CEP57L1 (centrosomal protein 57 like 1)

Gene

• Entrez ID: 285753
• Gene name: Centrosomal protein 57 like 1
• Gene symbol: CEP57L1
• Synonyms (NCBI Gene): C6orf182, bA487F23.2, cep57R
• Chromosome: 6
• Chromosome location: 6q21

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020044	hsa-miR-375	Microarray	20215506
MIRT681114	hsa-miR-4324	HITS-CLIP	23706177
MIRT681113	hsa-miR-6761-5p	HITS-CLIP	23706177
MIRT681112	hsa-miR-3160-3p	HITS-CLIP	23706177
MIRT681111	hsa-miR-558	HITS-CLIP	23706177
MIRT681110	hsa-miR-4487	HITS-CLIP	23706177
MIRT681109	hsa-miR-6134	HITS-CLIP	23706177
MIRT681108	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT681107	hsa-miR-6086	HITS-CLIP	23706177
MIRT681106	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681105	hsa-miR-3689d	HITS-CLIP	23706177
MIRT681104	hsa-miR-6851-5p	HITS-CLIP	23706177
MIRT681103	hsa-miR-6880-5p	HITS-CLIP	23706177
MIRT681102	hsa-miR-7847-3p	HITS-CLIP	23706177
MIRT681101	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT681100	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT670327	hsa-miR-3929	HITS-CLIP	23824327
MIRT670326	hsa-miR-4419b	HITS-CLIP	23824327
MIRT670325	hsa-miR-4478	HITS-CLIP	23824327
MIRT670324	hsa-miR-5693	HITS-CLIP	23824327
MIRT670323	hsa-miR-4486	HITS-CLIP	23824327
MIRT670322	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT670321	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT670320	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT670319	hsa-miR-4284	HITS-CLIP	23824327
MIRT670318	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT670317	hsa-miR-4505	HITS-CLIP	23824327
MIRT670316	hsa-miR-5787	HITS-CLIP	23824327
MIRT670315	hsa-miR-3178	HITS-CLIP	23824327
MIRT670314	hsa-miR-7977	HITS-CLIP	23824327
MIRT670313	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT619277	hsa-miR-10b-3p	HITS-CLIP	23824327
MIRT619275	hsa-miR-4330	HITS-CLIP	23824327
MIRT619274	hsa-miR-4252	HITS-CLIP	23824327
MIRT619273	hsa-miR-3064-3p	HITS-CLIP	23824327
MIRT619272	hsa-miR-4715-3p	HITS-CLIP	23824327
MIRT619271	hsa-miR-4776-3p	HITS-CLIP	23824327
MIRT619270	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT619276	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT619274	hsa-miR-4252	HITS-CLIP	23824327
MIRT619273	hsa-miR-3064-3p	HITS-CLIP	23824327
MIRT619272	hsa-miR-4715-3p	HITS-CLIP	23824327
MIRT619271	hsa-miR-4776-3p	HITS-CLIP	23824327
MIRT619277	hsa-miR-10b-3p	HITS-CLIP	23824327
MIRT619276	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT619275	hsa-miR-4330	HITS-CLIP	23824327
MIRT619274	hsa-miR-4252	HITS-CLIP	23824327
MIRT619273	hsa-miR-3064-3p	HITS-CLIP	23824327
MIRT619272	hsa-miR-4715-3p	HITS-CLIP	23824327
MIRT619271	hsa-miR-4776-3p	HITS-CLIP	23824327
MIRT619270	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT619277	hsa-miR-10b-3p	HITS-CLIP	23824327
MIRT619276	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT619275	hsa-miR-4330	HITS-CLIP	23824327
