HID1 (HID1 domain containing)

Gene

• Entrez ID: 283987
• Gene name: HID1 domain containing
• Gene symbol: HID1
• Synonyms (NCBI Gene): 17orf28, C17orf28, DEE105, DMC1, HID-1
• Chromosome: 17
• Chromosome location: 17q25.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019203	hsa-miR-335-5p	Microarray	18185580
MIRT624135	hsa-miR-5580-3p	HITS-CLIP	23824327
MIRT624134	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT624133	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT624132	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT624131	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT624130	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT624129	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT624128	hsa-miR-4319	HITS-CLIP	23824327
MIRT624127	hsa-miR-3140-5p	HITS-CLIP	23824327
MIRT624126	hsa-miR-4680-3p	HITS-CLIP	23824327
MIRT624125	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT624135	hsa-miR-5580-3p	HITS-CLIP	23824327
MIRT624134	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT624133	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT624132	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT624131	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT624130	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT624129	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT624128	hsa-miR-4319	HITS-CLIP	23824327
MIRT624127	hsa-miR-3140-5p	HITS-CLIP	23824327
MIRT624126	hsa-miR-4680-3p	HITS-CLIP	23824327
MIRT624125	hsa-miR-670-5p	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000138	Component	Golgi trans cisterna	IBA
GO:0000138	Component	Golgi trans cisterna	IDA	21337012
GO:0000139	Component	Golgi membrane	IEA
GO:0005515	Function	Protein binding	IPI	20368287, 25416956, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IDA	21337012
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005797	Component	Golgi medial cisterna	IBA
GO:0005797	Component	Golgi medial cisterna	IDA	21337012
GO:0005829	Component	Cytosol	IDA
GO:0005881	Component	Cytoplasmic microtubule	IDA	23264731
GO:0009749	Process	Response to glucose	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0030070	Process	Insulin processing	IEA
GO:0042144	Process	Vacuole fusion, non-autophagic	IEA
GO:0061792	Process	Secretory granule maturation	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0098548	Component	Cytoplasmic side of Golgi membrane	IDA	21337012

Other IDs

• MIM: 605752
• HGNC: 15736
• e!Ensembl: ENSG00000167861

Protein

• UniProt ID: Q8IV36
• Protein name: Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog)
• Protein function: May play an important role in the development of cancers in a broad range of tissues.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12722	Hid1	1 → 785	High-temperature-induced dauer-formation protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in heart, skeletal muscle, colon, spleen, kidney, liver, small intestine and lung. Highest expression is seen in brain and placenta. Loss of expression is seen in some breast, cervical, hepatocellular, lung, thyroid, gastric
• Sequence:

  MGSTDSKLNFRKAVIQLTTKTQPVEATDDAFWDQFWADTATSVQDVFALVPAAEIRAVRE
  ESPSNLATLCYKAVEKLVQGAESGCHSEKEKQIVLNCSRLLTRVLPYIFEDPDWRGFFWS
  TVPGAGRGGQGEEDDEHARPLAESLLLAIADLLFCPDFTVQSHRRSTVDSAEDVHSLDSC
  EYIWEAGVGFAHSPQPNYIHDMNRMELLKLLLTCFSEAMYLPPAPESGSTNPWVQFFCST
  ENRHALPLFTSLLNTVCAYDPVGYGIPYNHLLFSDYREPLVEEAAQVLIVTLDHDSASSA
  SPTVDGTTTGTAMDDADPPGPENLFVNYLSRIHREEDFQFILKGIARLLSNPLLQTYLPN
  STKKIQFHQELLVLFWKLCDFNKKFLFFVLKSSDVLDILVPILFFLNDARADQSRVGLMH
  IGVFILLLLSGERNFGVRLNKPYSIRVPMDIPVFTGTHADLLIVVFHKIITSGHQRLQPL
  FDCLLTIVVNVSPYLKSLSMVTANKLLHLLEAFSTTWFLFSAAQNHHLVFFLLEVFNNII
  QYQFDGNSNLVYAIIRKRSIFHQLANLPTDPPTIHKALQRRRRTPEPLSRTGSQEGTSME
  GSRPAAPAEPGTLKTSLVATPGIDKLTEKSQVSEDGTLRSLEPEPQQSLEDGSPAKGEPS
  QAWREQRRPSTSSASGQWSPTPEWVLSWKSKLPLQTIMRLLQVLVPQVEKICIDKGLTDE
  SEILRFLQHGTLVGLLPVPHPILIRKYQANSGTAMWFRTYMWGVIYLRNVDPPVWYDTDV
  KLFEIQRV

• Sequence length: 788

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Developmental and epileptic encephalopathy 105 with hypopituitarism	Pathogenic	rs994473385, rs2039300041, rs2039494684	RCV002274871 RCV002274872 RCV002274873	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Atrophy	Atrophy	Pubtator	33999436	Associate	★☆☆☆☆ Found in Text Mining only
Azoospermia	Azoospermia	Pubtator	35172124	Associate	★☆☆☆☆ Found in Text Mining only
Bloom Syndrome	Bloom Syndrome	BEFREE	10652259		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	39456830	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	40179422	Associate	★☆☆☆☆ Found in Text Mining only
Central Nervous System Diseases	Central nervous system disease	Pubtator	33999436	Associate	★☆☆☆☆ Found in Text Mining only
Gastric ulcer	Gastric ulcer	BEFREE	28365824		★☆☆☆☆ Found in Text Mining only
Hypopituitarism	Hypopituitarism	Pubtator	33999436	Associate	★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	11281419		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	18066084, 25906155, 25971253, 29458771		★☆☆☆☆ Found in Text Mining only
NON RARE IN EUROPE: Primary ovarian failure	Ovarian Failure	Orphanet			★☆☆☆☆ Found in Text Mining only
Non-obstructive azoospermia	Non-obstructive azoospermia	BEFREE	29331980		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	27460604		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	30177354	Associate	★☆☆☆☆ Found in Text Mining only
Ovarian Failure, Premature	Ovarian Failure	BEFREE	18166824, 23265958, 29331980		★☆☆☆☆ Found in Text Mining only
Ovarian Failure, Premature	Ovarian Failure	LHGDN	18166824		★☆☆☆☆ Found in Text Mining only
Premature Menopause	Premature Menopause	BEFREE	18166824, 23265958		★☆☆☆☆ Found in Text Mining only
Uterine Cervical Dysplasia	Uterine disease	Pubtator	20084279	Associate	★☆☆☆☆ Found in Text Mining only