Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	27351
Gene name	Desumoylating isopeptidase 1
Gene symbol	DESI1
Synonyms (NCBI Gene)	D15Wsu75eDESI2DJ347H13.4DeSI-1FAM152BPOSTPPPDE2
Chromosome	22
Chromosome location	22q13.2

146

Show/Hide all (146)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019706	hsa-miR-375	Microarray	20215506
MIRT027140	hsa-miR-103a-3p	Sequencing	20371350
MIRT031588	hsa-miR-16-5p	Sequencing	20371350
MIRT045472	hsa-miR-149-5p	CLASH	23622248
MIRT039862	hsa-miR-615-3p	CLASH	23622248
MIRT037590	hsa-miR-744-5p	CLASH	23622248
MIRT670930	hsa-miR-1321	HITS-CLIP	23824327
MIRT670929	hsa-miR-4739	HITS-CLIP	23824327
MIRT670928	hsa-miR-4756-5p	HITS-CLIP	23824327
MIRT670927	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT670926	hsa-miR-6134	HITS-CLIP	23824327
MIRT670925	hsa-miR-3689d	HITS-CLIP	23824327
MIRT670924	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT670923	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT670922	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT670921	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT670920	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT670919	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT670918	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT670917	hsa-miR-7977	HITS-CLIP	23824327
MIRT670916	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT670915	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT670914	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT670913	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT670912	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT670911	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT670910	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT670909	hsa-miR-3689c	HITS-CLIP	23824327
MIRT670908	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT670907	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT670906	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT670905	hsa-miR-3122	HITS-CLIP	23824327
MIRT670904	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT670903	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT670902	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT572153	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT572152	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT572150	hsa-miR-3609	PAR-CLIP	20371350
MIRT572151	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT572149	hsa-miR-548p	PAR-CLIP	20371350
MIRT572146	hsa-miR-4774-5p	PAR-CLIP	20371350
MIRT572145	hsa-miR-4699-5p	PAR-CLIP	20371350
MIRT572144	hsa-miR-145-3p	PAR-CLIP	20371350
MIRT572143	hsa-miR-548aj-5p	PAR-CLIP	20371350
MIRT572142	hsa-miR-548f-5p	PAR-CLIP	20371350
MIRT572141	hsa-miR-548g-5p	PAR-CLIP	20371350
MIRT572140	hsa-miR-548x-5p	PAR-CLIP	20371350
MIRT572139	hsa-miR-5681b	PAR-CLIP	20371350
MIRT572138	hsa-miR-1343-3p	PAR-CLIP	20371350
MIRT572137	hsa-miR-6783-3p	PAR-CLIP	20371350
MIRT572136	hsa-miR-599	PAR-CLIP	20371350
MIRT572153	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT572152	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT572150	hsa-miR-3609	PAR-CLIP	20371350
MIRT572151	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT572149	hsa-miR-548p	PAR-CLIP	20371350
MIRT572148	hsa-miR-3074-3p	PAR-CLIP	20371350
MIRT572147	hsa-miR-4761-5p	PAR-CLIP	20371350
MIRT572146	hsa-miR-4774-5p	PAR-CLIP	20371350
MIRT572145	hsa-miR-4699-5p	PAR-CLIP	20371350
MIRT572144	hsa-miR-145-3p	PAR-CLIP	20371350
MIRT572143	hsa-miR-548aj-5p	PAR-CLIP	20371350
MIRT572142	hsa-miR-548f-5p	PAR-CLIP	20371350
MIRT572141	hsa-miR-548g-5p	PAR-CLIP	20371350
MIRT572140	hsa-miR-548x-5p	PAR-CLIP	20371350
MIRT572139	hsa-miR-5681b	PAR-CLIP	20371350
MIRT572138	hsa-miR-1343-3p	PAR-CLIP	20371350
MIRT572137	hsa-miR-6783-3p	PAR-CLIP	20371350
MIRT572136	hsa-miR-599	PAR-CLIP	20371350
MIRT495900	hsa-miR-6815-5p	PAR-CLIP	22291592
MIRT495899	hsa-miR-6865-5p	PAR-CLIP	22291592
MIRT495898	hsa-miR-3135a	PAR-CLIP	22291592
MIRT495897	hsa-miR-184	PAR-CLIP	22291592
MIRT495896	hsa-miR-8071	PAR-CLIP	22291592
MIRT495895	hsa-miR-6802-5p	PAR-CLIP	22291592
MIRT495894	hsa-miR-4804-5p	PAR-CLIP	22291592
MIRT670930	hsa-miR-1321	HITS-CLIP	23824327
MIRT670929	hsa-miR-4739	HITS-CLIP	23824327
MIRT670928	hsa-miR-4756-5p	HITS-CLIP	23824327
MIRT670927	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT670926	hsa-miR-6134	HITS-CLIP	23824327
MIRT670925	hsa-miR-3689d	HITS-CLIP	23824327
MIRT670924	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT670923	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT670922	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT670921	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT670920	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT670919	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT670918	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT670917	hsa-miR-7977	HITS-CLIP	23824327
MIRT670916	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT670915	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT670914	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT670913	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT670912	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT670911	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT670910	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT670909	hsa-miR-3689c	HITS-CLIP	23824327
MIRT670908	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT670907	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT670906	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT670905	hsa-miR-3122	HITS-CLIP	23824327
MIRT670904	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT670903	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT670902	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT572153	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT572152	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT572150	hsa-miR-3609	PAR-CLIP	20371350
MIRT572151	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT572149	hsa-miR-548p	PAR-CLIP	20371350
MIRT572146	hsa-miR-4774-5p	PAR-CLIP	20371350
MIRT572145	hsa-miR-4699-5p	PAR-CLIP	20371350
MIRT572144	hsa-miR-145-3p	PAR-CLIP	20371350
MIRT572143	hsa-miR-548aj-5p	PAR-CLIP	20371350
MIRT572142	hsa-miR-548f-5p	PAR-CLIP	20371350
MIRT572141	hsa-miR-548g-5p	PAR-CLIP	20371350
MIRT572140	hsa-miR-548x-5p	PAR-CLIP	20371350
MIRT572139	hsa-miR-5681b	PAR-CLIP	20371350
MIRT572138	hsa-miR-1343-3p	PAR-CLIP	20371350
MIRT572137	hsa-miR-6783-3p	PAR-CLIP	20371350
MIRT572136	hsa-miR-599	PAR-CLIP	20371350
MIRT572153	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT572152	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT572150	hsa-miR-3609	PAR-CLIP	20371350
MIRT572151	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT572149	hsa-miR-548p	PAR-CLIP	20371350
MIRT572148	hsa-miR-3074-3p	PAR-CLIP	20371350
MIRT572147	hsa-miR-4761-5p	PAR-CLIP	20371350
MIRT572146	hsa-miR-4774-5p	PAR-CLIP	20371350
MIRT572145	hsa-miR-4699-5p	PAR-CLIP	20371350
MIRT572144	hsa-miR-145-3p	PAR-CLIP	20371350
MIRT572143	hsa-miR-548aj-5p	PAR-CLIP	20371350
MIRT572142	hsa-miR-548f-5p	PAR-CLIP	20371350
MIRT572141	hsa-miR-548g-5p	PAR-CLIP	20371350
MIRT572140	hsa-miR-548x-5p	PAR-CLIP	20371350
MIRT572139	hsa-miR-5681b	PAR-CLIP	20371350
MIRT572138	hsa-miR-1343-3p	PAR-CLIP	20371350
MIRT572137	hsa-miR-6783-3p	PAR-CLIP	20371350
MIRT572136	hsa-miR-599	PAR-CLIP	20371350
MIRT495900	hsa-miR-6815-5p	PAR-CLIP	22291592
MIRT495899	hsa-miR-6865-5p	PAR-CLIP	22291592
MIRT495898	hsa-miR-3135a	PAR-CLIP	22291592
MIRT495897	hsa-miR-184	PAR-CLIP	22291592
MIRT495896	hsa-miR-8071	PAR-CLIP	22291592
MIRT495895	hsa-miR-6802-5p	PAR-CLIP	22291592
MIRT495894	hsa-miR-4804-5p	PAR-CLIP	22291592

