Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	283471
Gene name	Transmembrane serine protease 12
Gene symbol	TMPRSS12
Synonyms (NCBI Gene)	CT151
Chromosome	12
Chromosome location	12q13.12

100

Show/Hide all (100)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016740	hsa-miR-335-5p	Microarray	18185580
MIRT689698	hsa-miR-4761-5p	HITS-CLIP	23313552
MIRT689697	hsa-miR-3614-5p	HITS-CLIP	23313552
MIRT689696	hsa-miR-6500-3p	HITS-CLIP	23313552
MIRT689695	hsa-miR-1288-5p	HITS-CLIP	23313552
MIRT689694	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT689693	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT689692	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT689691	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT689690	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT689689	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT689688	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT689687	hsa-miR-6721-5p	HITS-CLIP	23313552
MIRT689686	hsa-miR-541-3p	HITS-CLIP	23313552
MIRT689685	hsa-miR-654-5p	HITS-CLIP	23313552
MIRT689684	hsa-miR-7977	HITS-CLIP	23313552
MIRT525460	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT525459	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT525458	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT689683	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT689682	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT689681	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT689680	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT689679	hsa-miR-3689c	HITS-CLIP	23313552
MIRT689678	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT689677	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT689676	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT689675	hsa-miR-3122	HITS-CLIP	23313552
MIRT689674	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT689673	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT689672	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT525467	hsa-miR-4282	PAR-CLIP	22012620
MIRT525466	hsa-miR-6871-5p	PAR-CLIP	22012620
MIRT525465	hsa-miR-139-5p	PAR-CLIP	22012620
MIRT525464	hsa-miR-6878-5p	PAR-CLIP	22012620
MIRT525463	hsa-miR-6731-5p	PAR-CLIP	22012620
MIRT525462	hsa-miR-8085	PAR-CLIP	22012620
MIRT525461	hsa-miR-3618	PAR-CLIP	22012620
MIRT525460	hsa-miR-30c-1-3p	PAR-CLIP	22012620
MIRT525459	hsa-miR-30c-2-3p	PAR-CLIP	22012620
MIRT525458	hsa-miR-6788-5p	PAR-CLIP	22012620
MIRT525457	hsa-let-7c-3p	PAR-CLIP	22012620
MIRT525456	hsa-let-7a-2-3p	PAR-CLIP	22012620
MIRT525455	hsa-let-7g-3p	PAR-CLIP	22012620
MIRT525454	hsa-miR-493-5p	PAR-CLIP	22012620
MIRT689698	hsa-miR-4761-5p	HITS-CLIP	23313552
MIRT689697	hsa-miR-3614-5p	HITS-CLIP	23313552
MIRT689696	hsa-miR-6500-3p	HITS-CLIP	23313552
MIRT689695	hsa-miR-1288-5p	HITS-CLIP	23313552
MIRT689694	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT689693	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT689692	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT689691	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT689690	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT689689	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT689688	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT689687	hsa-miR-6721-5p	HITS-CLIP	23313552
MIRT689686	hsa-miR-541-3p	HITS-CLIP	23313552
MIRT689685	hsa-miR-654-5p	HITS-CLIP	23313552
MIRT689684	hsa-miR-7977	HITS-CLIP	23313552
MIRT525460	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT525459	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT525458	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT689683	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT689682	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT689681	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT689680	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT689679	hsa-miR-3689c	HITS-CLIP	23313552
MIRT689678	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT689677	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT689676	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT689675	hsa-miR-3122	HITS-CLIP	23313552
MIRT689674	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT689673	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT689672	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT525467	hsa-miR-4282	PAR-CLIP	22012620
MIRT525466	hsa-miR-6871-5p	PAR-CLIP	22012620
MIRT525465	hsa-miR-139-5p	PAR-CLIP	22012620
MIRT525464	hsa-miR-6878-5p	PAR-CLIP	22012620
MIRT525463	hsa-miR-6731-5p	PAR-CLIP	22012620
MIRT525462	hsa-miR-8085	PAR-CLIP	22012620
MIRT525461	hsa-miR-3618	PAR-CLIP	22012620
MIRT525460	hsa-miR-30c-1-3p	PAR-CLIP	22012620
MIRT525459	hsa-miR-30c-2-3p	PAR-CLIP	22012620
MIRT525458	hsa-miR-6788-5p	PAR-CLIP	22012620
MIRT525457	hsa-let-7c-3p	PAR-CLIP	22012620
MIRT525456	hsa-let-7a-2-3p	PAR-CLIP	22012620
MIRT525455	hsa-let-7g-3p	PAR-CLIP	22012620
MIRT525454	hsa-miR-493-5p	PAR-CLIP	22012620
MIRT1440997	hsa-miR-148a	CLIP-seq
MIRT1440998	hsa-miR-148b	CLIP-seq
MIRT1440999	hsa-miR-152	CLIP-seq
MIRT1441000	hsa-miR-3145-3p	CLIP-seq
MIRT1441001	hsa-miR-3607-5p	CLIP-seq
MIRT1441002	hsa-miR-4276	CLIP-seq
MIRT1441003	hsa-miR-4428	CLIP-seq
MIRT1441004	hsa-miR-498	CLIP-seq
MIRT2132038	hsa-miR-216b	CLIP-seq
MIRT2132039	hsa-miR-302f	CLIP-seq
MIRT2132040	hsa-miR-3675-3p	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence
GO:0001669	Component	Acrosomal vesicle	IBA
GO:0001669	Component	Acrosomal vesicle	IEA
GO:0001669	Component	Acrosomal vesicle	ISS
GO:0001675	Process	Acrosome assembly	IEA
GO:0001675	Process	Acrosome assembly	ISS
GO:0004252	Function	Serine-type endopeptidase activity	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	ISS
GO:0007338	Process	Single fertilization	IEA
GO:0007339	Process	Binding of sperm to zona pellucida	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	IBA
GO:0008236	Function	Serine-type peptidase activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016485	Process	Protein processing	IBA
GO:0016485	Process	Protein processing	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:1902492	Process	Positive regulation of sperm capacitation	IEA
GO:1902492	Process	Positive regulation of sperm capacitation	ISS

