Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	283927
Gene name	Nudix hydrolase 7
Gene symbol	NUDT7
Synonyms (NCBI Gene)	-
Chromosome	16
Chromosome location	16q23.1
Summary	The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofacto

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miRTarBase ID	miRNA	Experiments	Reference
MIRT715817	hsa-miR-590-3p	HITS-CLIP	19536157
MIRT715816	hsa-miR-379-3p	HITS-CLIP	19536157
MIRT715815	hsa-miR-411-3p	HITS-CLIP	19536157
MIRT715813	hsa-miR-4502	HITS-CLIP	19536157
MIRT715814	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT715811	hsa-miR-3171	HITS-CLIP	19536157
MIRT715812	hsa-miR-194-5p	HITS-CLIP	19536157
MIRT715810	hsa-miR-3192-3p	HITS-CLIP	19536157
MIRT715809	hsa-miR-4762-3p	HITS-CLIP	19536157
MIRT712691	hsa-miR-4464	HITS-CLIP	19536157
MIRT712690	hsa-miR-4748	HITS-CLIP	19536157
MIRT712689	hsa-miR-3938	HITS-CLIP	19536157
MIRT712688	hsa-miR-4780	HITS-CLIP	19536157
MIRT712687	hsa-miR-6780b-3p	HITS-CLIP	19536157
MIRT712686	hsa-miR-623	HITS-CLIP	19536157
MIRT712685	hsa-miR-204-5p	HITS-CLIP	19536157
MIRT712684	hsa-miR-211-5p	HITS-CLIP	19536157
MIRT712683	hsa-miR-7641	HITS-CLIP	19536157
MIRT712682	hsa-miR-4755-5p	HITS-CLIP	19536157
MIRT712681	hsa-miR-5006-3p	HITS-CLIP	19536157
MIRT689595	hsa-miR-548ac	HITS-CLIP	23313552
MIRT689594	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT689593	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT689592	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT689591	hsa-miR-548z	HITS-CLIP	23313552
MIRT689590	hsa-miR-548as-3p	HITS-CLIP	23313552
MIRT689589	hsa-miR-1273d	HITS-CLIP	23313552
MIRT689588	hsa-miR-942-3p	HITS-CLIP	23313552
MIRT689587	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT689586	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT689585	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT689584	hsa-miR-4470	HITS-CLIP	23313552
MIRT689583	hsa-miR-3926	HITS-CLIP	23313552
MIRT689582	hsa-miR-548s	HITS-CLIP	23313552
MIRT689581	hsa-miR-214-5p	HITS-CLIP	23313552
MIRT689580	hsa-miR-6811-3p	HITS-CLIP	23313552
MIRT689579	hsa-miR-6847-3p	HITS-CLIP	23313552
MIRT689578	hsa-miR-4284	HITS-CLIP	23313552
MIRT689577	hsa-miR-24-3p	HITS-CLIP	23313552
MIRT689576	hsa-miR-6514-3p	HITS-CLIP	23313552
MIRT689575	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT689574	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT689573	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT689572	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT689571	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT689570	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT689569	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT689568	hsa-miR-3689c	HITS-CLIP	23313552
MIRT689567	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT689566	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT689565	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT689564	hsa-miR-3122	HITS-CLIP	23313552
MIRT689563	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT689562	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT689561	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT689589	hsa-miR-1273d	PAR-CLIP	27292025
MIRT715817	hsa-miR-590-3p	HITS-CLIP	19536157
MIRT715816	hsa-miR-379-3p	HITS-CLIP	19536157
MIRT715815	hsa-miR-411-3p	HITS-CLIP	19536157
MIRT715813	hsa-miR-4502	HITS-CLIP	19536157
MIRT715814	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT715811	hsa-miR-3171	HITS-CLIP	19536157
MIRT715812	hsa-miR-194-5p	HITS-CLIP	19536157
MIRT715810	hsa-miR-3192-3p	HITS-CLIP	19536157
MIRT715809	hsa-miR-4762-3p	HITS-CLIP	19536157
MIRT712691	hsa-miR-4464	HITS-CLIP	19536157
MIRT712690	hsa-miR-4748	HITS-CLIP	19536157
MIRT712689	hsa-miR-3938	HITS-CLIP	19536157
MIRT712688	hsa-miR-4780	HITS-CLIP	19536157
MIRT712687	hsa-miR-6780b-3p	HITS-CLIP	19536157
MIRT712686	hsa-miR-623	HITS-CLIP	19536157
MIRT712685	hsa-miR-204-5p	HITS-CLIP	19536157
MIRT712684	hsa-miR-211-5p	HITS-CLIP	19536157
MIRT712683	hsa-miR-7641	HITS-CLIP	19536157
MIRT712682	hsa-miR-4755-5p	HITS-CLIP	19536157
MIRT712681	hsa-miR-5006-3p	HITS-CLIP	19536157
MIRT689595	hsa-miR-548ac	HITS-CLIP	23313552
MIRT689594	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT689593	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT689592	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT689591	hsa-miR-548z	HITS-CLIP	23313552
MIRT689590	hsa-miR-548as-3p	HITS-CLIP	23313552
MIRT689589	hsa-miR-1273d	HITS-CLIP	23313552
MIRT689588	hsa-miR-942-3p	HITS-CLIP	23313552
MIRT689587	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT689586	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT689585	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT689584	hsa-miR-4470	HITS-CLIP	23313552
MIRT689583	hsa-miR-3926	HITS-CLIP	23313552
MIRT689582	hsa-miR-548s	HITS-CLIP	23313552
MIRT689581	hsa-miR-214-5p	HITS-CLIP	23313552
MIRT689580	hsa-miR-6811-3p	HITS-CLIP	23313552
MIRT689579	hsa-miR-6847-3p	HITS-CLIP	23313552
MIRT689578	hsa-miR-4284	HITS-CLIP	23313552
MIRT689577	hsa-miR-24-3p	HITS-CLIP	23313552
MIRT689576	hsa-miR-6514-3p	HITS-CLIP	23313552
MIRT689575	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT689574	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT689573	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT689572	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT689571	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT689570	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT689569	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT689568	hsa-miR-3689c	HITS-CLIP	23313552
MIRT689567	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT689566	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT689565	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT689564	hsa-miR-3122	HITS-CLIP	23313552
MIRT689563	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT689562	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT689561	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT2285869	hsa-miR-1256	CLIP-seq
MIRT2285870	hsa-miR-135a	CLIP-seq
MIRT2285871	hsa-miR-135b	CLIP-seq
MIRT2285872	hsa-miR-3119	CLIP-seq
MIRT2285873	hsa-miR-4720-5p	CLIP-seq
MIRT2285874	hsa-miR-4790-3p	CLIP-seq
MIRT2285875	hsa-miR-4799-3p	CLIP-seq

Show/Hide all (36)

GO ID	Ontology	Definition	Evidence
GO:0000287	Function	Magnesium ion binding	IEA
GO:0000287	Function	Magnesium ion binding	ISS
GO:0003723	Function	RNA binding	IEA
GO:0005777	Component	Peroxisome	IEA
GO:0005777	Component	Peroxisome	ISS
GO:0005782	Component	Peroxisomal matrix	IEA
GO:0005782	Component	Peroxisomal matrix	TAS
GO:0005829	Component	Cytosol	TAS
GO:0009132	Process	Nucleoside diphosphate metabolic process	IEA
GO:0010945	Function	Coenzyme A diphosphatase activity	IEA
GO:0010945	Function	Coenzyme A diphosphatase activity	ISS
GO:0015938	Process	Coenzyme A catabolic process	IBA
GO:0015938	Process	Coenzyme A catabolic process	IEA
GO:0015938	Process	Coenzyme A catabolic process	ISS
GO:0016787	Function	Hydrolase activity	IEA
GO:0016818	Function	Hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEA
GO:0030145	Function	Manganese ion binding	IEA
GO:0030515	Function	SnoRNA binding	IEA
GO:0030515	Function	SnoRNA binding	ISS
GO:0036114	Process	Medium-chain fatty-acyl-CoA catabolic process	IEA
GO:0036114	Process	Medium-chain fatty-acyl-CoA catabolic process	ISS
GO:0044580	Process	Butyryl-CoA catabolic process	IEA
GO:0044580	Process	Butyryl-CoA catabolic process	ISS
GO:0046356	Process	Acetyl-CoA catabolic process	IEA
GO:0046356	Process	Acetyl-CoA catabolic process	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0050873	Process	Brown fat cell differentiation	IEA
GO:0140933	Function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	ISS
GO:1901289	Process	Succinyl-CoA catabolic process	IEA
GO:1901289	Process	Succinyl-CoA catabolic process	ISS
GO:1902858	Process	Propionyl-CoA metabolic process	IEA
GO:1902858	Process	Propionyl-CoA metabolic process	ISS
GO:1902859	Process	Propionyl-CoA catabolic process	IEA
GO:1902859	Process	Propionyl-CoA catabolic process	ISS
GO:2001294	Process	Malonyl-CoA catabolic process	IEA
GO:2001294	Process	Malonyl-CoA catabolic process	ISS

MIM	HGNC	e!Ensembl
609231	8054	ENSG00000140876

P0C024

Protein name

Peroxisomal coenzyme A diphosphatase NUDT7 (EC 3.6.1.-) (EC 3.6.1.77) (Nucleoside diphosphate-linked moiety X motif 7) (Nudix motif 7)

Protein function

Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies (By similarity). Pr

PDB

5QGG , 5QGH , 5QGI , 5QGJ , 5QGK , 5QGL , 5QGM , 5QGN , 5QGO , 5QGP , 5QGQ , 5QGR , 5QGS , 5QGT , 5QGU , 5QGV , 5QGW , 5QGX , 5QGY , 5QGZ , 5QH0 , 5QH1 , 5QH2 , 5QH3 , 5QH4 , 5QH5 , 5QH6 , 5QH7 , 5QH8 , 5QH9 , 5QHA , 5QHB , 5QHC , 5QHE , 5QHF , 5QHG , 5QHH , 5T3P

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00293	NUDIX	38 → 166	NUDIX domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in liver, kidney, pancreas, pituitary, small intestine, spleen, heart and placenta. Weakly expressed in brain. {ECO:0000269|PubMed:11415433}.

Sequence

MSRLGLPEEPVRNSLLDDAKARLRKYDIGGKYSHLPYNKYSVLLPLVAKEGKLHLLFTVR
SEKLRRAPGEVCFPGGKRDPTDMDDAATALREAQEEVGLRPHQVEVVCCLVPCLIDTDTL
ITPFVGLIDHNFQAQPNPAEVKDVFLVPLAYFLHPQVHDQHYVTRLGHRFINHIFEYTNP
EDGVTYQIKGMTANLAVLVAFIILEKKPTFEVQFNLNDVLASSEELFLKVHKKATSRL

Sequence length

238

Interactions

View interactions

	KEGG		Reactome
	Peroxisome		Peroxisomal lipid metabolism Peroxisomal protein import

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	24146633	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
CRANIOOSTEOARTHROPATHY	Cranioosteoarthropathy	BEFREE	29378847		★★★★★ ★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	30143643		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	CTD_human_DG	25058030		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of liver	Liver Cancer	CTD_human_DG	25058030		★★★★★ ★☆☆☆☆ Found in Text Mining only

NUDT7 (nudix hydrolase 7)