VPS4A (vacuolar protein sorting 4 homolog A)

Gene

• Entrez ID: 27183
• Gene name: Vacuolar protein sorting 4 homolog A
• Gene symbol: VPS4A
• Synonyms (NCBI Gene): CIMDAG, SKD1, SKD1A, SKD2, VPS4, VPS4-1
• Chromosome: 16
• Chromosome location: 16q22.1
• Summary: The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025928	hsa-miR-7-5p	Microarray	19073608
MIRT027230	hsa-miR-103a-3p	Sequencing	20371350
MIRT032063	hsa-miR-16-5p	Sequencing	20371350
MIRT042970	hsa-miR-324-3p	CLASH	23622248
MIRT039864	hsa-miR-615-3p	CLASH	23622248
MIRT037863	hsa-miR-455-3p	CLASH	23622248
MIRT075275	hsa-miR-107	PAR-CLIP	20371350
MIRT027230	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT075284	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT075279	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT075278	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT075277	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT032063	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT075273	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT075276	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT075281	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT075274	hsa-miR-32-3p	PAR-CLIP	20371350
MIRT075282	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT075280	hsa-miR-4310	PAR-CLIP	20371350
MIRT075285	hsa-miR-7157-5p	PAR-CLIP	20371350
MIRT500569	hsa-miR-4775	PAR-CLIP	20371350
MIRT075283	hsa-miR-6824-5p	PAR-CLIP	20371350
MIRT500567	hsa-miR-6789-5p	PAR-CLIP	20371350
MIRT500568	hsa-miR-4278	PAR-CLIP	20371350
MIRT500566	hsa-miR-2909	PAR-CLIP	20371350
MIRT075275	hsa-miR-107	PAR-CLIP	21572407
MIRT027230	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT075284	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT075279	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT075278	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT075277	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT032063	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT075273	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT075276	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT075281	hsa-miR-4668-3p	PAR-CLIP	21572407
MIRT075274	hsa-miR-32-3p	PAR-CLIP	21572407
MIRT075282	hsa-miR-6783-5p	PAR-CLIP	21572407
MIRT075280	hsa-miR-4310	PAR-CLIP	21572407
MIRT075285	hsa-miR-7157-5p	PAR-CLIP	21572407
MIRT500569	hsa-miR-4775	PAR-CLIP	21572407
MIRT075283	hsa-miR-6824-5p	PAR-CLIP	21572407
MIRT500567	hsa-miR-6789-5p	PAR-CLIP	21572407
MIRT500568	hsa-miR-4278	PAR-CLIP	21572407
MIRT500566	hsa-miR-2909	PAR-CLIP	21572407
MIRT075275	hsa-miR-107	PAR-CLIP	21572407
MIRT027230	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT075284	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT075279	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT075278	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT075277	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT032063	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT075273	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT075276	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT075281	hsa-miR-4668-3p	PAR-CLIP	21572407
MIRT075274	hsa-miR-32-3p	PAR-CLIP	21572407
MIRT075282	hsa-miR-6783-5p	PAR-CLIP	21572407
MIRT075280	hsa-miR-4310	PAR-CLIP	21572407
MIRT075285	hsa-miR-7157-5p	PAR-CLIP	21572407
MIRT500569	hsa-miR-4775	PAR-CLIP	21572407
MIRT075283	hsa-miR-6824-5p	PAR-CLIP	21572407
MIRT500567	hsa-miR-6789-5p	PAR-CLIP	21572407
MIRT500568	hsa-miR-4278	PAR-CLIP	21572407
MIRT500566	hsa-miR-2909	PAR-CLIP	21572407
MIRT533228	hsa-miR-532-3p	PAR-CLIP	22012620
MIRT533227	hsa-miR-4714-3p	PAR-CLIP	22012620
MIRT533226	hsa-miR-1224-3p	PAR-CLIP	22012620
MIRT533225	hsa-miR-5699-5p	PAR-CLIP	22012620
MIRT533224	hsa-miR-4758-3p	PAR-CLIP	22012620
MIRT533223	hsa-miR-3189-5p	PAR-CLIP	22012620
MIRT533222	hsa-miR-3167	PAR-CLIP	22012620
MIRT533221	hsa-miR-876-5p	PAR-CLIP	22012620
MIRT533220	hsa-miR-1290	PAR-CLIP	22012620
MIRT533219	hsa-miR-1260a	PAR-CLIP	22012620
MIRT533218	hsa-miR-1260b	PAR-CLIP	22012620
MIRT075275	hsa-miR-107	PAR-CLIP	23446348
MIRT027230	hsa-miR-103a-3p	PAR-CLIP	23446348
MIRT075284	hsa-miR-6838-5p	PAR-CLIP	23446348
MIRT075279	hsa-miR-497-5p	PAR-CLIP	23446348
