Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	27338
Gene name	Ubiquitin conjugating enzyme E2 S
Gene symbol	UBE2S
Synonyms (NCBI Gene)	E2-EPFE2EPFEPF5
Chromosome	19
Chromosome location	19q13.42
Summary	This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [pr

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001401	hsa-miR-16-5p	pSILAC	18668040
MIRT025286	hsa-miR-34a-5p	Proteomics	21566225
MIRT025286	hsa-miR-34a-5p	Proteomics	21566225
MIRT001401	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT050848	hsa-miR-17-5p	CLASH	23622248
MIRT045572	hsa-miR-149-5p	CLASH	23622248
MIRT043221	hsa-miR-324-5p	CLASH	23622248
MIRT042126	hsa-miR-484	CLASH	23622248
MIRT460902	hsa-miR-5692a	PAR-CLIP	23592263
MIRT460901	hsa-miR-32-3p	PAR-CLIP	23592263
MIRT460900	hsa-miR-4797-5p	PAR-CLIP	23592263
MIRT460899	hsa-miR-1321	PAR-CLIP	23592263
MIRT460898	hsa-miR-4739	PAR-CLIP	23592263
MIRT460897	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT460896	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT460895	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT460894	hsa-miR-4419a	PAR-CLIP	23592263
MIRT460893	hsa-miR-4510	PAR-CLIP	23592263
MIRT460892	hsa-miR-6127	PAR-CLIP	23592263
MIRT460891	hsa-miR-6129	PAR-CLIP	23592263
MIRT460890	hsa-miR-6130	PAR-CLIP	23592263
MIRT460889	hsa-miR-6133	PAR-CLIP	23592263
MIRT460888	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT460887	hsa-miR-6086	PAR-CLIP	23592263
MIRT460886	hsa-miR-571	PAR-CLIP	23592263
MIRT460885	hsa-miR-4533	PAR-CLIP	23592263
MIRT460884	hsa-miR-3202	PAR-CLIP	23592263
MIRT460883	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT460882	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT460881	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT460880	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT460879	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT460878	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT460877	hsa-miR-615-5p	PAR-CLIP	23592263
MIRT460876	hsa-miR-7704	PAR-CLIP	23592263
MIRT460875	hsa-miR-92a-1-5p	PAR-CLIP	23592263
MIRT460874	hsa-miR-3190-3p	PAR-CLIP	23592263
MIRT460873	hsa-miR-4443	PAR-CLIP	23592263
MIRT460872	hsa-miR-6515-5p	PAR-CLIP	23592263
MIRT460871	hsa-miR-6737-5p	PAR-CLIP	23592263
MIRT460870	hsa-miR-6812-5p	PAR-CLIP	23592263
MIRT460869	hsa-miR-6819-5p	PAR-CLIP	23592263
MIRT460868	hsa-miR-3170	PAR-CLIP	23592263
MIRT460867	hsa-miR-6855-5p	PAR-CLIP	23592263
MIRT460866	hsa-miR-1303	PAR-CLIP	23592263
MIRT460865	hsa-miR-5572	PAR-CLIP	23592263
MIRT460883	hsa-miR-1249-5p	PAR-CLIP	26701625
MIRT460883	hsa-miR-1249-5p	PAR-CLIP	26701625
MIRT460883	hsa-miR-1249-5p	PAR-CLIP	26701625
MIRT460883	hsa-miR-1249-5p	PAR-CLIP	26701625
MIRT460883	hsa-miR-1249-5p	PAR-CLIP	26701625
MIRT460866	hsa-miR-1303	PAR-CLIP	26701625
MIRT460866	hsa-miR-1303	PAR-CLIP	26701625
MIRT460866	hsa-miR-1303	PAR-CLIP	26701625
MIRT460899	hsa-miR-1321	PAR-CLIP	26701625
MIRT460899	hsa-miR-1321	PAR-CLIP	26701625
MIRT460899	hsa-miR-1321	PAR-CLIP	26701625
MIRT460899	hsa-miR-1321	PAR-CLIP	26701625
MIRT460899	hsa-miR-1321	PAR-CLIP	26701625
MIRT460881	hsa-miR-149-3p	PAR-CLIP	26701625
MIRT460881	hsa-miR-149-3p	PAR-CLIP	26701625
