SESN1 (sestrin 1)

Gene

• Entrez ID: 27244
• Gene name: Sestrin 1
• Gene symbol: SESN1
• Synonyms (NCBI Gene): PA26, SEST1
• Chromosome: 6
• Chromosome location: 6q21
• Summary: This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activatin

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019830	hsa-miR-375	Microarray	20215506
MIRT029242	hsa-miR-26b-5p	Microarray	19088304
MIRT030465	hsa-miR-24-3p	Sequencing	20371350
MIRT030465	hsa-miR-24-3p	Microarray	19748357
MIRT002414	hsa-miR-21-5p	Microarray	18591254
MIRT052642	hsa-let-7a-5p	CLASH	23622248
MIRT439674	hsa-miR-154-5p	HITS-CLIP	24374217
MIRT439673	hsa-miR-377-3p	HITS-CLIP	24374217
MIRT439674	hsa-miR-154-5p	HITS-CLIP	24374217
MIRT439673	hsa-miR-377-3p	HITS-CLIP	24374217
MIRT030465	hsa-miR-24-3p	PAR-CLIP	26701625
MIRT030465	hsa-miR-24-3p	PAR-CLIP	26701625
MIRT030465	hsa-miR-24-3p	PAR-CLIP	26701625
MIRT439673	hsa-miR-377-3p	PAR-CLIP	26701625
MIRT439673	hsa-miR-377-3p	PAR-CLIP	26701625
MIRT439673	hsa-miR-377-3p	PAR-CLIP	26701625
MIRT1339266	hsa-miR-1270	CLIP-seq
MIRT1339267	hsa-miR-185	CLIP-seq
MIRT1339268	hsa-miR-203	CLIP-seq
MIRT1339269	hsa-miR-3143	CLIP-seq
MIRT1339270	hsa-miR-377	CLIP-seq
MIRT1339271	hsa-miR-3941	CLIP-seq
MIRT1339272	hsa-miR-4306	CLIP-seq
MIRT1339273	hsa-miR-4531	CLIP-seq
MIRT1339274	hsa-miR-4644	CLIP-seq
MIRT1339275	hsa-miR-466	CLIP-seq
MIRT1339276	hsa-miR-4672	CLIP-seq
MIRT1339277	hsa-miR-4718	CLIP-seq
MIRT1339278	hsa-miR-4742-3p	CLIP-seq
MIRT1339279	hsa-miR-4775	CLIP-seq
MIRT1339280	hsa-miR-4803	CLIP-seq
MIRT1339281	hsa-miR-620	CLIP-seq
MIRT1339282	hsa-miR-935	CLIP-seq
MIRT1339283	hsa-miR-1298	CLIP-seq
MIRT1339284	hsa-miR-15a	CLIP-seq
MIRT1339285	hsa-miR-15b	CLIP-seq
MIRT1339286	hsa-miR-16	CLIP-seq
MIRT1339287	hsa-miR-195	CLIP-seq
MIRT1339288	hsa-miR-200b	CLIP-seq
MIRT1339289	hsa-miR-200c	CLIP-seq
MIRT1339290	hsa-miR-21	CLIP-seq
MIRT1339291	hsa-miR-214	CLIP-seq
MIRT1339292	hsa-miR-24	CLIP-seq
MIRT1339293	hsa-miR-29a	CLIP-seq
MIRT1339294	hsa-miR-29b	CLIP-seq
MIRT1339295	hsa-miR-29c	CLIP-seq
MIRT1339296	hsa-miR-3065-3p	CLIP-seq
MIRT1339297	hsa-miR-3140-3p	CLIP-seq
MIRT1339298	hsa-miR-3156-5p	CLIP-seq
MIRT1339299	hsa-miR-3159	CLIP-seq
MIRT1339300	hsa-miR-3185	CLIP-seq
MIRT1339301	hsa-miR-329	CLIP-seq
MIRT1339302	hsa-miR-338-3p	CLIP-seq
MIRT1339303	hsa-miR-3619-5p	CLIP-seq
MIRT1339304	hsa-miR-362-3p	CLIP-seq
MIRT1339305	hsa-miR-3658	CLIP-seq
MIRT1339270	hsa-miR-377	CLIP-seq
MIRT1339271	hsa-miR-3941	CLIP-seq
MIRT1339306	hsa-miR-424	CLIP-seq
MIRT1339307	hsa-miR-4524	CLIP-seq
MIRT1339308	hsa-miR-4530	CLIP-seq
MIRT1339275	hsa-miR-466	CLIP-seq
MIRT1339276	hsa-miR-4672	CLIP-seq
