GNAL (G protein subunit alpha L)

Gene

• Entrez ID: 2774
• Gene name: G protein subunit alpha L
• Gene symbol: GNAL
• Synonyms (NCBI Gene): DYT25, HG1O
• Chromosome: 18
• Chromosome location: 18p11.21
• Summary: This gene encodes a stimulatory G protein alpha subunit which mediates odorant signaling in the olfactory epithelium. This protein couples dopamine type 1 receptors and adenosine A2A receptors and is widely expressed in the central nervous system. Mutatio

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs398122923	G>A	Pathogenic	Missense variant, coding sequence variant, genic upstream transcript variant
rs398122924	C>A	Pathogenic	Genic downstream transcript variant, coding sequence variant, stop gained
rs398122925	G>A	Pathogenic	Missense variant, coding sequence variant, genic upstream transcript variant
rs398122926	->T	Pathogenic	Frameshift variant, coding sequence variant, genic upstream transcript variant
rs398122927	->A	Pathogenic	5 prime UTR variant, frameshift variant, genic downstream transcript variant, coding sequence variant
rs398122928	C>T	Pathogenic	Intron variant, coding sequence variant, stop gained, genic upstream transcript variant
rs766177601	T>C	Pathogenic	Genic upstream transcript variant, intron variant
rs1057519098	GA>-	Likely-pathogenic	Frameshift variant, genic upstream transcript variant, coding sequence variant
rs1064794741	G>A	Likely-pathogenic	Missense variant, genic downstream transcript variant, coding sequence variant
rs1252185897	C>T	Pathogenic	Coding sequence variant, genic downstream transcript variant, stop gained
rs1555646537	G>T	Likely-pathogenic	Genic upstream transcript variant, splice donor variant
rs1568010705	G>T	Likely-pathogenic	Genic upstream transcript variant, stop gained, coding sequence variant
rs1598429555	C>T	Likely-pathogenic	Coding sequence variant, genic upstream transcript variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051131	hsa-miR-16-5p	CLASH	23622248
MIRT048626	hsa-miR-99a-5p	CLASH	23622248
MIRT047629	hsa-miR-10a-5p	CLASH	23622248
MIRT476279	hsa-miR-489-3p	HITS-CLIP	21572407
MIRT476278	hsa-miR-409-3p	HITS-CLIP	21572407
MIRT476277	hsa-miR-33a-3p	HITS-CLIP	21572407
MIRT476276	hsa-miR-15a-5p	HITS-CLIP	21572407
MIRT476275	hsa-miR-15b-5p	HITS-CLIP	21572407
MIRT051131	hsa-miR-16-5p	HITS-CLIP	21572407
MIRT476274	hsa-miR-195-5p	HITS-CLIP	21572407
MIRT476273	hsa-miR-424-5p	HITS-CLIP	21572407
MIRT476272	hsa-miR-497-5p	HITS-CLIP	21572407
MIRT476270	hsa-miR-6838-5p	HITS-CLIP	21572407
MIRT476271	hsa-miR-759	HITS-CLIP	21572407
MIRT476269	hsa-miR-214-3p	HITS-CLIP	21572407
MIRT476268	hsa-miR-3619-5p	HITS-CLIP	21572407
MIRT476267	hsa-miR-761	HITS-CLIP	21572407
MIRT476266	hsa-miR-6792-5p	HITS-CLIP	21572407
MIRT476265	hsa-miR-3942-3p	HITS-CLIP	21572407
MIRT476264	hsa-miR-30a-3p	HITS-CLIP	21572407
MIRT476263	hsa-miR-30d-3p	HITS-CLIP	21572407
MIRT476262	hsa-miR-30e-3p	HITS-CLIP	21572407
MIRT476261	hsa-miR-335-3p	HITS-CLIP	21572407
MIRT611186	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT615779	hsa-miR-4761-5p	HITS-CLIP	23824327
MIRT611185	hsa-miR-6735-3p	HITS-CLIP	23824327
MIRT611184	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT611183	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT611185	hsa-miR-6735-3p	HITS-CLIP	23824327
MIRT611184	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT611183	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT611186	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT615779	hsa-miR-4761-5p	HITS-CLIP	23824327
MIRT611185	hsa-miR-6735-3p	HITS-CLIP	23824327
