Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2831
Gene name	Neuropeptides B and W receptor 1
Gene symbol	NPBWR1
Synonyms (NCBI Gene)	GPR7
Chromosome	8
Chromosome location	8q11.23

104

Show/Hide all (104)

miRTarBase ID	miRNA	Experiments	Reference
MIRT718355	hsa-miR-6805-5p	HITS-CLIP	19536157
MIRT718354	hsa-miR-6798-5p	HITS-CLIP	19536157
MIRT718353	hsa-miR-1292-3p	HITS-CLIP	19536157
MIRT718352	hsa-miR-3195	HITS-CLIP	19536157
MIRT718351	hsa-miR-4783-5p	HITS-CLIP	19536157
MIRT718350	hsa-miR-1237-5p	HITS-CLIP	19536157
MIRT718349	hsa-miR-4488	HITS-CLIP	19536157
MIRT718348	hsa-miR-4697-5p	HITS-CLIP	19536157
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611206	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611206	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611206	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT619951	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT619950	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT619949	hsa-miR-603	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT619948	hsa-miR-3941	HITS-CLIP	23824327
MIRT611206	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611206	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT718355	hsa-miR-6805-5p	HITS-CLIP	19536157
MIRT718354	hsa-miR-6798-5p	HITS-CLIP	19536157
MIRT718353	hsa-miR-1292-3p	HITS-CLIP	19536157
MIRT718352	hsa-miR-3195	HITS-CLIP	19536157
MIRT718351	hsa-miR-4783-5p	HITS-CLIP	19536157
MIRT718350	hsa-miR-1237-5p	HITS-CLIP	19536157
MIRT718349	hsa-miR-4488	HITS-CLIP	19536157
MIRT718348	hsa-miR-4697-5p	HITS-CLIP	19536157
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611206	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611206	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611206	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT619951	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT619950	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT619949	hsa-miR-603	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT619948	hsa-miR-3941	HITS-CLIP	23824327
MIRT611206	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611211	hsa-miR-8485	HITS-CLIP	23824327
MIRT611209	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611208	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT611207	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT611206	hsa-miR-4789-5p	HITS-CLIP	23824327

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004985	Function	G protein-coupled opioid receptor activity	IEA
GO:0004985	Function	G protein-coupled opioid receptor activity	TAS	7590751
GO:0005515	Function	Protein binding	IPI	12401809, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	12401809
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007218	Process	Neuropeptide signaling pathway	IBA
GO:0007268	Process	Chemical synaptic transmission	TAS	7590751
GO:0008188	Function	Neuropeptide receptor activity	IEA
GO:0016020	Component	Membrane	IC	12401809
GO:0016020	Component	Membrane	IEA
GO:0019222	Process	Regulation of metabolic process	IEA
GO:0038003	Process	G protein-coupled opioid receptor signaling pathway	IEA
GO:0042923	Function	Neuropeptide binding	IBA
GO:0043005	Component	Neuron projection	IBA
GO:0045202	Component	Synapse	IEA

MIM	HGNC	e!Ensembl
600730	4522	ENSG00000288611

P48145

Protein name

Neuropeptides B/W receptor type 1 (G-protein coupled receptor 7)

Protein function

Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	54 → 307	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and trachea; at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver. Also detected at high le

Sequence

MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLY
VLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNT
FSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLD
DEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAK
ALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANS
CLNPFLYAFLDASFRRNLRQLITCRAAA

Sequence length

328

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction		Peptide ligand-binding receptors G alpha (i) signalling events

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTROCYTOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Cerebral Palsy	Cerebral palsy	Pubtator	35705018	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	26536090		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	17437806		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuropathy	Neuropathy	BEFREE	15607941		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	17437806		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	LHGDN	17437806		★★★★★ ★☆☆☆☆ Found in Text Mining only

NPBWR1 (neuropeptides B and W receptor 1)