MIRT075278	hsa-miR-424-5p	PAR-CLIP	23446348
MIRT075277	hsa-miR-195-5p	PAR-CLIP	23446348
MIRT032063	hsa-miR-16-5p	PAR-CLIP	23446348
MIRT075273	hsa-miR-15a-5p	PAR-CLIP	23446348
MIRT075276	hsa-miR-15b-5p	PAR-CLIP	23446348
MIRT075281	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT075274	hsa-miR-32-3p	PAR-CLIP	23446348
MIRT075282	hsa-miR-6783-5p	PAR-CLIP	23446348
MIRT075280	hsa-miR-4310	PAR-CLIP	23446348
MIRT075285	hsa-miR-7157-5p	PAR-CLIP	23446348
MIRT500569	hsa-miR-4775	PAR-CLIP	23446348
MIRT075283	hsa-miR-6824-5p	PAR-CLIP	23446348
MIRT500567	hsa-miR-6789-5p	PAR-CLIP	23446348
MIRT500568	hsa-miR-4278	PAR-CLIP	23446348
MIRT500566	hsa-miR-2909	PAR-CLIP	23446348
MIRT075275	hsa-miR-107	PAR-CLIP	24398324
MIRT027230	hsa-miR-103a-3p	PAR-CLIP	24398324
MIRT075284	hsa-miR-6838-5p	PAR-CLIP	24398324
MIRT075279	hsa-miR-497-5p	PAR-CLIP	24398324
MIRT075278	hsa-miR-424-5p	PAR-CLIP	24398324
MIRT075277	hsa-miR-195-5p	PAR-CLIP	24398324
MIRT032063	hsa-miR-16-5p	PAR-CLIP	24398324
MIRT075273	hsa-miR-15a-5p	PAR-CLIP	24398324
MIRT075276	hsa-miR-15b-5p	PAR-CLIP	24398324
MIRT075281	hsa-miR-4668-3p	PAR-CLIP	24398324
MIRT075274	hsa-miR-32-3p	PAR-CLIP	24398324
MIRT075282	hsa-miR-6783-5p	PAR-CLIP	24398324
MIRT075280	hsa-miR-4310	PAR-CLIP	24398324
MIRT075285	hsa-miR-7157-5p	PAR-CLIP	24398324
MIRT500569	hsa-miR-4775	PAR-CLIP	24398324
MIRT075283	hsa-miR-6824-5p	PAR-CLIP	24398324
MIRT500567	hsa-miR-6789-5p	PAR-CLIP	24398324
MIRT500568	hsa-miR-4278	PAR-CLIP	24398324
MIRT500566	hsa-miR-2909	PAR-CLIP	24398324
MIRT464091	hsa-miR-665	PAR-CLIP	23592263
MIRT464090	hsa-miR-2278	PAR-CLIP	23592263
MIRT464088	hsa-miR-4519	PAR-CLIP	23592263
MIRT464089	hsa-miR-4476	PAR-CLIP	23592263
MIRT464087	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT464086	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT464085	hsa-miR-6733-3p	PAR-CLIP	23592263
MIRT464084	hsa-miR-181a-2-3p	PAR-CLIP	23592263
MIRT464083	hsa-miR-1273g-3p	PAR-CLIP	23592263
MIRT464082	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT464081	hsa-miR-6077	PAR-CLIP	23592263
MIRT464080	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT464079	hsa-miR-8065	PAR-CLIP	23592263
MIRT464078	hsa-miR-6509-3p	PAR-CLIP	23592263
MIRT464083	hsa-miR-1273g-3p	PAR-CLIP	26701625
MIRT464084	hsa-miR-181a-2-3p	PAR-CLIP	26701625
MIRT464090	hsa-miR-2278	PAR-CLIP	26701625
MIRT464089	hsa-miR-4476	PAR-CLIP	26701625
MIRT464088	hsa-miR-4519	PAR-CLIP	26701625
MIRT464086	hsa-miR-4768-3p	PAR-CLIP	26701625
MIRT464081	hsa-miR-6077	PAR-CLIP	26701625
MIRT464082	hsa-miR-6499-3p	PAR-CLIP	26701625
MIRT464078	hsa-miR-6509-3p	PAR-CLIP	26701625
MIRT464091	hsa-miR-665	PAR-CLIP	26701625
MIRT464085	hsa-miR-6733-3p	PAR-CLIP	26701625
MIRT464087	hsa-miR-6876-5p	PAR-CLIP	26701625
MIRT464080	hsa-miR-766-5p	PAR-CLIP	26701625
MIRT464079	hsa-miR-8065	PAR-CLIP	26701625
MIRT075275	hsa-miR-107	PAR-CLIP	20371350
MIRT027230	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT075284	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT075279	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT075278	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT075277	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT032063	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT075273	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT075276	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT075281	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT075274	hsa-miR-32-3p	PAR-CLIP	20371350
MIRT075282	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT075280	hsa-miR-4310	PAR-CLIP	20371350
MIRT075285	hsa-miR-7157-5p	PAR-CLIP	20371350
MIRT500569	hsa-miR-4775	PAR-CLIP	20371350
MIRT075283	hsa-miR-6824-5p	PAR-CLIP	20371350
MIRT500567	hsa-miR-6789-5p	PAR-CLIP	20371350
MIRT500568	hsa-miR-4278	PAR-CLIP	20371350
MIRT500566	hsa-miR-2909	PAR-CLIP	20371350
MIRT075275	hsa-miR-107	PAR-CLIP	21572407
MIRT027230	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT075284	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT075279	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT075278	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT075277	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT032063	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT075273	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT075276	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT075281	hsa-miR-4668-3p	PAR-CLIP	21572407
