CNPY1 (canopy FGF signaling regulator 1)

Gene

• Entrez ID: 285888
• Gene name: Canopy FGF signaling regulator 1
• Gene symbol: CNPY1
• Synonyms (NCBI Gene): -
• Chromosome: 7
• Chromosome location: 7q36.3
• Summary: Cnpy1 is expressed in the midbrain-hindbrain (MHB) boundary in zebrafish, binds FGFR1 (MIM 136350), and plays a role in FGF signaling (Hirate and Okamoto, 2006 [PubMed 16488878]).[supplied by OMIM, Dec 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT901271	hsa-miR-219-2-3p	CLIP-seq
MIRT901272	hsa-miR-28-5p	CLIP-seq
MIRT901273	hsa-miR-3074-5p	CLIP-seq
MIRT901274	hsa-miR-3139	CLIP-seq
MIRT901275	hsa-miR-3168	CLIP-seq
MIRT901276	hsa-miR-3668	CLIP-seq
MIRT901277	hsa-miR-370	CLIP-seq
MIRT901278	hsa-miR-3924	CLIP-seq
MIRT901279	hsa-miR-4277	CLIP-seq
MIRT901280	hsa-miR-4433	CLIP-seq
MIRT901281	hsa-miR-4459	CLIP-seq
MIRT901282	hsa-miR-4709-3p	CLIP-seq
MIRT901283	hsa-miR-4768-3p	CLIP-seq
MIRT901284	hsa-miR-4795-3p	CLIP-seq
MIRT901285	hsa-miR-587	CLIP-seq
MIRT901286	hsa-miR-639	CLIP-seq
MIRT901287	hsa-miR-708	CLIP-seq
MIRT901288	hsa-miR-944	CLIP-seq
MIRT901271	hsa-miR-219-2-3p	CLIP-seq
MIRT901273	hsa-miR-3074-5p	CLIP-seq
MIRT901277	hsa-miR-370	CLIP-seq
MIRT901280	hsa-miR-4433	CLIP-seq
MIRT901281	hsa-miR-4459	CLIP-seq
MIRT901282	hsa-miR-4709-3p	CLIP-seq
MIRT901283	hsa-miR-4768-3p	CLIP-seq
MIRT2386294	hsa-miR-4327	CLIP-seq
MIRT2447344	hsa-miR-2276	CLIP-seq
MIRT2447345	hsa-miR-4698	CLIP-seq
MIRT2447346	hsa-miR-4772-3p	CLIP-seq
MIRT2447347	hsa-miR-518a-5p	CLIP-seq
MIRT2447348	hsa-miR-527	CLIP-seq
MIRT2505941	hsa-miR-1229	CLIP-seq
MIRT2505942	hsa-miR-1912	CLIP-seq
MIRT2505943	hsa-miR-4493	CLIP-seq
MIRT2505941	hsa-miR-1229	CLIP-seq
MIRT2505942	hsa-miR-1912	CLIP-seq
MIRT2505943	hsa-miR-4493	CLIP-seq

Other IDs

• MIM: 612493
• HGNC: 27786
• e!Ensembl: ENSG00000146910

Protein

• UniProt ID: Q3B7I2
• Protein name: Protein canopy homolog 1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF11938	DUF3456	1 → 83	TLR4 regulator and MIR-interacting MSAP	Family

• Sequence:

  MNDYKLEEDPVTKERTFKRFAPRKGDKIYQEFKKLYFYSDAYRPLKFACETIIEEYEDEI
  SSLIAQETHYLADKLCSEKSDLCETSANHTEL

• Sequence length: 92

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
COLORECTAL CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Obesity	Obesity	Pubtator	28207535	Associate	★☆☆☆☆ Found in Text Mining only