SIGLEC8 (sialic acid binding Ig like lectin 8)

Gene

• Entrez ID: 27181
• Gene name: Sialic acid binding Ig like lectin 8
• Gene symbol: SIGLEC8
• Synonyms (NCBI Gene): SAF2, SIGLEC-8, SIGLEC8L
• Chromosome: 19
• Chromosome location: 19q13.41
• Summary: Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup o

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017964	hsa-miR-335-5p	Microarray	18185580
MIRT723520	hsa-miR-4324	HITS-CLIP	19536157
MIRT723519	hsa-miR-544b	HITS-CLIP	19536157
MIRT723518	hsa-miR-4421	HITS-CLIP	19536157
MIRT723517	hsa-miR-5699-3p	HITS-CLIP	19536157
MIRT723516	hsa-miR-4329	HITS-CLIP	19536157
MIRT723515	hsa-miR-873-3p	HITS-CLIP	19536157
MIRT723514	hsa-miR-6804-3p	HITS-CLIP	19536157
MIRT723513	hsa-miR-431-5p	HITS-CLIP	19536157
MIRT723512	hsa-miR-4326	HITS-CLIP	19536157
MIRT723511	hsa-miR-378a-5p	HITS-CLIP	19536157
MIRT723510	hsa-miR-1200	HITS-CLIP	19536157
MIRT723509	hsa-miR-3672	HITS-CLIP	19536157
MIRT723508	hsa-miR-6864-3p	HITS-CLIP	19536157
MIRT723507	hsa-miR-500a-3p	HITS-CLIP	19536157
MIRT723520	hsa-miR-4324	HITS-CLIP	19536157
MIRT723519	hsa-miR-544b	HITS-CLIP	19536157
MIRT723518	hsa-miR-4421	HITS-CLIP	19536157
MIRT723517	hsa-miR-5699-3p	HITS-CLIP	19536157
MIRT723516	hsa-miR-4329	HITS-CLIP	19536157
MIRT723515	hsa-miR-873-3p	HITS-CLIP	19536157
MIRT723514	hsa-miR-6804-3p	HITS-CLIP	19536157
MIRT723513	hsa-miR-431-5p	HITS-CLIP	19536157
MIRT723512	hsa-miR-4326	HITS-CLIP	19536157
MIRT723511	hsa-miR-378a-5p	HITS-CLIP	19536157
MIRT723510	hsa-miR-1200	HITS-CLIP	19536157
MIRT723509	hsa-miR-3672	HITS-CLIP	19536157
MIRT723508	hsa-miR-6864-3p	HITS-CLIP	19536157
MIRT723507	hsa-miR-500a-3p	HITS-CLIP	19536157
MIRT1348573	hsa-miR-1262	CLIP-seq
MIRT1348574	hsa-miR-128	CLIP-seq
MIRT1348575	hsa-miR-1282	CLIP-seq
MIRT1348576	hsa-miR-1285	CLIP-seq
MIRT1348577	hsa-miR-1293	CLIP-seq
MIRT1348578	hsa-miR-1827	CLIP-seq
MIRT1348579	hsa-miR-1908	CLIP-seq
MIRT1348580	hsa-miR-24	CLIP-seq
MIRT1348581	hsa-miR-2681	CLIP-seq
MIRT1348582	hsa-miR-27a	CLIP-seq
MIRT1348583	hsa-miR-27b	CLIP-seq
MIRT1348584	hsa-miR-3122	CLIP-seq
MIRT1348585	hsa-miR-3144-5p	CLIP-seq
MIRT1348586	hsa-miR-3179	CLIP-seq
MIRT1348587	hsa-miR-3187-5p	CLIP-seq
MIRT1348588	hsa-miR-3191	CLIP-seq
MIRT1348589	hsa-miR-3202	CLIP-seq
MIRT1348590	hsa-miR-3614-5p	CLIP-seq
MIRT1348591	hsa-miR-3664-3p	CLIP-seq
MIRT1348592	hsa-miR-3689a-3p	CLIP-seq
MIRT1348593	hsa-miR-3689c	CLIP-seq
MIRT1348594	hsa-miR-3689d	CLIP-seq
MIRT1348595	hsa-miR-3692	CLIP-seq
MIRT1348596	hsa-miR-3714	CLIP-seq
MIRT1348597	hsa-miR-3913-5p	CLIP-seq
MIRT1348598	hsa-miR-4284	CLIP-seq
MIRT1348599	hsa-miR-4433	CLIP-seq
MIRT1348600	hsa-miR-4459	CLIP-seq
MIRT1348601	hsa-miR-4466	CLIP-seq
MIRT1348602	hsa-miR-4468	CLIP-seq
MIRT1348603	hsa-miR-4483	CLIP-seq
MIRT1348604	hsa-miR-4496	CLIP-seq
MIRT1348605	hsa-miR-4514	CLIP-seq
MIRT1348606	hsa-miR-4649-3p	CLIP-seq
MIRT1348607	hsa-miR-4652-5p	CLIP-seq
MIRT1348608	hsa-miR-4692	CLIP-seq
MIRT1348609	hsa-miR-4701-3p	CLIP-seq
MIRT1348610	hsa-miR-4717-3p	CLIP-seq
MIRT1348611	hsa-miR-4722-5p	CLIP-seq
MIRT1348612	hsa-miR-4723-5p	CLIP-seq
MIRT1348613	hsa-miR-4728-5p	CLIP-seq
MIRT1348614	hsa-miR-4730	CLIP-seq
MIRT1348615	hsa-miR-4746-3p	CLIP-seq
MIRT1348616	hsa-miR-4747-5p	CLIP-seq
MIRT1348617	hsa-miR-4756-3p	CLIP-seq
MIRT1348618	hsa-miR-4768-3p	CLIP-seq
MIRT1348619	hsa-miR-4793-3p	CLIP-seq
MIRT1348620	hsa-miR-491-5p	CLIP-seq
MIRT1348621	hsa-miR-495	CLIP-seq
MIRT1348622	hsa-miR-508-5p	CLIP-seq
MIRT1348623	hsa-miR-605	CLIP-seq
MIRT1348624	hsa-miR-612	CLIP-seq
MIRT1348625	hsa-miR-661	CLIP-seq
MIRT1348626	hsa-miR-663	CLIP-seq
MIRT1348627	hsa-miR-665	CLIP-seq
MIRT1348628	hsa-miR-675	CLIP-seq
MIRT1348629	hsa-miR-766	CLIP-seq
MIRT1348630	hsa-miR-873	CLIP-seq
MIRT1348631	hsa-miR-890	CLIP-seq
MIRT1348632	hsa-miR-940	CLIP-seq
MIRT2103338	hsa-miR-1207-5p	CLIP-seq
MIRT2103339	hsa-miR-1255a	CLIP-seq
MIRT2103340	hsa-miR-1255b	CLIP-seq
MIRT1348574	hsa-miR-128	CLIP-seq
MIRT1348579	hsa-miR-1908	CLIP-seq
MIRT1348582	hsa-miR-27a	CLIP-seq
MIRT1348583	hsa-miR-27b	CLIP-seq
MIRT1348584	hsa-miR-3122	CLIP-seq
MIRT1348590	hsa-miR-3614-5p	CLIP-seq
MIRT1348591	hsa-miR-3664-3p	CLIP-seq
MIRT1348592	hsa-miR-3689a-3p	CLIP-seq
MIRT1348593	hsa-miR-3689c	CLIP-seq
MIRT1348595	hsa-miR-3692	CLIP-seq
MIRT1348596	hsa-miR-3714	CLIP-seq
MIRT1348597	hsa-miR-3913-5p	CLIP-seq
MIRT2103341	hsa-miR-3925-5p	CLIP-seq
MIRT1348600	hsa-miR-4459	CLIP-seq
