Gene Gene information from NCBI Gene database.
Entrez ID 284161
Gene name Glycerophosphodiester phosphodiesterase domain containing 1
Gene symbol GDPD1
Synonyms (NCBI Gene)
GDE4
Chromosome 17
Chromosome location 17q22
Summary This gene encodes a member of the glycerophosphodiester phosphodiesterase family of enzymes that catalyze the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol. The encoded protein is localized to the cytoplasm and concentrat
miRNA miRNA information provided by mirtarbase database.
425
miRTarBase ID miRNA Experiments Reference
MIRT016859 hsa-miR-335-5p Microarray 18185580
MIRT668148 hsa-miR-1234-3p HITS-CLIP 23824327
MIRT668147 hsa-miR-7107-5p HITS-CLIP 23824327
MIRT668146 hsa-miR-2116-3p HITS-CLIP 23824327
MIRT668145 hsa-miR-4454 HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
GO ID Ontology Definition Evidence Reference
GO:0004622 Function Phosphatidylcholine lysophospholipase activity IBA
GO:0004622 Function Phosphatidylcholine lysophospholipase activity IEA
GO:0004622 Function Phosphatidylcholine lysophospholipase activity IMP 25596343
GO:0005737 Component Cytoplasm IEA
GO:0005783 Component Endoplasmic reticulum IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616317 20883 ENSG00000153982
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8N9F7
Protein name Lysophospholipase D GDPD1 (EC 3.1.4.-) (Glycerophosphodiester phosphodiesterase 4) (Glycerophosphodiester phosphodiesterase domain-containing protein 1)
Protein function Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:25596343, PubMed:27637550). Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (ly
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03009 GDPD 45 202 Glycerophosphoryl diester phosphodiesterase family Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed with high expression level in testis. {ECO:0000269|PubMed:16147865, ECO:0000269|PubMed:27637550}.
Sequence
MSSTAAFYLLSTLGGYLVTSFLLLKYPTLLHQRKKQRFLSKHISHRGGAGENLENTMAAF
QHAVKIGTDMLELDCHITKDEQVVVSHDENLKRATGVNVNISDLKYCELPPYLGKLDVSF
QRACQCEGKDNRIPLLKEVFEAFPNTPINIDIKVNNNVLIKKVSELVKRYNREHLTVWGN
ANYEIVEKCYKENSDIPILFSL
QRVLLILGLFFTGLLPFVPIREQFFEIPMPSIILKLKE
PHTMSRSQKFLIWLSDLLLMRKALFDHLTARGIQVYIWVLNEEQEYKRAFDLGATGVMTD
YPTKLRDFLHNFSA
Sequence length 314
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Ether lipid metabolism
Metabolic pathways
 
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
OCULAR HYPERTENSION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
RETINITIS PIGMENTOSA Disgenet, Orphanet
Disgenet, Orphanet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
RETINITIS PIGMENTOSA 1 CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations