Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	283078
Gene name	Mohawk homeobox
Gene symbol	MKX
Synonyms (NCBI Gene)	C10orf48IFRXIRXL1
Chromosome	10
Chromosome location	10p12.1
Summary	The protein encoded by this gene is an IRX family-related homeobox protein that may play a role in cell adhesion. Studies in mice suggest that this protein may be a regulator of tendon development. Two transcript variants encoding the same protein have be

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019321	hsa-miR-148b-3p	Microarray	17612493
MIRT022766	hsa-miR-124-3p	Microarray	18668037
MIRT637125	hsa-miR-6715a-3p	HITS-CLIP	23824327
MIRT637124	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT637123	hsa-miR-3682-5p	HITS-CLIP	23824327
MIRT637122	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT637121	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT637125	hsa-miR-6715a-3p	HITS-CLIP	23824327
MIRT637124	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT637123	hsa-miR-3682-5p	HITS-CLIP	23824327
MIRT637122	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT637121	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT645382	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT645381	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT645380	hsa-miR-3163	HITS-CLIP	23824327
MIRT645379	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT645378	hsa-miR-9-5p	HITS-CLIP	23824327
MIRT645377	hsa-miR-5681b	HITS-CLIP	23824327
MIRT645376	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT637125	hsa-miR-6715a-3p	HITS-CLIP	23824327
MIRT637124	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT637123	hsa-miR-3682-5p	HITS-CLIP	23824327
MIRT637122	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT637121	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT547411	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT547410	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT547409	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT547408	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT547407	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT547406	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT547405	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT547404	hsa-miR-6835-3p	PAR-CLIP	21572407
MIRT547403	hsa-miR-4422	PAR-CLIP	21572407
MIRT547402	hsa-miR-548p	PAR-CLIP	21572407
MIRT547401	hsa-miR-5586-5p	PAR-CLIP	21572407
MIRT547400	hsa-miR-545-3p	PAR-CLIP	21572407
MIRT547399	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT547398	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT547397	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT547396	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT547395	hsa-miR-9-3p	PAR-CLIP	21572407
MIRT637125	hsa-miR-6715a-3p	HITS-CLIP	23824327
MIRT637124	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT637123	hsa-miR-3682-5p	HITS-CLIP	23824327
MIRT637122	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT637121	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT637125	hsa-miR-6715a-3p	HITS-CLIP	23824327
MIRT637124	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT637123	hsa-miR-3682-5p	HITS-CLIP	23824327
MIRT637122	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT637121	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT645382	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT645381	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT645380	hsa-miR-3163	HITS-CLIP	23824327
MIRT645379	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT645378	hsa-miR-9-5p	HITS-CLIP	23824327
MIRT645377	hsa-miR-5681b	HITS-CLIP	23824327
MIRT645376	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT637125	hsa-miR-6715a-3p	HITS-CLIP	23824327
MIRT637124	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT637123	hsa-miR-3682-5p	HITS-CLIP	23824327
MIRT637122	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT637121	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT547411	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT547410	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT547409	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT547408	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT547407	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT547406	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT547405	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT547404	hsa-miR-6835-3p	PAR-CLIP	21572407
MIRT547403	hsa-miR-4422	PAR-CLIP	21572407
MIRT547402	hsa-miR-548p	PAR-CLIP	21572407
MIRT547401	hsa-miR-5586-5p	PAR-CLIP	21572407
MIRT547400	hsa-miR-545-3p	PAR-CLIP	21572407
MIRT547399	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT547398	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT547397	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT547396	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT547395	hsa-miR-9-3p	PAR-CLIP	21572407
MIRT1150495	hsa-miR-1179	CLIP-seq
MIRT1150496	hsa-miR-1229	CLIP-seq
MIRT1150497	hsa-miR-1298	CLIP-seq
MIRT1150498	hsa-miR-185	CLIP-seq
MIRT1150499	hsa-miR-194	CLIP-seq
MIRT1150500	hsa-miR-3122	CLIP-seq
MIRT1150501	hsa-miR-3143	CLIP-seq
MIRT1150502	hsa-miR-3158-3p	CLIP-seq
MIRT1150503	hsa-miR-338-3p	CLIP-seq
MIRT1150504	hsa-miR-34b	CLIP-seq
MIRT1150505	hsa-miR-3653	CLIP-seq
MIRT1150506	hsa-miR-3662	CLIP-seq
MIRT1150507	hsa-miR-3671	CLIP-seq
MIRT1150508	hsa-miR-3689a-3p	CLIP-seq
MIRT1150509	hsa-miR-3689c	CLIP-seq
MIRT1150510	hsa-miR-3913-5p	CLIP-seq
MIRT1150511	hsa-miR-4282	CLIP-seq
MIRT1150512	hsa-miR-4306	CLIP-seq
MIRT1150513	hsa-miR-4310	CLIP-seq
MIRT1150514	hsa-miR-4464	CLIP-seq
MIRT1150515	hsa-miR-4477a	CLIP-seq
MIRT1150516	hsa-miR-4639-3p	CLIP-seq
MIRT1150517	hsa-miR-4644	CLIP-seq
MIRT1150518	hsa-miR-4714-5p	CLIP-seq
MIRT1150519	hsa-miR-4729	CLIP-seq
MIRT1150520	hsa-miR-4748	CLIP-seq
MIRT1150521	hsa-miR-4766-5p	CLIP-seq
MIRT1150522	hsa-miR-4803	CLIP-seq
MIRT1150523	hsa-miR-498	CLIP-seq
MIRT1150524	hsa-miR-579	CLIP-seq
MIRT1150525	hsa-miR-607	CLIP-seq
MIRT1150526	hsa-miR-634	CLIP-seq
MIRT1150527	hsa-miR-664	CLIP-seq
MIRT1150528	hsa-miR-668	CLIP-seq
MIRT1150529	hsa-miR-889	CLIP-seq
MIRT2272497	hsa-miR-377	CLIP-seq
MIRT2272498	hsa-miR-4470	CLIP-seq
MIRT2272499	hsa-miR-4725-5p	CLIP-seq
MIRT2272500	hsa-miR-504	CLIP-seq
MIRT2390937	hsa-miR-639	CLIP-seq
MIRT2390938	hsa-miR-720	CLIP-seq
MIRT2571419	hsa-miR-1256	CLIP-seq
MIRT2571420	hsa-miR-1271	CLIP-seq
MIRT2571421	hsa-miR-182	CLIP-seq
MIRT2571422	hsa-miR-23a	CLIP-seq
MIRT2571423	hsa-miR-23b	CLIP-seq
MIRT2571424	hsa-miR-23c	CLIP-seq
MIRT2571425	hsa-miR-3149	CLIP-seq
MIRT2571426	hsa-miR-4642	CLIP-seq
MIRT2571427	hsa-miR-96	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0007517	Process	Muscle organ development	IBA
GO:0007517	Process	Muscle organ development	ISS	16408284
GO:0048468	Process	Cell development	IBA

