Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2733
Gene name	GLE1 RNA export mediator
Gene symbol	GLE1
Synonyms (NCBI Gene)	CAAHCCAAHDGLE1LLCCSLCCS1hGLE1
Chromosome	9
Chromosome location	9q34.11
Summary	This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection o

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SNP ID	Visualize variation	Clinical significance	Consequence
rs146800850	G>A	Conflicting-interpretations-of-pathogenicity, likely-benign, uncertain-significance	Missense variant, coding sequence variant
rs386833693	A>C,G,T	Pathogenic	Intron variant
rs1589040836	TCTCT>-	Pathogenic	Intron variant

365

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miRTarBase ID	miRNA	Experiments	Reference
MIRT020250	hsa-miR-130b-3p	Sequencing	20371350
MIRT028211	hsa-miR-33a-5p	Sequencing	20371350
MIRT1020683	hsa-miR-103a	CLIP-seq
MIRT1020684	hsa-miR-107	CLIP-seq
MIRT1020685	hsa-miR-1184	CLIP-seq
MIRT1020686	hsa-miR-1205	CLIP-seq
MIRT1020687	hsa-miR-1301	CLIP-seq
MIRT1020688	hsa-miR-137	CLIP-seq
MIRT1020689	hsa-miR-145	CLIP-seq
MIRT1020690	hsa-miR-1910	CLIP-seq
MIRT1020691	hsa-miR-1972	CLIP-seq
MIRT1020692	hsa-miR-19a	CLIP-seq
MIRT1020693	hsa-miR-19b	CLIP-seq
MIRT1020694	hsa-miR-2053	CLIP-seq
MIRT1020695	hsa-miR-3123	CLIP-seq
MIRT1020696	hsa-miR-3124-3p	CLIP-seq
MIRT1020697	hsa-miR-3132	CLIP-seq
MIRT1020698	hsa-miR-3152-5p	CLIP-seq
MIRT1020699	hsa-miR-3158-5p	CLIP-seq
MIRT1020700	hsa-miR-3180-5p	CLIP-seq
MIRT1020701	hsa-miR-3649	CLIP-seq
MIRT1020702	hsa-miR-3692	CLIP-seq
MIRT1020703	hsa-miR-376a	CLIP-seq
MIRT1020704	hsa-miR-376b	CLIP-seq
MIRT1020705	hsa-miR-4311	CLIP-seq
MIRT1020706	hsa-miR-4470	CLIP-seq
MIRT1020707	hsa-miR-4474-5p	CLIP-seq
MIRT1020708	hsa-miR-4475	CLIP-seq
MIRT1020709	hsa-miR-4506	CLIP-seq
MIRT1020710	hsa-miR-4650-5p	CLIP-seq
MIRT1020711	hsa-miR-4710	CLIP-seq
MIRT1020712	hsa-miR-4717-5p	CLIP-seq
MIRT1020713	hsa-miR-4795-3p	CLIP-seq
MIRT1020714	hsa-miR-503	CLIP-seq
MIRT1020715	hsa-miR-5047	CLIP-seq
MIRT1020716	hsa-miR-513a-3p	CLIP-seq
MIRT1020717	hsa-miR-548c-3p	CLIP-seq
MIRT1020718	hsa-miR-569	CLIP-seq
MIRT1020719	hsa-miR-1225-5p	CLIP-seq
MIRT1020720	hsa-miR-1323	CLIP-seq
MIRT1020721	hsa-miR-214	CLIP-seq
MIRT1020722	hsa-miR-29a	CLIP-seq
MIRT1020723	hsa-miR-29b	CLIP-seq
MIRT1020724	hsa-miR-29c	CLIP-seq
MIRT1020725	hsa-miR-3189-3p	CLIP-seq
MIRT1020726	hsa-miR-3200-5p	CLIP-seq
MIRT1020727	hsa-miR-3619-5p	CLIP-seq
MIRT1020728	hsa-miR-4424	CLIP-seq
MIRT1020729	hsa-miR-4530	CLIP-seq
MIRT1020730	hsa-miR-4649-3p	CLIP-seq
MIRT1020731	hsa-miR-548aa	CLIP-seq
MIRT1020732	hsa-miR-548o	CLIP-seq
MIRT1020733	hsa-miR-634	CLIP-seq
MIRT1020734	hsa-miR-761	CLIP-seq
MIRT2002313	hsa-miR-1246	CLIP-seq
MIRT2002314	hsa-miR-1271	CLIP-seq
