HCAR1 (hydroxycarboxylic acid receptor 1)

Gene

• Entrez ID: 27198
• Gene name: Hydroxycarboxylic acid receptor 1
• Gene symbol: HCAR1
• Synonyms (NCBI Gene): FKSG80, GPR104, GPR81, HCA1, LACR1, TA-GPCR, TAGPCR
• Chromosome: 12
• Chromosome location: 12q24.31
• Summary: G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Feb 2005]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017279	hsa-miR-335-5p	Microarray	18185580
MIRT631184	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT631183	hsa-miR-764	HITS-CLIP	23824327
MIRT631182	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631181	hsa-miR-622	HITS-CLIP	23824327
MIRT631180	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT631179	hsa-miR-4264	HITS-CLIP	23824327
MIRT631178	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631177	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT631176	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT631175	hsa-miR-4454	HITS-CLIP	23824327
MIRT631174	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT631184	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT631183	hsa-miR-764	HITS-CLIP	23824327
MIRT631182	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631181	hsa-miR-622	HITS-CLIP	23824327
MIRT631180	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT631179	hsa-miR-4264	HITS-CLIP	23824327
MIRT631178	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631177	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT631176	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT631175	hsa-miR-4454	HITS-CLIP	23824327
MIRT631174	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT1041616	hsa-miR-1224-3p	CLIP-seq
MIRT1041617	hsa-miR-1227	CLIP-seq
MIRT1041618	hsa-miR-1260	CLIP-seq
MIRT1041619	hsa-miR-1260b	CLIP-seq
MIRT1041620	hsa-miR-1273e	CLIP-seq
MIRT1041621	hsa-miR-1280	CLIP-seq
MIRT1041622	hsa-miR-1285	CLIP-seq
MIRT1041623	hsa-miR-1302	CLIP-seq
MIRT1041624	hsa-miR-1343	CLIP-seq
MIRT1041625	hsa-miR-136	CLIP-seq
MIRT1041626	hsa-miR-24	CLIP-seq
MIRT1041627	hsa-miR-28-5p	CLIP-seq
MIRT1041628	hsa-miR-2964a-3p	CLIP-seq
MIRT1041629	hsa-miR-302f	CLIP-seq
MIRT1041630	hsa-miR-3122	CLIP-seq
MIRT1041631	hsa-miR-3132	CLIP-seq
MIRT1041632	hsa-miR-3139	CLIP-seq
MIRT1041633	hsa-miR-3155	CLIP-seq
MIRT1041634	hsa-miR-3155b	CLIP-seq
MIRT1041635	hsa-miR-3187-5p	CLIP-seq
MIRT1041636	hsa-miR-3613-3p	CLIP-seq
MIRT1041637	hsa-miR-3622a-3p	CLIP-seq
MIRT1041638	hsa-miR-3622a-5p	CLIP-seq
MIRT1041639	hsa-miR-3622b-3p	CLIP-seq
MIRT1041640	hsa-miR-3663-5p	CLIP-seq
MIRT1041641	hsa-miR-3689a-3p	CLIP-seq
MIRT1041642	hsa-miR-3689c	CLIP-seq