MIRT1348605	hsa-miR-4514	CLIP-seq
MIRT1348608	hsa-miR-4692	CLIP-seq
MIRT1348610	hsa-miR-4717-3p	CLIP-seq
MIRT1348612	hsa-miR-4723-5p	CLIP-seq
MIRT1348613	hsa-miR-4728-5p	CLIP-seq
MIRT2103342	hsa-miR-4763-3p	CLIP-seq
MIRT1348618	hsa-miR-4768-3p	CLIP-seq
MIRT2103343	hsa-miR-4802-3p	CLIP-seq
MIRT2103344	hsa-miR-490-5p	CLIP-seq
MIRT1348623	hsa-miR-605	CLIP-seq
MIRT1348626	hsa-miR-663	CLIP-seq
MIRT1348632	hsa-miR-940	CLIP-seq
MIRT2103338	hsa-miR-1207-5p	CLIP-seq
MIRT2327637	hsa-miR-1224-3p	CLIP-seq
MIRT2327638	hsa-miR-1260	CLIP-seq
MIRT2327639	hsa-miR-1260b	CLIP-seq
MIRT1348573	hsa-miR-1262	CLIP-seq
MIRT1348574	hsa-miR-128	CLIP-seq
MIRT2327640	hsa-miR-1280	CLIP-seq
MIRT1348575	hsa-miR-1282	CLIP-seq
MIRT1348577	hsa-miR-1293	CLIP-seq
MIRT2327641	hsa-miR-1470	CLIP-seq
MIRT1348578	hsa-miR-1827	CLIP-seq
MIRT1348579	hsa-miR-1908	CLIP-seq
MIRT1348581	hsa-miR-2681	CLIP-seq
MIRT1348582	hsa-miR-27a	CLIP-seq
MIRT1348583	hsa-miR-27b	CLIP-seq
MIRT1348584	hsa-miR-3122	CLIP-seq
MIRT1348585	hsa-miR-3144-5p	CLIP-seq
MIRT1348586	hsa-miR-3179	CLIP-seq
MIRT1348588	hsa-miR-3191	CLIP-seq
MIRT1348589	hsa-miR-3202	CLIP-seq
MIRT2327642	hsa-miR-361-3p	CLIP-seq
MIRT1348590	hsa-miR-3614-5p	CLIP-seq
MIRT1348591	hsa-miR-3664-3p	CLIP-seq
MIRT2327643	hsa-miR-3680	CLIP-seq
MIRT1348592	hsa-miR-3689a-3p	CLIP-seq
MIRT1348593	hsa-miR-3689c	CLIP-seq
MIRT1348594	hsa-miR-3689d	CLIP-seq
MIRT1348595	hsa-miR-3692	CLIP-seq
MIRT1348596	hsa-miR-3714	CLIP-seq
MIRT1348597	hsa-miR-3913-5p	CLIP-seq
MIRT1348599	hsa-miR-4433	CLIP-seq
MIRT1348600	hsa-miR-4459	CLIP-seq
MIRT1348602	hsa-miR-4468	CLIP-seq
MIRT1348603	hsa-miR-4483	CLIP-seq
MIRT1348604	hsa-miR-4496	CLIP-seq
MIRT1348605	hsa-miR-4514	CLIP-seq
MIRT2327644	hsa-miR-4643	CLIP-seq
MIRT1348606	hsa-miR-4649-3p	CLIP-seq
MIRT1348607	hsa-miR-4652-5p	CLIP-seq
MIRT2327645	hsa-miR-4666-5p	CLIP-seq
MIRT2327646	hsa-miR-4667-3p	CLIP-seq
MIRT1348608	hsa-miR-4692	CLIP-seq
MIRT1348609	hsa-miR-4701-3p	CLIP-seq
MIRT1348610	hsa-miR-4717-3p	CLIP-seq
MIRT1348611	hsa-miR-4722-5p	CLIP-seq
MIRT1348612	hsa-miR-4723-5p	CLIP-seq
MIRT1348613	hsa-miR-4728-5p	CLIP-seq
MIRT1348614	hsa-miR-4730	CLIP-seq
MIRT2327647	hsa-miR-4733-3p	CLIP-seq
MIRT1348617	hsa-miR-4756-3p	CLIP-seq
MIRT2103342	hsa-miR-4763-3p	CLIP-seq
MIRT1348618	hsa-miR-4768-3p	CLIP-seq
MIRT2103343	hsa-miR-4802-3p	CLIP-seq
MIRT1348620	hsa-miR-491-5p	CLIP-seq
MIRT2327648	hsa-miR-532-3p	CLIP-seq
MIRT2327649	hsa-miR-600	CLIP-seq
MIRT1348623	hsa-miR-605	CLIP-seq
MIRT2327650	hsa-miR-634	CLIP-seq
MIRT1348626	hsa-miR-663	CLIP-seq
MIRT1348627	hsa-miR-665	CLIP-seq
MIRT1348630	hsa-miR-873	CLIP-seq
MIRT1348632	hsa-miR-940	CLIP-seq
MIRT1348584	hsa-miR-3122	CLIP-seq
MIRT1348590	hsa-miR-3614-5p	CLIP-seq
MIRT1348592	hsa-miR-3689a-3p	CLIP-seq
MIRT1348593	hsa-miR-3689c	CLIP-seq
MIRT1348596	hsa-miR-3714	CLIP-seq
MIRT1348597	hsa-miR-3913-5p	CLIP-seq
MIRT1348599	hsa-miR-4433	CLIP-seq
MIRT1348600	hsa-miR-4459	CLIP-seq
MIRT1348605	hsa-miR-4514	CLIP-seq
MIRT1348608	hsa-miR-4692	CLIP-seq
MIRT1348610	hsa-miR-4717-3p	CLIP-seq
MIRT1348613	hsa-miR-4728-5p	CLIP-seq
MIRT1348618	hsa-miR-4768-3p	CLIP-seq
MIRT1348632	hsa-miR-940	CLIP-seq
MIRT2459376	hsa-miR-1268	CLIP-seq
MIRT2459377	hsa-miR-1268b	CLIP-seq
MIRT1348574	hsa-miR-128	CLIP-seq
MIRT1348575	hsa-miR-1282	CLIP-seq
MIRT1348578	hsa-miR-1827	CLIP-seq
MIRT1348579	hsa-miR-1908	CLIP-seq
MIRT1348582	hsa-miR-27a	CLIP-seq
MIRT1348583	hsa-miR-27b	CLIP-seq
MIRT1348584	hsa-miR-3122	CLIP-seq
MIRT2459378	hsa-miR-3606	CLIP-seq
MIRT1348591	hsa-miR-3664-3p	CLIP-seq
MIRT1348592	hsa-miR-3689a-3p	CLIP-seq
MIRT1348593	hsa-miR-3689c	CLIP-seq
MIRT1348594	hsa-miR-3689d	CLIP-seq
MIRT1348595	hsa-miR-3692	CLIP-seq
MIRT1348596	hsa-miR-3714	CLIP-seq
MIRT1348597	hsa-miR-3913-5p	CLIP-seq
MIRT1348600	hsa-miR-4459	CLIP-seq
MIRT2459379	hsa-miR-4486	CLIP-seq
MIRT1348605	hsa-miR-4514	CLIP-seq
MIRT2459380	hsa-miR-4684-5p	CLIP-seq
MIRT1348608	hsa-miR-4692	CLIP-seq
MIRT1348610	hsa-miR-4717-3p	CLIP-seq
MIRT1348611	hsa-miR-4722-5p	CLIP-seq
MIRT1348612	hsa-miR-4723-5p	CLIP-seq
MIRT1348613	hsa-miR-4728-5p	CLIP-seq
MIRT1348618	hsa-miR-4768-3p	CLIP-seq
MIRT2459381	hsa-miR-585	CLIP-seq
MIRT1348623	hsa-miR-605	CLIP-seq
MIRT1348626	hsa-miR-663	CLIP-seq
MIRT1348627	hsa-miR-665	CLIP-seq
MIRT1348630	hsa-miR-873	CLIP-seq
MIRT1348632	hsa-miR-940	CLIP-seq
MIRT1348574	hsa-miR-128	CLIP-seq
MIRT1348579	hsa-miR-1908	CLIP-seq
MIRT1348582	hsa-miR-27a	CLIP-seq
MIRT1348583	hsa-miR-27b	CLIP-seq
