Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	2824
Gene name	Glycoprotein M6B
Gene symbol	GPM6B
Synonyms (NCBI Gene)	M6B
Chromosome	X
Chromosome location	Xp22.2
Summary	This gene encodes a membrane glycoprotein that belongs to the proteolipid protein family. Proteolipid protein family members are expressed in most brain regions and are thought to be involved in cellular housekeeping functions such as membrane trafficking

152

Show/Hide all (152)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020640	hsa-miR-155-5p	Reporter assay	20680360
MIRT022309	hsa-miR-124-3p	Microarray	18668037
MIRT052418	hsa-let-7a-5p	CLASH	23622248
MIRT052287	hsa-let-7b-5p	CLASH	23622248
MIRT051427	hsa-let-7e-5p	CLASH	23622248
MIRT609593	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT609592	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT609591	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT609590	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT609589	hsa-miR-3919	HITS-CLIP	23824327
MIRT609588	hsa-miR-146a-5p	HITS-CLIP	23824327
MIRT609587	hsa-miR-146b-5p	HITS-CLIP	23824327
MIRT609586	hsa-miR-7153-5p	HITS-CLIP	23824327
MIRT609585	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT609584	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT609583	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT609593	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT609592	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT609591	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT609590	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT609589	hsa-miR-3919	HITS-CLIP	23824327
MIRT609588	hsa-miR-146a-5p	HITS-CLIP	23824327
MIRT609587	hsa-miR-146b-5p	HITS-CLIP	23824327
MIRT609586	hsa-miR-7153-5p	HITS-CLIP	23824327
MIRT609585	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT609584	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT609583	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT609593	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT609592	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT609591	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT609590	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT609589	hsa-miR-3919	HITS-CLIP	23824327
MIRT609588	hsa-miR-146a-5p	HITS-CLIP	23824327
MIRT609587	hsa-miR-146b-5p	HITS-CLIP	23824327
MIRT609586	hsa-miR-7153-5p	HITS-CLIP	23824327
MIRT609585	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT609584	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT609583	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT609588	hsa-miR-146a-5p	HITS-CLIP	27418678
MIRT609588	hsa-miR-146a-5p	HITS-CLIP	27418678
MIRT609588	hsa-miR-146a-5p	HITS-CLIP	27418678
MIRT609588	hsa-miR-146a-5p	HITS-CLIP	27418678
MIRT609588	hsa-miR-146a-5p	HITS-CLIP	27418678
MIRT609587	hsa-miR-146b-5p	HITS-CLIP	27418678
MIRT609587	hsa-miR-146b-5p	HITS-CLIP	27418678
MIRT609587	hsa-miR-146b-5p	HITS-CLIP	27418678
MIRT609587	hsa-miR-146b-5p	HITS-CLIP	27418678
MIRT609587	hsa-miR-146b-5p	HITS-CLIP	27418678
MIRT609583	hsa-miR-3180-5p	HITS-CLIP	27418678
MIRT609583	hsa-miR-3180-5p	HITS-CLIP	27418678
MIRT609583	hsa-miR-3180-5p	HITS-CLIP	27418678
MIRT609583	hsa-miR-3180-5p	HITS-CLIP	27418678
MIRT609583	hsa-miR-3180-5p	HITS-CLIP	27418678
MIRT609589	hsa-miR-3919	HITS-CLIP	27418678
MIRT609589	hsa-miR-3919	HITS-CLIP	27418678
MIRT609589	hsa-miR-3919	HITS-CLIP	27418678
MIRT609589	hsa-miR-3919	HITS-CLIP	27418678
MIRT609589	hsa-miR-3919	HITS-CLIP	27418678
MIRT609591	hsa-miR-3925-5p	HITS-CLIP	27418678
MIRT609591	hsa-miR-3925-5p	HITS-CLIP	27418678
MIRT609591	hsa-miR-3925-5p	HITS-CLIP	27418678
MIRT609591	hsa-miR-3925-5p	HITS-CLIP	27418678
MIRT609591	hsa-miR-3925-5p	HITS-CLIP	27418678
MIRT609592	hsa-miR-500a-5p	HITS-CLIP	27418678
MIRT609592	hsa-miR-500a-5p	HITS-CLIP	27418678
MIRT609592	hsa-miR-500a-5p	HITS-CLIP	27418678
MIRT609590	hsa-miR-501-5p	HITS-CLIP	27418678
MIRT609590	hsa-miR-501-5p	HITS-CLIP	27418678
MIRT609590	hsa-miR-501-5p	HITS-CLIP	27418678
MIRT609590	hsa-miR-501-5p	HITS-CLIP	27418678
MIRT609590	hsa-miR-501-5p	HITS-CLIP	27418678
MIRT609585	hsa-miR-520a-5p	HITS-CLIP	27418678
MIRT609585	hsa-miR-520a-5p	HITS-CLIP	27418678
MIRT609585	hsa-miR-520a-5p	HITS-CLIP	27418678
MIRT609585	hsa-miR-520a-5p	HITS-CLIP	27418678
MIRT609585	hsa-miR-520a-5p	HITS-CLIP	27418678
MIRT609584	hsa-miR-525-5p	HITS-CLIP	27418678
MIRT609584	hsa-miR-525-5p	HITS-CLIP	27418678
MIRT609584	hsa-miR-525-5p	HITS-CLIP	27418678
MIRT609584	hsa-miR-525-5p	HITS-CLIP	27418678