MIRT460881	hsa-miR-149-3p	PAR-CLIP	26701625
MIRT460881	hsa-miR-149-3p	PAR-CLIP	26701625
MIRT460881	hsa-miR-149-3p	PAR-CLIP	26701625
MIRT460868	hsa-miR-3170	PAR-CLIP	26701625
MIRT460868	hsa-miR-3170	PAR-CLIP	26701625
MIRT460868	hsa-miR-3170	PAR-CLIP	26701625
MIRT460868	hsa-miR-3170	PAR-CLIP	26701625
MIRT460868	hsa-miR-3170	PAR-CLIP	26701625
MIRT460874	hsa-miR-3190-3p	PAR-CLIP	26701625
MIRT460874	hsa-miR-3190-3p	PAR-CLIP	26701625
MIRT460874	hsa-miR-3190-3p	PAR-CLIP	26701625
MIRT460874	hsa-miR-3190-3p	PAR-CLIP	26701625
MIRT460874	hsa-miR-3190-3p	PAR-CLIP	26701625
MIRT460874	hsa-miR-3190-3p	PAR-CLIP	26701625
MIRT460884	hsa-miR-3202	PAR-CLIP	26701625
MIRT460884	hsa-miR-3202	PAR-CLIP	26701625
MIRT460884	hsa-miR-3202	PAR-CLIP	26701625
MIRT460884	hsa-miR-3202	PAR-CLIP	26701625
MIRT460884	hsa-miR-3202	PAR-CLIP	26701625
MIRT460884	hsa-miR-3202	PAR-CLIP	26701625
MIRT460888	hsa-miR-377-5p	PAR-CLIP	26701625
MIRT460888	hsa-miR-377-5p	PAR-CLIP	26701625
MIRT460888	hsa-miR-377-5p	PAR-CLIP	26701625
MIRT460888	hsa-miR-377-5p	PAR-CLIP	26701625
MIRT460888	hsa-miR-377-5p	PAR-CLIP	26701625
MIRT460894	hsa-miR-4419a	PAR-CLIP	26701625
MIRT460894	hsa-miR-4419a	PAR-CLIP	26701625
MIRT460894	hsa-miR-4419a	PAR-CLIP	26701625
MIRT460894	hsa-miR-4419a	PAR-CLIP	26701625
MIRT460894	hsa-miR-4419a	PAR-CLIP	26701625
MIRT460873	hsa-miR-4443	PAR-CLIP	26701625
MIRT460873	hsa-miR-4443	PAR-CLIP	26701625
MIRT460873	hsa-miR-4443	PAR-CLIP	26701625
MIRT460873	hsa-miR-4443	PAR-CLIP	26701625
MIRT460873	hsa-miR-4443	PAR-CLIP	26701625
MIRT460893	hsa-miR-4510	PAR-CLIP	26701625
MIRT460893	hsa-miR-4510	PAR-CLIP	26701625
MIRT460893	hsa-miR-4510	PAR-CLIP	26701625
MIRT460893	hsa-miR-4510	PAR-CLIP	26701625
MIRT460893	hsa-miR-4510	PAR-CLIP	26701625
MIRT460895	hsa-miR-4524a-3p	PAR-CLIP	26701625
MIRT460895	hsa-miR-4524a-3p	PAR-CLIP	26701625
MIRT460895	hsa-miR-4524a-3p	PAR-CLIP	26701625
MIRT460895	hsa-miR-4524a-3p	PAR-CLIP	26701625
MIRT460895	hsa-miR-4524a-3p	PAR-CLIP	26701625
MIRT460885	hsa-miR-4533	PAR-CLIP	26701625
MIRT460885	hsa-miR-4533	PAR-CLIP	26701625
MIRT460885	hsa-miR-4533	PAR-CLIP	26701625
MIRT460885	hsa-miR-4533	PAR-CLIP	26701625
MIRT460885	hsa-miR-4533	PAR-CLIP	26701625
MIRT460885	hsa-miR-4533	PAR-CLIP	26701625
MIRT460880	hsa-miR-4728-5p	PAR-CLIP	26701625
MIRT460880	hsa-miR-4728-5p	PAR-CLIP	26701625
MIRT460880	hsa-miR-4728-5p	PAR-CLIP	26701625
MIRT460880	hsa-miR-4728-5p	PAR-CLIP	26701625
MIRT460880	hsa-miR-4728-5p	PAR-CLIP	26701625
MIRT460898	hsa-miR-4739	PAR-CLIP	26701625
MIRT460898	hsa-miR-4739	PAR-CLIP	26701625
MIRT460898	hsa-miR-4739	PAR-CLIP	26701625
MIRT460898	hsa-miR-4739	PAR-CLIP	26701625
MIRT460898	hsa-miR-4739	PAR-CLIP	26701625
MIRT460897	hsa-miR-4756-5p	PAR-CLIP	26701625
MIRT460897	hsa-miR-4756-5p	PAR-CLIP	26701625
MIRT460897	hsa-miR-4756-5p	PAR-CLIP	26701625
MIRT460897	hsa-miR-4756-5p	PAR-CLIP	26701625
MIRT460897	hsa-miR-4756-5p	PAR-CLIP	26701625
MIRT460896	hsa-miR-4768-3p	PAR-CLIP	26701625
MIRT460896	hsa-miR-4768-3p	PAR-CLIP	26701625
MIRT460896	hsa-miR-4768-3p	PAR-CLIP	26701625
MIRT460896	hsa-miR-4768-3p	PAR-CLIP	26701625
MIRT460896	hsa-miR-4768-3p	PAR-CLIP	26701625