MIRT2002315	hsa-miR-129-5p	CLIP-seq
MIRT1020688	hsa-miR-137	CLIP-seq
MIRT2002316	hsa-miR-182	CLIP-seq
MIRT2002317	hsa-miR-1911	CLIP-seq
MIRT1020691	hsa-miR-1972	CLIP-seq
MIRT2002318	hsa-miR-3074-5p	CLIP-seq
MIRT1020695	hsa-miR-3123	CLIP-seq
MIRT1020696	hsa-miR-3124-3p	CLIP-seq
MIRT2002319	hsa-miR-335	CLIP-seq
MIRT1020702	hsa-miR-3692	CLIP-seq
MIRT1020703	hsa-miR-376a	CLIP-seq
MIRT1020704	hsa-miR-376b	CLIP-seq
MIRT2002320	hsa-miR-4277	CLIP-seq
MIRT1020707	hsa-miR-4474-5p	CLIP-seq
MIRT1020709	hsa-miR-4506	CLIP-seq
MIRT1020710	hsa-miR-4650-5p	CLIP-seq
MIRT1020712	hsa-miR-4717-5p	CLIP-seq
MIRT2002321	hsa-miR-4722-3p	CLIP-seq
MIRT2002322	hsa-miR-4760-3p	CLIP-seq
MIRT2002323	hsa-miR-4775	CLIP-seq
MIRT1020713	hsa-miR-4795-3p	CLIP-seq
MIRT2002324	hsa-miR-590-3p	CLIP-seq
MIRT2002325	hsa-miR-626	CLIP-seq
MIRT2002326	hsa-miR-96	CLIP-seq
MIRT1020683	hsa-miR-103a	CLIP-seq
MIRT1020684	hsa-miR-107	CLIP-seq
MIRT2235308	hsa-miR-1251	CLIP-seq
MIRT2235309	hsa-miR-1262	CLIP-seq
MIRT2235310	hsa-miR-1273d	CLIP-seq
MIRT2235311	hsa-miR-1279	CLIP-seq
MIRT2235312	hsa-miR-1290	CLIP-seq
MIRT1020687	hsa-miR-1301	CLIP-seq
MIRT2235313	hsa-miR-136	CLIP-seq
MIRT1020688	hsa-miR-137	CLIP-seq
MIRT2235314	hsa-miR-142-3p	CLIP-seq
MIRT2235315	hsa-miR-1470	CLIP-seq
MIRT2002317	hsa-miR-1911	CLIP-seq
MIRT2235316	hsa-miR-1912	CLIP-seq
MIRT1020691	hsa-miR-1972	CLIP-seq
MIRT1020692	hsa-miR-19a	CLIP-seq
MIRT1020693	hsa-miR-19b	CLIP-seq
MIRT1020694	hsa-miR-2053	CLIP-seq
MIRT2235317	hsa-miR-3074-3p	CLIP-seq
MIRT2235318	hsa-miR-3117-5p	CLIP-seq
MIRT2235319	hsa-miR-3119	CLIP-seq
MIRT2235320	hsa-miR-3125	CLIP-seq
MIRT1020697	hsa-miR-3132	CLIP-seq
MIRT2235321	hsa-miR-3134	CLIP-seq
MIRT2235322	hsa-miR-3137	CLIP-seq
MIRT1020698	hsa-miR-3152-5p	CLIP-seq
MIRT2235323	hsa-miR-3167	CLIP-seq
MIRT2235324	hsa-miR-329	CLIP-seq
MIRT2002319	hsa-miR-335	CLIP-seq
MIRT2235325	hsa-miR-3613-3p	CLIP-seq
MIRT2235326	hsa-miR-361-3p	CLIP-seq
MIRT2235327	hsa-miR-3620	CLIP-seq
MIRT2235328	hsa-miR-362-3p	CLIP-seq
MIRT2235329	hsa-miR-3677-5p	CLIP-seq
MIRT2235330	hsa-miR-3686	CLIP-seq
MIRT2235331	hsa-miR-3910	CLIP-seq
MIRT2235332	hsa-miR-3916	CLIP-seq
MIRT2235333	hsa-miR-3928	CLIP-seq
MIRT2235334	hsa-miR-4251	CLIP-seq
MIRT2235335	hsa-miR-4255	CLIP-seq
MIRT2235336	hsa-miR-4267	CLIP-seq
MIRT2235337	hsa-miR-4269	CLIP-seq
MIRT2235338	hsa-miR-4274	CLIP-seq
MIRT2002320	hsa-miR-4277	CLIP-seq
MIRT2235339	hsa-miR-4417	CLIP-seq
MIRT2235340	hsa-miR-4427	CLIP-seq
MIRT2235341	hsa-miR-4437	CLIP-seq
MIRT2235342	hsa-miR-4457	CLIP-seq
MIRT2235343	hsa-miR-4469	CLIP-seq
MIRT1020706	hsa-miR-4470	CLIP-seq
MIRT2235344	hsa-miR-4514	CLIP-seq
MIRT2235345	hsa-miR-4519	CLIP-seq
MIRT2235346	hsa-miR-4524	CLIP-seq
MIRT2235347	hsa-miR-4534	CLIP-seq
MIRT2235348	hsa-miR-4539	CLIP-seq
MIRT2235349	hsa-miR-4540	CLIP-seq
MIRT1020710	hsa-miR-4650-5p	CLIP-seq
MIRT2235350	hsa-miR-4652-3p	CLIP-seq
MIRT2235351	hsa-miR-4667-3p	CLIP-seq
MIRT2235352	hsa-miR-4674	CLIP-seq
MIRT2235353	hsa-miR-4678	CLIP-seq
MIRT2235354	hsa-miR-4680-3p	CLIP-seq
MIRT2235355	hsa-miR-4692	CLIP-seq
MIRT2235356	hsa-miR-4701-3p	CLIP-seq
MIRT2235357	hsa-miR-4704-5p	CLIP-seq
MIRT1020711	hsa-miR-4710	CLIP-seq
MIRT2235358	hsa-miR-4716-5p	CLIP-seq
MIRT1020712	hsa-miR-4717-5p	CLIP-seq
MIRT2002321	hsa-miR-4722-3p	CLIP-seq
MIRT2235359	hsa-miR-4729	CLIP-seq
MIRT2235360	hsa-miR-4742-5p	CLIP-seq
MIRT2235361	hsa-miR-4753-5p	CLIP-seq
MIRT2002322	hsa-miR-4760-3p	CLIP-seq
MIRT2235362	hsa-miR-4762-3p	CLIP-seq
MIRT2235363	hsa-miR-4782-5p	CLIP-seq
MIRT1020713	hsa-miR-4795-3p	CLIP-seq
MIRT2235364	hsa-miR-499a-5p	CLIP-seq
MIRT1020714	hsa-miR-503	CLIP-seq
MIRT1020715	hsa-miR-5047	CLIP-seq
MIRT1020716	hsa-miR-513a-3p	CLIP-seq
MIRT2235365	hsa-miR-513b	CLIP-seq
MIRT2235366	hsa-miR-522	CLIP-seq
MIRT2235367	hsa-miR-539	CLIP-seq
MIRT2235368	hsa-miR-541	CLIP-seq
MIRT2235369	hsa-miR-548ag	CLIP-seq
MIRT2235370	hsa-miR-548ai	CLIP-seq
MIRT2235371	hsa-miR-548an	CLIP-seq
MIRT1020717	hsa-miR-548c-3p	CLIP-seq
MIRT2002324	hsa-miR-590-3p	CLIP-seq
MIRT2235372	hsa-miR-617	CLIP-seq
MIRT2235373	hsa-miR-654-5p	CLIP-seq
MIRT2235374	hsa-miR-759	CLIP-seq
MIRT2235375	hsa-miR-766	CLIP-seq
MIRT2235376	hsa-miR-876-5p	CLIP-seq
MIRT1020685	hsa-miR-1184	CLIP-seq
MIRT1020686	hsa-miR-1205	CLIP-seq
MIRT2235312	hsa-miR-1290	CLIP-seq
MIRT2539104	hsa-miR-1321	CLIP-seq
MIRT2235313	hsa-miR-136	CLIP-seq
MIRT1020688	hsa-miR-137	CLIP-seq
MIRT2235314	hsa-miR-142-3p	CLIP-seq
MIRT1020689	hsa-miR-145	CLIP-seq
MIRT2235315	hsa-miR-1470	CLIP-seq
MIRT2539105	hsa-miR-150	CLIP-seq
MIRT1020690	hsa-miR-1910	CLIP-seq
MIRT1020694	hsa-miR-2053	CLIP-seq
MIRT2539106	hsa-miR-216b	CLIP-seq
MIRT2539107	hsa-miR-302a	CLIP-seq
MIRT2539108	hsa-miR-302b	CLIP-seq
MIRT2539109	hsa-miR-302c	CLIP-seq
MIRT2539110	hsa-miR-302d	CLIP-seq
MIRT2539111	hsa-miR-302e	CLIP-seq
MIRT2539112	hsa-miR-3064-3p	CLIP-seq
MIRT2235318	hsa-miR-3117-5p	CLIP-seq
MIRT2235319	hsa-miR-3119	CLIP-seq
MIRT1020695	hsa-miR-3123	CLIP-seq
MIRT1020696	hsa-miR-3124-3p	CLIP-seq
MIRT2235320	hsa-miR-3125	CLIP-seq
MIRT2235322	hsa-miR-3137	CLIP-seq
MIRT2539113	hsa-miR-3150b-3p	CLIP-seq
MIRT1020699	hsa-miR-3158-5p	CLIP-seq
MIRT2235323	hsa-miR-3167	CLIP-seq
MIRT1020700	hsa-miR-3180-5p	CLIP-seq
MIRT2539114	hsa-miR-3183	CLIP-seq
MIRT2539115	hsa-miR-326	CLIP-seq
MIRT2539116	hsa-miR-330-5p	CLIP-seq
MIRT2539117	hsa-miR-34c-3p	CLIP-seq
MIRT2235325	hsa-miR-3613-3p	CLIP-seq
MIRT2539118	hsa-miR-3617	CLIP-seq
MIRT2539119	hsa-miR-3647-3p	CLIP-seq
MIRT2235329	hsa-miR-3677-5p	CLIP-seq