MIRT1348595	hsa-miR-3692	CLIP-seq
MIRT2459379	hsa-miR-4486	CLIP-seq
MIRT2459380	hsa-miR-4684-5p	CLIP-seq
MIRT1348610	hsa-miR-4717-3p	CLIP-seq
MIRT1348612	hsa-miR-4723-5p	CLIP-seq
MIRT1348626	hsa-miR-663	CLIP-seq
MIRT2103339	hsa-miR-1255a	CLIP-seq
MIRT2103340	hsa-miR-1255b	CLIP-seq
MIRT2459376	hsa-miR-1268	CLIP-seq
MIRT2459377	hsa-miR-1268b	CLIP-seq
MIRT1348574	hsa-miR-128	CLIP-seq
MIRT1348575	hsa-miR-1282	CLIP-seq
MIRT1348576	hsa-miR-1285	CLIP-seq
MIRT1348578	hsa-miR-1827	CLIP-seq
MIRT1348579	hsa-miR-1908	CLIP-seq
MIRT1348582	hsa-miR-27a	CLIP-seq
MIRT1348583	hsa-miR-27b	CLIP-seq
MIRT1348584	hsa-miR-3122	CLIP-seq
MIRT1348587	hsa-miR-3187-5p	CLIP-seq
MIRT2459378	hsa-miR-3606	CLIP-seq
MIRT1348590	hsa-miR-3614-5p	CLIP-seq
MIRT1348591	hsa-miR-3664-3p	CLIP-seq
MIRT1348592	hsa-miR-3689a-3p	CLIP-seq
MIRT1348593	hsa-miR-3689c	CLIP-seq
MIRT1348594	hsa-miR-3689d	CLIP-seq
MIRT1348595	hsa-miR-3692	CLIP-seq
MIRT1348596	hsa-miR-3714	CLIP-seq
MIRT1348597	hsa-miR-3913-5p	CLIP-seq
MIRT2103341	hsa-miR-3925-5p	CLIP-seq
MIRT1348600	hsa-miR-4459	CLIP-seq
MIRT2459379	hsa-miR-4486	CLIP-seq
MIRT1348604	hsa-miR-4496	CLIP-seq
MIRT1348605	hsa-miR-4514	CLIP-seq
MIRT2459380	hsa-miR-4684-5p	CLIP-seq
MIRT1348608	hsa-miR-4692	CLIP-seq
MIRT1348610	hsa-miR-4717-3p	CLIP-seq
MIRT1348611	hsa-miR-4722-5p	CLIP-seq
MIRT1348612	hsa-miR-4723-5p	CLIP-seq
MIRT1348613	hsa-miR-4728-5p	CLIP-seq
MIRT1348618	hsa-miR-4768-3p	CLIP-seq
MIRT1348619	hsa-miR-4793-3p	CLIP-seq
MIRT2103343	hsa-miR-4802-3p	CLIP-seq
MIRT2103344	hsa-miR-490-5p	CLIP-seq
MIRT1348622	hsa-miR-508-5p	CLIP-seq
MIRT2459381	hsa-miR-585	CLIP-seq
MIRT1348623	hsa-miR-605	CLIP-seq
MIRT1348624	hsa-miR-612	CLIP-seq
MIRT1348625	hsa-miR-661	CLIP-seq
MIRT1348626	hsa-miR-663	CLIP-seq
MIRT1348627	hsa-miR-665	CLIP-seq
MIRT1348629	hsa-miR-766	CLIP-seq
MIRT1348630	hsa-miR-873	CLIP-seq
MIRT1348632	hsa-miR-940	CLIP-seq
MIRT2459376	hsa-miR-1268	CLIP-seq
MIRT2459377	hsa-miR-1268b	CLIP-seq
MIRT1348574	hsa-miR-128	CLIP-seq
MIRT1348576	hsa-miR-1285	CLIP-seq
MIRT1348579	hsa-miR-1908	CLIP-seq
MIRT1348582	hsa-miR-27a	CLIP-seq
MIRT1348583	hsa-miR-27b	CLIP-seq
MIRT1348584	hsa-miR-3122	CLIP-seq
MIRT1348587	hsa-miR-3187-5p	CLIP-seq