MIRT075274	hsa-miR-32-3p	PAR-CLIP	21572407
MIRT075282	hsa-miR-6783-5p	PAR-CLIP	21572407
MIRT075280	hsa-miR-4310	PAR-CLIP	21572407
MIRT075285	hsa-miR-7157-5p	PAR-CLIP	21572407
MIRT500569	hsa-miR-4775	PAR-CLIP	21572407
MIRT075283	hsa-miR-6824-5p	PAR-CLIP	21572407
MIRT500567	hsa-miR-6789-5p	PAR-CLIP	21572407
MIRT500568	hsa-miR-4278	PAR-CLIP	21572407
MIRT500566	hsa-miR-2909	PAR-CLIP	21572407
MIRT075275	hsa-miR-107	PAR-CLIP	21572407
MIRT027230	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT075284	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT075279	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT075278	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT075277	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT032063	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT075273	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT075276	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT075281	hsa-miR-4668-3p	PAR-CLIP	21572407
MIRT075274	hsa-miR-32-3p	PAR-CLIP	21572407
MIRT075282	hsa-miR-6783-5p	PAR-CLIP	21572407
MIRT075280	hsa-miR-4310	PAR-CLIP	21572407
MIRT075285	hsa-miR-7157-5p	PAR-CLIP	21572407
MIRT500569	hsa-miR-4775	PAR-CLIP	21572407
MIRT075283	hsa-miR-6824-5p	PAR-CLIP	21572407
MIRT500567	hsa-miR-6789-5p	PAR-CLIP	21572407
MIRT500568	hsa-miR-4278	PAR-CLIP	21572407
MIRT500566	hsa-miR-2909	PAR-CLIP	21572407
MIRT533228	hsa-miR-532-3p	PAR-CLIP	22012620
MIRT533227	hsa-miR-4714-3p	PAR-CLIP	22012620
MIRT533226	hsa-miR-1224-3p	PAR-CLIP	22012620
MIRT533225	hsa-miR-5699-5p	PAR-CLIP	22012620
MIRT533224	hsa-miR-4758-3p	PAR-CLIP	22012620
MIRT533223	hsa-miR-3189-5p	PAR-CLIP	22012620
MIRT533222	hsa-miR-3167	PAR-CLIP	22012620
MIRT533221	hsa-miR-876-5p	PAR-CLIP	22012620
MIRT533220	hsa-miR-1290	PAR-CLIP	22012620
MIRT533219	hsa-miR-1260a	PAR-CLIP	22012620
MIRT533218	hsa-miR-1260b	PAR-CLIP	22012620
MIRT075275	hsa-miR-107	PAR-CLIP	23446348
MIRT027230	hsa-miR-103a-3p	PAR-CLIP	23446348
MIRT075284	hsa-miR-6838-5p	PAR-CLIP	23446348
MIRT075279	hsa-miR-497-5p	PAR-CLIP	23446348
MIRT075278	hsa-miR-424-5p	PAR-CLIP	23446348
MIRT075277	hsa-miR-195-5p	PAR-CLIP	23446348
MIRT032063	hsa-miR-16-5p	PAR-CLIP	23446348
MIRT075273	hsa-miR-15a-5p	PAR-CLIP	23446348
MIRT075276	hsa-miR-15b-5p	PAR-CLIP	23446348
MIRT075281	hsa-miR-4668-3p	PAR-CLIP	23446348
MIRT075274	hsa-miR-32-3p	PAR-CLIP	23446348
MIRT075282	hsa-miR-6783-5p	PAR-CLIP	23446348
MIRT075280	hsa-miR-4310	PAR-CLIP	23446348
MIRT075285	hsa-miR-7157-5p	PAR-CLIP	23446348
MIRT500569	hsa-miR-4775	PAR-CLIP	23446348
MIRT075283	hsa-miR-6824-5p	PAR-CLIP	23446348
MIRT500567	hsa-miR-6789-5p	PAR-CLIP	23446348
MIRT500568	hsa-miR-4278	PAR-CLIP	23446348
MIRT500566	hsa-miR-2909	PAR-CLIP	23446348
MIRT075275	hsa-miR-107	PAR-CLIP	24398324
MIRT027230	hsa-miR-103a-3p	PAR-CLIP	24398324
MIRT075284	hsa-miR-6838-5p	PAR-CLIP	24398324
MIRT075279	hsa-miR-497-5p	PAR-CLIP	24398324
MIRT075278	hsa-miR-424-5p	PAR-CLIP	24398324
MIRT075277	hsa-miR-195-5p	PAR-CLIP	24398324
MIRT032063	hsa-miR-16-5p	PAR-CLIP	24398324
MIRT075273	hsa-miR-15a-5p	PAR-CLIP	24398324
MIRT075276	hsa-miR-15b-5p	PAR-CLIP	24398324
MIRT075281	hsa-miR-4668-3p	PAR-CLIP	24398324
MIRT075274	hsa-miR-32-3p	PAR-CLIP	24398324
MIRT075282	hsa-miR-6783-5p	PAR-CLIP	24398324
MIRT075280	hsa-miR-4310	PAR-CLIP	24398324
MIRT075285	hsa-miR-7157-5p	PAR-CLIP	24398324
MIRT500569	hsa-miR-4775	PAR-CLIP	24398324
MIRT075283	hsa-miR-6824-5p	PAR-CLIP	24398324
MIRT500567	hsa-miR-6789-5p	PAR-CLIP	24398324
MIRT500568	hsa-miR-4278	PAR-CLIP	24398324
MIRT500566	hsa-miR-2909	PAR-CLIP	24398324
MIRT464091	hsa-miR-665	PAR-CLIP	23592263
MIRT464090	hsa-miR-2278	PAR-CLIP	23592263
MIRT464088	hsa-miR-4519	PAR-CLIP	23592263
MIRT464089	hsa-miR-4476	PAR-CLIP	23592263
MIRT464087	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT464086	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT464085	hsa-miR-6733-3p	PAR-CLIP	23592263
MIRT464084	hsa-miR-181a-2-3p	PAR-CLIP	23592263
MIRT464083	hsa-miR-1273g-3p	PAR-CLIP	23592263