MIRT611184	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT611183	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT611186	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT615779	hsa-miR-4761-5p	HITS-CLIP	23824327
MIRT611185	hsa-miR-6735-3p	HITS-CLIP	23824327
MIRT611184	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT611183	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT611186	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT615779	hsa-miR-4761-5p	HITS-CLIP	23824327
MIRT611185	hsa-miR-6735-3p	HITS-CLIP	23824327
MIRT611184	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT611183	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT611186	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT611185	hsa-miR-6735-3p	HITS-CLIP	23824327
MIRT611184	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT611183	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT476279	hsa-miR-489-3p	PAR-CLIP	20371350
MIRT476278	hsa-miR-409-3p	PAR-CLIP	20371350
MIRT476277	hsa-miR-33a-3p	PAR-CLIP	20371350
MIRT476276	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT476275	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT051131	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT476274	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT476273	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT476272	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT476270	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT476271	hsa-miR-759	PAR-CLIP	20371350
MIRT476269	hsa-miR-214-3p	PAR-CLIP	20371350
MIRT476268	hsa-miR-3619-5p	PAR-CLIP	20371350
MIRT476267	hsa-miR-761	PAR-CLIP	20371350
MIRT476266	hsa-miR-6792-5p	PAR-CLIP	20371350
MIRT476265	hsa-miR-3942-3p	PAR-CLIP	20371350
MIRT476264	hsa-miR-30a-3p	PAR-CLIP	20371350
MIRT476263	hsa-miR-30d-3p	PAR-CLIP	20371350
MIRT476262	hsa-miR-30e-3p	PAR-CLIP	20371350
MIRT476261	hsa-miR-335-3p	PAR-CLIP	20371350
MIRT476279	hsa-miR-489-3p	PAR-CLIP	21572407
MIRT476278	hsa-miR-409-3p	PAR-CLIP	21572407
MIRT476277	hsa-miR-33a-3p	PAR-CLIP	21572407
MIRT476276	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT476275	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT051131	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT476274	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT476273	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT476272	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT476270	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT476271	hsa-miR-759	PAR-CLIP	21572407
MIRT476269	hsa-miR-214-3p	PAR-CLIP	21572407
MIRT476268	hsa-miR-3619-5p	PAR-CLIP	21572407
MIRT476267	hsa-miR-761	PAR-CLIP	21572407
MIRT476266	hsa-miR-6792-5p	PAR-CLIP	21572407
MIRT476265	hsa-miR-3942-3p	PAR-CLIP	21572407
MIRT476264	hsa-miR-30a-3p	PAR-CLIP	21572407
MIRT476263	hsa-miR-30d-3p	PAR-CLIP	21572407
MIRT476262	hsa-miR-30e-3p	PAR-CLIP	21572407
MIRT476261	hsa-miR-335-3p	PAR-CLIP	21572407
MIRT476279	hsa-miR-489-3p	PAR-CLIP	21572407
MIRT476278	hsa-miR-409-3p	PAR-CLIP	21572407
MIRT476277	hsa-miR-33a-3p	PAR-CLIP	21572407
MIRT476276	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT476275	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT051131	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT476274	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT476273	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT476272	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT476270	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT476271	hsa-miR-759	PAR-CLIP	21572407
MIRT476269	hsa-miR-214-3p	PAR-CLIP	21572407
MIRT476268	hsa-miR-3619-5p	PAR-CLIP	21572407
MIRT476267	hsa-miR-761	PAR-CLIP	21572407
