Gene Gene information from NCBI Gene database.
Entrez ID 285605
Gene name DTW motif tRNA-uridine aminocarboxypropyltransferase 2
Gene symbol DTWD2
Synonyms (NCBI Gene)
-
Chromosome 5
Chromosome location 5q23.1
miRNA miRNA information provided by mirtarbase database.
394
miRTarBase ID miRNA Experiments Reference
MIRT048932 hsa-miR-92a-3p CLASH 23622248
MIRT685163 hsa-miR-6082 HITS-CLIP 23313552
MIRT685162 hsa-miR-433-5p HITS-CLIP 23313552
MIRT685161 hsa-miR-6502-3p HITS-CLIP 23313552
MIRT685160 hsa-miR-6888-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
GO ID Ontology Definition Evidence Reference
GO:0005634 Component Nucleus IDA 31804502
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IDA 31804502
GO:0005737 Component Cytoplasm IEA
GO:0006400 Process TRNA modification IDA 31804502
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
621117 19334 ENSG00000169570
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NBA8
Protein name tRNA-uridine aminocarboxypropyltransferase 2 (EC 2.5.1.25) (DTW domain-containing protein 2)
Protein function Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)) (PubMed:31804502, PubMed:39173631). Also has a weak activity to form acp3U at position 20 in the D-loop
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03942 DTW 66 256 DTW domain Domain
Sequence
Sequence length 298
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
GRAVES DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HEMOLYTIC ANEMIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPEROPIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MALE REPRODUCTIVE ORGAN CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Glaucoma Open Angle Open angle glaucoma Pubtator 21310917 Associate
★☆☆☆☆
Found in Text Mining only