Gene Gene information from NCBI Gene database.
Entrez ID 27131
Gene name Sorting nexin 5
Gene symbol SNX5
Synonyms (NCBI Gene)
-
Chromosome 20
Chromosome location 20p11.23
Summary This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoi
miRNA miRNA information provided by mirtarbase database.
455
miRTarBase ID miRNA Experiments Reference
MIRT027465 hsa-miR-98-5p Microarray 19088304
MIRT039538 hsa-miR-652-3p CLASH 23622248
MIRT498068 hsa-miR-454-3p PAR-CLIP 20371350
MIRT498067 hsa-miR-301b-3p PAR-CLIP 20371350
MIRT498066 hsa-miR-3666 PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
52
GO ID Ontology Definition Evidence Reference
GO:0001726 Component Ruffle IEA
GO:0001891 Component Phagocytic cup IEA
GO:0005515 Function Protein binding IPI 19619496, 21988832, 23085988, 25416956, 25588945, 28514442, 32296183, 33961781, 35271311, 39073202
GO:0005737 Component Cytoplasm IEA
GO:0005768 Component Endosome IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605937 14969 ENSG00000089006
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y5X3
Protein name Sorting nexin-5
Protein function Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of t
PDB 1SYS , 5TGH , 5TGI , 5TGJ , 5WY2 , 6N5X , 6N5Y , 6N5Z , 8A1G , 8ABQ , 8AFZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00787 PX 55 169 PX domain Domain
PF09325 Vps5 179 398 Vps5 C terminal like Domain
Sequence
Sequence length 404
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Endocytosis   Golgi Associated Vesicle Biogenesis
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
STOMACH NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Differentiated Thyroid Gland Carcinoma Thyroid Carcinoma BEFREE 28771744
★☆☆☆☆
Found in Text Mining only
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) Anemia BEFREE 10600472
★☆☆☆☆
Found in Text Mining only
Glioma Glioma Pubtator 33982667 Associate
★☆☆☆☆
Found in Text Mining only
Hereditary Diffuse Gastric Cancer Gastric Cancer CTD_human_DG 21364753
★☆☆☆☆
Found in Text Mining only
Hyperinsulinism Hyperinsulinism BEFREE 29080975
★☆☆☆☆
Found in Text Mining only
Hypertensive disease Hypertension BEFREE 29080975
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma BEFREE 31819169
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of stomach Stomach Neoplasms CTD_human_DG 21364753
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of thyroid Thyroid cancer BEFREE 28771744
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 10600472
★☆☆☆☆
Found in Text Mining only