MIRT609584	hsa-miR-525-5p	HITS-CLIP	27418678
MIRT609586	hsa-miR-7153-5p	HITS-CLIP	27418678
MIRT609586	hsa-miR-7153-5p	HITS-CLIP	27418678
MIRT609586	hsa-miR-7153-5p	HITS-CLIP	27418678
MIRT609586	hsa-miR-7153-5p	HITS-CLIP	27418678
MIRT609586	hsa-miR-7153-5p	HITS-CLIP	27418678
MIRT609583	hsa-miR-3180-5p	HITS-CLIP	28735896
MIRT609589	hsa-miR-3919	HITS-CLIP	28735896
MIRT609591	hsa-miR-3925-5p	HITS-CLIP	28735896
MIRT609590	hsa-miR-501-5p	HITS-CLIP	28735896
MIRT609585	hsa-miR-520a-5p	HITS-CLIP	28735896
MIRT609584	hsa-miR-525-5p	HITS-CLIP	28735896
MIRT609593	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT609592	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT609591	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT609590	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT609589	hsa-miR-3919	HITS-CLIP	23824327
MIRT609588	hsa-miR-146a-5p	HITS-CLIP	23824327
MIRT609587	hsa-miR-146b-5p	HITS-CLIP	23824327
MIRT609586	hsa-miR-7153-5p	HITS-CLIP	23824327
MIRT609585	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT609584	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT609583	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT609593	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT609592	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT609591	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT609590	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT609589	hsa-miR-3919	HITS-CLIP	23824327
MIRT609588	hsa-miR-146a-5p	HITS-CLIP	23824327
MIRT609587	hsa-miR-146b-5p	HITS-CLIP	23824327
MIRT609586	hsa-miR-7153-5p	HITS-CLIP	23824327
MIRT609585	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT609584	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT609583	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT609593	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT609592	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT609591	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT609590	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT609589	hsa-miR-3919	HITS-CLIP	23824327
MIRT609588	hsa-miR-146a-5p	HITS-CLIP	23824327
MIRT609587	hsa-miR-146b-5p	HITS-CLIP	23824327
MIRT609586	hsa-miR-7153-5p	HITS-CLIP	23824327
MIRT609585	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT609584	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT609583	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT1029600	hsa-miR-1299	CLIP-seq
MIRT1029601	hsa-miR-320a	CLIP-seq
MIRT1029602	hsa-miR-320b	CLIP-seq
MIRT1029603	hsa-miR-320c	CLIP-seq
MIRT1029604	hsa-miR-320d	CLIP-seq
MIRT1029605	hsa-miR-409-3p	CLIP-seq
MIRT1029606	hsa-miR-4429	CLIP-seq
MIRT1029607	hsa-miR-4704-3p	CLIP-seq
MIRT1029608	hsa-miR-4782-5p	CLIP-seq
MIRT1029609	hsa-miR-513c	CLIP-seq
MIRT1029610	hsa-miR-514b-5p	CLIP-seq
MIRT1029611	hsa-miR-516b	CLIP-seq
MIRT1029612	hsa-miR-875-3p	CLIP-seq
MIRT1029600	hsa-miR-1299	CLIP-seq
MIRT2005481	hsa-miR-3647-3p	CLIP-seq
MIRT2005482	hsa-miR-4496	CLIP-seq
MIRT2005483	hsa-miR-4795-3p	CLIP-seq
MIRT2005484	hsa-miR-665	CLIP-seq
MIRT2238134	hsa-miR-141	CLIP-seq
MIRT2238135	hsa-miR-200a	CLIP-seq
MIRT2238136	hsa-miR-520d-5p	CLIP-seq
MIRT2238137	hsa-miR-524-5p	CLIP-seq
MIRT2238138	hsa-miR-577	CLIP-seq
MIRT2442230	hsa-miR-3065-3p	CLIP-seq
MIRT2442231	hsa-miR-4291	CLIP-seq
MIRT2442230	hsa-miR-3065-3p	CLIP-seq
MIRT2442231	hsa-miR-4291	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001503	Process	Ossification	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0007399	Process	Nervous system development	IEA
GO:0007399	Process	Nervous system development	NAS	8661015
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0019911	Function	Structural constituent of myelin sheath	IBA
GO:0022010	Process	Central nervous system myelination	IBA
GO:0030154	Process	Cell differentiation	IEA
GO:0030501	Process	Positive regulation of bone mineralization	IMP	21638316
GO:0032956	Process	Regulation of actin cytoskeleton organization	IMP	21638316
GO:0043209	Component	Myelin sheath	IBA
GO:0045121	Component	Membrane raft	IBA
GO:0045121	Component	Membrane raft	ISS
GO:0051612	Process	Negative regulation of serotonin uptake	IBA
GO:0051612	Process	Negative regulation of serotonin uptake	ISS
GO:0051893	Process	Regulation of focal adhesion assembly	IMP	21638316
GO:0061564	Process	Axon development	IBA
GO:0085029	Process	Extracellular matrix assembly	IMP	21638316
GO:2000009	Process	Negative regulation of protein localization to cell surface	ISS

MIM	HGNC	e!Ensembl
300051	4461	ENSG00000046653

Q13491

Protein name

Neuronal membrane glycoprotein M6-b (M6b)

Protein function

May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01275	Myelin_PLP	22 → 258	Myelin proteolipid protein (PLP or lipophilin)	Family

Tissue specificity

TISSUE SPECIFICITY: Neurons and glia; cerebellar Bergmann glia, in glia within white matter tracts of the cerebellum and cerebrum, and in embryonic dorsal root ganglia.

Sequence

MKPAMETAAEENTEQSQERKGCFECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALA
GTVAILEQHFSTNASDHALLSEVIQLMQYVIYGIASFFFLYGIILLAEGFYTTSAVKELH
GEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQTNGTT
GVEQICVDIRQYGIIPWNAFPGKICGSALENICNTNEFYMSYHLFIVACAGAGATVIALL
IYMMATTYNYAVLKFKSREDCCTKF

Sequence length

265

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
GLAUCOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (20)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Brain Neoplasms	Brain neoplasms	Pubtator	20235875	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	24696529		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	24696529, 33294057	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	23950870	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive Disorder Major	Major depressive disorder	Pubtator	37511534	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	20235875		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	20235875	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	20235875		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypersensitivity Delayed	Hypersensitivity	Pubtator	29230059	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukodystrophy	Leukodystrophy	BEFREE	16416265		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	33294057	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	24696529		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	24916915		★★★★★ ★☆☆☆☆ Found in Text Mining only
Meningioma	Meningioma	Pubtator	20235875	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mood Disorders	Mood disorder	Pubtator	37511534	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	25113253		★★★★★ ★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	8661015		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pelizaeus-Merzbacher Disease	Pelizaeus-Merzbacher disease	BEFREE	16416265		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	33294057	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Rett Syndrome	Rett Syndrome	BEFREE	9674909		★★★★★ ★☆☆☆☆ Found in Text Mining only

GPM6B (glycoprotein M6B)