MIRT2235330	hsa-miR-3686	CLIP-seq
MIRT1020702	hsa-miR-3692	CLIP-seq
MIRT2539120	hsa-miR-372	CLIP-seq
MIRT2539121	hsa-miR-373	CLIP-seq
MIRT2235331	hsa-miR-3910	CLIP-seq
MIRT2235332	hsa-miR-3916	CLIP-seq
MIRT2235333	hsa-miR-3928	CLIP-seq
MIRT2539122	hsa-miR-4252	CLIP-seq
MIRT2235336	hsa-miR-4267	CLIP-seq
MIRT2235337	hsa-miR-4269	CLIP-seq
MIRT2002320	hsa-miR-4277	CLIP-seq
MIRT2539123	hsa-miR-4279	CLIP-seq
MIRT1020705	hsa-miR-4311	CLIP-seq
MIRT2235339	hsa-miR-4417	CLIP-seq
MIRT2235341	hsa-miR-4437	CLIP-seq
MIRT2235342	hsa-miR-4457	CLIP-seq
MIRT2235343	hsa-miR-4469	CLIP-seq
MIRT1020706	hsa-miR-4470	CLIP-seq
MIRT1020707	hsa-miR-4474-5p	CLIP-seq
MIRT2539124	hsa-miR-450b-5p	CLIP-seq
MIRT2235344	hsa-miR-4514	CLIP-seq
MIRT2235350	hsa-miR-4652-3p	CLIP-seq
MIRT2235351	hsa-miR-4667-3p	CLIP-seq
MIRT2235352	hsa-miR-4674	CLIP-seq
MIRT2235355	hsa-miR-4692	CLIP-seq
MIRT2539125	hsa-miR-4701-5p	CLIP-seq
MIRT2235357	hsa-miR-4704-5p	CLIP-seq
MIRT2539126	hsa-miR-4713-5p	CLIP-seq
MIRT2539127	hsa-miR-4723-3p	CLIP-seq
MIRT2235359	hsa-miR-4729	CLIP-seq
MIRT2539128	hsa-miR-4739	CLIP-seq
MIRT2235360	hsa-miR-4742-5p	CLIP-seq
MIRT2539129	hsa-miR-4744	CLIP-seq
MIRT2235361	hsa-miR-4753-5p	CLIP-seq
MIRT2539130	hsa-miR-4756-5p	CLIP-seq
MIRT2235363	hsa-miR-4782-5p	CLIP-seq
MIRT2539131	hsa-miR-4784	CLIP-seq
MIRT2539132	hsa-miR-4786-5p	CLIP-seq
MIRT1020713	hsa-miR-4795-3p	CLIP-seq
MIRT2539133	hsa-miR-507	CLIP-seq
MIRT2235365	hsa-miR-513b	CLIP-seq
MIRT2539134	hsa-miR-518a-5p	CLIP-seq
MIRT2539135	hsa-miR-520a-3p	CLIP-seq
MIRT2539136	hsa-miR-520b	CLIP-seq
MIRT2539137	hsa-miR-520c-3p	CLIP-seq
MIRT2539138	hsa-miR-520d-3p	CLIP-seq
MIRT2539139	hsa-miR-520e	CLIP-seq
MIRT2539140	hsa-miR-527	CLIP-seq
MIRT2539141	hsa-miR-532-3p	CLIP-seq
MIRT2235368	hsa-miR-541	CLIP-seq
MIRT1020717	hsa-miR-548c-3p	CLIP-seq
MIRT2539142	hsa-miR-548u	CLIP-seq
MIRT2539143	hsa-miR-557	CLIP-seq
MIRT1020718	hsa-miR-569	CLIP-seq
MIRT2539144	hsa-miR-588	CLIP-seq
MIRT2002324	hsa-miR-590-3p	CLIP-seq
MIRT2235372	hsa-miR-617	CLIP-seq
MIRT2002325	hsa-miR-626	CLIP-seq
MIRT2539145	hsa-miR-641	CLIP-seq
MIRT2235373	hsa-miR-654-5p	CLIP-seq
MIRT2235374	hsa-miR-759	CLIP-seq
MIRT2539146	hsa-miR-765	CLIP-seq
MIRT2235375	hsa-miR-766	CLIP-seq
MIRT2235376	hsa-miR-876-5p	CLIP-seq
MIRT1020685	hsa-miR-1184	CLIP-seq
MIRT1020686	hsa-miR-1205	CLIP-seq
MIRT2235311	hsa-miR-1279	CLIP-seq
MIRT2235312	hsa-miR-1290	CLIP-seq
MIRT2539104	hsa-miR-1321	CLIP-seq
MIRT2235313	hsa-miR-136	CLIP-seq
MIRT1020688	hsa-miR-137	CLIP-seq
MIRT2235314	hsa-miR-142-3p	CLIP-seq
MIRT2539105	hsa-miR-150	CLIP-seq
MIRT2539106	hsa-miR-216b	CLIP-seq
MIRT2539107	hsa-miR-302a	CLIP-seq
MIRT2539108	hsa-miR-302b	CLIP-seq
MIRT2539109	hsa-miR-302c	CLIP-seq