MIRT1339309	hsa-miR-4691-5p	CLIP-seq
MIRT1339310	hsa-miR-4709-3p	CLIP-seq
MIRT1339311	hsa-miR-4729	CLIP-seq
MIRT1339312	hsa-miR-4799-5p	CLIP-seq
MIRT1339313	hsa-miR-4804-3p	CLIP-seq
MIRT1339314	hsa-miR-494	CLIP-seq
MIRT1339315	hsa-miR-497	CLIP-seq
MIRT1339316	hsa-miR-499a-5p	CLIP-seq
MIRT1339317	hsa-miR-503	CLIP-seq
MIRT1339318	hsa-miR-548c-3p	CLIP-seq
MIRT1339319	hsa-miR-556-3p	CLIP-seq
MIRT1339320	hsa-miR-579	CLIP-seq
MIRT1339321	hsa-miR-590-5p	CLIP-seq
MIRT1339322	hsa-miR-603	CLIP-seq
MIRT1339323	hsa-miR-646	CLIP-seq
MIRT1339324	hsa-miR-651	CLIP-seq
MIRT1339325	hsa-miR-664	CLIP-seq
MIRT1339326	hsa-miR-761	CLIP-seq
MIRT1339327	hsa-miR-766	CLIP-seq
MIRT1339328	hsa-miR-1288	CLIP-seq
MIRT1339283	hsa-miR-1298	CLIP-seq
MIRT1339329	hsa-miR-142-5p	CLIP-seq
MIRT1339284	hsa-miR-15a	CLIP-seq
MIRT1339285	hsa-miR-15b	CLIP-seq
MIRT1339286	hsa-miR-16	CLIP-seq
MIRT1339287	hsa-miR-195	CLIP-seq
MIRT1339288	hsa-miR-200b	CLIP-seq
MIRT1339289	hsa-miR-200c	CLIP-seq
MIRT1339268	hsa-miR-203	CLIP-seq
MIRT1339290	hsa-miR-21	CLIP-seq
MIRT1339291	hsa-miR-214	CLIP-seq
MIRT1339330	hsa-miR-224	CLIP-seq
MIRT1339292	hsa-miR-24	CLIP-seq
MIRT1339293	hsa-miR-29a	CLIP-seq
MIRT1339294	hsa-miR-29b	CLIP-seq
MIRT1339295	hsa-miR-29c	CLIP-seq
MIRT1339296	hsa-miR-3065-3p	CLIP-seq
MIRT1339298	hsa-miR-3156-5p	CLIP-seq
MIRT1339331	hsa-miR-3169	CLIP-seq
MIRT1339332	hsa-miR-320a	CLIP-seq
MIRT1339333	hsa-miR-320b	CLIP-seq
MIRT1339334	hsa-miR-320c	CLIP-seq
MIRT1339335	hsa-miR-320d	CLIP-seq
MIRT1339302	hsa-miR-338-3p	CLIP-seq
MIRT1339336	hsa-miR-340	CLIP-seq
MIRT1339303	hsa-miR-3619-5p	CLIP-seq
MIRT1339337	hsa-miR-3691-3p	CLIP-seq
MIRT1339270	hsa-miR-377	CLIP-seq
MIRT1339306	hsa-miR-424	CLIP-seq
MIRT1339338	hsa-miR-4429	CLIP-seq
MIRT1339307	hsa-miR-4524	CLIP-seq
MIRT1339339	hsa-miR-4528	CLIP-seq
MIRT1339308	hsa-miR-4530	CLIP-seq
MIRT1339309	hsa-miR-4691-5p	CLIP-seq
MIRT1339340	hsa-miR-4720-3p	CLIP-seq
MIRT1339279	hsa-miR-4775	CLIP-seq
MIRT1339313	hsa-miR-4804-3p	CLIP-seq
MIRT1339314	hsa-miR-494	CLIP-seq
MIRT1339315	hsa-miR-497	CLIP-seq
MIRT1339316	hsa-miR-499a-5p	CLIP-seq
MIRT1339317	hsa-miR-503	CLIP-seq
MIRT1339318	hsa-miR-548c-3p	CLIP-seq
MIRT1339319	hsa-miR-556-3p	CLIP-seq
MIRT1339321	hsa-miR-590-5p	CLIP-seq
MIRT1339323	hsa-miR-646	CLIP-seq
MIRT1339325	hsa-miR-664	CLIP-seq
MIRT1339326	hsa-miR-761	CLIP-seq
MIRT1339327	hsa-miR-766	CLIP-seq
MIRT1339283	hsa-miR-1298	CLIP-seq
MIRT1339288	hsa-miR-200b	CLIP-seq
MIRT1339289	hsa-miR-200c	CLIP-seq
MIRT1339291	hsa-miR-214	CLIP-seq
MIRT2100306	hsa-miR-2681	CLIP-seq
MIRT1339302	hsa-miR-338-3p	CLIP-seq
MIRT1339303	hsa-miR-3619-5p	CLIP-seq
