Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	284266
Gene name	Sialic acid binding Ig like lectin 15
Gene symbol	SIGLEC15
Synonyms (NCBI Gene)	CD33L3HsT1361SIGLEC-15
Chromosome	18
Chromosome location	18q12.3

160

Show/Hide all (160)

miRTarBase ID	miRNA	Experiments	Reference
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT625635	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT625634	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT618484	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT625633	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT618481	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT625635	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT625634	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT618484	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT618483	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT618482	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT625633	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT618481	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618480	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT625635	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT625634	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT618484	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT618483	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT618482	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT618481	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618480	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT625635	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT625634	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT618484	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT618483	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT618482	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT625633	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT618481	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618480	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT625635	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT625634	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT618484	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT625633	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT618481	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT618484	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT618483	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT618482	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT618481	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618480	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT625635	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT625634	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT625633	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT618481	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT625635	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT625634	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT625633	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT618481	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT618484	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT618481	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT625635	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT625634	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT625633	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT625635	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT625634	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT625633	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT618484	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT618483	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT618482	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT618481	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618480	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT625635	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT625634	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT618484	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT625633	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT618481	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT625635	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT625634	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT618484	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT618483	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT618482	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT625633	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT618481	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618480	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT625635	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT625634	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT618484	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT618483	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT618482	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT618481	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618480	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT625635	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT625634	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT618484	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT618483	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT618482	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT625633	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT618481	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618480	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT625635	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT625634	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT618484	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT625633	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT618481	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT618484	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT618483	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT618482	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT618481	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618480	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT625635	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT625634	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT625633	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT618481	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT625635	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT625634	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT625633	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT618481	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT618484	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT618481	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT625635	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT625634	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT625633	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT625635	hsa-miR-501-3p	HITS-CLIP	23824327
MIRT625634	hsa-miR-502-3p	HITS-CLIP	23824327
MIRT625633	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT618485	hsa-miR-8485	HITS-CLIP	23824327
MIRT618484	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT618483	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT618482	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT618481	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618480	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT1348558	hsa-miR-1245b-3p	CLIP-seq
MIRT1348559	hsa-miR-377	CLIP-seq
MIRT1348560	hsa-miR-4266	CLIP-seq
MIRT1348561	hsa-miR-4695-5p	CLIP-seq
MIRT1348562	hsa-miR-4779	CLIP-seq
MIRT1348559	hsa-miR-377	CLIP-seq
MIRT2459370	hsa-miR-1182	CLIP-seq
MIRT2459371	hsa-miR-1909	CLIP-seq
MIRT2459372	hsa-miR-192	CLIP-seq
MIRT2459373	hsa-miR-193a-5p	CLIP-seq
MIRT2459374	hsa-miR-215	CLIP-seq
MIRT2459375	hsa-miR-4468	CLIP-seq
MIRT2459370	hsa-miR-1182	CLIP-seq
MIRT2459371	hsa-miR-1909	CLIP-seq
MIRT2459372	hsa-miR-192	CLIP-seq
MIRT2459373	hsa-miR-193a-5p	CLIP-seq
MIRT2459374	hsa-miR-215	CLIP-seq
MIRT2459375	hsa-miR-4468	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0032956	Process	Regulation of actin cytoskeleton organization	IBA
GO:0032956	Process	Regulation of actin cytoskeleton organization	IEA
GO:0032991	Component	Protein-containing complex	IEA
GO:0045124	Process	Regulation of bone resorption	IBA
GO:0045124	Process	Regulation of bone resorption	IEA
GO:2001204	Process	Regulation of osteoclast development	IBA
GO:2001204	Process	Regulation of osteoclast development	IEA

MIM	HGNC	e!Ensembl
618105	27596	ENSG00000197046

Q6ZMC9

Protein name

Sialic acid-binding Ig-like lectin 15 (Siglec-15) (CD33 antigen-like 3)

Protein function

Binds sialylated glycoproteins.

PDB

7ZOZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07686	V-set	47 → 165	Immunoglobulin V-set domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in macrophage and/or dendritic cells of spleen and lymph nodes.

Sequence

MEKSIWLLACLAWVLPTGSFVRTKIDTTENLLNTEVHSSPAQRWSMQVPPEVSAEAGDAA
VLPCTFTHPHRHYDGPLTAIWRAGEPYAGPQVFRCAAARGSELCQTALSLHGRFRLLGNP
RRNDLSLRVERLALADDRRYFCRVEFAGDVHDRYESRHGVRLHVTAAPRIVNISVLPSPA
HAFRALCTAEGEPPPALAWSGPALGNSLAAVRSPREGHGHLVTAELPALTHDGRYTCTAA
NSLGRSEASVYLFRFHGASGASTVALLLGALGFKALLLLGVLAARAARRRPEHLDTPDTP
PRSQAQESNYENLSQMNPRSPPATMCSP

Sequence length

328

Interactions

View interactions

	Reactome
			DAP12 interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BRONCHIAL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESOPHAGEAL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (26)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Aortic Aneurysm Abdominal	Aortic aneurysm	Pubtator	37055467	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	35151947, 35581307, 37222841	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34328657, 35237695, 36614238	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	35083884	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	32780490	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	34814302, 36424637, 37869015	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	36648946	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Giant Cell Tumor of Bone	Giant cell tumor of bone	Pubtator	36290882	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	37325664	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome	Hereditary breast and ovarian cancer syndrome	Pubtator	35581307	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary pancreatitis	Pancreatitis	Pubtator	37325664	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	32939323, 35459795	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	36159823	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	33441719	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30833750		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	35729260	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30833750, 31806628		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	BEFREE	30076992		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	35154101	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	36438917, 38182638	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	35581307	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	33666065	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Carcinoma Anaplastic	Thyroid cancer	Pubtator	35769818	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	35769818	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	36159823	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	33537076, 35581307	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

SIGLEC15 (sialic acid binding Ig like lectin 15)