Gene Gene information from NCBI Gene database.
Entrez ID 285
Gene name Angiopoietin 2
Gene symbol ANGPT2
Synonyms (NCBI Gene)
AGPT2ANG2LMPHM10
Chromosome 8
Chromosome location 8p23.1
Summary This gene belongs to the angiopoietin family of growth factors. The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. Angiopoietin 2 is
miRNA miRNA information provided by mirtarbase database.
135
miRTarBase ID miRNA Experiments Reference
MIRT438090 hsa-miR-542-3p Luciferase reporter assayqRT-PCRWestern blot 24403060
MIRT438090 hsa-miR-542-3p Luciferase reporter assayqRT-PCRWestern blot 24403060
MIRT438090 hsa-miR-542-3p Luciferase reporter assayqRT-PCRWestern blot 24403060
MIRT438090 hsa-miR-542-3p Luciferase reporter assayqRT-PCRWestern blot 24403060
MIRT438013 hsa-miR-145-5p Luciferase reporter assayqRT-PCR 24384875
Transcription factors Transcription factors information provided by TRRUST V2 database.
9
Transcription factor Regulation Reference
ETS1 Activation 15003510
ETS2 Activation 15003510
FOXC2 Unknown 20213583
FOXO1 Unknown 20213583
GATA2 Unknown 22792348
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
44
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IBA
GO:0001525 Process Angiogenesis IEA
GO:0001525 Process Angiogenesis IEA
GO:0001666 Process Response to hypoxia IEA
GO:0005102 Function Signaling receptor binding TAS 9204896, 10766762
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601922 485 ENSG00000091879
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O15123
Protein name Angiopoietin-2 (ANG-2)
Protein function Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1 (PubMed:15284
PDB 1Z3S , 1Z3U , 2GY7 , 4JZC , 4ZFG , 8VGP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00147 Fibrinogen_C 280 494 Fibrinogen beta and gamma chains, C-terminal globular domain Domain
Sequence
MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPY
VSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQ
TAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSE
INKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVN
NSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTL
TFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFV
SQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPG
NDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGS
GYSLKATTMMIRPA
DF
Sequence length 496
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
HIF-1 signaling pathway
PI3K-Akt signaling pathway
Kaposi sarcoma-associated herpesvirus infection
  Tie2 Signaling
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
9
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Lymphatic malformation 10 Pathogenic rs61733318, rs2129565840 RCV001479013
RCV001479014
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANGPT2-related disorder Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTOSOMAL RECESSIVE PRIMARY MICROCEPHALY Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DENTAL CARIES GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HEMANGIOSARCOMA CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Coronary Syndrome Coronary Syndrome BEFREE 31390228
★☆☆☆☆
Found in Text Mining only
Acute pancreatitis Pancreatitis BEFREE 28208708, 28368336
★☆☆☆☆
Found in Text Mining only
Addison Disease Addison`s Disease BEFREE 31075757
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 17785951
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 17785951
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of large intestine Colorectal Cancer BEFREE 17785951
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of pancreas Pancreatic adenocarcinoma BEFREE 15501112
★☆☆☆☆
Found in Text Mining only
Age related macular degeneration Age-related macular degeneration BEFREE 28585908
★☆☆☆☆
Found in Text Mining only
Alopecia Alopecia BEFREE 29724581
★☆☆☆☆
Found in Text Mining only
Anaplasia Anaplasia BEFREE 14600132, 15094228, 31348822
★☆☆☆☆
Found in Text Mining only