ZNF311 (zinc finger protein 311)

Gene

• Entrez ID: 282890
• Gene name: Zinc finger protein 311
• Gene symbol: ZNF311
• Synonyms (NCBI Gene): zf31
• Chromosome: 6
• Chromosome location: 6p22.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1521755	hsa-miR-2110	CLIP-seq
MIRT1521756	hsa-miR-216a	CLIP-seq
MIRT1521757	hsa-miR-3150a-3p	CLIP-seq
MIRT1521758	hsa-miR-342-3p	CLIP-seq
MIRT1521759	hsa-miR-3606	CLIP-seq
MIRT1521760	hsa-miR-3653	CLIP-seq
MIRT1521761	hsa-miR-4260	CLIP-seq
MIRT1521762	hsa-miR-4271	CLIP-seq
MIRT1521763	hsa-miR-4725-3p	CLIP-seq
MIRT1521764	hsa-miR-511	CLIP-seq
MIRT1521765	hsa-miR-548ag	CLIP-seq
MIRT1521766	hsa-miR-548ai	CLIP-seq
MIRT1521767	hsa-miR-9	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q5JNZ3
• Protein name: Zinc finger protein 311 (Zinc finger protein zfp-31)
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01352	KRAB	63 → 104	KRAB box	Family
  PF00096	zf-C2H2	275 → 297	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	303 → 325	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	387 → 409	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	415 → 437	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	443 → 465	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	499 → 521	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	527 → 549	Zinc finger, C2H2 type	Domain
  PF13912	zf-C2H2_6	583 → 608		Domain
  PF00096	zf-C2H2	611 → 634	Zinc finger, C2H2 type	Domain

• Sequence:

  MQEVVLLDESSGPPSQLLWTRQDTQLPQESALLPAPYPAFTKDGSQGNLPQADITLMSQA
  QESVTFEDVAVNFTNREWQCLTYAQRHLYKDVMLENYGNMVSLGFPFPKPPLISHLEREV
  DPCVQDPQDRESLSCSYPVSADKMWPENEKASSQQEIFENGEAYWMKFNSLLKVDSRDPK
  VREVCVQDVKLENQWETSIREKLREEKEGSEEVTCKKGKNQKVLSKNLNPNSKHSQCNKV
  LIAQKLHECARCGKNFSWHSDLILHEQIHSGEKPHVCNECGKAFKTRNQLSMHRIIHTGE
  KPFNCTQCGKAFNSRSALCRHKKTHSGEKPHECRDCGKAFKTRNRLCMHQLIHTGEKPYK
  CNCCGKAFQFKHSLTIHGRIHTGEKPYECEECGKAFSGSSDLTKHIRIHTGERPYECSKC
  GRAFSRSSDLSKHKRIHTREKHYGCPQCGKDFSIKAELTKHRRIHTEEKRYRCEECGKAF
  RHNCKRRAHEREHTGEKPYQCRDCGKTFQDKHCLTIHQRIHTGEKPYKCLECGKAFSGKS
  NLTNHRRIHTGEKPHKCEVCGMAFHHSSVLRQHKRIHTGEKPYTCSECGTSFRQGSALIG
  HKRVHTGEKPYECEECGKAFRVSSNLTGHKKRKHQVWSTHELDGSRKSLSPVTVSQTSVV
  SILTSA

• Sequence length: 666

Pathways

Reactome:

Generic Transcription Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOTHYROIDISM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Asthma	Asthma	GWASCAT_DG	31619474		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28981872		★☆☆☆☆ Found in Text Mining only