MIRT476266	hsa-miR-6792-5p	PAR-CLIP	21572407
MIRT476265	hsa-miR-3942-3p	PAR-CLIP	21572407
MIRT476264	hsa-miR-30a-3p	PAR-CLIP	21572407
MIRT476263	hsa-miR-30d-3p	PAR-CLIP	21572407
MIRT476262	hsa-miR-30e-3p	PAR-CLIP	21572407
MIRT476261	hsa-miR-335-3p	PAR-CLIP	21572407
MIRT476279	hsa-miR-489-3p	PAR-CLIP	23592263
MIRT476278	hsa-miR-409-3p	PAR-CLIP	23592263
MIRT476277	hsa-miR-33a-3p	PAR-CLIP	23592263
MIRT476276	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT476275	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT051131	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT476274	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT476273	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT476272	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT476270	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT476271	hsa-miR-759	PAR-CLIP	23592263
MIRT476269	hsa-miR-214-3p	PAR-CLIP	23592263
MIRT476268	hsa-miR-3619-5p	PAR-CLIP	23592263
MIRT476267	hsa-miR-761	PAR-CLIP	23592263
MIRT476266	hsa-miR-6792-5p	PAR-CLIP	23592263
MIRT476265	hsa-miR-3942-3p	PAR-CLIP	23592263
MIRT476264	hsa-miR-30a-3p	PAR-CLIP	23592263
MIRT476263	hsa-miR-30d-3p	PAR-CLIP	23592263
MIRT476262	hsa-miR-30e-3p	PAR-CLIP	23592263
MIRT476261	hsa-miR-335-3p	PAR-CLIP	23592263
MIRT611183	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT611186	hsa-miR-329-5p	HITS-CLIP	27418678
MIRT611185	hsa-miR-6735-3p	HITS-CLIP	27418678
MIRT611184	hsa-miR-6878-3p	HITS-CLIP	27418678
MIRT476279	hsa-miR-489-3p	HITS-CLIP	21572407
MIRT476278	hsa-miR-409-3p	HITS-CLIP	21572407
MIRT476277	hsa-miR-33a-3p	HITS-CLIP	21572407
MIRT476276	hsa-miR-15a-5p	HITS-CLIP	21572407
MIRT476275	hsa-miR-15b-5p	HITS-CLIP	21572407
MIRT051131	hsa-miR-16-5p	HITS-CLIP	21572407
MIRT476274	hsa-miR-195-5p	HITS-CLIP	21572407
MIRT476273	hsa-miR-424-5p	HITS-CLIP	21572407
MIRT476272	hsa-miR-497-5p	HITS-CLIP	21572407
MIRT476270	hsa-miR-6838-5p	HITS-CLIP	21572407
MIRT476271	hsa-miR-759	HITS-CLIP	21572407
MIRT476269	hsa-miR-214-3p	HITS-CLIP	21572407
MIRT476268	hsa-miR-3619-5p	HITS-CLIP	21572407
MIRT476267	hsa-miR-761	HITS-CLIP	21572407
MIRT476266	hsa-miR-6792-5p	HITS-CLIP	21572407
MIRT476265	hsa-miR-3942-3p	HITS-CLIP	21572407
MIRT476264	hsa-miR-30a-3p	HITS-CLIP	21572407
MIRT476263	hsa-miR-30d-3p	HITS-CLIP	21572407
MIRT476262	hsa-miR-30e-3p	HITS-CLIP	21572407
MIRT476261	hsa-miR-335-3p	HITS-CLIP	21572407
MIRT611186	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT615779	hsa-miR-4761-5p	HITS-CLIP	23824327
MIRT611185	hsa-miR-6735-3p	HITS-CLIP	23824327
MIRT611184	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT611183	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT611185	hsa-miR-6735-3p	HITS-CLIP	23824327
MIRT611184	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT611183	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT611186	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT615779	hsa-miR-4761-5p	HITS-CLIP	23824327
MIRT611185	hsa-miR-6735-3p	HITS-CLIP	23824327
MIRT611184	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT611183	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT611186	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT615779	hsa-miR-4761-5p	HITS-CLIP	23824327
MIRT611185	hsa-miR-6735-3p	HITS-CLIP	23824327
MIRT611184	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT611183	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT611186	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT615779	hsa-miR-4761-5p	HITS-CLIP	23824327
MIRT611185	hsa-miR-6735-3p	HITS-CLIP	23824327
