Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	27134
Gene name	Tight junction protein 3
Gene symbol	TJP3
Synonyms (NCBI Gene)	ZO-3ZO3
Chromosome	19
Chromosome location	19p13.3
Summary	The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In ad

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018043	hsa-miR-335-5p	Microarray	18185580
MIRT451441	hsa-miR-3173-3p	PAR-CLIP	20371350
MIRT451440	hsa-miR-6891-5p	PAR-CLIP	20371350
MIRT451438	hsa-miR-6760-5p	PAR-CLIP	20371350
MIRT451437	hsa-miR-1321	PAR-CLIP	20371350
MIRT451436	hsa-miR-4739	PAR-CLIP	20371350
MIRT451435	hsa-miR-4756-5p	PAR-CLIP	20371350
MIRT568689	hsa-miR-1207-3p	PAR-CLIP	20371350
MIRT451433	hsa-miR-4270	PAR-CLIP	20371350
MIRT451434	hsa-miR-4441	PAR-CLIP	20371350
MIRT451432	hsa-miR-6754-5p	PAR-CLIP	20371350
MIRT451428	hsa-miR-6770-5p	PAR-CLIP	20371350
MIRT451427	hsa-miR-4419a	PAR-CLIP	20371350
MIRT451426	hsa-miR-4510	PAR-CLIP	20371350
MIRT451425	hsa-miR-6127	PAR-CLIP	20371350
MIRT451424	hsa-miR-6129	PAR-CLIP	20371350
MIRT451423	hsa-miR-6130	PAR-CLIP	20371350
MIRT451422	hsa-miR-6133	PAR-CLIP	20371350
MIRT451421	hsa-miR-184	PAR-CLIP	20371350
MIRT451420	hsa-miR-4434	PAR-CLIP	20371350
MIRT451419	hsa-miR-4516	PAR-CLIP	20371350
MIRT451418	hsa-miR-5703	PAR-CLIP	20371350
MIRT451417	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT451416	hsa-miR-1249-5p	PAR-CLIP	20371350
MIRT451415	hsa-miR-6797-5p	PAR-CLIP	20371350
MIRT451414	hsa-miR-6878-5p	PAR-CLIP	20371350
MIRT451413	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT451412	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT451411	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT451409	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT451410	hsa-miR-6746-5p	PAR-CLIP	20371350
MIRT451441	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT451440	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT451439	hsa-miR-4323	PAR-CLIP	23592263
MIRT451438	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT451437	hsa-miR-1321	PAR-CLIP	23592263
MIRT451436	hsa-miR-4739	PAR-CLIP	23592263
MIRT451435	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT451433	hsa-miR-4270	PAR-CLIP	23592263
MIRT451434	hsa-miR-4441	PAR-CLIP	23592263
MIRT451432	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT451431	hsa-miR-7113-5p	PAR-CLIP	23592263
MIRT451430	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT451429	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT451428	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT451427	hsa-miR-4419a	PAR-CLIP	23592263
MIRT451426	hsa-miR-4510	PAR-CLIP	23592263
MIRT451425	hsa-miR-6127	PAR-CLIP	23592263
MIRT451424	hsa-miR-6129	PAR-CLIP	23592263
MIRT451423	hsa-miR-6130	PAR-CLIP	23592263
MIRT451422	hsa-miR-6133	PAR-CLIP	23592263
MIRT451421	hsa-miR-184	PAR-CLIP	23592263
MIRT451420	hsa-miR-4434	PAR-CLIP	23592263
MIRT451419	hsa-miR-4516	PAR-CLIP	23592263
MIRT451418	hsa-miR-5703	PAR-CLIP	23592263
MIRT451417	hsa-miR-7154-3p	PAR-CLIP	23592263
MIRT451416	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT451415	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT451414	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT451413	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT451412	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT451411	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT451409	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT451410	hsa-miR-6746-5p	PAR-CLIP	23592263
MIRT451441	hsa-miR-3173-3p	PAR-CLIP	20371350
MIRT451440	hsa-miR-6891-5p	PAR-CLIP	20371350
MIRT451438	hsa-miR-6760-5p	PAR-CLIP	20371350
MIRT451437	hsa-miR-1321	PAR-CLIP	20371350
MIRT451436	hsa-miR-4739	PAR-CLIP	20371350
MIRT451435	hsa-miR-4756-5p	PAR-CLIP	20371350
MIRT568689	hsa-miR-1207-3p	PAR-CLIP	20371350
MIRT451433	hsa-miR-4270	PAR-CLIP	20371350
MIRT451434	hsa-miR-4441	PAR-CLIP	20371350
MIRT451432	hsa-miR-6754-5p	PAR-CLIP	20371350
MIRT451428	hsa-miR-6770-5p	PAR-CLIP	20371350
MIRT451427	hsa-miR-4419a	PAR-CLIP	20371350
MIRT451426	hsa-miR-4510	PAR-CLIP	20371350
MIRT451425	hsa-miR-6127	PAR-CLIP	20371350
MIRT451424	hsa-miR-6129	PAR-CLIP	20371350
MIRT451423	hsa-miR-6130	PAR-CLIP	20371350
MIRT451422	hsa-miR-6133	PAR-CLIP	20371350
MIRT451421	hsa-miR-184	PAR-CLIP	20371350
MIRT451420	hsa-miR-4434	PAR-CLIP	20371350
MIRT451419	hsa-miR-4516	PAR-CLIP	20371350
MIRT451418	hsa-miR-5703	PAR-CLIP	20371350
MIRT451417	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT451416	hsa-miR-1249-5p	PAR-CLIP	20371350
MIRT451415	hsa-miR-6797-5p	PAR-CLIP	20371350
MIRT451414	hsa-miR-6878-5p	PAR-CLIP	20371350
MIRT451413	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT451412	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT451411	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT451409	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT451410	hsa-miR-6746-5p	PAR-CLIP	20371350
MIRT451441	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT451440	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT451439	hsa-miR-4323	PAR-CLIP	23592263
MIRT451438	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT451437	hsa-miR-1321	PAR-CLIP	23592263
MIRT451436	hsa-miR-4739	PAR-CLIP	23592263
MIRT451435	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT451433	hsa-miR-4270	PAR-CLIP	23592263
MIRT451434	hsa-miR-4441	PAR-CLIP	23592263
MIRT451432	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT451431	hsa-miR-7113-5p	PAR-CLIP	23592263
MIRT451430	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT451429	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT451428	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT451427	hsa-miR-4419a	PAR-CLIP	23592263
MIRT451426	hsa-miR-4510	PAR-CLIP	23592263
MIRT451425	hsa-miR-6127	PAR-CLIP	23592263
MIRT451424	hsa-miR-6129	PAR-CLIP	23592263
MIRT451423	hsa-miR-6130	PAR-CLIP	23592263
MIRT451422	hsa-miR-6133	PAR-CLIP	23592263
MIRT451421	hsa-miR-184	PAR-CLIP	23592263
MIRT451420	hsa-miR-4434	PAR-CLIP	23592263
MIRT451419	hsa-miR-4516	PAR-CLIP	23592263
MIRT451418	hsa-miR-5703	PAR-CLIP	23592263
MIRT451417	hsa-miR-7154-3p	PAR-CLIP	23592263
MIRT451416	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT451415	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT451414	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT451413	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT451412	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT451411	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT451409	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT451410	hsa-miR-6746-5p	PAR-CLIP	23592263