MIRT1041643	hsa-miR-3714	CLIP-seq
MIRT1041644	hsa-miR-3913-5p	CLIP-seq
MIRT1041645	hsa-miR-3926	CLIP-seq
MIRT1041646	hsa-miR-3929	CLIP-seq
MIRT1041647	hsa-miR-3937	CLIP-seq
MIRT1041648	hsa-miR-3945	CLIP-seq
MIRT1041649	hsa-miR-4253	CLIP-seq
MIRT1041650	hsa-miR-4269	CLIP-seq
MIRT1041651	hsa-miR-4284	CLIP-seq
MIRT1041652	hsa-miR-4298	CLIP-seq
MIRT1041653	hsa-miR-4419b	CLIP-seq
MIRT1041654	hsa-miR-4433	CLIP-seq
MIRT1041655	hsa-miR-4451	CLIP-seq
MIRT1041656	hsa-miR-4459	CLIP-seq
MIRT1041657	hsa-miR-4478	CLIP-seq
MIRT1041658	hsa-miR-4649-3p	CLIP-seq
MIRT1041659	hsa-miR-4679	CLIP-seq
MIRT1041660	hsa-miR-4693-5p	CLIP-seq
MIRT1041661	hsa-miR-4716-5p	CLIP-seq
MIRT1041662	hsa-miR-4722-5p	CLIP-seq
MIRT1041663	hsa-miR-4728-5p	CLIP-seq
MIRT1041664	hsa-miR-4768-3p	CLIP-seq
MIRT1041665	hsa-miR-4781-3p	CLIP-seq
MIRT1041666	hsa-miR-4786-5p	CLIP-seq
MIRT1041667	hsa-miR-4797-5p	CLIP-seq
MIRT1041668	hsa-miR-484	CLIP-seq
MIRT1041669	hsa-miR-485-5p	CLIP-seq
MIRT1041670	hsa-miR-508-5p	CLIP-seq
MIRT1041671	hsa-miR-515-5p	CLIP-seq
MIRT1041672	hsa-miR-544b	CLIP-seq
MIRT1041673	hsa-miR-548ae	CLIP-seq
MIRT1041674	hsa-miR-548aj	CLIP-seq
MIRT1041675	hsa-miR-548am	CLIP-seq
MIRT1041676	hsa-miR-548s	CLIP-seq
MIRT1041677	hsa-miR-548x	CLIP-seq
MIRT1041678	hsa-miR-564	CLIP-seq
MIRT1041679	hsa-miR-601	CLIP-seq
MIRT1041680	hsa-miR-612	CLIP-seq
MIRT1041681	hsa-miR-661	CLIP-seq
MIRT1041682	hsa-miR-708	CLIP-seq
MIRT1041683	hsa-miR-766	CLIP-seq
MIRT1041684	hsa-miR-940	CLIP-seq
MIRT1041685	hsa-miR-942	CLIP-seq
MIRT1041630	hsa-miR-3122	CLIP-seq
MIRT1041637	hsa-miR-3622a-3p	CLIP-seq
MIRT1041639	hsa-miR-3622b-3p	CLIP-seq
MIRT1041641	hsa-miR-3689a-3p	CLIP-seq
MIRT1041642	hsa-miR-3689c	CLIP-seq
MIRT1041643	hsa-miR-3714	CLIP-seq
MIRT1041644	hsa-miR-3913-5p	CLIP-seq
MIRT1041647	hsa-miR-3937	CLIP-seq
MIRT1041663	hsa-miR-4728-5p	CLIP-seq
MIRT1041672	hsa-miR-544b	CLIP-seq
MIRT1041684	hsa-miR-940	CLIP-seq
MIRT2008740	hsa-miR-10a	CLIP-seq
MIRT2008741	hsa-miR-10b	CLIP-seq
MIRT1041620	hsa-miR-1273e	CLIP-seq
MIRT2008742	hsa-miR-146a	CLIP-seq
MIRT2008743	hsa-miR-146b-5p	CLIP-seq
MIRT2008744	hsa-miR-150	CLIP-seq
MIRT2008745	hsa-miR-219-1-3p	CLIP-seq
MIRT1041628	hsa-miR-2964a-3p	CLIP-seq
MIRT1041629	hsa-miR-302f	CLIP-seq
MIRT2008746	hsa-miR-3173-3p	CLIP-seq
MIRT2008747	hsa-miR-339-5p	CLIP-seq
MIRT1041645	hsa-miR-3926	CLIP-seq
MIRT1041646	hsa-miR-3929	CLIP-seq
MIRT2008748	hsa-miR-3943	CLIP-seq
MIRT1041653	hsa-miR-4419b	CLIP-seq
MIRT2008749	hsa-miR-4421	CLIP-seq
MIRT2008750	hsa-miR-4428	CLIP-seq
MIRT2008751	hsa-miR-4470	CLIP-seq
MIRT2008752	hsa-miR-4477b	CLIP-seq
MIRT1041657	hsa-miR-4478	CLIP-seq