MIRT611184	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT611183	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT611186	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT611185	hsa-miR-6735-3p	HITS-CLIP	23824327
MIRT611184	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT611183	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT476279	hsa-miR-489-3p	PAR-CLIP	20371350
MIRT476278	hsa-miR-409-3p	PAR-CLIP	20371350
MIRT476277	hsa-miR-33a-3p	PAR-CLIP	20371350
MIRT476276	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT476275	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT051131	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT476274	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT476273	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT476272	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT476270	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT476271	hsa-miR-759	PAR-CLIP	20371350
MIRT476269	hsa-miR-214-3p	PAR-CLIP	20371350
MIRT476268	hsa-miR-3619-5p	PAR-CLIP	20371350
MIRT476267	hsa-miR-761	PAR-CLIP	20371350
MIRT476266	hsa-miR-6792-5p	PAR-CLIP	20371350
MIRT476265	hsa-miR-3942-3p	PAR-CLIP	20371350
MIRT476264	hsa-miR-30a-3p	PAR-CLIP	20371350
MIRT476263	hsa-miR-30d-3p	PAR-CLIP	20371350
MIRT476262	hsa-miR-30e-3p	PAR-CLIP	20371350
MIRT476261	hsa-miR-335-3p	PAR-CLIP	20371350
MIRT476279	hsa-miR-489-3p	PAR-CLIP	21572407
MIRT476278	hsa-miR-409-3p	PAR-CLIP	21572407
MIRT476277	hsa-miR-33a-3p	PAR-CLIP	21572407
MIRT476276	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT476275	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT051131	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT476274	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT476273	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT476272	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT476270	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT476271	hsa-miR-759	PAR-CLIP	21572407
MIRT476269	hsa-miR-214-3p	PAR-CLIP	21572407
MIRT476268	hsa-miR-3619-5p	PAR-CLIP	21572407
MIRT476267	hsa-miR-761	PAR-CLIP	21572407
MIRT476266	hsa-miR-6792-5p	PAR-CLIP	21572407
MIRT476265	hsa-miR-3942-3p	PAR-CLIP	21572407
MIRT476264	hsa-miR-30a-3p	PAR-CLIP	21572407
MIRT476263	hsa-miR-30d-3p	PAR-CLIP	21572407
MIRT476262	hsa-miR-30e-3p	PAR-CLIP	21572407
MIRT476261	hsa-miR-335-3p	PAR-CLIP	21572407
MIRT476279	hsa-miR-489-3p	PAR-CLIP	21572407
MIRT476278	hsa-miR-409-3p	PAR-CLIP	21572407
MIRT476277	hsa-miR-33a-3p	PAR-CLIP	21572407
MIRT476276	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT476275	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT051131	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT476274	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT476273	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT476272	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT476270	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT476271	hsa-miR-759	PAR-CLIP	21572407
MIRT476269	hsa-miR-214-3p	PAR-CLIP	21572407
MIRT476268	hsa-miR-3619-5p	PAR-CLIP	21572407
MIRT476267	hsa-miR-761	PAR-CLIP	21572407
MIRT476266	hsa-miR-6792-5p	PAR-CLIP	21572407
MIRT476265	hsa-miR-3942-3p	PAR-CLIP	21572407
MIRT476264	hsa-miR-30a-3p	PAR-CLIP	21572407
MIRT476263	hsa-miR-30d-3p	PAR-CLIP	21572407
MIRT476262	hsa-miR-30e-3p	PAR-CLIP	21572407
MIRT476261	hsa-miR-335-3p	PAR-CLIP	21572407
MIRT476279	hsa-miR-489-3p	PAR-CLIP	23592263
MIRT476278	hsa-miR-409-3p	PAR-CLIP	23592263
MIRT476277	hsa-miR-33a-3p	PAR-CLIP	23592263
