Gene Gene information from NCBI Gene database.
Entrez ID 283349
Gene name Ras association domain family member 3
Gene symbol RASSF3
Synonyms (NCBI Gene)
RASSF5
Chromosome 12
Chromosome location 12q14.2
Summary The RAS oncogene (MIM 190020) is mutated in nearly one-third of all human cancers. Members of the RAS superfamily are plasma membrane GTP-binding proteins that modulate intracellular signal transduction pathways. A subfamily of RAS effectors, including RA
miRNA miRNA information provided by mirtarbase database.
371
miRTarBase ID miRNA Experiments Reference
MIRT016387 hsa-miR-193b-3p Microarray 20304954
MIRT031332 hsa-miR-18a-5p Sequencing 20371350
MIRT038969 hsa-miR-20a-3p CLASH 23622248
MIRT1292752 hsa-miR-101 CLIP-seq
MIRT1292753 hsa-miR-1197 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 20920251, 23455922, 24255178, 24366813, 28514442, 32296183, 32707033, 33961781, 35271311
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol IDA
GO:0005856 Component Cytoskeleton IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607019 14271 ENSG00000153179
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86WH2
Protein name Ras association domain-containing protein 3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00788 RA 79 187 Ras association (RalGDS/AF-6) domain Domain
PF16517 Nore1-SARAH 192 231 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11965544}.
Sequence
Sequence length 238
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
LUNG ADENOCARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER, FAMILIAL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma of lung (disorder) Lung adenocarcinoma GWASCAT_DG 28604730
★☆☆☆☆
Found in Text Mining only
Adrenal Gland Pheochromocytoma Adrenal Gland Pheochromocytoma BEFREE 17395981
★☆☆☆☆
Found in Text Mining only
Astrocytoma Astrocytoma BEFREE 18616639
★☆☆☆☆
Found in Text Mining only
Autistic Disorder Autism GWASDB_DG 22843504
★☆☆☆☆
Found in Text Mining only
Brain Diseases Brain disease Pubtator 29484035 Associate
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 19148488
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 23538446 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 23347832, 28090674 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 24563371 Inhibit
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 12584574, 15378027, 20434789
★☆☆☆☆
Found in Text Mining only