MIRT1041658	hsa-miR-4649-3p	CLIP-seq
MIRT2008753	hsa-miR-4684-5p	CLIP-seq
MIRT1041661	hsa-miR-4716-5p	CLIP-seq
MIRT1041662	hsa-miR-4722-5p	CLIP-seq
MIRT1041664	hsa-miR-4768-3p	CLIP-seq
MIRT1041669	hsa-miR-485-5p	CLIP-seq
MIRT1041676	hsa-miR-548s	CLIP-seq
MIRT2008754	hsa-miR-580	CLIP-seq
MIRT2008755	hsa-miR-589	CLIP-seq
MIRT2008756	hsa-miR-593	CLIP-seq
MIRT1041684	hsa-miR-940	CLIP-seq
MIRT2241171	hsa-miR-1206	CLIP-seq
MIRT1041616	hsa-miR-1224-3p	CLIP-seq
MIRT1041617	hsa-miR-1227	CLIP-seq
MIRT1041618	hsa-miR-1260	CLIP-seq
MIRT1041619	hsa-miR-1260b	CLIP-seq
MIRT1041620	hsa-miR-1273e	CLIP-seq
MIRT1041621	hsa-miR-1280	CLIP-seq
MIRT1041623	hsa-miR-1302	CLIP-seq
MIRT2008742	hsa-miR-146a	CLIP-seq
MIRT2008743	hsa-miR-146b-5p	CLIP-seq
MIRT2008744	hsa-miR-150	CLIP-seq
MIRT2008745	hsa-miR-219-1-3p	CLIP-seq
MIRT1041626	hsa-miR-24	CLIP-seq
MIRT1041627	hsa-miR-28-5p	CLIP-seq
MIRT1041628	hsa-miR-2964a-3p	CLIP-seq
MIRT1041629	hsa-miR-302f	CLIP-seq
MIRT1041630	hsa-miR-3122	CLIP-seq
MIRT1041632	hsa-miR-3139	CLIP-seq
MIRT1041633	hsa-miR-3155	CLIP-seq
MIRT1041634	hsa-miR-3155b	CLIP-seq
MIRT2008746	hsa-miR-3173-3p	CLIP-seq
MIRT2241172	hsa-miR-3607-5p	CLIP-seq
MIRT1041637	hsa-miR-3622a-3p	CLIP-seq
MIRT1041638	hsa-miR-3622a-5p	CLIP-seq
MIRT1041639	hsa-miR-3622b-3p	CLIP-seq
MIRT1041640	hsa-miR-3663-5p	CLIP-seq
MIRT2241173	hsa-miR-3672	CLIP-seq
MIRT1041641	hsa-miR-3689a-3p	CLIP-seq
MIRT1041642	hsa-miR-3689c	CLIP-seq
MIRT1041643	hsa-miR-3714	CLIP-seq
MIRT1041644	hsa-miR-3913-5p	CLIP-seq
MIRT1041645	hsa-miR-3926	CLIP-seq
MIRT1041646	hsa-miR-3929	CLIP-seq
MIRT2241174	hsa-miR-3934	CLIP-seq
MIRT1041647	hsa-miR-3937	CLIP-seq
MIRT2008748	hsa-miR-3943	CLIP-seq
MIRT1041650	hsa-miR-4269	CLIP-seq
MIRT1041651	hsa-miR-4284	CLIP-seq
MIRT1041652	hsa-miR-4298	CLIP-seq
MIRT2241175	hsa-miR-431	CLIP-seq
MIRT2241176	hsa-miR-4323	CLIP-seq
MIRT1041653	hsa-miR-4419b	CLIP-seq
MIRT2008750	hsa-miR-4428	CLIP-seq
MIRT1041654	hsa-miR-4433	CLIP-seq
MIRT1041656	hsa-miR-4459	CLIP-seq
MIRT2008752	hsa-miR-4477b	CLIP-seq
MIRT1041657	hsa-miR-4478	CLIP-seq
MIRT2241177	hsa-miR-4643	CLIP-seq
MIRT1041658	hsa-miR-4649-3p	CLIP-seq
MIRT1041659	hsa-miR-4679	CLIP-seq
MIRT2241178	hsa-miR-4705	CLIP-seq
MIRT1041661	hsa-miR-4716-5p	CLIP-seq
MIRT1041662	hsa-miR-4722-5p	CLIP-seq
MIRT1041663	hsa-miR-4728-5p	CLIP-seq
MIRT1041664	hsa-miR-4768-3p	CLIP-seq
MIRT1041665	hsa-miR-4781-3p	CLIP-seq
MIRT1041666	hsa-miR-4786-5p	CLIP-seq
MIRT1041667	hsa-miR-4797-5p	CLIP-seq
MIRT1041668	hsa-miR-484	CLIP-seq
MIRT1041669	hsa-miR-485-5p	CLIP-seq
MIRT1041670	hsa-miR-508-5p	CLIP-seq
MIRT1041672	hsa-miR-544b	CLIP-seq