MIRT619274	hsa-miR-4252	HITS-CLIP	23824327
MIRT619273	hsa-miR-3064-3p	HITS-CLIP	23824327
MIRT619272	hsa-miR-4715-3p	HITS-CLIP	23824327
MIRT619271	hsa-miR-4776-3p	HITS-CLIP	23824327
MIRT619270	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT619277	hsa-miR-10b-3p	HITS-CLIP	23824327
MIRT619276	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT619275	hsa-miR-4330	HITS-CLIP	23824327
MIRT619274	hsa-miR-4252	HITS-CLIP	23824327
MIRT619273	hsa-miR-3064-3p	HITS-CLIP	23824327
MIRT619272	hsa-miR-4715-3p	HITS-CLIP	23824327
MIRT619271	hsa-miR-4776-3p	HITS-CLIP	23824327
MIRT619270	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT528686	hsa-miR-4524b-3p	PAR-CLIP	22012620
MIRT528680	hsa-miR-411-5p	PAR-CLIP	22012620
MIRT528685	hsa-miR-4781-3p	PAR-CLIP	22012620
MIRT528684	hsa-miR-4717-3p	PAR-CLIP	22012620
MIRT528683	hsa-miR-6823-5p	PAR-CLIP	22012620
MIRT528682	hsa-miR-4524a-3p	PAR-CLIP	22012620
MIRT528681	hsa-miR-6832-5p	PAR-CLIP	22012620
MIRT528680	hsa-miR-411-5p	PAR-CLIP	22012620
MIRT528679	hsa-miR-130a-5p	PAR-CLIP	22012620
MIRT528678	hsa-miR-23a-3p	PAR-CLIP	22012620
MIRT528677	hsa-miR-23b-3p	PAR-CLIP	22012620
MIRT528676	hsa-miR-23c	PAR-CLIP	22012620
MIRT528675	hsa-miR-548s	PAR-CLIP	22012620
MIRT528674	hsa-miR-4701-5p	PAR-CLIP	22012620
MIRT528673	hsa-miR-588	PAR-CLIP	22012620
MIRT528672	hsa-miR-4435	PAR-CLIP	22012620
MIRT528671	hsa-miR-3187-3p	PAR-CLIP	22012620
MIRT681114	hsa-miR-4324	HITS-CLIP	23706177
MIRT681113	hsa-miR-6761-5p	HITS-CLIP	23706177
MIRT681112	hsa-miR-3160-3p	HITS-CLIP	23706177
MIRT681111	hsa-miR-558	HITS-CLIP	23706177
MIRT681110	hsa-miR-4487	HITS-CLIP	23706177
MIRT681109	hsa-miR-6134	HITS-CLIP	23706177
MIRT681108	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT681107	hsa-miR-6086	HITS-CLIP	23706177
MIRT681106	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681105	hsa-miR-3689d	HITS-CLIP	23706177
MIRT681104	hsa-miR-6851-5p	HITS-CLIP	23706177
MIRT681103	hsa-miR-6880-5p	HITS-CLIP	23706177
MIRT681102	hsa-miR-7847-3p	HITS-CLIP	23706177
MIRT681101	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT681100	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT670327	hsa-miR-3929	HITS-CLIP	23824327
MIRT670326	hsa-miR-4419b	HITS-CLIP	23824327
MIRT670325	hsa-miR-4478	HITS-CLIP	23824327
MIRT670324	hsa-miR-5693	HITS-CLIP	23824327
MIRT670323	hsa-miR-4486	HITS-CLIP	23824327
MIRT670322	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT670321	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT670320	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT670319	hsa-miR-4284	HITS-CLIP	23824327
MIRT670318	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT670317	hsa-miR-4505	HITS-CLIP	23824327
MIRT670316	hsa-miR-5787	HITS-CLIP	23824327
MIRT670315	hsa-miR-3178	HITS-CLIP	23824327
MIRT670314	hsa-miR-7977	HITS-CLIP	23824327
MIRT670313	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT619277	hsa-miR-10b-3p	HITS-CLIP	23824327