MIRT2100307	hsa-miR-4509	CLIP-seq
MIRT1339308	hsa-miR-4530	CLIP-seq
MIRT1339309	hsa-miR-4691-5p	CLIP-seq
MIRT1339314	hsa-miR-494	CLIP-seq
MIRT1339316	hsa-miR-499a-5p	CLIP-seq
MIRT1339318	hsa-miR-548c-3p	CLIP-seq
MIRT2100308	hsa-miR-578	CLIP-seq
MIRT1339325	hsa-miR-664	CLIP-seq
MIRT1339326	hsa-miR-761	CLIP-seq
MIRT1339327	hsa-miR-766	CLIP-seq
MIRT2100309	hsa-miR-944	CLIP-seq
MIRT2325075	hsa-miR-132	CLIP-seq
MIRT2325076	hsa-miR-212	CLIP-seq
MIRT2325077	hsa-miR-4704-3p	CLIP-seq
MIRT1339284	hsa-miR-15a	CLIP-seq
MIRT1339285	hsa-miR-15b	CLIP-seq
MIRT1339286	hsa-miR-16	CLIP-seq
MIRT1339287	hsa-miR-195	CLIP-seq
MIRT1339288	hsa-miR-200b	CLIP-seq
MIRT1339289	hsa-miR-200c	CLIP-seq
MIRT1339291	hsa-miR-214	CLIP-seq
MIRT1339293	hsa-miR-29a	CLIP-seq
MIRT1339294	hsa-miR-29b	CLIP-seq
MIRT1339295	hsa-miR-29c	CLIP-seq
MIRT1339296	hsa-miR-3065-3p	CLIP-seq
MIRT1339298	hsa-miR-3156-5p	CLIP-seq
MIRT1339302	hsa-miR-338-3p	CLIP-seq
MIRT1339303	hsa-miR-3619-5p	CLIP-seq
MIRT1339306	hsa-miR-424	CLIP-seq
MIRT1339307	hsa-miR-4524	CLIP-seq
MIRT1339308	hsa-miR-4530	CLIP-seq
MIRT1339315	hsa-miR-497	CLIP-seq
MIRT1339317	hsa-miR-503	CLIP-seq
MIRT1339323	hsa-miR-646	CLIP-seq
MIRT1339326	hsa-miR-761	CLIP-seq
MIRT1339327	hsa-miR-766	CLIP-seq
MIRT1339283	hsa-miR-1298	CLIP-seq
MIRT1339284	hsa-miR-15a	CLIP-seq
MIRT1339285	hsa-miR-15b	CLIP-seq
MIRT1339286	hsa-miR-16	CLIP-seq
MIRT1339287	hsa-miR-195	CLIP-seq
MIRT1339291	hsa-miR-214	CLIP-seq
MIRT1339293	hsa-miR-29a	CLIP-seq
MIRT1339294	hsa-miR-29b	CLIP-seq
MIRT1339295	hsa-miR-29c	CLIP-seq
MIRT1339296	hsa-miR-3065-3p	CLIP-seq
MIRT1339298	hsa-miR-3156-5p	CLIP-seq
MIRT1339302	hsa-miR-338-3p	CLIP-seq
MIRT1339303	hsa-miR-3619-5p	CLIP-seq
MIRT1339306	hsa-miR-424	CLIP-seq
MIRT1339307	hsa-miR-4524	CLIP-seq
MIRT1339308	hsa-miR-4530	CLIP-seq
MIRT1339309	hsa-miR-4691-5p	CLIP-seq
MIRT1339312	hsa-miR-4799-5p	CLIP-seq
MIRT1339314	hsa-miR-494	CLIP-seq
MIRT1339315	hsa-miR-497	CLIP-seq
MIRT1339317	hsa-miR-503	CLIP-seq
MIRT1339323	hsa-miR-646	CLIP-seq
MIRT1339325	hsa-miR-664	CLIP-seq
MIRT1339326	hsa-miR-761	CLIP-seq
MIRT1339327	hsa-miR-766	CLIP-seq
MIRT1339283	hsa-miR-1298	CLIP-seq
MIRT2620724	hsa-miR-1305	CLIP-seq
MIRT1339329	hsa-miR-142-5p	CLIP-seq
MIRT1339284	hsa-miR-15a	CLIP-seq
MIRT1339285	hsa-miR-15b	CLIP-seq
MIRT1339286	hsa-miR-16	CLIP-seq
MIRT1339287	hsa-miR-195	CLIP-seq
MIRT2620725	hsa-miR-2115	CLIP-seq
MIRT1339291	hsa-miR-214	CLIP-seq
MIRT1339330	hsa-miR-224	CLIP-seq
MIRT1339293	hsa-miR-29a	CLIP-seq
MIRT1339294	hsa-miR-29b	CLIP-seq
MIRT1339295	hsa-miR-29c	CLIP-seq
MIRT1339296	hsa-miR-3065-3p	CLIP-seq
MIRT1339298	hsa-miR-3156-5p	CLIP-seq
MIRT2620726	hsa-miR-3180-5p	CLIP-seq
MIRT1339332	hsa-miR-320a	CLIP-seq
MIRT1339333	hsa-miR-320b	CLIP-seq
MIRT1339334	hsa-miR-320c	CLIP-seq
MIRT1339335	hsa-miR-320d	CLIP-seq
MIRT1339302	hsa-miR-338-3p	CLIP-seq
MIRT2620727	hsa-miR-33a	CLIP-seq
MIRT2620728	hsa-miR-33b	CLIP-seq
MIRT1339336	hsa-miR-340	CLIP-seq
MIRT1339303	hsa-miR-3619-5p	CLIP-seq
MIRT1339337	hsa-miR-3691-3p	CLIP-seq
MIRT2620729	hsa-miR-374c	CLIP-seq
MIRT2620730	hsa-miR-3973	CLIP-seq
MIRT1339306	hsa-miR-424	CLIP-seq
MIRT2620731	hsa-miR-4282	CLIP-seq
MIRT1339338	hsa-miR-4429	CLIP-seq
MIRT1339307	hsa-miR-4524	CLIP-seq
MIRT1339339	hsa-miR-4528	CLIP-seq
MIRT1339308	hsa-miR-4530	CLIP-seq
MIRT1339309	hsa-miR-4691-5p	CLIP-seq
MIRT1339340	hsa-miR-4720-3p	CLIP-seq
MIRT1339312	hsa-miR-4799-5p	CLIP-seq
MIRT1339314	hsa-miR-494	CLIP-seq
MIRT1339315	hsa-miR-497	CLIP-seq
MIRT1339316	hsa-miR-499a-5p	CLIP-seq
MIRT1339317	hsa-miR-503	CLIP-seq
MIRT2620732	hsa-miR-520a-5p	CLIP-seq
MIRT2620733	hsa-miR-520d-5p	CLIP-seq
MIRT2620734	hsa-miR-524-5p	CLIP-seq
MIRT2620735	hsa-miR-525-5p	CLIP-seq
MIRT2620736	hsa-miR-548k	CLIP-seq
MIRT2620737	hsa-miR-607	CLIP-seq
MIRT1339323	hsa-miR-646	CLIP-seq
MIRT2620738	hsa-miR-649	CLIP-seq
MIRT2620739	hsa-miR-655	CLIP-seq
MIRT1339325	hsa-miR-664	CLIP-seq
MIRT1339326	hsa-miR-761	CLIP-seq
MIRT1339327	hsa-miR-766	CLIP-seq
MIRT1339283	hsa-miR-1298	CLIP-seq
MIRT1339329	hsa-miR-142-5p	CLIP-seq
MIRT1339284	hsa-miR-15a	CLIP-seq
MIRT1339285	hsa-miR-15b	CLIP-seq
MIRT1339286	hsa-miR-16	CLIP-seq
MIRT1339287	hsa-miR-195	CLIP-seq
MIRT1339291	hsa-miR-214	CLIP-seq
MIRT1339330	hsa-miR-224	CLIP-seq
MIRT1339293	hsa-miR-29a	CLIP-seq
MIRT1339294	hsa-miR-29b	CLIP-seq
MIRT1339295	hsa-miR-29c	CLIP-seq
MIRT1339296	hsa-miR-3065-3p	CLIP-seq
MIRT1339298	hsa-miR-3156-5p	CLIP-seq
MIRT1339332	hsa-miR-320a	CLIP-seq
MIRT1339333	hsa-miR-320b	CLIP-seq
MIRT1339334	hsa-miR-320c	CLIP-seq
MIRT1339335	hsa-miR-320d	CLIP-seq
MIRT1339302	hsa-miR-338-3p	CLIP-seq
MIRT1339336	hsa-miR-340	CLIP-seq
MIRT1339303	hsa-miR-3619-5p	CLIP-seq
MIRT1339306	hsa-miR-424	CLIP-seq
MIRT2620731	hsa-miR-4282	CLIP-seq
MIRT1339338	hsa-miR-4429	CLIP-seq
MIRT1339307	hsa-miR-4524	CLIP-seq
MIRT1339308	hsa-miR-4530	CLIP-seq
MIRT1339309	hsa-miR-4691-5p	CLIP-seq
MIRT1339340	hsa-miR-4720-3p	CLIP-seq
MIRT1339312	hsa-miR-4799-5p	CLIP-seq
MIRT1339314	hsa-miR-494	CLIP-seq
MIRT1339315	hsa-miR-497	CLIP-seq
MIRT1339317	hsa-miR-503	CLIP-seq
MIRT1339323	hsa-miR-646	CLIP-seq
MIRT1339325	hsa-miR-664	CLIP-seq
MIRT1339326	hsa-miR-761	CLIP-seq
MIRT1339327	hsa-miR-766	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
AR	Unknown	16751804

