Gene Gene information from NCBI Gene database.
Entrez ID 284996
Gene name Ring finger protein 149
Gene symbol RNF149
Synonyms (NCBI Gene)
DNAPTP2
Chromosome 2
Chromosome location 2q11.2
miRNA miRNA information provided by mirtarbase database.
386
miRTarBase ID miRNA Experiments Reference
MIRT002520 hsa-miR-373-3p Microarray 15685193
MIRT002520 hsa-miR-373-3p Microarray;Other 15685193
MIRT031790 hsa-miR-16-5p Sequencing 20371350
MIRT046533 hsa-miR-15b-5p CLASH 23622248
MIRT045180 hsa-miR-186-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0005737 Component Cytoplasm IBA
GO:0005770 Component Late endosome IBA
GO:0005783 Component Endoplasmic reticulum IBA
GO:0005794 Component Golgi apparatus IBA
GO:0006511 Process Ubiquitin-dependent protein catabolic process IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NC42
Protein name E3 ubiquitin-protein ligase RNF149 (EC 2.3.2.27) (DNA polymerase-transactivated protein 2) (RING finger protein 149) (RING-type E3 ubiquitin transferase RNF149)
Protein function E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02225 PA 76 171 PA domain Family
PF13639 zf-RING_2 267 310 Ring finger domain Domain
Sequence
MAWRRREASVGARGVLALALLALALCVPGARGRALEWFSAVVNIEYVDPQTNLTVWSVSE
SGRFGDSSPKEGAHGLVGVPWAPGGDLEGCAPDTRFFVPEPGGRGAAPWVALVARGGCTF
KDKVLVAARRNASAVVLYNEERYGNITLPMSHAGTGNIVVIMISYPKGREI
LELVQKGIP
VTMTIGVGTRHVQEFISGQSVVFVAIAFITMMIISLAWLIFYYIQRFLYTGSQIGSQSHR
KETKKVIGQLLLHTVKHGEKGIDVDAENCAVCIENFKVKDIIRILPCKHIFHRICIDPWL
LDHRTCPMCK
LDVIKALGYWGEPGDVQEMPAPESPPGRDPAANLSLALPDDDGSDDSSPP
SASPAESEPQCDPSFKGDAGENTALLEAGRSDSRHGGPIS
Sequence length 400
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
PANCREATIC CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Heart Defects Congenital Congenital heart defect Pubtator 37404133 Associate
★☆☆☆☆
Found in Text Mining only
Hypoplastic Left Heart Syndrome Hypoplastic left heart syndrome Pubtator 37404133 Associate
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of breast Breast Cancer UNIPROT_DG
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of prostate Prostate cancer BEFREE 29890952
★☆☆☆☆
Found in Text Mining only
Nuclear cataract Cataract BEFREE 29182452
★☆☆☆☆
Found in Text Mining only
Prostate carcinoma Prostate cancer BEFREE 29890952
★☆☆☆☆
Found in Text Mining only
Thromboangiitis Obliterans Thromboangiitis obliterans Pubtator 38275601 Associate
★☆☆☆☆
Found in Text Mining only