MIRT2539110	hsa-miR-302d	CLIP-seq
MIRT2539111	hsa-miR-302e	CLIP-seq
MIRT2539112	hsa-miR-3064-3p	CLIP-seq
MIRT2002318	hsa-miR-3074-5p	CLIP-seq
MIRT2235318	hsa-miR-3117-5p	CLIP-seq
MIRT2235319	hsa-miR-3119	CLIP-seq
MIRT1020695	hsa-miR-3123	CLIP-seq
MIRT1020696	hsa-miR-3124-3p	CLIP-seq
MIRT2235320	hsa-miR-3125	CLIP-seq
MIRT2235322	hsa-miR-3137	CLIP-seq
MIRT2539113	hsa-miR-3150b-3p	CLIP-seq
MIRT1020699	hsa-miR-3158-5p	CLIP-seq
MIRT2235323	hsa-miR-3167	CLIP-seq
MIRT2539114	hsa-miR-3183	CLIP-seq
MIRT2539115	hsa-miR-326	CLIP-seq
MIRT2539116	hsa-miR-330-5p	CLIP-seq
MIRT2539117	hsa-miR-34c-3p	CLIP-seq
MIRT2235325	hsa-miR-3613-3p	CLIP-seq
MIRT2539118	hsa-miR-3617	CLIP-seq
MIRT2539119	hsa-miR-3647-3p	CLIP-seq
MIRT2235329	hsa-miR-3677-5p	CLIP-seq
MIRT2235330	hsa-miR-3686	CLIP-seq
MIRT1020702	hsa-miR-3692	CLIP-seq
MIRT2539120	hsa-miR-372	CLIP-seq
MIRT2539121	hsa-miR-373	CLIP-seq
MIRT2235331	hsa-miR-3910	CLIP-seq
MIRT2235332	hsa-miR-3916	CLIP-seq
MIRT2235333	hsa-miR-3928	CLIP-seq
MIRT2539122	hsa-miR-4252	CLIP-seq
MIRT2235335	hsa-miR-4255	CLIP-seq
MIRT2235337	hsa-miR-4269	CLIP-seq
MIRT2235338	hsa-miR-4274	CLIP-seq
MIRT2002320	hsa-miR-4277	CLIP-seq
MIRT2539123	hsa-miR-4279	CLIP-seq
MIRT1020705	hsa-miR-4311	CLIP-seq
MIRT2235342	hsa-miR-4457	CLIP-seq
MIRT1020707	hsa-miR-4474-5p	CLIP-seq
MIRT2539124	hsa-miR-450b-5p	CLIP-seq
MIRT2235344	hsa-miR-4514	CLIP-seq
MIRT2235345	hsa-miR-4519	CLIP-seq
MIRT2235346	hsa-miR-4524	CLIP-seq
MIRT2235350	hsa-miR-4652-3p	CLIP-seq
MIRT2235355	hsa-miR-4692	CLIP-seq
MIRT2539125	hsa-miR-4701-5p	CLIP-seq
MIRT2235357	hsa-miR-4704-5p	CLIP-seq
MIRT2539126	hsa-miR-4713-5p	CLIP-seq
MIRT2002321	hsa-miR-4722-3p	CLIP-seq
MIRT2539127	hsa-miR-4723-3p	CLIP-seq
MIRT2235359	hsa-miR-4729	CLIP-seq
MIRT2539128	hsa-miR-4739	CLIP-seq
MIRT2235360	hsa-miR-4742-5p	CLIP-seq
MIRT2539129	hsa-miR-4744	CLIP-seq
MIRT2235361	hsa-miR-4753-5p	CLIP-seq
MIRT2539130	hsa-miR-4756-5p	CLIP-seq
MIRT2235363	hsa-miR-4782-5p	CLIP-seq
MIRT2539131	hsa-miR-4784	CLIP-seq
MIRT2539132	hsa-miR-4786-5p	CLIP-seq
MIRT1020713	hsa-miR-4795-3p	CLIP-seq
MIRT2539133	hsa-miR-507	CLIP-seq
MIRT2235365	hsa-miR-513b	CLIP-seq
MIRT2539134	hsa-miR-518a-5p	CLIP-seq
MIRT2539135	hsa-miR-520a-3p	CLIP-seq
MIRT2539136	hsa-miR-520b	CLIP-seq
MIRT2539137	hsa-miR-520c-3p	CLIP-seq
MIRT2539138	hsa-miR-520d-3p	CLIP-seq
MIRT2539139	hsa-miR-520e	CLIP-seq
MIRT2539140	hsa-miR-527	CLIP-seq
MIRT2539141	hsa-miR-532-3p	CLIP-seq
MIRT2539142	hsa-miR-548u	CLIP-seq
MIRT2539143	hsa-miR-557	CLIP-seq
MIRT2539144	hsa-miR-588	CLIP-seq
MIRT2002324	hsa-miR-590-3p	CLIP-seq
MIRT2235372	hsa-miR-617	CLIP-seq
MIRT2002325	hsa-miR-626	CLIP-seq
MIRT2539145	hsa-miR-641	CLIP-seq
MIRT2539146	hsa-miR-765	CLIP-seq
MIRT2235376	hsa-miR-876-5p	CLIP-seq

Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000822	Function	Inositol hexakisphosphate binding	IBA
GO:0005515	Function	Protein binding	IPI	18724935, 24243016, 32814053
GO:0005543	Function	Phospholipid binding	IBA
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005634	Component	Nucleus	IEA
GO:0005635	Component	Nuclear envelope	IDA	24315095, 28035044
GO:0005643	Component	Nuclear pore	IEA
GO:0005643	Component	Nuclear pore	NAS	24315095
GO:0005643	Component	Nuclear pore	TAS	9618489
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA	28035044
GO:0005814	Component	Centriole	IDA	28035044
GO:0005829	Component	Cytosol	IDA
GO:0006406	Process	MRNA export from nucleus	IEA
GO:0006406	Process	MRNA export from nucleus	TAS	9618489
GO:0006913	Process	Nucleocytoplasmic transport	NAS	27016207
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016973	Process	Poly(A)+ mRNA export from nucleus	IBA
GO:0016973	Process	Poly(A)+ mRNA export from nucleus	IEA
GO:0031369	Function	Translation initiation factor binding	IBA
GO:0031965	Component	Nuclear membrane	IDA
GO:0036064	Component	Ciliary basal body	IDA	28035044
GO:0042802	Function	Identical protein binding	IPI	24243016
GO:0044614	Component	Nuclear pore cytoplasmic filaments	IBA
GO:0051028	Process	MRNA transport	IEA