MIRT464082	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT464081	hsa-miR-6077	PAR-CLIP	23592263
MIRT464080	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT464079	hsa-miR-8065	PAR-CLIP	23592263
MIRT464078	hsa-miR-6509-3p	PAR-CLIP	23592263
MIRT756375	hsa-miR-4454	Luciferase reporter assay	34777698
MIRT1487033	hsa-miR-103a	CLIP-seq
MIRT1487034	hsa-miR-1254	CLIP-seq
MIRT1487035	hsa-miR-1304	CLIP-seq
MIRT1487036	hsa-miR-1587	CLIP-seq
MIRT1487037	hsa-miR-15a	CLIP-seq
MIRT1487038	hsa-miR-15b	CLIP-seq
MIRT1487039	hsa-miR-16	CLIP-seq
MIRT1487040	hsa-miR-1827	CLIP-seq
MIRT1487041	hsa-miR-1915	CLIP-seq
MIRT1487042	hsa-miR-195	CLIP-seq
MIRT1487043	hsa-miR-2682	CLIP-seq
MIRT1487044	hsa-miR-3116	CLIP-seq
MIRT1487045	hsa-miR-3154	CLIP-seq
MIRT1487046	hsa-miR-3180-5p	CLIP-seq
MIRT1487047	hsa-miR-34a	CLIP-seq
MIRT1487048	hsa-miR-34c-5p	CLIP-seq
MIRT1487049	hsa-miR-3647-3p	CLIP-seq
MIRT1487050	hsa-miR-3684	CLIP-seq
MIRT1487051	hsa-miR-3714	CLIP-seq
MIRT1487052	hsa-miR-424	CLIP-seq
MIRT1487053	hsa-miR-4426	CLIP-seq
MIRT1487054	hsa-miR-4436a	CLIP-seq
MIRT1487055	hsa-miR-4453	CLIP-seq
MIRT1487056	hsa-miR-4492	CLIP-seq
MIRT1487057	hsa-miR-4498	CLIP-seq
MIRT1487058	hsa-miR-449a	CLIP-seq
MIRT1487059	hsa-miR-449b	CLIP-seq
MIRT1487060	hsa-miR-449c	CLIP-seq
MIRT1487061	hsa-miR-4502	CLIP-seq
MIRT1487062	hsa-miR-4505	CLIP-seq
MIRT1487063	hsa-miR-4538	CLIP-seq
MIRT1487064	hsa-miR-4647	CLIP-seq
MIRT1487065	hsa-miR-4656	CLIP-seq
MIRT1487066	hsa-miR-4662b	CLIP-seq
MIRT1487067	hsa-miR-4668-5p	CLIP-seq
MIRT1487068	hsa-miR-4674	CLIP-seq
MIRT1487069	hsa-miR-4675	CLIP-seq
MIRT1487070	hsa-miR-4685-5p	CLIP-seq
MIRT1487071	hsa-miR-4731-5p	CLIP-seq
MIRT1487072	hsa-miR-4741	CLIP-seq
MIRT1487073	hsa-miR-497	CLIP-seq
MIRT1487074	hsa-miR-515-3p	CLIP-seq
MIRT1487075	hsa-miR-519e	CLIP-seq
MIRT1487076	hsa-miR-548an	CLIP-seq
MIRT1487077	hsa-miR-550a	CLIP-seq
MIRT1487078	hsa-miR-635	CLIP-seq
MIRT1487079	hsa-miR-661	CLIP-seq
MIRT1487080	hsa-miR-762	CLIP-seq
MIRT1487081	hsa-miR-892a	CLIP-seq
MIRT1487035	hsa-miR-1304	CLIP-seq
MIRT2146542	hsa-miR-1323	CLIP-seq
MIRT2146543	hsa-miR-1324	CLIP-seq
MIRT2146544	hsa-miR-135a	CLIP-seq
MIRT2146545	hsa-miR-135b	CLIP-seq
MIRT2146546	hsa-miR-149	CLIP-seq
MIRT1487036	hsa-miR-1587	CLIP-seq
MIRT1487040	hsa-miR-1827	CLIP-seq
MIRT2146547	hsa-miR-1909	CLIP-seq
MIRT2146548	hsa-miR-2467-3p	CLIP-seq
MIRT2146549	hsa-miR-3064-5p	CLIP-seq
MIRT2146550	hsa-miR-3117-5p	CLIP-seq
MIRT2146551	hsa-miR-3157-5p	CLIP-seq
MIRT2146552	hsa-miR-3170	CLIP-seq
MIRT2146553	hsa-miR-340	CLIP-seq
MIRT1487049	hsa-miR-3647-3p	CLIP-seq
MIRT2146554	hsa-miR-3664-5p	CLIP-seq
MIRT2146555	hsa-miR-4258	CLIP-seq
MIRT2146556	hsa-miR-4266	CLIP-seq
MIRT2146557	hsa-miR-4308	CLIP-seq
MIRT1487053	hsa-miR-4426	CLIP-seq
MIRT1487055	hsa-miR-4453	CLIP-seq
MIRT2146558	hsa-miR-4471	CLIP-seq
MIRT1487056	hsa-miR-4492	CLIP-seq
MIRT1487057	hsa-miR-4498	CLIP-seq
MIRT1487061	hsa-miR-4502	CLIP-seq
MIRT1487062	hsa-miR-4505	CLIP-seq
MIRT1487063	hsa-miR-4538	CLIP-seq
MIRT1487064	hsa-miR-4647	CLIP-seq
MIRT1487065	hsa-miR-4656	CLIP-seq
MIRT1487066	hsa-miR-4662b	CLIP-seq
MIRT1487068	hsa-miR-4674	CLIP-seq
MIRT1487069	hsa-miR-4675	CLIP-seq
MIRT2146559	hsa-miR-4680-5p	CLIP-seq
MIRT2146560	hsa-miR-4686	CLIP-seq
MIRT2146561	hsa-miR-4688	CLIP-seq
MIRT2146562	hsa-miR-4691-3p	CLIP-seq
MIRT2146563	hsa-miR-4695-5p	CLIP-seq
MIRT2146564	hsa-miR-4711-5p	CLIP-seq
MIRT2146565	hsa-miR-4713-5p	CLIP-seq
MIRT1487071	hsa-miR-4731-5p	CLIP-seq
MIRT1487072	hsa-miR-4741	CLIP-seq
MIRT2146566	hsa-miR-4764-5p	CLIP-seq
MIRT2146567	hsa-miR-4779	CLIP-seq
MIRT2146568	hsa-miR-4794	CLIP-seq
MIRT2146569	hsa-miR-513c	CLIP-seq
MIRT2146570	hsa-miR-514b-5p	CLIP-seq
MIRT2146571	hsa-miR-548o	CLIP-seq
MIRT2146572	hsa-miR-548p	CLIP-seq
MIRT1487078	hsa-miR-635	CLIP-seq
MIRT2146573	hsa-miR-668	CLIP-seq
MIRT1487080	hsa-miR-762	CLIP-seq
MIRT2146574	hsa-miR-767-3p	CLIP-seq
MIRT2146575	hsa-miR-922	CLIP-seq
MIRT1487035	hsa-miR-1304	CLIP-seq
MIRT2146543	hsa-miR-1324	CLIP-seq
MIRT1487036	hsa-miR-1587	CLIP-seq
MIRT1487040	hsa-miR-1827	CLIP-seq
MIRT2146547	hsa-miR-1909	CLIP-seq
MIRT2146548	hsa-miR-2467-3p	CLIP-seq
MIRT1487043	hsa-miR-2682	CLIP-seq
MIRT2367176	hsa-miR-3125	CLIP-seq
MIRT2146551	hsa-miR-3157-5p	CLIP-seq
MIRT2146552	hsa-miR-3170	CLIP-seq
