP	22012620
MIRT518123	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT518127	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT518126	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT518125	hsa-miR-4795-3p	PAR-CLIP	23446348
MIRT518124	hsa-miR-6083	PAR-CLIP	23446348
MIRT518123	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT439279	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439279	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT707490	hsa-miR-6074	HITS-CLIP	21572407
MIRT707489	hsa-miR-3924	HITS-CLIP	21572407
MIRT518127	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT518126	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT518125	hsa-miR-4795-3p	HITS-CLIP	21572407
MIRT518123	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT518127	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT518126	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT518125	hsa-miR-4795-3p	HITS-CLIP	23313552
MIRT518123	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT518127	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT518126	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT518125	hsa-miR-4795-3p	HITS-CLIP	23313552
MIRT518124	hsa-miR-6083	HITS-CLIP	23313552
MIRT518123	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT620492	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT620491	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT620490	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT620489	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT620488	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT620487	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT620486	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT620484	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT620485	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT620483	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT620482	hsa-miR-3198	HITS-CLIP	23824327
MIRT620481	hsa-miR-4309	HITS-CLIP	23824327
MIRT620480	hsa-miR-7850-5p	HITS-CLIP	23824327
MIRT518127	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518126	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT518125	hsa-miR-4795-3p	HITS-CLIP	23824327
MIRT518124	hsa-miR-6083	HITS-CLIP	23824327
MIRT518123	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT651439	hsa-miR-4455	HITS-CLIP	23824327
MIRT620492	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT620491	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT620490	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT620489	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT620488	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT620487	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT620486	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT620484	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT620485	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT620483	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT620482	hsa-miR-3198	HITS-CLIP	23824327
MIRT620481	hsa-miR-4309	HITS-CLIP	23824327
MIRT620480	hsa-miR-7850-5p	HITS-CLIP	23824327
MIRT620492	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT620491	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT620490	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT620489	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT620488	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT620487	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT620486	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT620484	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT620485	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT620483	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT620482	hsa-miR-3198	HITS-CLIP	23824327
MIRT620481	hsa-miR-4309	HITS-CLIP	23824327
MIRT620480	hsa-miR-7850-5p	HITS-CLIP	23824327
MIRT518127	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518126	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT518125	hsa-miR-4795-3p	HITS-CLIP	23824327
MIRT518124	hsa-miR-6083	HITS-CLIP	23824327
MIRT518123	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT518127	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT518126	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT518125	hsa-miR-4795-3p	PAR-CLIP	22012620
MIRT518123	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT518127	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT518126	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT518125	hsa-miR-4795-3p	PAR-CLIP	23446348
MIRT518124	hsa-miR-6083	PAR-CLIP	23446348
MIRT518123	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT1495905	hsa-miR-129-5p	CLIP-seq
MIRT1495906	hsa-miR-2964a-5p	CLIP-seq
MIRT1495907	hsa-miR-3177-5p	CLIP-seq
MIRT1495908	hsa-miR-3646	CLIP-seq
MIRT1495909	hsa-miR-3662	CLIP-seq
MIRT1495910	hsa-miR-4446-5p	CLIP-seq
MIRT1495911	hsa-miR-4663	CLIP-seq
MIRT1495912	hsa-miR-4682	CLIP-seq
MIRT1495913	hsa-miR-4719	CLIP-seq
MIRT1495914	hsa-miR-4728-3p	CLIP-seq
MIRT1495915	hsa-miR-4729	CLIP-seq
MIRT1495916	hsa-miR-4762-5p	CLIP-seq
MIRT1495917	hsa-miR-4775	CLIP-seq
MIRT1495918	hsa-miR-556-3p	CLIP-seq
MIRT1495919	hsa-miR-579	CLIP-seq
MIRT1495920	hsa-miR-590-3p	CLIP-seq
MIRT1495921	hsa-miR-599	CLIP-seq
MIRT2149327	hsa-miR-3688-3p	CLIP-seq
MIRT2149328	hsa-miR-4261	CLIP-seq
MIRT1495917	hsa-miR-4775	CLIP-seq
MIRT2369766	hsa-miR-2116	CLIP-seq
MIRT2369767	hsa-miR-29a	CLIP-seq
MIRT2369768	hsa-miR-29b	CLIP-seq
MIRT2369769	hsa-miR-29c	CLIP-seq
MIRT2369770	hsa-miR-3065-3p	CLIP-seq
MIRT2369771	hsa-miR-375	CLIP-seq
MIRT2369772	hsa-miR-4273	CLIP-seq
MIRT2369773	hsa-miR-4677-5p	CLIP-seq
MIRT2369774	hsa-miR-4705	CLIP-seq
MIRT2369775	hsa-miR-520a-5p	CLIP-seq
MIRT2369776	hsa-miR-525-5p	CLIP-seq
MIRT1495921	hsa-miR-599	CLIP-seq
MIRT2369777	hsa-miR-876-3p	CLIP-seq
MIRT2369777	hsa-miR-876-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0016020	Component	Membrane	IEA
GO:0043652	Process	Engulfment of apoptotic cell	IBA
GO:0070782	Process	Phosphatidylserine exposure on apoptotic cell surface	IBA
GO:1902742	Process	Apoptotic process involved in development	IBA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q5GH73
• Protein name: XK-related protein 6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09815	XK-related	130 → 501	XK-related protein	Family