MIM	HGNC	e!Ensembl
601332	23729	ENSG00000150051

Q8IYA7

Protein name

Homeobox protein Mohawk

Protein function

May act as a morphogenetic regulator of cell adhesion.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05920	Homeobox_KN	88 → 127	Homeobox KN domain	Family

Sequence

MNTIVFNKLSGAVLFEDGGASERERGGRPYSGVLDSPHARPEVGIPDGPPLKDNLGLRHR
RTGARQNGGKVRHKRQALQDMARPLKQWLYKHRDNPYPTKTEKILLALGSQMTLVQVSNW
FANARRRLKNTVRQPDLSWALRIKLYNKYVQGNAERLSVSSDDSCSEDGENPPRTHMNEG
GYNTPVHHPVIKSENSVIKAGVRPESRASEDYVAPPKYKSSLLNRYLNDSLRHVMATNTT
MMGKTRQRNHSGSFSSNEFEEELVSPSSSETEGNFVYRTDTLENGSNKGESAANRKGPSK
DDTYWKEINAAMALTNLAQGKDKLQGTTSCIIQKSSHIAEVKTVKVPLVQQF

Sequence length

352

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARPAL TUNNEL SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEART CONDUCTION DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MKX-related disorder	Uncertain significance; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Anterior Cruciate Ligament Injuries	Anterior cruciate ligament injury	Pubtator	23686683	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cleft Palate	Cleft palate	Pubtator	19401770	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cryptorchidism	Cryptorchidism	BEFREE	25073539		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic syndrome	Pubtator	36834493	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	36834493	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	23686683	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	28641578	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

MKX (mohawk homeobox)