MIRT1487047	hsa-miR-34a	CLIP-seq
MIRT1487048	hsa-miR-34c-5p	CLIP-seq
MIRT1487051	hsa-miR-3714	CLIP-seq
MIRT2367177	hsa-miR-3916	CLIP-seq
MIRT2367178	hsa-miR-4257	CLIP-seq
MIRT2367179	hsa-miR-4286	CLIP-seq
MIRT1487055	hsa-miR-4453	CLIP-seq
MIRT1487056	hsa-miR-4492	CLIP-seq
MIRT1487057	hsa-miR-4498	CLIP-seq
MIRT1487058	hsa-miR-449a	CLIP-seq
MIRT1487059	hsa-miR-449b	CLIP-seq
MIRT1487060	hsa-miR-449c	CLIP-seq
MIRT1487062	hsa-miR-4505	CLIP-seq
MIRT1487063	hsa-miR-4538	CLIP-seq
MIRT1487065	hsa-miR-4656	CLIP-seq
MIRT1487068	hsa-miR-4674	CLIP-seq
MIRT1487069	hsa-miR-4675	CLIP-seq
MIRT2146560	hsa-miR-4686	CLIP-seq
MIRT2146561	hsa-miR-4688	CLIP-seq
MIRT2146562	hsa-miR-4691-3p	CLIP-seq
MIRT2146564	hsa-miR-4711-5p	CLIP-seq
MIRT1487071	hsa-miR-4731-5p	CLIP-seq
MIRT1487072	hsa-miR-4741	CLIP-seq
MIRT2367180	hsa-miR-483-3p	CLIP-seq
MIRT1487076	hsa-miR-548an	CLIP-seq
MIRT2367181	hsa-miR-574-3p	CLIP-seq
MIRT1487078	hsa-miR-635	CLIP-seq
MIRT2146573	hsa-miR-668	CLIP-seq
MIRT1487080	hsa-miR-762	CLIP-seq
MIRT2146575	hsa-miR-922	CLIP-seq
MIRT1487033	hsa-miR-103a	CLIP-seq
MIRT1487037	hsa-miR-15a	CLIP-seq
MIRT1487038	hsa-miR-15b	CLIP-seq
MIRT1487039	hsa-miR-16	CLIP-seq
MIRT1487042	hsa-miR-195	CLIP-seq
MIRT1487049	hsa-miR-3647-3p	CLIP-seq
MIRT1487052	hsa-miR-424	CLIP-seq
MIRT2146555	hsa-miR-4258	CLIP-seq
MIRT1487073	hsa-miR-497	CLIP-seq
MIRT1487033	hsa-miR-103a	CLIP-seq
MIRT2463298	hsa-miR-1231	CLIP-seq
MIRT2463299	hsa-miR-1233	CLIP-seq
MIRT1487034	hsa-miR-1254	CLIP-seq
MIRT2463300	hsa-miR-125a-3p	CLIP-seq
MIRT2463301	hsa-miR-1260	CLIP-seq
MIRT2463302	hsa-miR-1267	CLIP-seq
MIRT2463303	hsa-miR-1280	CLIP-seq
MIRT2463304	hsa-miR-1302	CLIP-seq
MIRT2463305	hsa-miR-146b-3p	CLIP-seq
MIRT2146546	hsa-miR-149	CLIP-seq
MIRT1487037	hsa-miR-15a	CLIP-seq
MIRT1487038	hsa-miR-15b	CLIP-seq
MIRT1487039	hsa-miR-16	CLIP-seq
MIRT1487042	hsa-miR-195	CLIP-seq
MIRT2463306	hsa-miR-197	CLIP-seq
MIRT1487043	hsa-miR-2682	CLIP-seq
MIRT2146549	hsa-miR-3064-5p	CLIP-seq
MIRT1487044	hsa-miR-3116	CLIP-seq
MIRT2146550	hsa-miR-3117-5p	CLIP-seq
MIRT2463307	hsa-miR-3120-5p	CLIP-seq
MIRT2367176	hsa-miR-3125	CLIP-seq
MIRT2463308	hsa-miR-3148	CLIP-seq
MIRT2463309	hsa-miR-3150a-3p	CLIP-seq
MIRT2463310	hsa-miR-3175	CLIP-seq
MIRT2463311	hsa-miR-339-5p	CLIP-seq
MIRT2146553	hsa-miR-340	CLIP-seq
MIRT1487047	hsa-miR-34a	CLIP-seq
MIRT1487048	hsa-miR-34c-5p	CLIP-seq
MIRT1487049	hsa-miR-3647-3p	CLIP-seq
MIRT2463312	hsa-miR-3688-3p	CLIP-seq
MIRT1487051	hsa-miR-3714	CLIP-seq
MIRT2367177	hsa-miR-3916	CLIP-seq
MIRT2463313	hsa-miR-412	CLIP-seq
MIRT1487052	hsa-miR-424	CLIP-seq
MIRT2463314	hsa-miR-4254	CLIP-seq
MIRT2367178	hsa-miR-4257	CLIP-seq
MIRT2463315	hsa-miR-4298	CLIP-seq
MIRT2146557	hsa-miR-4308	CLIP-seq
MIRT2463316	hsa-miR-4317	CLIP-seq
MIRT2463317	hsa-miR-4421	CLIP-seq
MIRT1487053	hsa-miR-4426	CLIP-seq
MIRT1487058	hsa-miR-449a	CLIP-seq
MIRT1487059	hsa-miR-449b	CLIP-seq
MIRT1487060	hsa-miR-449c	CLIP-seq
MIRT1487064	hsa-miR-4647	CLIP-seq
MIRT1487066	hsa-miR-4662b	CLIP-seq
MIRT2463318	hsa-miR-4687-3p	CLIP-seq
MIRT2146568	hsa-miR-4794	CLIP-seq
MIRT2463319	hsa-miR-489	CLIP-seq
MIRT1487073	hsa-miR-497	CLIP-seq
MIRT1487074	hsa-miR-515-3p	CLIP-seq
MIRT1487075	hsa-miR-519e	CLIP-seq
MIRT1487076	hsa-miR-548an	CLIP-seq
MIRT1487077	hsa-miR-550a	CLIP-seq
MIRT2367181	hsa-miR-574-3p	CLIP-seq
MIRT1487079	hsa-miR-661	CLIP-seq
MIRT2463320	hsa-miR-939	CLIP-seq
MIRT1487043	hsa-miR-2682	CLIP-seq
MIRT2367176	hsa-miR-3125	CLIP-seq
MIRT1487047	hsa-miR-34a	CLIP-seq
MIRT1487048	hsa-miR-34c-5p	CLIP-seq
MIRT1487051	hsa-miR-3714	CLIP-seq
MIRT2367177	hsa-miR-3916	CLIP-seq
MIRT2367178	hsa-miR-4257	CLIP-seq
MIRT1487058	hsa-miR-449a	CLIP-seq
MIRT1487059	hsa-miR-449b	CLIP-seq
MIRT1487060	hsa-miR-449c	CLIP-seq
MIRT1487076	hsa-miR-548an	CLIP-seq
MIRT2367181	hsa-miR-574-3p	CLIP-seq
MIRT1487033	hsa-miR-103a	CLIP-seq
MIRT2463298	hsa-miR-1231	CLIP-seq
MIRT2463299	hsa-miR-1233	CLIP-seq
MIRT1487034	hsa-miR-1254	CLIP-seq
MIRT2463300	hsa-miR-125a-3p	CLIP-seq
MIRT2463301	hsa-miR-1260	CLIP-seq
MIRT2463302	hsa-miR-1267	CLIP-seq
MIRT2463303	hsa-miR-1280	CLIP-seq
MIRT2463304	hsa-miR-1302	CLIP-seq
MIRT2463305	hsa-miR-146b-3p	CLIP-seq
MIRT2146546	hsa-miR-149	CLIP-seq
MIRT1487037	hsa-miR-15a	CLIP-seq
MIRT1487038	hsa-miR-15b	CLIP-seq