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	18823282, 33864728
GO:0005634	Component	Nucleus	IDA	18823282
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005911	Component	Cell-cell junction	IEA
GO:0005923	Component	Bicellular tight junction	IBA
GO:0005923	Component	Bicellular tight junction	IDA	18823282
GO:0005923	Component	Bicellular tight junction	IEA
GO:0016020	Component	Membrane	IEA
GO:0030054	Component	Cell junction	IDA
GO:0035633	Process	Maintenance of blood-brain barrier	NAS	30280653
GO:0045216	Process	Cell-cell junction organization	IBA
GO:0050839	Function	Cell adhesion molecule binding	IBA
GO:0070160	Component	Tight junction	IEA
GO:0070161	Component	Anchoring junction	IEA
GO:0090557	Process	Establishment of endothelial intestinal barrier	IBA
GO:0098609	Process	Cell-cell adhesion	IBA
GO:0150105	Process	Protein localization to cell-cell junction	IBA
GO:1905605	Process	Positive regulation of blood-brain barrier permeability	IBA

MIM	HGNC	e!Ensembl
612689	11829	ENSG00000105289

O95049

Protein name

Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3)

Protein function

TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts

PDB

3KFV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00595	PDZ	11 → 90	PDZ domain	Domain
PF00595	PDZ	195 → 269	PDZ domain	Domain
PF00595	PDZ	381 → 459	PDZ domain	Domain
PF07653	SH3_2	479 → 547	Variant SH3 domain	Domain
PF00625	Guanylate_kin	658 → 763	Guanylate kinase	Domain

Sequence

MEELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPAEGRLQTGDHIVM
VNGVSMENATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQR
VEEVDQGRGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALVSGF
KRLPRQDVQMKPVKSVLVKRRDSEEFGVKLGSQIFIKHITDSGLAARHRGLQEGDLILQI
NGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSDSSPLEDISDLASE
LSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESS
YDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIGLRLAGGNDVGIFVSGVQAGSPADGQGI
QEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKMVQSRVGDSFYI
RTHFELEPSPPSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMGRDLREQERGIIP
NQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAKKTTQRSREDLSALTR
QGRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEIAETVSRTDSPSKIIK
LDTVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRS
TRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIWTAEDQLDGSLE
DNLDLPHHGLADSSADLSCDSRVNSDYETDGEGGAYTDGEGYTDGEGGPYTDVDDEPPAP
ALARSSEPVQADESQSPRDRGRISAHQGAQVDSRHPQGQWRQDSMRTYEREALKKKFMRV
HDAESSDEDGYDWGPATDL

Sequence length

919

Interactions

View interactions

	KEGG
	Tight junction

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTISM SPECTRUM DISORDER	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIFFUSE GASTRIC ADENOCARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MELANOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	37950731	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	17585317	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Breast Carcinoma	Breast Cancer	BEFREE	20830311		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	CTD_human_DG	17013881		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	32945443	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	CTD_human_DG	17013881		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Rhinitis Allergic	Rhinitis	Pubtator	35480562	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

TJP3 (tight junction protein 3)