MIRT1041676	hsa-miR-548s	CLIP-seq
MIRT1041678	hsa-miR-564	CLIP-seq
MIRT2008754	hsa-miR-580	CLIP-seq
MIRT2008755	hsa-miR-589	CLIP-seq
MIRT1041679	hsa-miR-601	CLIP-seq
MIRT1041681	hsa-miR-661	CLIP-seq
MIRT1041682	hsa-miR-708	CLIP-seq
MIRT2241179	hsa-miR-759	CLIP-seq
MIRT1041683	hsa-miR-766	CLIP-seq
MIRT1041684	hsa-miR-940	CLIP-seq
MIRT1041627	hsa-miR-28-5p	CLIP-seq
MIRT1041630	hsa-miR-3122	CLIP-seq
MIRT1041632	hsa-miR-3139	CLIP-seq
MIRT1041637	hsa-miR-3622a-3p	CLIP-seq
MIRT1041639	hsa-miR-3622b-3p	CLIP-seq
MIRT1041641	hsa-miR-3689a-3p	CLIP-seq
MIRT1041642	hsa-miR-3689c	CLIP-seq
MIRT1041643	hsa-miR-3714	CLIP-seq
MIRT1041644	hsa-miR-3913-5p	CLIP-seq
MIRT1041647	hsa-miR-3937	CLIP-seq
MIRT1041654	hsa-miR-4433	CLIP-seq
MIRT1041656	hsa-miR-4459	CLIP-seq
MIRT1041663	hsa-miR-4728-5p	CLIP-seq
MIRT1041664	hsa-miR-4768-3p	CLIP-seq
MIRT1041666	hsa-miR-4786-5p	CLIP-seq
MIRT1041672	hsa-miR-544b	CLIP-seq
MIRT1041682	hsa-miR-708	CLIP-seq
MIRT1041684	hsa-miR-940	CLIP-seq
MIRT2008740	hsa-miR-10a	CLIP-seq
MIRT2008741	hsa-miR-10b	CLIP-seq
MIRT1041620	hsa-miR-1273e	CLIP-seq
MIRT2451000	hsa-miR-1323	CLIP-seq
MIRT1041628	hsa-miR-2964a-3p	CLIP-seq
MIRT1041629	hsa-miR-302f	CLIP-seq
MIRT2451001	hsa-miR-3120-5p	CLIP-seq
MIRT2008747	hsa-miR-339-5p	CLIP-seq
MIRT2451002	hsa-miR-3650	CLIP-seq
MIRT2451003	hsa-miR-3664-5p	CLIP-seq
MIRT2241173	hsa-miR-3672	CLIP-seq
MIRT2451004	hsa-miR-371-5p	CLIP-seq
MIRT2451005	hsa-miR-371b-5p	CLIP-seq
MIRT1041645	hsa-miR-3926	CLIP-seq
MIRT2008749	hsa-miR-4421	CLIP-seq
MIRT2451006	hsa-miR-4455	CLIP-seq
MIRT2008751	hsa-miR-4470	CLIP-seq
MIRT2451007	hsa-miR-4522	CLIP-seq
MIRT2008753	hsa-miR-4684-5p	CLIP-seq
MIRT1041662	hsa-miR-4722-5p	CLIP-seq
MIRT1041664	hsa-miR-4768-3p	CLIP-seq
MIRT1041666	hsa-miR-4786-5p	CLIP-seq
MIRT2451008	hsa-miR-495	CLIP-seq
MIRT2451009	hsa-miR-548c-3p	CLIP-seq
MIRT2451010	hsa-miR-548o	CLIP-seq
MIRT1041676	hsa-miR-548s	CLIP-seq
MIRT2008756	hsa-miR-593	CLIP-seq
MIRT1041684	hsa-miR-940	CLIP-seq
MIRT2008740	hsa-miR-10a	CLIP-seq
MIRT2008741	hsa-miR-10b	CLIP-seq
MIRT2008747	hsa-miR-339-5p	CLIP-seq
MIRT1041645	hsa-miR-3926	CLIP-seq
MIRT2008749	hsa-miR-4421	CLIP-seq
MIRT2008751	hsa-miR-4470	CLIP-seq
MIRT2008753	hsa-miR-4684-5p	CLIP-seq
MIRT1041666	hsa-miR-4786-5p	CLIP-seq
MIRT2451009	hsa-miR-548c-3p	CLIP-seq
MIRT1041676	hsa-miR-548s	CLIP-seq
MIRT2008756	hsa-miR-593	CLIP-seq
MIRT2008740	hsa-miR-10a	CLIP-seq
MIRT2008741	hsa-miR-10b	CLIP-seq
MIRT1041616	hsa-miR-1224-3p	CLIP-seq
MIRT1041618	hsa-miR-1260	CLIP-seq
MIRT1041619	hsa-miR-1260b	CLIP-seq
MIRT1041620	hsa-miR-1273e	CLIP-seq
MIRT1041621	hsa-miR-1280	CLIP-seq
MIRT2451000	hsa-miR-1323	CLIP-seq