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001650	Component	Fibrillar center	IDA
GO:0005515	Function	Protein binding	IPI	15105503
GO:0005634	Component	Nucleus	IDA	9926927
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	15105503
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0016239	Process	Positive regulation of macroautophagy	IBA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016684	Function	Oxidoreductase activity, acting on peroxide as acceptor	IBA
GO:0030308	Process	Negative regulation of cell growth	IEA
GO:0034198	Process	Cellular response to amino acid starvation	IEA
GO:0034198	Process	Cellular response to amino acid starvation	IMP	25263562
GO:0042149	Process	Cellular response to glucose starvation	IEA
GO:0042149	Process	Cellular response to glucose starvation	IMP	25263562
GO:0051896	Process	Regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0061700	Component	GATOR2 complex	IDA	25263562, 26449471
GO:0070728	Function	L-leucine binding	IBA
GO:0070728	Function	L-leucine binding	IDA	26449471
GO:0071230	Process	Cellular response to amino acid stimulus	IEA
GO:0071233	Process	Cellular response to L-leucine	IBA
GO:0072593	Process	Reactive oxygen species metabolic process	IMP	15105503
GO:0098869	Process	Cellular oxidant detoxification	IMP	15105503
GO:1901031	Process	Regulation of response to reactive oxygen species	IEA
GO:1904262	Process	Negative regulation of TORC1 signaling	IBA
GO:1904262	Process	Negative regulation of TORC1 signaling	IEA
GO:1904262	Process	Negative regulation of TORC1 signaling	IMP	18692468, 25263562
GO:1990253	Process	Cellular response to leucine starvation	IBA

Other IDs

• MIM: 606103
• HGNC: 21595
• e!Ensembl: ENSG00000080546

Protein

• UniProt ID: Q9Y6P5
• Protein name: Sestrin-1 (EC 1.11.1.-) (p53-regulated protein PA26)
• Protein function: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disr
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04636	PA26	47 → 491	PA26 p53-induced protein (sestrin)	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:12607115}.
• Sequence:

  MRLAAAANEAYTAPLAVSGLLGCKQCGGGRDQDEELGIRIPRPLGQGPSRFIPEKEILQV
  GSEDAQMHALFADSFAALGRLDNITLVMVFHPQYLESFLKTQHYLLQMDGPLPLHYRHYI
  GIMAAARHQCSYLVNLHVNDFLHVGGDPKWLNGLENAPQKLQNLGELNKVLAHRPWLITK
  EHIEGLLKAEEHSWSLAELVHAVVLLTHYHSLASFTFGCGISPEIHCDGGHTFRPPSVSN
  YCICDITNGNHSVDEMPVNSAENVSVSDSFFEVEALMEKMRQLQECRDEEEASQEEMASR
  FEIEKRESMFVFSSDDEEVTPARAVSRHFEDTSYGYKDFSRHGMHVPTFRVQDYCWEDHG
  YSLVNRLYPDVGQLIDEKFHIAYNLTYNTMAMHKDVDTSMLRRAIWNYIHCMFGIRYDDY
  DYGEINQLLDRSFKVYIKTVVCTPEKVTKRMYDSFWRQFKHSEKVHVNLLLIEARMQAEL
  LYALRAITRYMT

• Sequence length: 492

Pathways

KEGG:

p53 signaling pathway
Longevity regulating pathway

Reactome:

TP53 Regulates Metabolic Genes
Amino acids regulate mTORC1

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTROCYTOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOTHYROIDISM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Atherosclerosis	Atherosclerosis	Pubtator	35293601	Associate	★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial fibrillation	Pubtator	28397812	Stimulate	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	27118659, 38019229	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	22363791	Inhibit	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	35865544	Associate	★☆☆☆☆ Found in Text Mining only
Carotid Stenosis	Carotid artery stenosis	Pubtator	32626541	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	24129397		★☆☆☆☆ Found in Text Mining only
Endometrial Carcinoma	Endometrial carcinoma	BEFREE	31073887		★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	31073887	Associate	★☆☆☆☆ Found in Text Mining only
Head and Neck Carcinoma	Head And Neck Carcinoma	BEFREE	30300027		★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	30300027	Associate	★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	32626541	Stimulate	★☆☆☆☆ Found in Text Mining only
Malignant Head and Neck Neoplasm	Head and neck cancer	BEFREE	30300027		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of endometrium	Endometrial Cancer	BEFREE	31073887		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	30795533	Associate	★☆☆☆☆ Found in Text Mining only
Mouth Neoplasms	Mouth neoplasm	Pubtator	35421271	Associate	★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	35655142	Associate	★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	34168019	Associate	★☆☆☆☆ Found in Text Mining only
Situs ambiguus	Situs ambiguus	BEFREE	12607115		★☆☆☆☆ Found in Text Mining only
Situs Inversus	Situs Inversus	LHGDN	12607115		★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	29498706	Associate	★☆☆☆☆ Found in Text Mining only