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	29666234, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	29666234
GO:0006508	Process	Proteolysis	IEA
GO:0006611	Process	Protein export from nucleus	IBA
GO:0006611	Process	Protein export from nucleus	IPI	29666234
GO:0008233	Function	Peptidase activity	IEA
GO:0008474	Function	Palmitoyl-(protein) hydrolase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016926	Process	Protein desumoylation	IEA
GO:0016929	Function	DeSUMOylase activity	IEA
GO:0032434	Process	Regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA
GO:0032434	Process	Regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA	29666234
GO:0032991	Component	Protein-containing complex	IDA	29666234
GO:0042802	Function	Identical protein binding	IEA
GO:0052816	Function	Long-chain fatty acyl-CoA hydrolase activity	IDA	35427157
GO:0061676	Function	Importin-alpha family protein binding	IPI	29666234
GO:0098734	Process	Macromolecule depalmitoylation	IEA

MIM	HGNC	e!Ensembl
614637	24577	ENSG00000100418

Q6ICB0

Protein name

Desumoylating isopeptidase 1 (DeSI-1) (EC 3.4.-.-) (PPPDE peptidase domain-containing protein 2) (Palmitoyl protein thioesterase DESI1) (EC 3.1.2.22) (Polyubiquitinated substrate transporter) (POST) (S-depalmitoylase DESI1)

Protein function

Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Desumoylates ZBTB46 (By similarity). Collaborates with UBQLN4 in the export of ubiquitinated prot

PDB

3EBQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05903	Peptidase_C97	7 → 149	PPPDE putative peptidase domain	Domain

Sequence

MEPPNLYPVKLYVYDLSKGLARRLSPIMLGKQLEGIWHTSIVVHKDEFFFGSGGISSCPP
GGTLLGPPDSVVDVGSTEVTEEIFLEYLSSLGESLFRGEAYNLFEHNCNTFSNEVAQFLT
GRKIPSYITDLPSEVLSTPFGQALRPLLDSIQIQPPGGSSVGRPNGQS

Sequence length

168

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

DESI1 (desumoylating isopeptidase 1)