DCAF4L1 (DDB1 and CUL4 associated factor 4 like 1)

Gene

• Entrez ID: 285429
• Gene name: DDB1 and CUL4 associated factor 4 like 1
• Gene symbol: DCAF4L1
• Synonyms (NCBI Gene): WDR21B
• Chromosome: 4
• Chromosome location: 4p13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT707399	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT707398	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707397	hsa-miR-2115-3p	HITS-CLIP	21572407
MIRT707396	hsa-miR-654-3p	HITS-CLIP	21572407
MIRT707395	hsa-miR-1324	HITS-CLIP	21572407
MIRT707394	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707393	hsa-miR-361-5p	HITS-CLIP	21572407
MIRT707392	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT517347	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT517346	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT626246	hsa-miR-139-5p	HITS-CLIP	23824327
MIRT517347	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT517346	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT626246	hsa-miR-139-5p	HITS-CLIP	23824327
MIRT517348	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT517347	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT517346	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT626246	hsa-miR-139-5p	HITS-CLIP	23824327
MIRT517348	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT517347	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT517346	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT517348	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT517347	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT517346	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT517348	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT517347	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT517346	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT517345	hsa-miR-501-5p	PAR-CLIP	20371350
MIRT517348	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT517347	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT517346	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT517345	hsa-miR-501-5p	PAR-CLIP	20371350
MIRT517348	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT517347	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT517346	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT517345	hsa-miR-501-5p	PAR-CLIP	20371350
MIRT517348	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT517347	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT517346	hsa-miR-500a-5p	PAR-CLIP	23446348
MIRT517345	hsa-miR-501-5p	PAR-CLIP	23446348
MIRT707399	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT707398	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707397	hsa-miR-2115-3p	HITS-CLIP	21572407
MIRT707396	hsa-miR-654-3p	HITS-CLIP	21572407
MIRT707395	hsa-miR-1324	HITS-CLIP	21572407
MIRT707394	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707393	hsa-miR-361-5p	HITS-CLIP	21572407
MIRT707392	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT517347	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT517346	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT626246	hsa-miR-139-5p	HITS-CLIP	23824327
MIRT517347	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT517346	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT626246	hsa-miR-139-5p	HITS-CLIP	23824327
MIRT517348	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT517347	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT517346	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT626246	hsa-miR-139-5p	HITS-CLIP	23824327
MIRT517348	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT517347	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT517346	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT517348	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT517347	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT517346	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT517348	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT517347	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT517346	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT517345	hsa-miR-501-5p	PAR-CLIP	20371350
MIRT517348	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT517347	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT517346	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT517345	hsa-miR-501-5p	PAR-CLIP	20371350
MIRT517348	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT517347	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT517346	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT517345	hsa-miR-501-5p	PAR-CLIP	20371350
MIRT517348	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT517347	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT517346	hsa-miR-500a-5p	PAR-CLIP	23446348
MIRT517345	hsa-miR-501-5p	PAR-CLIP	23446348
MIRT925018	hsa-miR-1226	CLIP-seq
MIRT925019	hsa-miR-203	CLIP-seq
MIRT925020	hsa-miR-22	CLIP-seq
MIRT925021	hsa-miR-3074-3p	CLIP-seq
MIRT925022	hsa-miR-3128	CLIP-seq
MIRT925023	hsa-miR-3138	CLIP-seq
MIRT925024	hsa-miR-3165	CLIP-seq
MIRT925025	hsa-miR-320a	CLIP-seq
MIRT925026	hsa-miR-320b	CLIP-seq
MIRT925027	hsa-miR-320c	CLIP-seq
MIRT925028	hsa-miR-320d	CLIP-seq
MIRT925029	hsa-miR-338-3p	CLIP-seq
MIRT925030	hsa-miR-3613-3p	CLIP-seq
MIRT925031	hsa-miR-3622b-5p	CLIP-seq
MIRT925032	hsa-miR-3646	CLIP-seq
MIRT925033	hsa-miR-371-5p	CLIP-seq
MIRT925034	hsa-miR-371b-5p	CLIP-seq
MIRT925035	hsa-miR-376a	CLIP-seq
MIRT925036	hsa-miR-376b	CLIP-seq
MIRT925037	hsa-miR-3908	CLIP-seq
MIRT925038	hsa-miR-3920	CLIP-seq
MIRT925039	hsa-miR-3942-5p	CLIP-seq
MIRT925040	hsa-miR-425	CLIP-seq
MIRT925041	hsa-miR-4275	CLIP-seq
MIRT925042	hsa-miR-4429	CLIP-seq
MIRT925043	hsa-miR-4637	CLIP-seq
MIRT925044	hsa-miR-4684-5p	CLIP-seq
MIRT925045	hsa-miR-4703-5p	CLIP-seq
MIRT925046	hsa-miR-4720-5p	CLIP-seq
MIRT925047	hsa-miR-4762-3p	CLIP-seq
MIRT925048	hsa-miR-4766-3p	CLIP-seq
MIRT925049	hsa-miR-4769-3p	CLIP-seq
MIRT925050	hsa-miR-4799-3p	CLIP-seq
MIRT925051	hsa-miR-495	CLIP-seq
MIRT925052	hsa-miR-584	CLIP-seq
MIRT925053	hsa-miR-586	CLIP-seq
MIRT925054	hsa-miR-634	CLIP-seq
MIRT925055	hsa-miR-889	CLIP-seq
MIRT925056	hsa-miR-942	CLIP-seq
MIRT1974007	hsa-miR-1273	CLIP-seq
MIRT1974008	hsa-miR-129-5p	CLIP-seq
MIRT1974009	hsa-miR-3140-3p	CLIP-seq
MIRT1974010	hsa-miR-3545-3p	CLIP-seq
MIRT1974011	hsa-miR-4252	CLIP-seq
MIRT1974012	hsa-miR-4486	CLIP-seq
MIRT1974013	hsa-miR-450b-5p	CLIP-seq
MIRT1974014	hsa-miR-4537	CLIP-seq
MIRT1974015	hsa-miR-4649-5p	CLIP-seq
MIRT1974016	hsa-miR-4793-3p	CLIP-seq
MIRT1974017	hsa-miR-507	CLIP-seq
MIRT1974018	hsa-miR-508-5p	CLIP-seq
MIRT1974019	hsa-miR-550b	CLIP-seq
MIRT1974020	hsa-miR-557	CLIP-seq
MIRT1974021	hsa-miR-661	CLIP-seq
MIRT1974022	hsa-miR-766	CLIP-seq
MIRT925056	hsa-miR-942	CLIP-seq
MIRT1974008	hsa-miR-129-5p	CLIP-seq
MIRT2209594	hsa-miR-140-5p	CLIP-seq
MIRT2209595	hsa-miR-1910	CLIP-seq
MIRT2209596	hsa-miR-198	CLIP-seq
MIRT2209597	hsa-miR-3065-5p	CLIP-seq
MIRT2209598	hsa-miR-3182	CLIP-seq
MIRT2209599	hsa-miR-421	CLIP-seq
MIRT2209600	hsa-miR-4272	CLIP-seq
MIRT2209601	hsa-miR-455-3p	CLIP-seq
MIRT2209602	hsa-miR-4659a-3p	CLIP-seq
MIRT2209603	hsa-miR-4659b-3p	CLIP-seq
MIRT2209604	hsa-miR-4776-3p	CLIP-seq
MIRT2209605	hsa-miR-4777-3p	CLIP-seq
MIRT2209606	hsa-miR-488	CLIP-seq
MIRT925020	hsa-miR-22	CLIP-seq
MIRT925025	hsa-miR-320a	CLIP-seq
MIRT925026	hsa-miR-320b	CLIP-seq
MIRT925027	hsa-miR-320c	CLIP-seq
MIRT925028	hsa-miR-320d	CLIP-seq
MIRT2448051	hsa-miR-3591-3p	CLIP-seq
MIRT925030	hsa-miR-3613-3p	CLIP-seq
MIRT925034	hsa-miR-371b-5p	CLIP-seq
MIRT925042	hsa-miR-4429	CLIP-seq
MIRT2448052	hsa-miR-548a-3p	CLIP-seq
MIRT2448053	hsa-miR-548e	CLIP-seq
MIRT2448054	hsa-miR-548f	CLIP-seq
MIRT2448051	hsa-miR-3591-3p	CLIP-seq
MIRT2448052	hsa-miR-548a-3p	CLIP-seq
MIRT2448053	hsa-miR-548e	CLIP-seq
MIRT2448054	hsa-miR-548f	CLIP-seq
MIRT2448051	hsa-miR-3591-3p	CLIP-seq
MIRT2448052	hsa-miR-548a-3p	CLIP-seq
MIRT2448053	hsa-miR-548e	CLIP-seq
MIRT2448054	hsa-miR-548f	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IDA	31429579
GO:0005737	Component	Cytoplasm	IEA
GO:0080008	Component	Cul4-RING E3 ubiquitin ligase complex	IBA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q3SXM0
• Protein name: DDB1- and CUL4-associated factor 4-like protein 1 (WD repeat-containing protein 21B)
• Sequence:

  MEAERLRLLEEEAKLKKVARMGFNASSMLRKSQLGFLNVTSYSRLANELRVSCMERKKVQ
  IRSLDPSSLASDRFNFILASTNSDQLFVVNQVEVEGSKYGIISLRTLKIPSFHVYVLRNL
  YVPNRKVKSLCWASLNQLDSHVLLCFEGITDAPSCAVLLPASRFLSVHTRVNQPGMLCSF
  QIPEAWSCAWSLNTRAYHCFSAGLSQQVLLTSVATGHQQSFDTSSDVLAQQFASTAPLLF
  NGCRSGEIFAIDLRCRNRGKGWRATRLFHDSAVTSVQILQEEQCLMASDMTGKIKLWDLR
  ATKCVRQYEGHVNESAYLPLHVHEEEGIVVAVGQDCYTRIWSLHDAHLLRTIPSPYSASE
  DDIPSVAFASRLGGIRGAAPGLLMAVRQDLYCFPFS

• Sequence length: 396

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations