Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2791
Gene name	G protein subunit gamma 11
Gene symbol	GNG11
Synonyms (NCBI Gene)	GNGT11HG3H1
Chromosome	7
Chromosome location	7q21.3
Summary	This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling sy

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miRTarBase ID	miRNA	Experiments
MIRT2236514	hsa-miR-127-5p	CLIP-seq
MIRT2236515	hsa-miR-3942-5p	CLIP-seq
MIRT2236516	hsa-miR-4703-5p	CLIP-seq
MIRT2540245	hsa-miR-1265	CLIP-seq
MIRT2540246	hsa-miR-1298	CLIP-seq
MIRT2540247	hsa-miR-150	CLIP-seq
MIRT2540248	hsa-miR-153	CLIP-seq
MIRT2540249	hsa-miR-217	CLIP-seq
MIRT2540250	hsa-miR-2392	CLIP-seq
MIRT2540251	hsa-miR-3126-3p	CLIP-seq
MIRT2540252	hsa-miR-3140-3p	CLIP-seq
MIRT2540253	hsa-miR-3168	CLIP-seq
MIRT2540254	hsa-miR-3174	CLIP-seq
MIRT2540255	hsa-miR-3192	CLIP-seq
MIRT2540256	hsa-miR-3653	CLIP-seq
MIRT2540257	hsa-miR-3658	CLIP-seq
MIRT2540258	hsa-miR-3667-3p	CLIP-seq
MIRT2540259	hsa-miR-3907	CLIP-seq
MIRT2540260	hsa-miR-4314	CLIP-seq
MIRT2540261	hsa-miR-4422	CLIP-seq
MIRT2540262	hsa-miR-4436b-5p	CLIP-seq
MIRT2540263	hsa-miR-4646-5p	CLIP-seq
MIRT2540264	hsa-miR-4713-5p	CLIP-seq
MIRT2540265	hsa-miR-4720-3p	CLIP-seq
MIRT2540266	hsa-miR-4775	CLIP-seq
MIRT2540267	hsa-miR-4781-3p	CLIP-seq
MIRT2540268	hsa-miR-4789-5p	CLIP-seq
MIRT2540269	hsa-miR-4804-3p	CLIP-seq
MIRT2540270	hsa-miR-495	CLIP-seq
MIRT2540271	hsa-miR-532-3p	CLIP-seq
MIRT2540272	hsa-miR-548u	CLIP-seq
MIRT2540273	hsa-miR-651	CLIP-seq
MIRT2540274	hsa-miR-767-3p	CLIP-seq
MIRT2540275	hsa-miR-921	CLIP-seq
MIRT2540245	hsa-miR-1265	CLIP-seq
MIRT2540246	hsa-miR-1298	CLIP-seq
MIRT2540247	hsa-miR-150	CLIP-seq
MIRT2540248	hsa-miR-153	CLIP-seq
MIRT2540249	hsa-miR-217	CLIP-seq
MIRT2540250	hsa-miR-2392	CLIP-seq
MIRT2540251	hsa-miR-3126-3p	CLIP-seq
MIRT2540252	hsa-miR-3140-3p	CLIP-seq
MIRT2681741	hsa-miR-3153	CLIP-seq
MIRT2540253	hsa-miR-3168	CLIP-seq
MIRT2540254	hsa-miR-3174	CLIP-seq
MIRT2540255	hsa-miR-3192	CLIP-seq
MIRT2540256	hsa-miR-3653	CLIP-seq
MIRT2540257	hsa-miR-3658	CLIP-seq
MIRT2540258	hsa-miR-3667-3p	CLIP-seq
MIRT2540259	hsa-miR-3907	CLIP-seq
MIRT2540260	hsa-miR-4314	CLIP-seq
MIRT2540261	hsa-miR-4422	CLIP-seq
MIRT2540262	hsa-miR-4436b-5p	CLIP-seq
MIRT2540263	hsa-miR-4646-5p	CLIP-seq
MIRT2681742	hsa-miR-4668-5p	CLIP-seq
MIRT2540264	hsa-miR-4713-5p	CLIP-seq
MIRT2540265	hsa-miR-4720-3p	CLIP-seq
MIRT2540266	hsa-miR-4775	CLIP-seq
MIRT2540267	hsa-miR-4781-3p	CLIP-seq
MIRT2540268	hsa-miR-4789-5p	CLIP-seq
MIRT2540269	hsa-miR-4804-3p	CLIP-seq
MIRT2540270	hsa-miR-495	CLIP-seq
MIRT2540271	hsa-miR-532-3p	CLIP-seq
MIRT2540272	hsa-miR-548u	CLIP-seq
MIRT2540273	hsa-miR-651	CLIP-seq
MIRT2540274	hsa-miR-767-3p	CLIP-seq
MIRT2540275	hsa-miR-921	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003924	Function	GTPase activity	TAS	7665596
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005834	Component	Heterotrimeric G-protein complex	IBA
GO:0005834	Component	Heterotrimeric G-protein complex	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	TAS	7665596
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0016020	Component	Membrane	IEA
GO:0031681	Function	G-protein beta-subunit binding	IBA
GO:0031681	Function	G-protein beta-subunit binding	IEA

MIM	HGNC	e!Ensembl
604390	4403	ENSG00000127920

P61952

Protein name

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11

Protein function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G prote

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00631	G-gamma	9 → 73	GGL domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Abundantly expressed in all tissues tested except for brain.

Sequence

MPALHIEDLPEKEKLKMEVEQLRKEVKLQRQQVSKCSEEIKNYIEERSGEDPLVKGIPED
KNPFKEKGSCVIS

Sequence length

Interactions

View interactions

	KEGG		Reactome
	Ras signaling pathway Chemokine signaling pathway Hormone signaling PI3K-Akt signaling pathway Apelin signaling pathway Circadian entrainment Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Relaxin signaling pathway Morphine addiction Alcoholism Human cytomegalovirus infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Pathways in cancer		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ARTHRITIS, JUVENILE	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
JUVENILE CHRONIC POLYARTHRITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MONOARTICULAR JUVENILE RHEUMATOID ARTHRITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PAUCIARTICULAR JUVENILE RHEUMATOID ARTHRITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (19)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	20670477		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	CTD_human_DG	24366584		★★★★★ ★☆☆☆☆ Found in Text Mining only
Blood Coagulation Disorders	Blood coagulation disorder	Pubtator	21829388	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	31258663		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Gestational	Gestational diabetes	Pubtator	35370940	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	22706224	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glomerulonephritis IGA	Iga nephropathy	Pubtator	34861820	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Juvenile arthritis	Arthritis	CTD_human_DG	19565504		★★★★★ ★☆☆☆☆ Found in Text Mining only
Juvenile psoriatic arthritis	Juvenile arthritis	CTD_human_DG	19565504		★★★★★ ★☆☆☆☆ Found in Text Mining only
Juvenile-Onset Still Disease	Still Disease	CTD_human_DG	19565504		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	20670477	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	20670477	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	20670477		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	35120576	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	35342758	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polyarthritis, Juvenile, Rheumatoid Factor Negative	Seronegative polyarthritis	CTD_human_DG	19565504		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polyarthritis, Juvenile, Rheumatoid Factor Positive	Polyarthritis, Rheumatoid Factor Positive	CTD_human_DG	19565504		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	BEFREE	20670477		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	BEFREE	31258663		★★★★★ ★☆☆☆☆ Found in Text Mining only

GNG11 (G protein subunit gamma 11)