Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	27102
Gene name	Eukaryotic translation initiation factor 2 alpha kinase 1
Gene symbol	EIF2AK1
Synonyms (NCBI Gene)	HCRHRILEMSPADhHRI
Chromosome	7
Chromosome location	7p22.1
Summary	The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms hav

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024150	hsa-miR-221-3p	Sequencing	20371350
MIRT025934	hsa-miR-7-5p	Microarray	19073608
MIRT052113	hsa-let-7b-5p	CLASH	23622248
MIRT049608	hsa-miR-92a-3p	CLASH	23622248
MIRT040713	hsa-miR-92b-3p	CLASH	23622248
MIRT038895	hsa-miR-93-3p	CLASH	23622248
MIRT956364	hsa-miR-1	CLIP-seq
MIRT956365	hsa-miR-1185	CLIP-seq
MIRT956366	hsa-miR-1207-3p	CLIP-seq
MIRT956367	hsa-miR-1207-5p	CLIP-seq
MIRT956368	hsa-miR-1224-5p	CLIP-seq
MIRT956369	hsa-miR-1254	CLIP-seq
MIRT956370	hsa-miR-1255a	CLIP-seq
MIRT956371	hsa-miR-1255b	CLIP-seq
MIRT956372	hsa-miR-1270	CLIP-seq
MIRT956373	hsa-miR-1273g	CLIP-seq
MIRT956374	hsa-miR-132	CLIP-seq
MIRT956375	hsa-miR-1323	CLIP-seq
MIRT956376	hsa-miR-1324	CLIP-seq
MIRT956377	hsa-miR-148a	CLIP-seq
MIRT956378	hsa-miR-148b	CLIP-seq
MIRT956379	hsa-miR-152	CLIP-seq
MIRT956380	hsa-miR-1538	CLIP-seq
MIRT956381	hsa-miR-1825	CLIP-seq
MIRT956382	hsa-miR-185	CLIP-seq
MIRT956383	hsa-miR-1909	CLIP-seq
MIRT956384	hsa-miR-196a	CLIP-seq
MIRT956385	hsa-miR-196b	CLIP-seq
MIRT956386	hsa-miR-199a-5p	CLIP-seq
MIRT956387	hsa-miR-199b-5p	CLIP-seq
MIRT956388	hsa-miR-206	CLIP-seq
MIRT956389	hsa-miR-212	CLIP-seq
MIRT956390	hsa-miR-219-1-3p	CLIP-seq
MIRT956391	hsa-miR-22	CLIP-seq
MIRT956392	hsa-miR-221	CLIP-seq
MIRT956393	hsa-miR-222	CLIP-seq
MIRT956394	hsa-miR-28-5p	CLIP-seq
MIRT956395	hsa-miR-302f	CLIP-seq
MIRT956396	hsa-miR-3116	CLIP-seq
MIRT956397	hsa-miR-3125	CLIP-seq
MIRT956398	hsa-miR-3139	CLIP-seq
MIRT956399	hsa-miR-3151	CLIP-seq
MIRT956400	hsa-miR-3157-3p	CLIP-seq
MIRT956401	hsa-miR-3160-3p	CLIP-seq
MIRT956402	hsa-miR-3168	CLIP-seq
MIRT956403	hsa-miR-3173-3p	CLIP-seq
MIRT956404	hsa-miR-3174	CLIP-seq
MIRT956405	hsa-miR-3192	CLIP-seq
MIRT956406	hsa-miR-3200-5p	CLIP-seq
MIRT956407	hsa-miR-331-5p	CLIP-seq
MIRT956408	hsa-miR-338-5p	CLIP-seq
MIRT956409	hsa-miR-34a	CLIP-seq
MIRT956410	hsa-miR-34c-5p	CLIP-seq
MIRT956411	hsa-miR-3605-5p	CLIP-seq
MIRT956412	hsa-miR-3613-3p	CLIP-seq
MIRT956413	hsa-miR-3616-3p	CLIP-seq
MIRT956414	hsa-miR-3673	CLIP-seq
MIRT956415	hsa-miR-3679-5p	CLIP-seq
MIRT956416	hsa-miR-3691-3p	CLIP-seq
MIRT956417	hsa-miR-3714	CLIP-seq
MIRT956418	hsa-miR-3915	CLIP-seq
MIRT956419	hsa-miR-3916	CLIP-seq
MIRT956420	hsa-miR-3919	CLIP-seq
MIRT956421	hsa-miR-3925-5p	CLIP-seq
MIRT956422	hsa-miR-3927	CLIP-seq
MIRT956423	hsa-miR-3942-3p	CLIP-seq
MIRT956424	hsa-miR-3944-5p	CLIP-seq
MIRT956425	hsa-miR-421	CLIP-seq
MIRT956426	hsa-miR-4254	CLIP-seq
MIRT956427	hsa-miR-4265	CLIP-seq
MIRT956428	hsa-miR-4270	CLIP-seq
