Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	283383
Gene name	Adhesion G protein-coupled receptor D1
Gene symbol	ADGRD1
Synonyms (NCBI Gene)	GPR133PGR25
Chromosome	12
Chromosome location	12q24.33
Summary	The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G p

Show/Hide all (48)

miRTarBase ID	miRNA	Experiments	Reference
MIRT740339	hsa-miR-892a	HITS-CLIP	19536157
MIRT740340	hsa-miR-6840-5p	HITS-CLIP	19536157
MIRT740341	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT740342	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT740343	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT740344	hsa-miR-204-3p	HITS-CLIP	19536157
MIRT740345	hsa-miR-4646-5p	HITS-CLIP	19536157
MIRT740346	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT740347	hsa-miR-3657	HITS-CLIP	19536157
MIRT740348	hsa-miR-4669	HITS-CLIP	19536157
MIRT740349	hsa-miR-1343-3p	HITS-CLIP	19536157
MIRT740350	hsa-miR-6783-3p	HITS-CLIP	19536157
MIRT740339	hsa-miR-892a	HITS-CLIP	19536157
MIRT740340	hsa-miR-6840-5p	HITS-CLIP	19536157
MIRT740341	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT740342	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT740343	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT740344	hsa-miR-204-3p	HITS-CLIP	19536157
MIRT740345	hsa-miR-4646-5p	HITS-CLIP	19536157
MIRT740346	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT740347	hsa-miR-3657	HITS-CLIP	19536157
MIRT740348	hsa-miR-4669	HITS-CLIP	19536157
MIRT740349	hsa-miR-1343-3p	HITS-CLIP	19536157
MIRT740350	hsa-miR-6783-3p	HITS-CLIP	19536157
MIRT740339	hsa-miR-892a	HITS-CLIP	19536157
MIRT740340	hsa-miR-6840-5p	HITS-CLIP	19536157
MIRT740341	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT740342	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT740343	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT740344	hsa-miR-204-3p	HITS-CLIP	19536157
MIRT740345	hsa-miR-4646-5p	HITS-CLIP	19536157
MIRT740346	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT740347	hsa-miR-3657	HITS-CLIP	19536157
MIRT740348	hsa-miR-4669	HITS-CLIP	19536157
MIRT740349	hsa-miR-1343-3p	HITS-CLIP	19536157
MIRT740350	hsa-miR-6783-3p	HITS-CLIP	19536157
MIRT740339	hsa-miR-892a	HITS-CLIP	19536157
MIRT740340	hsa-miR-6840-5p	HITS-CLIP	19536157
MIRT740341	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT740342	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT740343	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT740344	hsa-miR-204-3p	HITS-CLIP	19536157
MIRT740345	hsa-miR-4646-5p	HITS-CLIP	19536157
MIRT740346	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT740347	hsa-miR-3657	HITS-CLIP	19536157
MIRT740348	hsa-miR-4669	HITS-CLIP	19536157
MIRT740349	hsa-miR-1343-3p	HITS-CLIP	19536157
MIRT740350	hsa-miR-6783-3p	HITS-CLIP	19536157

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IDA	22025619, 34022221, 35418678, 35418679, 35447113, 39884271
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	15203201
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	34022221
GO:0005886	Component	Plasma membrane	IDA	22025619, 25533341
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	22025619
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	15203201
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	17110384
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	22025619, 35418678, 35418679, 35447113, 39884271
GO:0014819	Process	Regulation of skeletal muscle contraction	IDA	39884271
GO:0014819	Process	Regulation of skeletal muscle contraction	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	15203201
GO:0016607	Component	Nuclear speck	IDA

MIM	HGNC	e!Ensembl
613639	19893	ENSG00000111452

Q6QNK2

Protein name

Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133) (G-protein coupled receptor PGR25) [Cleaved into: Adhesion G-protein coupled receptor D1, N-terminal fragment (ADGRD1 N-terminal fragment); Adhesion G-protein coupled receptor D1, C-t

Protein function

Adhesion G-protein coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta-hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens (PubMed:39884271). Also activated by methenolone

PDB

7EPT , 7WU2 , 8X9S , 8X9T , 8X9U , 9IV1 , 9IV2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13385	Laminin_G_3	87 → 241		Domain
PF01825	GPS	508 → 550	GPCR proteolysis site, GPS, motif	Motif
PF00002	7tm_2	563 → 802	7 transmembrane receptor (Secretin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Up-regulated in CD133(+) cell population of glioblastoma. {ECO:0000269|PubMed:27775701}.

Sequence

MEKLLRLCCWYSWLLLFYYNFQVRGVYSRSQDHPGFQVLASASHYWPLENVDGIHELQDT
TGDIVEGKVNKGIYLKEEKGVTLLYYGRYNSSCISKPEQCGPEGVTFSFFWKTQGEQSRP
IPSAYGGQVISNGFKVCSSGGRGSVELYTRDNSMTWEASFSPPGPYWTHVLFTWKSKEGL
KVYVNGTLSTSDPSGKVSRDYGESNVNLVIGSEQDQAKCYENGAFDEFIIWERALTPDEI
AMYFTAAIGKHALLSSTLPSLFMTSTASPVMPTDAYHPIITNLTEERKTFQSPGVILSYL
QNVSLSLPSKSLSEQTALNLTKTFLKAVGEILLLPGWIALSEDSAVVLSLIDTIDTVMGH
VSSNLHGSTPQVTVEGSSAMAEFSVAKILPKTVNSSHYRFPAHGQSFIQIPHEAFHRHAW
STVVGLLYHSMHYYLNNIWPAHTKIAEAMHHQDCLLFATSHLISLEVSPPPTLSQNLSGS
PLITVHLKHRLTRKQHSEATNSSNRVFVYCAFLDFSSGEGVWSNHGCALTRGNLTYSVCR
CTHLTNFAILMQVVPLELARGHQVALSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQ
RYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLSAFAWMLVEGLHLYSM
VIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPA
LFVIVVNIGILIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAV
NGCAVVFQYMFATLNSLQGLFIFLFHCLLNSEVRAAFKHKTKVWSLTSSSARTSNAKPFH
SDLMNGTRPGMASTKLSPWDKSSHSAHRVDLSAV

Sequence length

874

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPORADIC AMYOTROPHIC LATERAL SCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (10)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
AMYOTROPHIC LATERAL SCLEROSIS 1	Lateral Sclerosis	GWASCAT_DG	24529757		★★★★★ ★☆☆☆☆ Found in Text Mining only
AMYOTROPHIC LATERAL SCLEROSIS 1, AUTOSOMAL RECESSIVE	Amyotrophic lateral sclerosis	GWASCAT_DG	24529757		★★★★★ ★☆☆☆☆ Found in Text Mining only
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)	Amyotrophic lateral sclerosis	GWASCAT_DG	24529757		★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis, Sporadic	Lateral Sclerosis	GWASCAT_DG	24529757		★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain neoplasms	Pubtator	37354459	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	36457341	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Gestational	Gestational diabetes	Pubtator	35721735	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	37354459	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	31153896	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	26213922	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ADGRD1 (adhesion G protein-coupled receptor D1)