MIRT476276	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT476275	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT051131	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT476274	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT476273	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT476272	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT476270	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT476271	hsa-miR-759	PAR-CLIP	23592263
MIRT476269	hsa-miR-214-3p	PAR-CLIP	23592263
MIRT476268	hsa-miR-3619-5p	PAR-CLIP	23592263
MIRT476267	hsa-miR-761	PAR-CLIP	23592263
MIRT476266	hsa-miR-6792-5p	PAR-CLIP	23592263
MIRT476265	hsa-miR-3942-3p	PAR-CLIP	23592263
MIRT476264	hsa-miR-30a-3p	PAR-CLIP	23592263
MIRT476263	hsa-miR-30d-3p	PAR-CLIP	23592263
MIRT476262	hsa-miR-30e-3p	PAR-CLIP	23592263
MIRT476261	hsa-miR-335-3p	PAR-CLIP	23592263
MIRT1023444	hsa-miR-2467-5p	CLIP-seq
MIRT1023445	hsa-miR-3919	CLIP-seq
MIRT1023446	hsa-miR-4464	CLIP-seq
MIRT1023447	hsa-miR-4536	CLIP-seq
MIRT1023448	hsa-miR-4727-5p	CLIP-seq
MIRT1023449	hsa-miR-4748	CLIP-seq
MIRT1023450	hsa-miR-4756-3p	CLIP-seq
MIRT1023451	hsa-miR-544	CLIP-seq
MIRT1023452	hsa-miR-106a	CLIP-seq
MIRT1023453	hsa-miR-106b	CLIP-seq
MIRT1023454	hsa-miR-1234	CLIP-seq
MIRT1023455	hsa-miR-150	CLIP-seq
MIRT1023456	hsa-miR-17	CLIP-seq
MIRT1023457	hsa-miR-20a	CLIP-seq
MIRT1023458	hsa-miR-20b	CLIP-seq
MIRT1023459	hsa-miR-302a	CLIP-seq
MIRT1023460	hsa-miR-302b	CLIP-seq
MIRT1023461	hsa-miR-302c	CLIP-seq
MIRT1023462	hsa-miR-302d	CLIP-seq
MIRT1023463	hsa-miR-302e	CLIP-seq
MIRT1023464	hsa-miR-372	CLIP-seq
MIRT1023465	hsa-miR-373	CLIP-seq
MIRT1023466	hsa-miR-4438	CLIP-seq
MIRT1023467	hsa-miR-4454	CLIP-seq
MIRT1023468	hsa-miR-4731-5p	CLIP-seq
MIRT1023469	hsa-miR-4763-5p	CLIP-seq
MIRT1023470	hsa-miR-5095	CLIP-seq
MIRT1023471	hsa-miR-512-3p	CLIP-seq
MIRT1023472	hsa-miR-519d	CLIP-seq
MIRT1023473	hsa-miR-520a-3p	CLIP-seq
MIRT1023474	hsa-miR-520b	CLIP-seq
MIRT1023475	hsa-miR-520c-3p	CLIP-seq
MIRT1023476	hsa-miR-520d-3p	CLIP-seq
MIRT1023477	hsa-miR-520e	CLIP-seq
MIRT1023478	hsa-miR-520g	CLIP-seq
MIRT1023479	hsa-miR-520h	CLIP-seq
MIRT1023480	hsa-miR-93	CLIP-seq
MIRT1023452	hsa-miR-106a	CLIP-seq
MIRT1023453	hsa-miR-106b	CLIP-seq
MIRT1023456	hsa-miR-17	CLIP-seq
MIRT1023457	hsa-miR-20a	CLIP-seq
MIRT1023458	hsa-miR-20b	CLIP-seq
MIRT1023459	hsa-miR-302a	CLIP-seq
MIRT1023460	hsa-miR-302b	CLIP-seq
MIRT1023461	hsa-miR-302c	CLIP-seq
MIRT1023462	hsa-miR-302d	CLIP-seq
MIRT1023463	hsa-miR-302e	CLIP-seq
MIRT1023464	hsa-miR-372	CLIP-seq
MIRT1023465	hsa-miR-373	CLIP-seq
MIRT1023466	hsa-miR-4438	CLIP-seq
MIRT1023481	hsa-miR-4701-5p	CLIP-seq
MIRT1023468	hsa-miR-4731-5p	CLIP-seq
MIRT1023470	hsa-miR-5095	CLIP-seq
MIRT1023471	hsa-miR-512-3p	CLIP-seq
MIRT1023472	hsa-miR-519d	CLIP-seq
MIRT1023473	hsa-miR-520a-3p	CLIP-seq
MIRT1023474	hsa-miR-520b	CLIP-seq
MIRT1023475	hsa-miR-520c-3p	CLIP-seq
MIRT1023476	hsa-miR-520d-3p	CLIP-seq
MIRT1023477	hsa-miR-520e	CLIP-seq
MIRT1023478	hsa-miR-520g	CLIP-seq
MIRT1023479	hsa-miR-520h	CLIP-seq
MIRT1023482	hsa-miR-588	CLIP-seq
MIRT1023480	hsa-miR-93	CLIP-seq
MIRT2003523	hsa-miR-1915	CLIP-seq
MIRT2003524	hsa-miR-1976	CLIP-seq
MIRT2003525	hsa-miR-335	CLIP-seq
MIRT2003526	hsa-miR-4270	CLIP-seq
MIRT2003527	hsa-miR-4279	CLIP-seq
MIRT2003528	hsa-miR-4441	CLIP-seq
MIRT2003529	hsa-miR-4716-5p	CLIP-seq
MIRT2003530	hsa-miR-4722-3p	CLIP-seq
MIRT2003531	hsa-miR-4726-3p	CLIP-seq
MIRT2003532	hsa-miR-496	CLIP-seq
MIRT2003533	hsa-miR-548v	CLIP-seq
MIRT2236338	hsa-miR-4695-3p	CLIP-seq
MIRT2236339	hsa-miR-564	CLIP-seq
MIRT2429397	hsa-miR-627	CLIP-seq
MIRT2429398	hsa-miR-924	CLIP-seq
MIRT2003523	hsa-miR-1915	CLIP-seq
MIRT2540070	hsa-miR-3149	CLIP-seq
MIRT2003525	hsa-miR-335	CLIP-seq
MIRT2540071	hsa-miR-3529	CLIP-seq
MIRT2540072	hsa-miR-379	CLIP-seq
MIRT2540073	hsa-miR-4258	CLIP-seq
MIRT2540074	hsa-miR-4451	CLIP-seq
MIRT2540075	hsa-miR-4650-3p	CLIP-seq
MIRT2540076	hsa-miR-4707-3p	CLIP-seq
MIRT2003531	hsa-miR-4726-3p	CLIP-seq
MIRT2540077	hsa-miR-4735-5p	CLIP-seq
MIRT2540078	hsa-miR-4775	CLIP-seq
MIRT2540079	hsa-miR-4794	CLIP-seq
MIRT2540080	hsa-miR-590-3p	CLIP-seq
MIRT2003523	hsa-miR-1915	CLIP-seq
MIRT2003524	hsa-miR-1976	CLIP-seq
MIRT2540070	hsa-miR-3149	CLIP-seq
MIRT2003525	hsa-miR-335	CLIP-seq
MIRT2540071	hsa-miR-3529	CLIP-seq
MIRT2540072	hsa-miR-379	CLIP-seq
MIRT2540073	hsa-miR-4258	CLIP-seq
MIRT2003527	hsa-miR-4279	CLIP-seq
MIRT2540074	hsa-miR-4451	CLIP-seq
MIRT2540075	hsa-miR-4650-3p	CLIP-seq
MIRT2540076	hsa-miR-4707-3p	CLIP-seq
MIRT2003530	hsa-miR-4722-3p	CLIP-seq
MIRT2003531	hsa-miR-4726-3p	CLIP-seq
MIRT2540077	hsa-miR-4735-5p	CLIP-seq
MIRT2540078	hsa-miR-4775	CLIP-seq
MIRT2540079	hsa-miR-4794	CLIP-seq
MIRT1023470	hsa-miR-5095	CLIP-seq
MIRT2681705	hsa-miR-552	CLIP-seq
MIRT2540080	hsa-miR-590-3p	CLIP-seq
MIRT2681706	hsa-miR-764	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001664	Function	G protein-coupled receptor binding	IBA
GO:0001975	Process	Response to amphetamine	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IEA
GO:0003924	Function	GTPase activity	TAS	8243272
GO:0003925	Function	G protein activity	IEA
GO:0003925	Function	G protein activity	ISS
GO:0005515	Function	Protein binding	IPI	23994616
GO:0005525	Function	GTP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005834	Component	Heterotrimeric G-protein complex	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	TAS	8243272
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS
GO:0007191	Process	Adenylate cyclase-activating dopamine receptor signaling pathway	IBA
GO:0007191	Process	Adenylate cyclase-activating dopamine receptor signaling pathway	IEA
GO:0007606	Process	Sensory perception of chemical stimulus	IBA
GO:0007608	Process	Sensory perception of smell	IEA
GO:0007608	Process	Sensory perception of smell	ISS
GO:0007608	Process	Sensory perception of smell	ISS
GO:0010854	Function	Adenylate cyclase regulator activity	ISS
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019001	Function	Guanyl nucleotide binding	IEA
GO:0031000	Process	Response to caffeine	IEA
GO:0031683	Function	G-protein beta/gamma-subunit complex binding	IBA
GO:0031683	Function	G-protein beta/gamma-subunit complex binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145

Other IDs

• MIM: 139312
• HGNC: 4388
• e!Ensembl: ENSG00000141404

Protein

• UniProt ID: P38405
• Protein name: Guanine nucleotide-binding protein G(olf) subunit alpha (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein, olfactory type)
• Protein function: Guanine nucleotide-binding protein (G protein) involved as transducer in olfactory signal transduction controlled by G protein-coupled receptors (GPCRs) (By similarity). Contains the guanine nucleotide binding site and alternates between an acti
• PDB: 8EL8, 8IW1, 8KGK, 8KH4
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00503	G-alpha	22 → 370	G-protein alpha subunit	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in olfactory neuroepithelium, brain, testis, and to a lower extent in retina, lung alveoli, spleen (PubMed:8243272). Trace amounts where seen in kidney, adrenal gland and liver (PubMed:8243272). Found to be expressed in all th
• Sequence:

  MGCLGGNSKTTEDQGVDEKERREANKKIEKQLQKERLAYKATHRLLLLGAGESGKSTIVK
  QMRILHVNGFNPEEKKQKILDIRKNVKDAIVTIVSAMSTIIPPVPLANPENQFRSDYIKS
  IAPITDFEYSQEFFDHVKKLWDDEGVKACFERSNEYQLIDCAQYFLERIDSVSLVDYTPT
  DQDLLRCRVLTSGIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIYVAACSSY
  NMVIREDNNTNRLRESLDLFESIWNNRWLRTISIILFLNKQDMLAEKVLAGKSKIEDYFP
  EYANYTVPEDATPDAGEDPKVTRAKFFIRDLFLRISTATGDGKHYCYPHFTCAVDTENIR
  RVFNDCRDIIQRMHLKQYELL

• Sequence length: 381

Pathways

KEGG:

Calcium signaling pathway
Dopaminergic synapse
Olfactory transduction
Parkinson disease
Chagas disease
Amoebiasis

Reactome:

Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
Olfactory Signaling Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Dysarthria	Likely pathogenic	rs1598429555	RCV001003996	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Dystonia 25	Likely pathogenic; Pathogenic	rs2510479553, rs398122924, rs398122925, rs398122926, rs398122927, rs398122928, rs1252185897	RCV003993561 RCV000033102 RCV000033103 RCV000033104 RCV000033105 RCV000033106 RCV000768577	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Dystonic disorder	Likely pathogenic; Pathogenic	rs2032882195, rs2143097031, rs2143096767, rs2143650879, rs2510353223, rs2510535483, rs2510259475, rs1252185897	RCV001348008 RCV001941774 RCV001993286 RCV001972728 RCV003050498 RCV003064500 RCV003587429 RCV005092208	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Limb dystonia	Likely pathogenic	rs1598429555	RCV001003996	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTOSOMAL DOMINANT FOCAL DYSTONIA DYT25 TYPE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTOSOMAL DOMINANT FOCAL DYSTONIA, DYT25 TYPE	—	Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DYSTONIA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DYSTONIA DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DYSTONIA MUSCULORUM DEFORMANS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DYSTONIC DISORDERS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FAMILIAL TORSION DYSTONIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GENETIC TORSION DYSTONIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GNAL-related disorder	Likely benign; Benign; Uncertain significance; Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IDIOPATHIC FAMILIAL DYSTONIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adult-Onset Dystonias	Dystonia	CTD_human_DG	23222958		★☆☆☆☆ Found in Text Mining only
Adult-Onset Dystonias	Dystonia	BEFREE	24729450		★☆☆☆☆ Found in Text Mining only
Adult-Onset Idiopathic Focal Dystonias	Dystonia	CTD_human_DG	23222958		★☆☆☆☆ Found in Text Mining only
Adult-Onset Idiopathic Torsion Dystonias	Dystonia	CTD_human_DG	23222958		★☆☆☆☆ Found in Text Mining only
Attention Deficit Disorder with Hyperactivity	Attention deficit hyperactivity disorder	Pubtator	17166517	Associate	★☆☆☆☆ Found in Text Mining only
Auditory Perceptual Disorders	Auditory perceptual disorder	Pubtator	17166517	Associate	★☆☆☆☆ Found in Text Mining only
Autosomal Dominant Familial Dystonia	Dystonia	CTD_human_DG	23222958		★☆☆☆☆ Found in Text Mining only
Autosomal dominant focal dystonia, DYT25 type	Dystonia	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autosomal Recessive Familial Dystonia	Dystonia	CTD_human_DG	23222958		★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	PSYGENET_DG	11032382		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	LHGDN	12782961, 16044173		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar disorder	Pubtator	19859903	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinogenesis	Carcinogenesis	Pubtator	19457610	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	24988079	Associate	★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	31611368	Associate	★☆☆☆☆ Found in Text Mining only