• Sequence:

  MAAKSDGGGVGVGFAQLHNLDEAVGSGGEEDGEPGGGGCGGGGDGSEPGESSSMHICHCC
  NTSSCYWGCRSACLRSLLGRKPRRSAAADGGDQPLQPPAAPGAGRQPPTPSAARPEPPPP
  QVERPWLDCLWIVLALLVFFGDVGTDLWLALDYYRKGDYVYFGLTLFFVLVPSLLVQSLS
  FRWFVQDYTGGGLGAVEGLTSRGPPMMGAGYVHGAARGGPGVRVSPTPGAQRLCRLSVWI
  WQSVIHLLQMGQVWRYIRTMYLGIQSQRRKEHQRRFYWAMMYEYADVNMLRLLETFLESA
  PQLVLQLYIMLQKNSAETLPCVSSVTSLMSLAWVLASYHKLLRDSRDDKKSMSYRGAIIQ
  VFWRLFTISSRVISFALFASIFQLYFGIFVVVHWCAMAFWIIHGGTDFCMSKWEEILFNM
  VVGIVYIFCWFNVKEGRTRYRMFAYYTIVLTENAALTFLWYFYRDPETTDSYAVPALCCV
  FISFVAGIAMMLLYYGVLHPTGPRAKILASSCCAELLWGIPLPPDVEPMAPEIPGYRGTQ
  VTPTRAVTEQQEDLTADTCLPVFQVRPMGPPTPLGRPYLPEGPLIKIDMPRKRYPAWDAH
  FVDRRLRRTINILQYVTPTAVGIRYRDGPLLYELLQYESSL

• Sequence length: 641

Pathways

KEGG:

Efferocytosis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BRAIN ANEURYSM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EOSINOPHILIC ESOPHAGITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOPATHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, HIP	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, KNEE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESTLESS LEGS SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEASONAL ALLERGIC RHINITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Asthma	Asthma	GWASCAT_DG	24388013		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cerebral Infarction	Ischemic stroke	Pubtator	31429711, 32024373	Associate	★☆☆☆☆ Found in Text Mining only
Coronary Arteriosclerosis	Coronary Arteriosclerosis	BEFREE	31429711		★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	31429711		★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	31429711	Associate	★☆☆☆☆ Found in Text Mining only
Coronary Disease	Coronary artery disease	Pubtator	32024373	Associate	★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	BEFREE	31429711		★☆☆☆☆ Found in Text Mining only
Dementia Vascular	Vascular dementia	Pubtator	39909351	Associate	★☆☆☆☆ Found in Text Mining only
Eosinophilic esophagitis	Eosinophilia	GWASCAT_DG	25017104		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypertension	Hypertension	Pubtator	32024373	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Idiopathic Pulmonary Fibrosis	Idiopathic pulmonary fibrosis	Pubtator	37266442	Associate	★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	BEFREE	31429711		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	23049788, 28289186, 29967481	Associate	★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	GWASDB_DG	18204446		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	GWASCAT_DG	28714469, 29967481		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	29967481, 30065249		★☆☆☆☆ Found in Text Mining only
Lupus Nephritis	Lupus Nephritis	BEFREE	23049788		★☆☆☆☆ Found in Text Mining only
Lupus Nephritis	Lupus nephritis	Pubtator	23049788	Associate	★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASCAT_DG	29559929		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Melanoma	Pubtator	32241263	Associate	★☆☆☆☆ Found in Text Mining only
NEUROTICISM	Neuroticism	BEFREE	28552732		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	GWASDB_DG	21866343		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASCAT_DG	27846195		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sjogren's Syndrome	Sjogren syndrome	Pubtator	35896530	Associate	★☆☆☆☆ Found in Text Mining only
Unipolar Depression	Mental Depression	GWASCAT_DG	29559929		★☆☆☆☆ Found in Text Mining only