MIRT1487039	hsa-miR-16	CLIP-seq
MIRT1487042	hsa-miR-195	CLIP-seq
MIRT2463306	hsa-miR-197	CLIP-seq
MIRT2146549	hsa-miR-3064-5p	CLIP-seq
MIRT1487044	hsa-miR-3116	CLIP-seq
MIRT2146550	hsa-miR-3117-5p	CLIP-seq
MIRT2463307	hsa-miR-3120-5p	CLIP-seq
MIRT2463308	hsa-miR-3148	CLIP-seq
MIRT2463309	hsa-miR-3150a-3p	CLIP-seq
MIRT2463310	hsa-miR-3175	CLIP-seq
MIRT2463311	hsa-miR-339-5p	CLIP-seq
MIRT2146553	hsa-miR-340	CLIP-seq
MIRT1487049	hsa-miR-3647-3p	CLIP-seq
MIRT2463312	hsa-miR-3688-3p	CLIP-seq
MIRT2463313	hsa-miR-412	CLIP-seq
MIRT1487052	hsa-miR-424	CLIP-seq
MIRT2463314	hsa-miR-4254	CLIP-seq
MIRT2463315	hsa-miR-4298	CLIP-seq
MIRT2146557	hsa-miR-4308	CLIP-seq
MIRT2463316	hsa-miR-4317	CLIP-seq
MIRT2463317	hsa-miR-4421	CLIP-seq
MIRT1487053	hsa-miR-4426	CLIP-seq
MIRT1487064	hsa-miR-4647	CLIP-seq
MIRT1487066	hsa-miR-4662b	CLIP-seq
MIRT2463318	hsa-miR-4687-3p	CLIP-seq
MIRT2660615	hsa-miR-4723-5p	CLIP-seq
MIRT2146568	hsa-miR-4794	CLIP-seq
MIRT2463319	hsa-miR-489	CLIP-seq
MIRT1487073	hsa-miR-497	CLIP-seq
MIRT1487074	hsa-miR-515-3p	CLIP-seq
MIRT1487075	hsa-miR-519e	CLIP-seq
MIRT1487077	hsa-miR-550a	CLIP-seq
MIRT1487079	hsa-miR-661	CLIP-seq
MIRT2463320	hsa-miR-939	CLIP-seq
MIRT1487033	hsa-miR-103a	CLIP-seq
MIRT2463298	hsa-miR-1231	CLIP-seq
MIRT2463299	hsa-miR-1233	CLIP-seq
MIRT1487034	hsa-miR-1254	CLIP-seq
MIRT2463300	hsa-miR-125a-3p	CLIP-seq
MIRT2463301	hsa-miR-1260	CLIP-seq
MIRT2463302	hsa-miR-1267	CLIP-seq
MIRT2463303	hsa-miR-1280	CLIP-seq
MIRT2463304	hsa-miR-1302	CLIP-seq
MIRT2463305	hsa-miR-146b-3p	CLIP-seq
MIRT2146546	hsa-miR-149	CLIP-seq
MIRT1487037	hsa-miR-15a	CLIP-seq
MIRT1487038	hsa-miR-15b	CLIP-seq
MIRT1487039	hsa-miR-16	CLIP-seq
MIRT1487042	hsa-miR-195	CLIP-seq
MIRT2463306	hsa-miR-197	CLIP-seq
MIRT2146549	hsa-miR-3064-5p	CLIP-seq
MIRT1487044	hsa-miR-3116	CLIP-seq
MIRT2146550	hsa-miR-3117-5p	CLIP-seq
MIRT2463307	hsa-miR-3120-5p	CLIP-seq
MIRT2463308	hsa-miR-3148	CLIP-seq
MIRT2463309	hsa-miR-3150a-3p	CLIP-seq
MIRT2463310	hsa-miR-3175	CLIP-seq
MIRT2463311	hsa-miR-339-5p	CLIP-seq
MIRT2146553	hsa-miR-340	CLIP-seq
MIRT1487049	hsa-miR-3647-3p	CLIP-seq
MIRT2463312	hsa-miR-3688-3p	CLIP-seq
MIRT2463313	hsa-miR-412	CLIP-seq
MIRT1487052	hsa-miR-424	CLIP-seq
MIRT2463314	hsa-miR-4254	CLIP-seq
MIRT2463315	hsa-miR-4298	CLIP-seq
MIRT2146557	hsa-miR-4308	CLIP-seq
MIRT2463316	hsa-miR-4317	CLIP-seq
MIRT2463317	hsa-miR-4421	CLIP-seq
MIRT1487053	hsa-miR-4426	CLIP-seq
MIRT1487064	hsa-miR-4647	CLIP-seq
MIRT1487066	hsa-miR-4662b	CLIP-seq
MIRT2463318	hsa-miR-4687-3p	CLIP-seq
MIRT2146568	hsa-miR-4794	CLIP-seq
MIRT2463319	hsa-miR-489	CLIP-seq
MIRT1487073	hsa-miR-497	CLIP-seq
MIRT1487074	hsa-miR-515-3p	CLIP-seq
MIRT1487075	hsa-miR-519e	CLIP-seq
MIRT1487077	hsa-miR-550a	CLIP-seq
MIRT1487079	hsa-miR-661	CLIP-seq
MIRT2463320	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000916	Process	Actomyosin contractile ring contraction	TAS	28242692
GO:0000922	Component	Spindle pole	IDA	20616062
GO:0000922	Component	Spindle pole	IEA
GO:0001778	Process	Plasma membrane repair	NAS	24482116
GO:0005515	Function	Protein binding	IPI	11559748, 11563910, 14505570, 14519844, 16174732, 16730941, 17110338, 17928862, 18385515, 18606141, 18997780, 19129479, 19129480, 21543490, 23105106, 24814515, 26618866, 31324722, 32296183, 33961781, 35156780, 35271311, 36012204
GO:0005524	Function	ATP binding	IEA
GO:0005524	Function	ATP binding	IMP
GO:0005634	Component	Nucleus	IDA	20616062
GO:0005643	Component	Nuclear pore	NAS	16505166
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	11563910, 15075231, 20616062
GO:0005737	Component	Cytoplasm	IEA
GO:0005764	Component	Lysosome	IDA
GO:0005768	Component	Endosome	IBA
GO:0005768	Component	Endosome	IDA	17940959
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IDA	15075231
GO:0005770	Component	Late endosome	IDA	15075231
GO:0005774	Component	Vacuolar membrane	IDA
GO:0005813	Component	Centrosome	IDA	20616062
GO:0005813	Component	Centrosome	IEA
GO:0005819	Component	Spindle	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA	17940959
GO:0005886	Component	Plasma membrane	NAS	19234443
GO:0006622	Process	Protein targeting to lysosome	IMP	16973552
GO:0006900	Process	Vesicle budding from membrane	IMP	15075231