Childhood Onset Dystonias	Dystonia	CTD_human_DG	23222958		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	33029194	Associate	★☆☆☆☆ Found in Text Mining only
Disruptive Impulse Control and Conduct Disorders	Disruptive, impulse control, and conduct disorders	Pubtator	17166517	Associate	★☆☆☆☆ Found in Text Mining only
Dystonia	Dystonia	Pubtator	26810727, 31731261	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DYSTONIA 25	Dystonia	CLINVAR_DG	23222958, 23449625, 24408567, 26506956		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
DYSTONIA 25	Dystonia	ORPHANET_DG	23222958		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
DYSTONIA 25	Dystonia	UNIPROT_DG	23222958		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
DYSTONIA 25	Dystonia	GENOMICS_ENGLAND_DG	24729450, 26725140, 27093447, 27222887		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
DYSTONIA 25	Dystonia	BEFREE	25155315, 28546310, 29219190		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Dystonia 6, torsion (disorder)	Dystonia	BEFREE	25155315		★☆☆☆☆ Found in Text Mining only
Dystonia Disorders	Dystonia	CTD_human_DG	23222958		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Dystonia Disorders	Dystonia	BEFREE	23449625, 23759320, 23911094, 24408567, 24535567, 24729450, 25155315, 26810727, 31034808, 31320448		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Dystonia Musculorum Deformans	Dystonia	BEFREE	23222958, 24151159, 24535567		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Dystonia musculorum deformans type 1	Dystonia musculorum deformans	Pubtator	23222958, 24535567	Associate	★☆☆☆☆ Found in Text Mining only
Dystonia, Primary	Dystonia	CTD_human_DG	23222958		★☆☆☆☆ Found in Text Mining only
Dystonia, Primary	Dystonia	BEFREE	23757263, 23759320, 23911094		★☆☆☆☆ Found in Text Mining only
Dystonia, Secondary	Dystonia	CTD_human_DG	23222958		★☆☆☆☆ Found in Text Mining only
Dystonias, Sporadic	Dystonia	CTD_human_DG	23222958		★☆☆☆☆ Found in Text Mining only
Dystonias, Sporadic	Dystonia	BEFREE	24408567, 24729450		★☆☆☆☆ Found in Text Mining only
Dystonic Disorders	Dystonia	Pubtator	23449625, 24500857	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Early onset torsion dystonia	Dystonia	BEFREE	23222958, 24151159, 24535567		★☆☆☆☆ Found in Text Mining only
Familial Dystonia	Dystonia	CTD_human_DG	23222958		★☆☆☆☆ Found in Text Mining only
Focal Dystonia	Focal dystonia	CTD_human_DG	23222958		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	39387560	Associate	★☆☆☆☆ Found in Text Mining only
Idiopathic familial dystonia	Dystonia	CTD_human_DG	23222958		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Laryngeal dystonia	Laryngeal dystonia	BEFREE	27093447		★☆☆☆☆ Found in Text Mining only
Laryngeal dystonia	Laryngeal dystonia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Laryngitis	Laryngitis	Pubtator	27093447	Associate	★☆☆☆☆ Found in Text Mining only
Movement Disorders	Movement Disorders	BEFREE	24408567, 31034808		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	24535567		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	36852447	Associate	★☆☆☆☆ Found in Text Mining only
Pili torti-deafness syndrome	Pili Torti-Deafness Syndrome	BEFREE	23222958, 24151159		★☆☆☆☆ Found in Text Mining only
Pseudodystonia	Pycnodysostosis	CTD_human_DG	23222958		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	11032382, 11317223		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	PSYGENET_DG	11317223		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	LHGDN	16044173		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Writer`s Cramp	Writer`s Cramp	CTD_human_DG	23222958		★☆☆☆☆ Found in Text Mining only