MIRT2459378	hsa-miR-3606	CLIP-seq
MIRT1348590	hsa-miR-3614-5p	CLIP-seq
MIRT1348591	hsa-miR-3664-3p	CLIP-seq
MIRT1348592	hsa-miR-3689a-3p	CLIP-seq
MIRT1348593	hsa-miR-3689c	CLIP-seq
MIRT1348595	hsa-miR-3692	CLIP-seq
MIRT1348596	hsa-miR-3714	CLIP-seq
MIRT1348597	hsa-miR-3913-5p	CLIP-seq
MIRT1348600	hsa-miR-4459	CLIP-seq
MIRT2459379	hsa-miR-4486	CLIP-seq
MIRT1348605	hsa-miR-4514	CLIP-seq
MIRT2459380	hsa-miR-4684-5p	CLIP-seq
MIRT1348608	hsa-miR-4692	CLIP-seq
MIRT1348610	hsa-miR-4717-3p	CLIP-seq
MIRT1348612	hsa-miR-4723-5p	CLIP-seq
MIRT1348613	hsa-miR-4728-5p	CLIP-seq
MIRT1348618	hsa-miR-4768-3p	CLIP-seq
MIRT1348619	hsa-miR-4793-3p	CLIP-seq
MIRT1348622	hsa-miR-508-5p	CLIP-seq
MIRT2459381	hsa-miR-585	CLIP-seq
MIRT1348623	hsa-miR-605	CLIP-seq
MIRT1348624	hsa-miR-612	CLIP-seq
MIRT1348625	hsa-miR-661	CLIP-seq
MIRT1348626	hsa-miR-663	CLIP-seq
MIRT1348629	hsa-miR-766	CLIP-seq
MIRT1348630	hsa-miR-873	CLIP-seq
MIRT1348632	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	TAS	10625619
GO:0005515	Function	Protein binding	IPI	21982860
GO:0005886	Component	Plasma membrane	IBA
GO:0007155	Process	Cell adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007165	Process	Signal transduction	TAS	10625619
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	10625619
GO:0030246	Function	Carbohydrate binding	IEA
GO:0030246	Function	Carbohydrate binding	TAS	10625619
GO:0033691	Function	Sialic acid binding	IBA

Other IDs

• MIM: 605639
• HGNC: 10877
• e!Ensembl: ENSG00000105366

Protein

• UniProt ID: Q9NYZ4
• Protein name: Sialic acid-binding Ig-like lectin 8 (Siglec-8) (Sialoadhesin family member 2) (SAF-2)
• Protein function: Putative adhesion molecule that mediates sialic-acid dependent binding to blood cells (PubMed:10625619, PubMed:10856141). Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recogniti
• PDB: 2N7A, 2N7B, 7QU6, 7QUH, 7QUI
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	30 → 144	Immunoglobulin V-set domain	Domain
  PF13927	Ig_3	266 → 332		Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed specifically on blood cells namely basophil, mast cells and eosinophils. {ECO:0000269|PubMed:10625619, ECO:0000269|PubMed:10856141}.