MIM	HGNC	e!Ensembl
603371	4315	ENSG00000119392

Q53GS7

Protein name

mRNA export factor GLE1 (hGLE1) (GLE1 RNA export mediator) (GLE1-like protein) (Nucleoporin GLE1)

Protein function

Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC). {ECO:0000269|PubMed:12668658, ECO:0000269|PubMed:16

PDB

6B4F , 6B4I , 6B4J

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07817	GLE1	397 → 649	GLE1-like protein	Family

Sequence

MPSEGRCWETLKALRSSDKGRLCYYRDWLLRREDVLEECMSLPKLSSYSGWVVEHVLPHM
QENQPLSETSPSSTSASALDQPSFVPKSPDASSAFSPASPATPNGTKGKDESQHTESMVL
QSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQ
HKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEE
GQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSES
SYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAH
KEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAKKIKM
DLQKAATIPVSQISTIAGSKLKEIFDKIHSLLSGKPVQSGGRSVSVTLNPQGLDFVQYKL
AEKFVKQGEEEVASHHEAAFPIAVVASGIWELHPRVGDLILAHLHKKCPYSVPFYPTFKE
GMALEDYQRMLGYQVKDSKVEQQDNFLKRMSGMIRLYAAIIQLRWPYGNRQEIHPHGLNH
GWRWLAQILNMEPLSDVTATLLFDFLEVCGNALMKQYQVQFWKMLILIKEDYFPRIEAIT
SSGQMGSFIRLKQFLEKCLQHKDIPVPKGFLTSSFWRS

Sequence length

698

Interactions

View interactions

	KEGG		Reactome
	Nucleocytoplasmic transport mRNA surveillance pathway Amyotrophic lateral sclerosis		Transport of Mature mRNA derived from an Intron-Containing Transcript