MIRT460900	hsa-miR-4797-5p	PAR-CLIP	26701625
MIRT460900	hsa-miR-4797-5p	PAR-CLIP	26701625
MIRT460900	hsa-miR-4797-5p	PAR-CLIP	26701625
MIRT460900	hsa-miR-4797-5p	PAR-CLIP	26701625
MIRT460900	hsa-miR-4797-5p	PAR-CLIP	26701625
MIRT460865	hsa-miR-5572	PAR-CLIP	26701625
MIRT460865	hsa-miR-5572	PAR-CLIP	26701625
MIRT460865	hsa-miR-5572	PAR-CLIP	26701625
MIRT460865	hsa-miR-5572	PAR-CLIP	26701625
MIRT460865	hsa-miR-5572	PAR-CLIP	26701625
MIRT460902	hsa-miR-5692a	PAR-CLIP	26701625
MIRT460902	hsa-miR-5692a	PAR-CLIP	26701625
MIRT460902	hsa-miR-5692a	PAR-CLIP	26701625
MIRT460886	hsa-miR-571	PAR-CLIP	26701625
MIRT460886	hsa-miR-571	PAR-CLIP	26701625
MIRT460886	hsa-miR-571	PAR-CLIP	26701625
MIRT460886	hsa-miR-571	PAR-CLIP	26701625
MIRT460886	hsa-miR-571	PAR-CLIP	26701625
MIRT460887	hsa-miR-6086	PAR-CLIP	26701625
MIRT460887	hsa-miR-6086	PAR-CLIP	26701625
MIRT460887	hsa-miR-6086	PAR-CLIP	26701625
MIRT460887	hsa-miR-6086	PAR-CLIP	26701625
MIRT460887	hsa-miR-6086	PAR-CLIP	26701625
MIRT460892	hsa-miR-6127	PAR-CLIP	26701625
MIRT460892	hsa-miR-6127	PAR-CLIP	26701625
MIRT460892	hsa-miR-6127	PAR-CLIP	26701625
MIRT460892	hsa-miR-6127	PAR-CLIP	26701625
MIRT460892	hsa-miR-6127	PAR-CLIP	26701625
MIRT460891	hsa-miR-6129	PAR-CLIP	26701625
MIRT460891	hsa-miR-6129	PAR-CLIP	26701625
MIRT460891	hsa-miR-6129	PAR-CLIP	26701625
MIRT460891	hsa-miR-6129	PAR-CLIP	26701625
MIRT460891	hsa-miR-6129	PAR-CLIP	26701625
MIRT460890	hsa-miR-6130	PAR-CLIP	26701625
MIRT460890	hsa-miR-6130	PAR-CLIP	26701625
MIRT460890	hsa-miR-6130	PAR-CLIP	26701625
MIRT460890	hsa-miR-6130	PAR-CLIP	26701625
MIRT460890	hsa-miR-6130	PAR-CLIP	26701625
MIRT460889	hsa-miR-6133	PAR-CLIP	26701625
MIRT460889	hsa-miR-6133	PAR-CLIP	26701625
MIRT460889	hsa-miR-6133	PAR-CLIP	26701625
MIRT460889	hsa-miR-6133	PAR-CLIP	26701625
MIRT460889	hsa-miR-6133	PAR-CLIP	26701625
MIRT460877	hsa-miR-615-5p	PAR-CLIP	26701625
MIRT460877	hsa-miR-615-5p	PAR-CLIP	26701625
MIRT460877	hsa-miR-615-5p	PAR-CLIP	26701625
MIRT460877	hsa-miR-615-5p	PAR-CLIP	26701625
MIRT460877	hsa-miR-615-5p	PAR-CLIP	26701625
MIRT460872	hsa-miR-6515-5p	PAR-CLIP	26701625
MIRT460872	hsa-miR-6515-5p	PAR-CLIP	26701625
MIRT460872	hsa-miR-6515-5p	PAR-CLIP	26701625
MIRT460872	hsa-miR-6515-5p	PAR-CLIP	26701625
MIRT460872	hsa-miR-6515-5p	PAR-CLIP	26701625
MIRT460871	hsa-miR-6737-5p	PAR-CLIP	26701625
MIRT460871	hsa-miR-6737-5p	PAR-CLIP	26701625
MIRT460871	hsa-miR-6737-5p	PAR-CLIP	26701625
MIRT460871	hsa-miR-6737-5p	PAR-CLIP	26701625
MIRT460871	hsa-miR-6737-5p	PAR-CLIP	26701625
MIRT460879	hsa-miR-6785-5p	PAR-CLIP	26701625
MIRT460879	hsa-miR-6785-5p	PAR-CLIP	26701625
MIRT460879	hsa-miR-6785-5p	PAR-CLIP	26701625
MIRT460879	hsa-miR-6785-5p	PAR-CLIP	26701625
MIRT460879	hsa-miR-6785-5p	PAR-CLIP	26701625
MIRT460882	hsa-miR-6797-5p	PAR-CLIP	26701625
MIRT460882	hsa-miR-6797-5p	PAR-CLIP	26701625
MIRT460882	hsa-miR-6797-5p	PAR-CLIP	26701625
MIRT460882	hsa-miR-6797-5p	PAR-CLIP	26701625
MIRT460882	hsa-miR-6797-5p	PAR-CLIP	26701625
MIRT460870	hsa-miR-6812-5p	PAR-CLIP	26701625
MIRT460870	hsa-miR-6812-5p	PAR-CLIP	26701625
MIRT460870	hsa-miR-6812-5p	PAR-CLIP	26701625
MIRT460870	hsa-miR-6812-5p	PAR-CLIP	26701625