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q86WS5

Protein name

Transmembrane protease serine 12 (EC 3.4.21.-)

Protein function

Required for male fertility (By similarity). Plays a critical role in sperm capacitation and acrosome reactions during fertilization, and also plays a role in the regulation of proteins involved in spermatogenesis (By similarity). Regulates prot

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00089	Trypsin	78 → 313	Trypsin	Domain

Tissue specificity

TISSUE SPECIFICITY: In testis, expressed in spermatocytes and spermatids (at protein level). {ECO:0000269|PubMed:23436708}.

Sequence

MRLGLLSVALLFVGSSHLYSDHYSPSGRHRLGPSPEPAASSQQAEAVRKRLRRRREGGAH
AEDCGTAPLKDVLQGSRIIGGTEAQAGAWPWVVSLQIKYGRVLVHVCGGTLVRERWVLTA
AHCTKDASDPLMWTAVIGTNNIHGRYPHTKKIKIKAIIIHPNFILESYVNDIALFHLKKA
VRYNDYIQPICLPFDVFQILDGNTKCFISGWGRTKEEGNATNILQDAEVHYISREMCNSE
RSYGGIIPNTSFCAGDEDGAFDTCRGDSGGPLMCYLPEYKRFFVMGITSYGHGCGRRGFP
GVYIGPSFYQKWLTEHFFHASTQGILTINILRGQILIALCFVILLATT

Sequence length

348

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	39208330	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Testicular Neoplasms	Testicular neoplasm	Pubtator	39208330	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

TMPRSS12 (transmembrane serine protease 12)