GO:0006914	Process	Autophagy	NAS	17428789
GO:0006997	Process	Nucleus organization	IEA
GO:0006997	Process	Nucleus organization	IMP	20616062
GO:0006997	Process	Nucleus organization	NAS	20616062
GO:0006998	Process	Nuclear envelope organization	TAS	28242692
GO:0007032	Process	Endosome organization	IEA
GO:0007033	Process	Vacuole organization	IBA
GO:0007041	Process	Lysosomal transport	IEA
GO:0007080	Process	Mitotic metaphase chromosome alignment	IEA
GO:0007080	Process	Mitotic metaphase chromosome alignment	IMP	20616062
GO:0007084	Process	Mitotic nuclear membrane reassembly	TAS
GO:0010008	Component	Endosome membrane	IMP	18606141
GO:0010389	Process	Regulation of G2/M transition of mitotic cell cycle	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IDA	11563910
GO:0016197	Process	Endosomal transport	IBA
GO:0016197	Process	Endosomal transport	IEA
GO:0016197	Process	Endosomal transport	IMP	11559748
GO:0016236	Process	Macroautophagy	NAS	20588296
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IBA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IMP
GO:0016887	Function	ATP hydrolysis activity	TAS
GO:0019076	Process	Viral release from host cell	IMP	11595185
GO:0030496	Component	Midbody	IDA	17853893, 19129479, 24814515
GO:0030496	Component	Midbody	IEA
GO:0030496	Component	Midbody	NAS	26040712
GO:0030496	Component	Midbody	TAS	28242692
GO:0031468	Process	Nuclear membrane reassembly	NAS	26040713
GO:0031468	Process	Nuclear membrane reassembly	TAS	28242692
GO:0031902	Component	Late endosome membrane	IEA
GO:0032367	Process	Intracellular cholesterol transport	IMP
GO:0032466	Process	Negative regulation of cytokinesis	IMP	24814515
GO:0032880	Process	Regulation of protein localization	IMP	18005716
GO:0034058	Process	Endosomal vesicle fusion	IMP	15075231
GO:0036258	Process	Multivesicular body assembly	IEA
GO:0036258	Process	Multivesicular body assembly	ISS
GO:0036258	Process	Multivesicular body assembly	NAS	16505166, 20588296
GO:0039702	Process	Viral budding via host ESCRT complex	IEA
GO:0039702	Process	Viral budding via host ESCRT complex	IGI	24107264
GO:0043162	Process	Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA
GO:0043162	Process	Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IEA
GO:0043162	Process	Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IMP	22547407
GO:0044877	Function	Protein-containing complex binding	IPI	18606141
GO:0044878	Process	Mitotic cytokinesis checkpoint signaling	IMP	24814515
GO:0046761	Process	Viral budding from plasma membrane	IEA
GO:0046761	Process	Viral budding from plasma membrane	IMP	16193069, 17940959
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	11563910
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051261	Process	Protein depolymerization	IEA
GO:0051301	Process	Cell division	IDA	17853893
GO:0051301	Process	Cell division	IEA
GO:0061640	Process	Cytoskeleton-dependent cytokinesis	TAS	28242692
GO:0061738	Process	Late endosomal microautophagy	IEA
GO:0061738	Process	Late endosomal microautophagy	ISS
GO:0061764	Process	Late endosome to lysosome transport via multivesicular body sorting pathway	NAS	9211789
GO:0061952	Process	Midbody abscission	IEA
GO:0061952	Process	Midbody abscission	IMP	20616062, 24814515
GO:0061952	Process	Midbody abscission	NAS	20616062
GO:0070062	Component	Extracellular exosome	HDA	19199708, 23533145
GO:0071985	Process	Multivesicular body sorting pathway	NAS	16505166
GO:0072319	Process	Vesicle uncoating	IMP	15075231
GO:0090148	Process	Membrane fission	NAS	19234443
GO:0090543	Component	Flemming body	IDA	20616062
GO:0090543	Component	Flemming body	IEA
GO:0090611	Process	Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway	IBA
GO:0090611	Process	Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway	IEA
GO:0090611	Process	Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway	IMP	22547407
GO:0097352	Process	Autophagosome maturation	NAS	9211789
GO:0140545	Function	ATP-dependent protein disaggregase activity	NAS	28242692
GO:1903076	Process	Regulation of protein localization to plasma membrane	IMP	24878737
GO:1903543	Process	Positive regulation of exosomal secretion	IEA
GO:1903543	Process	Positive regulation of exosomal secretion	IMP	22660413