MIRT619275	hsa-miR-4330	HITS-CLIP	23824327
MIRT619274	hsa-miR-4252	HITS-CLIP	23824327
MIRT619273	hsa-miR-3064-3p	HITS-CLIP	23824327
MIRT619272	hsa-miR-4715-3p	HITS-CLIP	23824327
MIRT619271	hsa-miR-4776-3p	HITS-CLIP	23824327
MIRT619270	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT619276	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT619274	hsa-miR-4252	HITS-CLIP	23824327
MIRT619273	hsa-miR-3064-3p	HITS-CLIP	23824327
MIRT619272	hsa-miR-4715-3p	HITS-CLIP	23824327
MIRT619271	hsa-miR-4776-3p	HITS-CLIP	23824327
MIRT619277	hsa-miR-10b-3p	HITS-CLIP	23824327
MIRT619276	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT619275	hsa-miR-4330	HITS-CLIP	23824327
MIRT619274	hsa-miR-4252	HITS-CLIP	23824327
MIRT619273	hsa-miR-3064-3p	HITS-CLIP	23824327
MIRT619272	hsa-miR-4715-3p	HITS-CLIP	23824327
MIRT619271	hsa-miR-4776-3p	HITS-CLIP	23824327
MIRT619270	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT619277	hsa-miR-10b-3p	HITS-CLIP	23824327
MIRT619276	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT619275	hsa-miR-4330	HITS-CLIP	23824327
MIRT619274	hsa-miR-4252	HITS-CLIP	23824327
MIRT619273	hsa-miR-3064-3p	HITS-CLIP	23824327
MIRT619272	hsa-miR-4715-3p	HITS-CLIP	23824327
MIRT619271	hsa-miR-4776-3p	HITS-CLIP	23824327
MIRT619270	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT619277	hsa-miR-10b-3p	HITS-CLIP	23824327
MIRT619276	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT619275	hsa-miR-4330	HITS-CLIP	23824327
MIRT619274	hsa-miR-4252	HITS-CLIP	23824327
MIRT619273	hsa-miR-3064-3p	HITS-CLIP	23824327
MIRT619272	hsa-miR-4715-3p	HITS-CLIP	23824327
MIRT619271	hsa-miR-4776-3p	HITS-CLIP	23824327
MIRT619270	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT528686	hsa-miR-4524b-3p	PAR-CLIP	22012620
MIRT528680	hsa-miR-411-5p	PAR-CLIP	22012620
MIRT528685	hsa-miR-4781-3p	PAR-CLIP	22012620
MIRT528684	hsa-miR-4717-3p	PAR-CLIP	22012620
MIRT528683	hsa-miR-6823-5p	PAR-CLIP	22012620
MIRT528682	hsa-miR-4524a-3p	PAR-CLIP	22012620
MIRT528681	hsa-miR-6832-5p	PAR-CLIP	22012620
MIRT528680	hsa-miR-411-5p	PAR-CLIP	22012620
MIRT528679	hsa-miR-130a-5p	PAR-CLIP	22012620
MIRT528678	hsa-miR-23a-3p	PAR-CLIP	22012620
MIRT528677	hsa-miR-23b-3p	PAR-CLIP	22012620
MIRT528676	hsa-miR-23c	PAR-CLIP	22012620
MIRT528675	hsa-miR-548s	PAR-CLIP	22012620
MIRT528674	hsa-miR-4701-5p	PAR-CLIP	22012620
MIRT528673	hsa-miR-588	PAR-CLIP	22012620
MIRT528672	hsa-miR-4435	PAR-CLIP	22012620
MIRT528671	hsa-miR-3187-3p	PAR-CLIP	22012620
MIRT886201	hsa-let-7a	CLIP-seq
MIRT886202	hsa-let-7b	CLIP-seq
MIRT886203	hsa-let-7c	CLIP-seq
MIRT886204	hsa-let-7d	CLIP-seq
MIRT886205	hsa-let-7e	CLIP-seq
MIRT886206	hsa-let-7f	CLIP-seq
MIRT886207	hsa-let-7g	CLIP-seq
MIRT886208	hsa-let-7i	CLIP-seq
MIRT886209	hsa-miR-1255a	CLIP-seq
MIRT886210	hsa-miR-1255b	CLIP-seq
MIRT886211	hsa-miR-1287	CLIP-seq
MIRT886212	hsa-miR-1323	CLIP-seq
MIRT886213	hsa-miR-155	CLIP-seq
MIRT886214	hsa-miR-202	CLIP-seq