MIRT1041628	hsa-miR-2964a-3p	CLIP-seq
MIRT1041629	hsa-miR-302f	CLIP-seq
MIRT2451001	hsa-miR-3120-5p	CLIP-seq
MIRT1041630	hsa-miR-3122	CLIP-seq
MIRT2008747	hsa-miR-339-5p	CLIP-seq
MIRT2451002	hsa-miR-3650	CLIP-seq
MIRT2451003	hsa-miR-3664-5p	CLIP-seq
MIRT2241173	hsa-miR-3672	CLIP-seq
MIRT1041641	hsa-miR-3689a-3p	CLIP-seq
MIRT1041642	hsa-miR-3689c	CLIP-seq
MIRT1041643	hsa-miR-3714	CLIP-seq
MIRT2451004	hsa-miR-371-5p	CLIP-seq
MIRT2451005	hsa-miR-371b-5p	CLIP-seq
MIRT1041644	hsa-miR-3913-5p	CLIP-seq
MIRT1041645	hsa-miR-3926	CLIP-seq
MIRT2008749	hsa-miR-4421	CLIP-seq
MIRT2451006	hsa-miR-4455	CLIP-seq
MIRT2008751	hsa-miR-4470	CLIP-seq
MIRT2451007	hsa-miR-4522	CLIP-seq
MIRT1041659	hsa-miR-4679	CLIP-seq
MIRT2008753	hsa-miR-4684-5p	CLIP-seq
MIRT1041662	hsa-miR-4722-5p	CLIP-seq
MIRT1041663	hsa-miR-4728-5p	CLIP-seq
MIRT1041664	hsa-miR-4768-3p	CLIP-seq
MIRT1041666	hsa-miR-4786-5p	CLIP-seq
MIRT2451008	hsa-miR-495	CLIP-seq
MIRT2451009	hsa-miR-548c-3p	CLIP-seq
MIRT2451010	hsa-miR-548o	CLIP-seq
MIRT1041676	hsa-miR-548s	CLIP-seq
MIRT2008756	hsa-miR-593	CLIP-seq
MIRT1041684	hsa-miR-940	CLIP-seq
MIRT2008740	hsa-miR-10a	CLIP-seq
MIRT2008741	hsa-miR-10b	CLIP-seq
MIRT1041616	hsa-miR-1224-3p	CLIP-seq
MIRT1041618	hsa-miR-1260	CLIP-seq
MIRT1041619	hsa-miR-1260b	CLIP-seq
MIRT1041620	hsa-miR-1273e	CLIP-seq
MIRT1041621	hsa-miR-1280	CLIP-seq
MIRT2451000	hsa-miR-1323	CLIP-seq
MIRT1041628	hsa-miR-2964a-3p	CLIP-seq
MIRT1041629	hsa-miR-302f	CLIP-seq
MIRT2451001	hsa-miR-3120-5p	CLIP-seq
MIRT1041630	hsa-miR-3122	CLIP-seq
MIRT2008747	hsa-miR-339-5p	CLIP-seq
MIRT2451002	hsa-miR-3650	CLIP-seq
MIRT2451003	hsa-miR-3664-5p	CLIP-seq
MIRT2241173	hsa-miR-3672	CLIP-seq
MIRT1041641	hsa-miR-3689a-3p	CLIP-seq
MIRT1041642	hsa-miR-3689c	CLIP-seq
MIRT1041643	hsa-miR-3714	CLIP-seq
MIRT2451004	hsa-miR-371-5p	CLIP-seq
MIRT2451005	hsa-miR-371b-5p	CLIP-seq
MIRT1041644	hsa-miR-3913-5p	CLIP-seq
MIRT1041645	hsa-miR-3926	CLIP-seq
MIRT2008749	hsa-miR-4421	CLIP-seq
MIRT2451006	hsa-miR-4455	CLIP-seq
MIRT2008751	hsa-miR-4470	CLIP-seq
MIRT2451007	hsa-miR-4522	CLIP-seq
MIRT1041659	hsa-miR-4679	CLIP-seq
MIRT2008753	hsa-miR-4684-5p	CLIP-seq
MIRT1041662	hsa-miR-4722-5p	CLIP-seq
MIRT1041663	hsa-miR-4728-5p	CLIP-seq
MIRT1041664	hsa-miR-4768-3p	CLIP-seq
MIRT1041666	hsa-miR-4786-5p	CLIP-seq
MIRT2451008	hsa-miR-495	CLIP-seq
MIRT2451009	hsa-miR-548c-3p	CLIP-seq
MIRT2451010	hsa-miR-548o	CLIP-seq
MIRT1041676	hsa-miR-548s	CLIP-seq
MIRT2008756	hsa-miR-593	CLIP-seq
MIRT1041684	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0050995	Process	Negative regulation of lipid catabolic process	IEA

Other IDs

• MIM: 606923
• HGNC: 4532
• e!Ensembl: ENSG00000196917

Protein

• UniProt ID: Q9BXC0
• Protein name: Hydroxycarboxylic acid receptor 1 (G-protein coupled receptor 104) (G-protein coupled receptor 81)
• Protein function: Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	32 → 278	7 transmembrane receptor (rhodopsin family)	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed abundantly in brown and white fat. It also detectable at lower levels in liver, kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the cortex, basal forebrain, caudate nucle
• Sequence:

  MYNGSCCRIEGDTISQVMPPLLIVAFVLGALGNGVALCGFCFHMKTWKPSTVYLFNLAVA
  DFLLMICLPFRTDYYLRRRHWAFGDIPCRVGLFTLAMNRAGSIVFLTVVAADRYFKVVHP
  HHAVNTISTRVAAGIVCTLWALVILGTVYLLLENHLCVQETAVSCESFIMESANGWHDIM
  FQLEFFMPLGIILFCSFKIVWSLRRRQQLARQARMKKATRFIMVVAIVFITCYLPSVSAR
  LYFLWTVPSSACDPSVHGALHITLSFTYMNSMLDPLVYYFSSPSFPKFYNKLKICSLKPK
  QPGHSKTQRPEEMPISNLGRRSCISVANSFQSQSDGQWDPHIVEWH

• Sequence length: 346

Pathways

KEGG:

cAMP signaling pathway

Reactome:

Hydroxycarboxylic acid-binding receptors
G alpha (i) signalling events

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	28318894		★☆☆☆☆ Found in Text Mining only
Arrhythmogenic Right Ventricular Dysplasia	Arrhythmogenic right ventricular cardiomyopathy	Pubtator	30664203	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	27765922		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	34852802, 35428832, 35775372, 37993804	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	35182679	Associate	★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	2756107		★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	28978803		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	28978803		★☆☆☆☆ Found in Text Mining only
Disorder of eye	Disorder Of Eye	BEFREE	28965419		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	30312866, 30926749, 31129502		★☆☆☆☆ Found in Text Mining only
Glaucoma	Glaucoma	BEFREE	28161252, 29462772, 29571155, 30312866, 31112841, 31237458, 31539777		★☆☆☆☆ Found in Text Mining only
Graves Ophthalmopathy	Graves ophthalmopathy	Pubtator	39735537	Associate	★☆☆☆☆ Found in Text Mining only
Hereditary pancreatitis	Pancreatitis	Pubtator	29151072	Associate	★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	28978803		★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	36656644, 37653539	Stimulate	★☆☆☆☆ Found in Text Mining only
Idiopathic Pulmonary Fibrosis	Idiopathic pulmonary fibrosis	Pubtator	36656644	Associate	★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	30171160		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	2756107		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	31666207	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	27765922, 28258841		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	24928781		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	24928781, 28512002, 29151072, 30312866, 31112841		★☆☆☆☆ Found in Text Mining only
Necrosis	Necrosis	Pubtator	37993804	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	20657160, 24928781, 26875933, 27765922, 28512002, 31083645, 31693947		★☆☆☆☆ Found in Text Mining only
Nijmegen Breakage Syndrome	Nijmegen Breakage Syndrome	BEFREE	28258841		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	30312866		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	24928781		★☆☆☆☆ Found in Text Mining only
Retinal Diseases	Retinal Diseases	BEFREE	31220454		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	32582969	Associate	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	26208712, 29151072, 34799549	Associate	★☆☆☆☆ Found in Text Mining only