GO:1903774	Process	Positive regulation of viral budding via host ESCRT complex	IMP	24878737
GO:1904896	Process	ESCRT complex disassembly	NAS	21118109
GO:1904903	Process	ESCRT III complex disassembly	NAS	20588296, 28242692
GO:1904949	Component	ATPase complex	NAS	19278657

Other IDs

• MIM: 609982
• HGNC: 13488
• e!Ensembl: ENSG00000132612

Protein

• UniProt ID: Q9UN37
• Protein name: Vacuolar protein sorting-associated protein 4A (EC 3.6.4.6) (Protein SKD2) (VPS4-1) (hVPS4)
• Protein function: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III componen
• PDB: 1YXR, 2JQ9, 2K3W
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04212	MIT	6 → 72	MIT (microtubule interacting and transport) domain	Domain
  PF00004	AAA	163 → 293	ATPase family associated with various cellular activities (AAA)	Domain
  PF17862	AAA_lid_3	316 → 357	AAA+ lid domain	Domain
  PF09336	Vps4_C	374 → 434	Vps4 C terminal oligomerisation domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:10637304, ECO:0000269|PubMed:11563910}.
• Sequence:

  MTTSTLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKC
  VQYLDRAEKLKDYLRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVME
  KPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAV
  ATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENE
  SEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARA
  QMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCG
  PSRTNPSMMIDDLLTPCSPGDPGAMEMTWMDVPGDKLLEPVVCMSDMLRSLATTRPTVNA
  DDLLKVKKFSEDFGQES

• Sequence length: 437

Pathways

KEGG:

Viral life cycle - HIV-1
Virion - Hepatitis viruses
Endocytosis
Necroptosis

Reactome:

Budding and maturation of HIV virion
Endosomal Sorting Complex Required For Transport (ESCRT)
HCMV Late Events
Sealing of the nuclear envelope (NE) by ESCRT-III

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Cerebellar hypoplasia-intellectual disability-congenital microcephaly-dystonia-anemia-growth retardation syndrome	Pathogenic; Likely pathogenic	rs1965484443, rs1965499910, rs1965431981, rs1965484288	RCV001374865 RCV001374864 RCV001374863 RCV001374867 RCV001374866	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Syndromic congenital hemolytic and dyserythropoietic anemia	Pathogenic; Likely pathogenic	rs1965499910, rs1965431981, rs1965484288	RCV001290970 RCV001290972 RCV001290971	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CIMDAG SYNDROME	—	Disgenet, HPO Disgenet, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTELLECTUAL DISABILITY	—	Disgenet, GenCC Disgenet, GenCC	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VPS4A-related disorder	Uncertain significance; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Amyloidosis	Amyloidosis	BEFREE	28835279		★☆☆☆☆ Found in Text Mining only
Anemia Dyserythropoietic Congenital	Congenital dyserythropoietic anemia	Pubtator	33186543	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	25503676, 34777698	Associate	★☆☆☆☆ Found in Text Mining only
Cataract Nuclear Progressive	Congenital cataract	Pubtator	34281622	Associate	★☆☆☆☆ Found in Text Mining only
Cognitive Dysfunction	Cognition disorder	Pubtator	24292993	Stimulate	★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	25033200		★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	Pubtator	24292993	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	27909058		★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	25033200		★☆☆☆☆ Found in Text Mining only
Heart Failure	Heart failure	Pubtator	25033200	Associate	★☆☆☆☆ Found in Text Mining only
Hypersensitivity Delayed	Hypersensitivity	Pubtator	33186543	Associate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31059752		★☆☆☆☆ Found in Text Mining only
Liver Neoplasms	Liver neoplasm	Pubtator	34281622	Associate	★☆☆☆☆ Found in Text Mining only
Mitochondrial Complex II Deficiency	Mitochondrial complex deficiency	Pubtator	34281622	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	31059752		★☆☆☆☆ Found in Text Mining only
Polycythemia Vera	Polycythemia Vera	BEFREE	28349933		★☆☆☆☆ Found in Text Mining only
Vesicular Stomatitis	Vesicular Stomatitis	LHGDN	17913808		★☆☆☆☆ Found in Text Mining only