MIRT886215	hsa-miR-3135b	CLIP-seq
MIRT886216	hsa-miR-3617	CLIP-seq
MIRT886217	hsa-miR-3646	CLIP-seq
MIRT886218	hsa-miR-365	CLIP-seq
MIRT886219	hsa-miR-412	CLIP-seq
MIRT886220	hsa-miR-4263	CLIP-seq
MIRT886221	hsa-miR-4458	CLIP-seq
MIRT886222	hsa-miR-4484	CLIP-seq
MIRT886223	hsa-miR-4500	CLIP-seq
MIRT886224	hsa-miR-4539	CLIP-seq
MIRT886225	hsa-miR-4705	CLIP-seq
MIRT886226	hsa-miR-4719	CLIP-seq
MIRT886227	hsa-miR-4762-3p	CLIP-seq
MIRT886228	hsa-miR-4778-3p	CLIP-seq
MIRT886229	hsa-miR-513b	CLIP-seq
MIRT886230	hsa-miR-516a-3p	CLIP-seq
MIRT886231	hsa-miR-544	CLIP-seq
MIRT886232	hsa-miR-548a-3p	CLIP-seq
MIRT886233	hsa-miR-548an	CLIP-seq
MIRT886234	hsa-miR-548e	CLIP-seq
MIRT886235	hsa-miR-548f	CLIP-seq
MIRT886236	hsa-miR-548g	CLIP-seq
MIRT886237	hsa-miR-548o	CLIP-seq
MIRT886238	hsa-miR-576-5p	CLIP-seq
MIRT886239	hsa-miR-641	CLIP-seq
MIRT886240	hsa-miR-890	CLIP-seq
MIRT886241	hsa-miR-892a	CLIP-seq
MIRT886242	hsa-miR-98	CLIP-seq
MIRT886243	hsa-miR-124	CLIP-seq
MIRT886244	hsa-miR-3121-3p	CLIP-seq
MIRT886245	hsa-miR-4733-3p	CLIP-seq
MIRT886246	hsa-miR-506	CLIP-seq
MIRT1962822	hsa-miR-4311	CLIP-seq
MIRT1962823	hsa-miR-4477a	CLIP-seq
MIRT2199193	hsa-miR-4775	CLIP-seq
MIRT2199194	hsa-miR-590-3p	CLIP-seq
MIRT2446893	hsa-miR-548aa	CLIP-seq
MIRT2446894	hsa-miR-656	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21516116, 25416956, 32296183, 36217029, 36217030
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IBA
GO:0005813	Component	Centrosome	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0008017	Function	Microtubule binding	IBA
GO:0008017	Function	Microtubule binding	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	25416956, 32296183
GO:0043015	Function	Gamma-tubulin binding	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8IYX8
• Protein name: Centrosomal protein CEP57L1 (Centrosomal protein 57kDa-like protein 1) (Centrosomal protein of 57 kDa-related protein) (Cep57R) (Cep57-related protein)
• Protein function: Centrosomal protein which may be required for microtubule attachment to centrosomes.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14073	Cep57_CLD	54 → 231	Centrosome localisation domain of Cep57	Coiled-coil
  PF06657	Cep57_MT_bd	311 → 384	Centrosome microtubule-binding domain of Cep57	Domain

• Sequence:

  MDSELMHSIVGSYHKPPERVFVPSFTQNEPSQNCHPANLEVTSPKILHSPNSQALILALK
  TLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS
  SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEK
  ECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHS
  KEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPS
  RTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDI
  ECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIK
  NSPRKCLTDTNLFQKNSSFHPIRVHNLQMKLRRDDIMWEQ

• Sequence length: 460

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTROCYTOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations