Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	285193
Gene name	Dual specificity phosphatase 28
Gene symbol	DUSP28
Synonyms (NCBI Gene)	DUSP26VHP
Chromosome	2
Chromosome location	2q37.3

166

Show/Hide all (166)

miRTarBase ID	miRNA	Experiments	Reference
MIRT643992	hsa-miR-4328	HITS-CLIP	23824327
MIRT643991	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT643990	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT643989	hsa-miR-3189-3p	HITS-CLIP	23824327
MIRT643988	hsa-miR-4469	HITS-CLIP	23824327
MIRT643987	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT643986	hsa-miR-4287	HITS-CLIP	23824327
MIRT643985	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT643984	hsa-miR-20a-3p	HITS-CLIP	23824327
MIRT643983	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT643982	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT643981	hsa-miR-8057	HITS-CLIP	23824327
MIRT643980	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT643979	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT539928	hsa-miR-6753-5p	PAR-CLIP	21572407
MIRT539927	hsa-miR-1321	PAR-CLIP	21572407
MIRT539926	hsa-miR-4739	PAR-CLIP	21572407
MIRT539925	hsa-miR-4756-5p	PAR-CLIP	21572407
MIRT539924	hsa-miR-4270	PAR-CLIP	21572407
MIRT539923	hsa-miR-4441	PAR-CLIP	21572407
MIRT539921	hsa-miR-6754-5p	PAR-CLIP	21572407
MIRT541801	hsa-miR-1273g-3p	PAR-CLIP	21572407
MIRT539922	hsa-miR-7113-5p	PAR-CLIP	21572407
MIRT541800	hsa-miR-4793-3p	PAR-CLIP	21572407
MIRT539920	hsa-miR-4537	PAR-CLIP	21572407
MIRT539919	hsa-miR-6087	PAR-CLIP	21572407
MIRT539918	hsa-miR-377-5p	PAR-CLIP	21572407
MIRT539917	hsa-miR-6086	PAR-CLIP	21572407
MIRT539916	hsa-miR-6499-3p	PAR-CLIP	21572407
MIRT541799	hsa-miR-4252	PAR-CLIP	21572407
MIRT539915	hsa-miR-658	PAR-CLIP	21572407
MIRT539914	hsa-miR-25-5p	PAR-CLIP	21572407
MIRT541798	hsa-miR-7703	PAR-CLIP	21572407
MIRT539913	hsa-miR-455-3p	PAR-CLIP	21572407
MIRT539912	hsa-miR-6516-5p	PAR-CLIP	21572407
MIRT539911	hsa-miR-4459	PAR-CLIP	21572407
MIRT539928	hsa-miR-6753-5p	PAR-CLIP	21572407
MIRT539927	hsa-miR-1321	PAR-CLIP	21572407
MIRT539926	hsa-miR-4739	PAR-CLIP	21572407
MIRT539925	hsa-miR-4756-5p	PAR-CLIP	21572407
MIRT539924	hsa-miR-4270	PAR-CLIP	21572407
MIRT539923	hsa-miR-4441	PAR-CLIP	21572407
MIRT539921	hsa-miR-6754-5p	PAR-CLIP	21572407
MIRT539922	hsa-miR-7113-5p	PAR-CLIP	21572407
MIRT539920	hsa-miR-4537	PAR-CLIP	21572407
MIRT539919	hsa-miR-6087	PAR-CLIP	21572407
MIRT539918	hsa-miR-377-5p	PAR-CLIP	21572407
MIRT539917	hsa-miR-6086	PAR-CLIP	21572407
MIRT539916	hsa-miR-6499-3p	PAR-CLIP	21572407
MIRT539915	hsa-miR-658	PAR-CLIP	21572407
MIRT539914	hsa-miR-25-5p	PAR-CLIP	21572407
MIRT539913	hsa-miR-455-3p	PAR-CLIP	21572407
MIRT539912	hsa-miR-6516-5p	PAR-CLIP	21572407
MIRT539911	hsa-miR-4459	PAR-CLIP	21572407
MIRT515257	hsa-miR-4738-5p	PAR-CLIP	23446348
MIRT515258	hsa-miR-6089	PAR-CLIP	23446348
MIRT515256	hsa-miR-7106-5p	PAR-CLIP	23446348
MIRT515255	hsa-miR-149-3p	PAR-CLIP	23446348
MIRT515254	hsa-miR-4728-5p	PAR-CLIP	23446348
MIRT515253	hsa-miR-6785-5p	PAR-CLIP	23446348
MIRT515252	hsa-miR-6883-5p	PAR-CLIP	23446348
MIRT515251	hsa-miR-6799-5p	PAR-CLIP	23446348
MIRT515249	hsa-miR-7977	PAR-CLIP	23446348
MIRT515250	hsa-miR-30c-1-3p	PAR-CLIP	23446348
MIRT515248	hsa-miR-30c-2-3p	PAR-CLIP	23446348
MIRT515247	hsa-miR-6788-5p	PAR-CLIP	23446348
MIRT515246	hsa-miR-1273h-5p	PAR-CLIP	23446348
MIRT515245	hsa-miR-30b-3p	PAR-CLIP	23446348
MIRT515244	hsa-miR-3689a-3p	PAR-CLIP	23446348
MIRT515243	hsa-miR-3689b-3p	PAR-CLIP	23446348
MIRT515242	hsa-miR-3689c	PAR-CLIP	23446348
MIRT515241	hsa-miR-6779-5p	PAR-CLIP	23446348
MIRT515240	hsa-miR-6780a-5p	PAR-CLIP	23446348
MIRT515239	hsa-miR-450a-1-3p	PAR-CLIP	23446348
MIRT515238	hsa-miR-3122	PAR-CLIP	23446348
MIRT515237	hsa-miR-3913-5p	PAR-CLIP	23446348
MIRT515236	hsa-miR-887-5p	PAR-CLIP	23446348
MIRT515235	hsa-miR-6513-5p	PAR-CLIP	23446348
MIRT643992	hsa-miR-4328	HITS-CLIP	23824327
MIRT643991	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT643990	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT643989	hsa-miR-3189-3p	HITS-CLIP	23824327
MIRT643988	hsa-miR-4469	HITS-CLIP	23824327
MIRT643987	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT643986	hsa-miR-4287	HITS-CLIP	23824327
MIRT643985	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT643984	hsa-miR-20a-3p	HITS-CLIP	23824327
MIRT643983	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT643982	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT643981	hsa-miR-8057	HITS-CLIP	23824327
MIRT643980	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT643979	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT539928	hsa-miR-6753-5p	PAR-CLIP	21572407
MIRT539927	hsa-miR-1321	PAR-CLIP	21572407
MIRT539926	hsa-miR-4739	PAR-CLIP	21572407
MIRT539925	hsa-miR-4756-5p	PAR-CLIP	21572407
MIRT539924	hsa-miR-4270	PAR-CLIP	21572407
MIRT539923	hsa-miR-4441	PAR-CLIP	21572407
MIRT539921	hsa-miR-6754-5p	PAR-CLIP	21572407
MIRT541801	hsa-miR-1273g-3p	PAR-CLIP	21572407
MIRT539922	hsa-miR-7113-5p	PAR-CLIP	21572407
MIRT541800	hsa-miR-4793-3p	PAR-CLIP	21572407
MIRT539920	hsa-miR-4537	PAR-CLIP	21572407
MIRT539919	hsa-miR-6087	PAR-CLIP	21572407
MIRT539918	hsa-miR-377-5p	PAR-CLIP	21572407
MIRT539917	hsa-miR-6086	PAR-CLIP	21572407
MIRT539916	hsa-miR-6499-3p	PAR-CLIP	21572407
MIRT541799	hsa-miR-4252	PAR-CLIP	21572407
MIRT539915	hsa-miR-658	PAR-CLIP	21572407
MIRT539914	hsa-miR-25-5p	PAR-CLIP	21572407
MIRT541798	hsa-miR-7703	PAR-CLIP	21572407
MIRT539913	hsa-miR-455-3p	PAR-CLIP	21572407
MIRT539912	hsa-miR-6516-5p	PAR-CLIP	21572407
MIRT539911	hsa-miR-4459	PAR-CLIP	21572407
MIRT539928	hsa-miR-6753-5p	PAR-CLIP	21572407
MIRT539927	hsa-miR-1321	PAR-CLIP	21572407
MIRT539926	hsa-miR-4739	PAR-CLIP	21572407
MIRT539925	hsa-miR-4756-5p	PAR-CLIP	21572407
MIRT539924	hsa-miR-4270	PAR-CLIP	21572407
MIRT539923	hsa-miR-4441	PAR-CLIP	21572407
MIRT539921	hsa-miR-6754-5p	PAR-CLIP	21572407
MIRT539922	hsa-miR-7113-5p	PAR-CLIP	21572407
MIRT539920	hsa-miR-4537	PAR-CLIP	21572407
MIRT539919	hsa-miR-6087	PAR-CLIP	21572407
MIRT539918	hsa-miR-377-5p	PAR-CLIP	21572407
MIRT539917	hsa-miR-6086	PAR-CLIP	21572407
MIRT539916	hsa-miR-6499-3p	PAR-CLIP	21572407
MIRT539915	hsa-miR-658	PAR-CLIP	21572407
MIRT539914	hsa-miR-25-5p	PAR-CLIP	21572407
MIRT539913	hsa-miR-455-3p	PAR-CLIP	21572407
MIRT539912	hsa-miR-6516-5p	PAR-CLIP	21572407
MIRT539911	hsa-miR-4459	PAR-CLIP	21572407
MIRT515257	hsa-miR-4738-5p	PAR-CLIP	23446348
MIRT515258	hsa-miR-6089	PAR-CLIP	23446348
MIRT515256	hsa-miR-7106-5p	PAR-CLIP	23446348
MIRT515255	hsa-miR-149-3p	PAR-CLIP	23446348
MIRT515254	hsa-miR-4728-5p	PAR-CLIP	23446348
MIRT515253	hsa-miR-6785-5p	PAR-CLIP	23446348
MIRT515252	hsa-miR-6883-5p	PAR-CLIP	23446348
MIRT515251	hsa-miR-6799-5p	PAR-CLIP	23446348
MIRT515249	hsa-miR-7977	PAR-CLIP	23446348
MIRT515250	hsa-miR-30c-1-3p	PAR-CLIP	23446348
MIRT515248	hsa-miR-30c-2-3p	PAR-CLIP	23446348
MIRT515247	hsa-miR-6788-5p	PAR-CLIP	23446348
MIRT515246	hsa-miR-1273h-5p	PAR-CLIP	23446348
MIRT515245	hsa-miR-30b-3p	PAR-CLIP	23446348
MIRT515244	hsa-miR-3689a-3p	PAR-CLIP	23446348
MIRT515243	hsa-miR-3689b-3p	PAR-CLIP	23446348
MIRT515242	hsa-miR-3689c	PAR-CLIP	23446348
MIRT515241	hsa-miR-6779-5p	PAR-CLIP	23446348
MIRT515240	hsa-miR-6780a-5p	PAR-CLIP	23446348
MIRT515239	hsa-miR-450a-1-3p	PAR-CLIP	23446348
MIRT515238	hsa-miR-3122	PAR-CLIP	23446348
MIRT515237	hsa-miR-3913-5p	PAR-CLIP	23446348
MIRT515236	hsa-miR-887-5p	PAR-CLIP	23446348
MIRT515235	hsa-miR-6513-5p	PAR-CLIP	23446348
MIRT947821	hsa-miR-148a	CLIP-seq
MIRT947822	hsa-miR-148b	CLIP-seq
MIRT947823	hsa-miR-152	CLIP-seq
MIRT947824	hsa-miR-3182	CLIP-seq
MIRT947825	hsa-miR-3686	CLIP-seq
MIRT947826	hsa-miR-4742-3p	CLIP-seq
MIRT1980837	hsa-miR-3617	CLIP-seq
MIRT1980838	hsa-miR-4462	CLIP-seq
MIRT1980839	hsa-miR-641	CLIP-seq
MIRT2215873	hsa-miR-3117-5p	CLIP-seq

Show/Hide all (6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0016311	Process	Dephosphorylation	IDA	24531476
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IDA	24531476

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q4G0W2

Protein name

Dual specificity phosphatase 28 (EC 3.1.3.16) (EC 3.1.3.48)

Protein function

Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro) (PubMed:24531476, PubMed:29121083). Has almost no detectable activity with phosphotyrosine, even less activity with phosphothreonine and

PDB

5Y15 , 5Y16

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00782	DSPc	26 → 156	Dual specificity phosphatase, catalytic domain	Domain

Sequence

MGPAEAGRRGAASPVPPPLVRVAPSLFLGSARAAGAEEQLARAGVTLCVNVSRQQPGPRA
PGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVYCKNGRSRSAAVCTAYLMR
HRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEALQAQSCLQGEPPALGLGPEA

Sequence length

176

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MULTIPLE SCLEROSIS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (31)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	26924229, 32614981	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Anaplastic thyroid carcinoma	Anaplastic thyroid cancer	BEFREE	16924234		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety	Anxiety Disorder	BEFREE	31541642		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety Disorders	Anxiety Disorder	BEFREE	31541642		★★★★★ ★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	Pubtator	27586084	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	31700183		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	31155289		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy, Temporal Lobe	Epilepsy	BEFREE	30098387		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty Liver	BEFREE	30582764		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	19043453		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	27586084	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	19043453		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	19043453		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	LHGDN	19043453		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	24050252, 27586084	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	BEFREE	31700183		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	26924229	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	25230705		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	27230679, 28986588, 29121083, 30902562		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	20562916, 30902562		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28986588		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	20562916, 23298255, 26247726		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	20562916, 23298255, 27583453	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-alcoholic Fatty Liver Disease	Non-Alcoholic Fatty Liver Disease	BEFREE	30582764		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	27230679, 28986588, 30902562		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	27230679	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Panic Attacks	Panic Disorder	BEFREE	31541642		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	31634513		★★★★★ ★☆☆☆☆ Found in Text Mining only
Steatohepatitis	Fatty Liver	BEFREE	30582764		★★★★★ ★☆☆☆☆ Found in Text Mining only
Tauopathies	Tauopathies	BEFREE	29133432		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasm	Thyroid Neoplasm	LHGDN	16924234		★★★★★ ★☆☆☆☆ Found in Text Mining only

DUSP28 (dual specificity phosphatase 28)