Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	27345
Gene name	Potassium calcium-activated channel subfamily M regulatory beta subunit 4
Gene symbol	KCNMB4
Synonyms (NCBI Gene)	-
Chromosome	12
Chromosome location	12q15
Summary	MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the

Show/Hide all (52)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024739	hsa-miR-215-5p	Microarray	19074876
MIRT026374	hsa-miR-192-5p	Microarray	19074876
MIRT657011	hsa-miR-4307	HITS-CLIP	23824327
MIRT657010	hsa-miR-1185-5p	HITS-CLIP	23824327
MIRT657009	hsa-miR-3679-5p	HITS-CLIP	23824327
MIRT657008	hsa-miR-190a-5p	HITS-CLIP	23824327
MIRT657007	hsa-miR-190b	HITS-CLIP	23824327
MIRT657005	hsa-miR-3201	HITS-CLIP	23824327
MIRT657006	hsa-miR-4791	HITS-CLIP	23824327
MIRT657004	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT640077	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT640076	hsa-miR-3074-3p	HITS-CLIP	23824327
MIRT640072	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT657002	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT657003	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT657001	hsa-miR-421	HITS-CLIP	23824327
MIRT640070	hsa-miR-1305	HITS-CLIP	23824327
MIRT640069	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT640077	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT640076	hsa-miR-3074-3p	HITS-CLIP	23824327
MIRT640075	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT640074	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT640073	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT640072	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT640071	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT640070	hsa-miR-1305	HITS-CLIP	23824327
MIRT640069	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT657011	hsa-miR-4307	HITS-CLIP	23824327
MIRT657010	hsa-miR-1185-5p	HITS-CLIP	23824327
MIRT657009	hsa-miR-3679-5p	HITS-CLIP	23824327
MIRT657008	hsa-miR-190a-5p	HITS-CLIP	23824327
MIRT657007	hsa-miR-190b	HITS-CLIP	23824327
MIRT657005	hsa-miR-3201	HITS-CLIP	23824327
MIRT657006	hsa-miR-4791	HITS-CLIP	23824327
MIRT657004	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT640077	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT640076	hsa-miR-3074-3p	HITS-CLIP	23824327
MIRT640072	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT657002	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT657003	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT657001	hsa-miR-421	HITS-CLIP	23824327
MIRT640070	hsa-miR-1305	HITS-CLIP	23824327
MIRT640069	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT640077	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT640076	hsa-miR-3074-3p	HITS-CLIP	23824327
MIRT640075	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT640074	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT640073	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT640072	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT640071	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT640070	hsa-miR-1305	HITS-CLIP	23824327
MIRT640069	hsa-miR-335-3p	HITS-CLIP	23824327

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001508	Process	Action potential	IDA	10692449
GO:0005513	Process	Detection of calcium ion	IBA
GO:0005513	Process	Detection of calcium ion	IDA	10692449
GO:0005515	Function	Protein binding	IPI	10692449, 32296183
GO:0005886	Component	Plasma membrane	IDA	10692449
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006813	Process	Potassium ion transport	IDA	10692449
GO:0006813	Process	Potassium ion transport	IEA
GO:0006813	Process	Potassium ion transport	TAS	10692449
GO:0007268	Process	Chemical synaptic transmission	TAS	10692449
GO:0008076	Component	Voltage-gated potassium channel complex	IBA
GO:0008076	Component	Voltage-gated potassium channel complex	IDA	10692449
GO:0008076	Component	Voltage-gated potassium channel complex	IEA
GO:0015269	Function	Calcium-activated potassium channel activity	IBA
GO:0015269	Function	Calcium-activated potassium channel activity	IDA	10692449
GO:0015269	Function	Calcium-activated potassium channel activity	IEA
GO:0015459	Function	Potassium channel regulator activity	IBA
GO:0016020	Component	Membrane	IEA
GO:0019228	Process	Neuronal action potential	IDA	10692449
GO:0019229	Process	Regulation of vasoconstriction	TAS	10692449
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0045202	Component	Synapse	IEA
GO:0046928	Process	Regulation of neurotransmitter secretion	TAS	10692449
GO:0071805	Process	Potassium ion transmembrane transport	IEA
GO:0099505	Process	Regulation of presynaptic membrane potential	IEA
GO:0099508	Function	Voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEA

MIM	HGNC	e!Ensembl
605223	6289	ENSG00000135643

Q86W47

Protein name

Calcium-activated potassium channel subunit beta-4 (BK channel subunit beta-4) (BKbeta4) (Hbeta4) (Calcium-activated potassium channel, subfamily M subunit beta-4) (Charybdotoxin receptor subunit beta-4) (K(VCA)beta-4) (Maxi K channel subunit beta-4) (Slo

Protein function

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivit

PDB

5Y7L , 6V22 , 6V35 , 9CZH , 9CZJ , 9CZK , 9CZM , 9CZO , 9CZQ , 9D18 , 9D19

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03185	CaKB	8 → 203	Calcium-activated potassium channel, beta subunit	Family

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substa

Sequence

MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQ
QIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKCSYIPPCK
RENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRPDDVLLHRTHDEIVLLHCFLWPLVT
FVVGVLIVVLTICAKSLAVKAEAMKKRKFS

Sequence length

210

Interactions

View interactions

	KEGG		Reactome
	cGMP-PKG signaling pathway Vascular smooth muscle contraction Insulin secretion		Ca2+ activated K+ channels

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autism Spectrum Disorder	Autism	Pubtator	22965006	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	Pubtator	34562210	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Blood Coagulation Disorders	Blood coagulation disorder	Pubtator	35039944	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy, Temporal Lobe	Epilepsy	BEFREE	23623847		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	25300797		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	25300797		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	25300797, 25418192	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

KCNMB4 (potassium calcium-activated channel subfamily M regulatory beta subunit 4)