MIRT460870	hsa-miR-6812-5p	PAR-CLIP	26701625
MIRT460869	hsa-miR-6819-5p	PAR-CLIP	26701625
MIRT460869	hsa-miR-6819-5p	PAR-CLIP	26701625
MIRT460869	hsa-miR-6819-5p	PAR-CLIP	26701625
MIRT460869	hsa-miR-6819-5p	PAR-CLIP	26701625
MIRT460869	hsa-miR-6819-5p	PAR-CLIP	26701625
MIRT460867	hsa-miR-6855-5p	PAR-CLIP	26701625
MIRT460867	hsa-miR-6855-5p	PAR-CLIP	26701625
MIRT460867	hsa-miR-6855-5p	PAR-CLIP	26701625
MIRT460867	hsa-miR-6855-5p	PAR-CLIP	26701625
MIRT460867	hsa-miR-6855-5p	PAR-CLIP	26701625
MIRT460878	hsa-miR-6883-5p	PAR-CLIP	26701625
MIRT460878	hsa-miR-6883-5p	PAR-CLIP	26701625
MIRT460878	hsa-miR-6883-5p	PAR-CLIP	26701625
MIRT460878	hsa-miR-6883-5p	PAR-CLIP	26701625
MIRT460878	hsa-miR-6883-5p	PAR-CLIP	26701625
MIRT460876	hsa-miR-7704	PAR-CLIP	26701625
MIRT460876	hsa-miR-7704	PAR-CLIP	26701625
MIRT460876	hsa-miR-7704	PAR-CLIP	26701625
MIRT460876	hsa-miR-7704	PAR-CLIP	26701625
MIRT460876	hsa-miR-7704	PAR-CLIP	26701625
MIRT460875	hsa-miR-92a-1-5p	PAR-CLIP	26701625
MIRT460875	hsa-miR-92a-1-5p	PAR-CLIP	26701625
MIRT460875	hsa-miR-92a-1-5p	PAR-CLIP	26701625
MIRT460875	hsa-miR-92a-1-5p	PAR-CLIP	26701625
MIRT460875	hsa-miR-92a-1-5p	PAR-CLIP	26701625
MIRT460902	hsa-miR-5692a	PAR-CLIP	23592263
MIRT460901	hsa-miR-32-3p	PAR-CLIP	23592263
MIRT460900	hsa-miR-4797-5p	PAR-CLIP	23592263
MIRT460899	hsa-miR-1321	PAR-CLIP	23592263
MIRT460898	hsa-miR-4739	PAR-CLIP	23592263
MIRT460897	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT460896	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT460895	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT460894	hsa-miR-4419a	PAR-CLIP	23592263
MIRT460893	hsa-miR-4510	PAR-CLIP	23592263
MIRT460892	hsa-miR-6127	PAR-CLIP	23592263
MIRT460891	hsa-miR-6129	PAR-CLIP	23592263
MIRT460890	hsa-miR-6130	PAR-CLIP	23592263
MIRT460889	hsa-miR-6133	PAR-CLIP	23592263
MIRT460888	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT460887	hsa-miR-6086	PAR-CLIP	23592263
MIRT460886	hsa-miR-571	PAR-CLIP	23592263
MIRT460885	hsa-miR-4533	PAR-CLIP	23592263
MIRT460884	hsa-miR-3202	PAR-CLIP	23592263
MIRT460883	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT460882	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT460881	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT460880	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT460879	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT460878	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT460877	hsa-miR-615-5p	PAR-CLIP	23592263
MIRT460876	hsa-miR-7704	PAR-CLIP	23592263
MIRT460875	hsa-miR-92a-1-5p	PAR-CLIP	23592263
MIRT460874	hsa-miR-3190-3p	PAR-CLIP	23592263
MIRT460873	hsa-miR-4443	PAR-CLIP	23592263
MIRT460872	hsa-miR-6515-5p	PAR-CLIP	23592263
MIRT460871	hsa-miR-6737-5p	PAR-CLIP	23592263
MIRT460870	hsa-miR-6812-5p	PAR-CLIP	23592263
MIRT460869	hsa-miR-6819-5p	PAR-CLIP	23592263
MIRT460868	hsa-miR-3170	PAR-CLIP	23592263
MIRT460867	hsa-miR-6855-5p	PAR-CLIP	23592263
MIRT460866	hsa-miR-1303	PAR-CLIP	23592263
MIRT460865	hsa-miR-5572	PAR-CLIP	23592263
MIRT2361891	hsa-miR-3173-3p	CLIP-seq
MIRT2361892	hsa-miR-3190	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
EGR1	Activation	18780286
SRF	Activation	18780286

Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000209	Process	Protein polyubiquitination	IBA
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	19820702, 19822757
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	20061386
GO:0005515	Function	Protein binding	IPI	23708001, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005680	Component	Anaphase-promoting complex	IDA	19822757
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA
GO:0010458	Process	Exit from mitosis	IDA	19820702
GO:0010458	Process	Exit from mitosis	IEA
GO:0010458	Process	Exit from mitosis	IMP	19822757
GO:0010994	Process	Free ubiquitin chain polymerization	IDA	19822757
GO:0010997	Function	Anaphase-promoting complex binding	IPI	23708001
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019787	Function	Ubiquitin-like protein transferase activity	IEA
GO:0031145	Process	Anaphase-promoting complex-dependent catabolic process	IDA	19820702, 19822757
GO:0031145	Process	Anaphase-promoting complex-dependent catabolic process	IEA
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA	22017875, 22017876, 22017877
GO:0032446	Process	Protein modification by small protein conjugation	IEA
GO:0035519	Process	Protein K29-linked ubiquitination	IDA	20061386
GO:0036211	Process	Protein modification process	TAS	1379239
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	27910872
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	27910872
GO:0044314	Process	Protein K27-linked ubiquitination	IDA	20061386
GO:0051301	Process	Cell division	IEA
GO:0061631	Function	Ubiquitin conjugating enzyme activity	IBA
GO:0061631	Function	Ubiquitin conjugating enzyme activity	IDA	21376237, 27910872
GO:0061631	Function	Ubiquitin conjugating enzyme activity	IEA
GO:0070534	Process	Protein K63-linked ubiquitination	IDA	20061386
GO:0070979	Process	Protein K11-linked ubiquitination	IDA	21376237
GO:0070979	Process	Protein K11-linked ubiquitination	IDA	19822757, 20061386, 20622874, 27910872
GO:0085020	Process	Protein K6-linked ubiquitination	IDA	20061386
GO:1904668	Process	Positive regulation of ubiquitin protein ligase activity	IDA	19820702, 19822757