• Sequence:

  MLLLLLLLPLLWGTKGMEGDRQYGDGYLLQVQELVTVQEGLCVHVPCSFSYPQDGWTDSD
  PVHGYWFRAGDRPYQDAPVATNNPDREVQAETQGRFQLLGDIWSNDCSLSIRDARKRDKG
  SYFFRLERGSMKWSYKSQLNYKTKQLSVFVTALTHRPDILILGTLESGHSRNLTCSVPWA
  CKQGTPPMISWIGASVSSPGPTTARSSVLTLTPKPQDHGTSLTCQVTLPGTGVTTTSTVR
  LDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLVCAVNSNPPARLSWTRGSL
  TLCPSRSSNPGLLELPRVHVRDEGEFTCRAQNAQGSQHISLSLSLQNEGTGTSRPVSQVT
  LAAVGGAGATALAFLSFCIIFIIVRSCRKKSARPAAGVGDTGMEDAKAIRGSASQGPLTE
  SWKDGNPLKKPPPAVAPSSGEEGELHYATLSFHKVKPQDPQGQEATDSEYSEIKIHKRET
  AETQACLRNHNPSSKEVRG

• Sequence length: 499

Pathways

Reactome:

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CHAGAS CARDIOMYOPATHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease, Late Onset	Alzheimer disease	BEFREE	24841380		★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	20087405, 22884075, 24841380		★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	20087405, 30876376, 32277847	Associate	★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	32542913	Stimulate	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	33670444	Associate	★☆☆☆☆ Found in Text Mining only
Chronic eosinophilic leukemia	Eosinophilic Leukemia	BEFREE	21938510		★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	BEFREE	24841380		★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	28619634		★☆☆☆☆ Found in Text Mining only
Dermatitis	Dermatitis	Pubtator	32277847	Associate	★☆☆☆☆ Found in Text Mining only
Eosinophilia, Tropical	Eosinophilia	BEFREE	29879704		★☆☆☆☆ Found in Text Mining only
Eosinophilic esophagitis	Eosinophilia	BEFREE	20087405, 31465299		★☆☆☆☆ Found in Text Mining only
Eosinophilic Esophagitis	Eosinophilia	Pubtator	30876376	Associate	★☆☆☆☆ Found in Text Mining only
Gastritis	Gastritis	BEFREE	31465299		★☆☆☆☆ Found in Text Mining only
Gastroenteritis	Gastroenteritis	BEFREE	31465299		★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic Neoplasms	BEFREE	21938510		★☆☆☆☆ Found in Text Mining only
Hirschsprung Disease	Hirschsprung Disease	BEFREE	28006787		★☆☆☆☆ Found in Text Mining only
Hirschsprung Disease	Hirschsprung disease	Pubtator	28006787	Associate	★☆☆☆☆ Found in Text Mining only
Hypereosinophilic Syndrome	Hypereosinophilic syndrome	Pubtator	30690753	Inhibit	★☆☆☆☆ Found in Text Mining only
Hypereosinophilic Syndrome	Hypereosinophilic syndrome	Pubtator	32542913	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Mast Cell	Mast cell leukemia	Pubtator	28734845	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia, Mast-Cell	Leukemia	BEFREE	28734845		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28619634		★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	32542913	Associate	★☆☆☆☆ Found in Text Mining only
Pulmonary Eosinophilia	Pulmonary Eosinophilia	BEFREE	29879704		★☆☆☆☆ Found in Text Mining only
Rhinitis	Rhinitis	Pubtator	32277847	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	26883254	Inhibit	★☆☆☆☆ Found in Text Mining only