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
GLE1-related disorder	Likely pathogenic; Pathogenic	rs1156305904, rs1847710909	RCV004536753 RCV004534410	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Lethal arthrogryposis-anterior horn cell disease syndrome	Likely pathogenic; Pathogenic	rs1564145502, rs2132430609, rs1847775573, rs1026034826, rs386833693, rs121434407, rs121434408, rs121434409, rs2540592843, rs775658412, rs1336481358, rs1589040836, rs765269946, rs374673335, rs772765696	RCV005040266 RCV005040378 RCV005042701 RCV005042595 RCV000049654 View all (10 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Lethal congenital contractural syndrome Finnish type	Likely pathogenic; Pathogenic	rs773083669, rs386833693, rs121434407, rs2540647541	RCV005614677 RCV001276648 RCV001276649 RCV005616737	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Lethal congenital contracture syndrome 1	Likely pathogenic; Pathogenic	rs1564145502, rs2132430609, rs1847775573, rs1026034826, rs386833693, rs121434407, rs2540592843, rs775658412, rs374673335, rs772765696	RCV005040266 RCV003444927 RCV005042701 RCV005042595 RCV000006833 View all (5 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (12)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Amyotrophic lateral sclerosis	Uncertain significance	ClinVar ClinGen, Disgenet, GWAS catalog, Orphanet ClinGen, Disgenet, GWAS catalog, Orphanet ClinGen, Disgenet, GWAS catalog, Orphanet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
ARTHROGRYPOSIS-ANTERIOR HORN CELL DISEASE SYNDROME	—	Orphanet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGENITAL ARTHROGRYPOSIS WITH ANTERIOR HORN CELL DISEASE	—	Disgenet, HPO Disgenet, HPO	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lethal congenital contracture syndrome	Uncertain significance	ClinVar Disgenet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
LETHAL CONGENITAL CONTRACTURE SYNDROME TYPE 1	—	Orphanet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (62)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Amniotic Bands	Amniotic Bands	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	25343993, 28980860, 29398120		★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	ORPHANET_DG	25343993		★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Amyotrophic lateral sclerosis	Amyotrophic Lateral Sclerosis	Orphanet			★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	25694449, 32537934	Associate	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	HPO_DG			★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Anterior Horn Cell Disease	Anterior Horn Cell Disease	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety	Anxiety Disorder	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthrogryposis	Arthrogryposis multiplex congenita	BEFREE	27684565, 28657126		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthrogryposis	Arthrogryposis	Pubtator	28729373, 32981894	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthrogryposis	Arthrogryposis multiplex congenita	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthrogryposis-anterior horn cell disease syndrome	Arthrogryposis-Anterior Horn Cell Disease Syndrome	Orphanet			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Blepharoptosis	Ptosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Byzanthine arch palate	High palate	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Clumsiness - motor delay	Motor delay	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital clubfoot	Congenital Clubfoot	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital hypoplasia of lung	Pulmonary hypoplasia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Contracture	Contracture	Pubtator	24243016, 28729373, 32537934	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cryptorchidism	Cryptorchidism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Dysarthria	Dysarthria	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Dysmorphic features	Dysmorphic Features	CLINVAR_DG	18204449, 23421748, 24961629, 25343993, 27684565, 28884921, 3993672		★★★★★ ★☆☆☆☆ Found in Text Mining only
Frontotemporal Lobar Degeneration	Frontotemporal dementia	BEFREE	28980860		★★★★★ ★☆☆☆☆ Found in Text Mining only
Growth Disorders	Growth disorder	Pubtator	32537934	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypersensitivity Delayed	Hypersensitivity	Pubtator	28884921	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Language Disorders	Language development disorders	Pubtator	32537934	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Laryngospasm	Laryngospasm	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Lethal Arthrogryposis With Anterior Horn Cell Disease	Lethal Arthrogryposis With Anterior Horn Cell Disease	GENOMICS_ENGLAND_DG	16892327, 18204449, 23421748		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lethal Arthrogryposis With Anterior Horn Cell Disease	Lethal Arthrogryposis With Anterior Horn Cell Disease	UNIPROT_DG	18204449		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lethal Arthrogryposis With Anterior Horn Cell Disease	Lethal Arthrogryposis With Anterior Horn Cell Disease	ORPHANET_DG	18204449		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lethal Arthrogryposis With Anterior Horn Cell Disease	Lethal Arthrogryposis With Anterior Horn Cell Disease	BEFREE	28657126, 28884921		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lethal Arthrogryposis With Anterior Horn Cell Disease	Lethal Arthrogryposis With Anterior Horn Cell Disease	CTD_human_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Lethal Arthrogryposis With Anterior Horn Cell Disease	Lethal Arthrogryposis With Anterior Horn Cell Disease	CLINVAR_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
LETHAL CONGENITAL CONTRACTURE SYNDROME 1	Lethal Congenital Contracture Syndrome	GENOMICS_ENGLAND_DG	16892327, 18204449, 23421748		★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
LETHAL CONGENITAL CONTRACTURE SYNDROME 1	Lethal Congenital Contracture Syndrome	ORPHANET_DG	18204449		★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
LETHAL CONGENITAL CONTRACTURE SYNDROME 1	Lethal Congenital Contracture Syndrome	CTD_human_DG	18204449		★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
LETHAL CONGENITAL CONTRACTURE SYNDROME 1	Lethal Congenital Contracture Syndrome	UNIPROT_DG	18204449		★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
LETHAL CONGENITAL CONTRACTURE SYNDROME 1	Lethal Congenital Contracture Syndrome	BEFREE	22357925, 24243016, 27684565, 28657126		★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Lethal congenital contracture syndrome 1	Lethal congenital contracture syndrome	Pubtator	24243016, 32537934	Associate	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
LETHAL CONGENITAL CONTRACTURE SYNDROME 1	Lethal Congenital Contracture Syndrome	CLINVAR_DG			★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Lethal Congenital Contracture Syndrome 2	Lethal congenital contracture syndrome	Pubtator	28884921	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lethal congenital contracture syndrome type 1	Lethal Congenital Contracture Syndrome	Orphanet			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Micrognathism	Micrognathism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Mood swings	Mood swings	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Motor Neuron Disease	Motor neuron disease	Pubtator	19048072, 28729373, 32537934	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Motor Neuron Disease	Motor Neuron Disease	BEFREE	28657126, 29899397		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple congenital anomalies	Multiple Congenital Anomalies	CLINVAR_DG	18204449, 23421748, 24961629, 25343993, 27684565, 28884921, 3993672		★★★★★ ★☆☆☆☆ Found in Text Mining only
Muscular Atrophy Spinal	Spinal muscular atrophy	Pubtator	30565205	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myopia	Myopia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Neck webbing	Neck Webbing	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	30429220, 30565205	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	30429220, 30565205		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pena-Shokeir syndrome type I	Pena Shokeir syndrome	BEFREE	24961629, 30991114		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pena-Shokeir syndrome type I	Pena Shokeir syndrome	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Peripheral axonal neuropathy	Peripheral axonal neuropathy	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Ptosis	Ptosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	34588774	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Respiratory Failure	Respiratory Failure	BEFREE	28884921		★★★★★ ★☆☆☆☆ Found in Text Mining only
Respiratory Failure	Respiratory Failure	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Scoliosis, unspecified	Scoliosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Vertical Talus	Vertical Talus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only

GLE1 (GLE1 RNA export mediator)