MIM	HGNC	e!Ensembl
610309	17895	ENSG00000108106

Q16763

Protein name

Ubiquitin-conjugating enzyme E2 S (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme S) (E2-EPF) (Ubiquitin carrier protein S) (Ubiquitin-conjugating enzyme E2-24 kDa) (Ubiquitin-conjugating enzyme E2-EPF5) (Ubiquitin-protein ligase S)

Protein function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:19820702, PubMed:19822757, PubMed:22496338, PubMed:27259151). Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the

PDB

1ZDN , 5BNB , 5L9T , 6QH3 , 6QHK , 6S96 , 6S98 , 7AHF , 8TAU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00179	UQ_con	15 → 152	Ubiquitin-conjugating enzyme	Domain

Sequence

MNSNVENLPPHIIRLVYKEVTTLTADPPDGIKVFPNEEDLTDLQVTIEGPEGTPYAGGLF
RMKLLLGKDFPASPPKGYFLTKIFHPNVGANGEICVNVLKRDWTAELGIRHVLLTIKCLL
IHPNPESALNEEAGRLLLENYEEYAARARLLTEIHGGAGGPSGRAEAGRALASGTEASST
DPGAPGGPGGAEGPMAKKHAGERDKKLAAKKKTDKKRALRRL

Sequence length

222

Interactions

View interactions

	KEGG		Reactome
	Ubiquitin mediated proteolysis		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (46)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	30545437		★★★★★ ★☆☆☆☆ Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	31814735		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	17710163		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	17710163, 26245992, 28187708, 29685151, 36123926	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	33589597, 34726341	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	21281817	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Ischemic stroke	Pubtator	35962388	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	28277581		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	28277581		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	29674637		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	33083497	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Carcinoma	Endometrial carcinoma	BEFREE	30690078		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	19083192, 21912958		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	19083192, 21912958		★★★★★ ★☆☆☆☆ Found in Text Mining only
Extraskeletal Myxoid Chondrosarcoma	Extraskeletal Myxoid Chondrosarcoma	BEFREE	30690078		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	27593939		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	27593939		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	28384045		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemochromatosis	Hemochromatosis	Pubtator	12480712	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hepatitis C	Hepatitis c	Pubtator	30381483	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	21281817	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	27325702		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lip and Oral Cavity Carcinoma	Lip and Oral Cavity Carcinoma	BEFREE	28257844		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	29928880, 30041036, 30903204		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	32038111	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	31494269	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	32038111	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Glioma	Glioma	BEFREE	28384045		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	17710163		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of endometrium	Endometrial Cancer	BEFREE	30690078		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	19083192, 21912958		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of mouth	Malignant neoplasm of mouth	BEFREE	28257844		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	31814735		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	17710163, 18780286, 22895574, 29674637, 29928880, 31814735		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	28277581		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	17710163		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	36534449	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	16819549, 17710163, 31814735		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	34535173, 35658829	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	31814735		★★★★★ ★☆☆☆☆ Found in Text Mining only
Papillary Renal Cell Carcinoma	Papillary Renal Carcinoma	BEFREE	21281817		★★★★★ ★☆☆☆☆ Found in Text Mining only
Papillary renal cell carcinoma, sporadic	Papillary renal carcinoma	BEFREE	21281817		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pemphigus	Pemphigus	Pubtator	1379239	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	36686485	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Rufous oculocutaneous albinism	Rufous oculocutaneous albinism	Pubtator	32038111	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	19083192		★★★★★ ★☆☆☆☆ Found in Text Mining only

UBE2S (ubiquitin conjugating enzyme E2 S)