MIRT956429	hsa-miR-4282	CLIP-seq
MIRT956430	hsa-miR-4290	CLIP-seq
MIRT956431	hsa-miR-4291	CLIP-seq
MIRT956432	hsa-miR-4296	CLIP-seq
MIRT956433	hsa-miR-4302	CLIP-seq
MIRT956434	hsa-miR-4303	CLIP-seq
MIRT956435	hsa-miR-4306	CLIP-seq
MIRT956436	hsa-miR-4311	CLIP-seq
MIRT956437	hsa-miR-4314	CLIP-seq
MIRT956438	hsa-miR-4322	CLIP-seq
MIRT956439	hsa-miR-4428	CLIP-seq
MIRT956440	hsa-miR-4436b-3p	CLIP-seq
MIRT956441	hsa-miR-4441	CLIP-seq
MIRT956442	hsa-miR-4447	CLIP-seq
MIRT956443	hsa-miR-4455	CLIP-seq
MIRT956444	hsa-miR-4463	CLIP-seq
MIRT956445	hsa-miR-4472	CLIP-seq
MIRT956446	hsa-miR-4487	CLIP-seq
MIRT956447	hsa-miR-4496	CLIP-seq
MIRT956448	hsa-miR-449a	CLIP-seq
MIRT956449	hsa-miR-449b	CLIP-seq
MIRT956450	hsa-miR-450b-5p	CLIP-seq
MIRT956451	hsa-miR-455-3p	CLIP-seq
MIRT956452	hsa-miR-455-5p	CLIP-seq
MIRT956453	hsa-miR-4644	CLIP-seq
MIRT956454	hsa-miR-4646-5p	CLIP-seq
MIRT956455	hsa-miR-4648	CLIP-seq
MIRT956456	hsa-miR-4654	CLIP-seq
MIRT956457	hsa-miR-4655-5p	CLIP-seq
MIRT956458	hsa-miR-4683	CLIP-seq
MIRT956459	hsa-miR-4688	CLIP-seq
MIRT956460	hsa-miR-4689	CLIP-seq
MIRT956461	hsa-miR-4708-3p	CLIP-seq
MIRT956462	hsa-miR-4709-5p	CLIP-seq
MIRT956463	hsa-miR-4724-3p	CLIP-seq
MIRT956464	hsa-miR-4734	CLIP-seq
MIRT956465	hsa-miR-4745-3p	CLIP-seq
MIRT956466	hsa-miR-4747-3p	CLIP-seq
MIRT956467	hsa-miR-4756-3p	CLIP-seq
MIRT956468	hsa-miR-4763-3p	CLIP-seq
MIRT956469	hsa-miR-4769-5p	CLIP-seq
MIRT956470	hsa-miR-4773	CLIP-seq
MIRT956471	hsa-miR-4777-5p	CLIP-seq
MIRT956472	hsa-miR-4797-5p	CLIP-seq
MIRT956473	hsa-miR-486-3p	CLIP-seq
MIRT956474	hsa-miR-487a	CLIP-seq
MIRT956475	hsa-miR-488	CLIP-seq
MIRT956476	hsa-miR-491-5p	CLIP-seq
MIRT956477	hsa-miR-493	CLIP-seq
MIRT956478	hsa-miR-496	CLIP-seq
MIRT956479	hsa-miR-505	CLIP-seq
MIRT956480	hsa-miR-518d-5p	CLIP-seq
MIRT956481	hsa-miR-519b-5p	CLIP-seq
MIRT956482	hsa-miR-519c-5p	CLIP-seq
MIRT956483	hsa-miR-520c-5p	CLIP-seq
MIRT956484	hsa-miR-526a	CLIP-seq
MIRT956485	hsa-miR-544	CLIP-seq
MIRT956486	hsa-miR-545	CLIP-seq
MIRT956487	hsa-miR-548a-3p	CLIP-seq
MIRT956488	hsa-miR-548aa	CLIP-seq
MIRT956489	hsa-miR-548ac	CLIP-seq
MIRT956490	hsa-miR-548an	CLIP-seq
MIRT956491	hsa-miR-548d-3p	CLIP-seq
MIRT956492	hsa-miR-548e	CLIP-seq
MIRT956493	hsa-miR-548f	CLIP-seq
MIRT956494	hsa-miR-548g	CLIP-seq
MIRT956495	hsa-miR-548o	CLIP-seq
MIRT956496	hsa-miR-548p	CLIP-seq
MIRT956497	hsa-miR-548v	CLIP-seq
MIRT956498	hsa-miR-548z	CLIP-seq
MIRT956499	hsa-miR-558	CLIP-seq
MIRT956500	hsa-miR-577	CLIP-seq
MIRT956501	hsa-miR-579	CLIP-seq
MIRT956502	hsa-miR-584	CLIP-seq
MIRT956503	hsa-miR-613	CLIP-seq
MIRT956504	hsa-miR-616	CLIP-seq
MIRT956505	hsa-miR-620	CLIP-seq
MIRT956506	hsa-miR-635	CLIP-seq
MIRT956507	hsa-miR-661	CLIP-seq
MIRT956508	hsa-miR-7	CLIP-seq
MIRT956509	hsa-miR-708	CLIP-seq
MIRT956510	hsa-miR-873	CLIP-seq
MIRT956511	hsa-miR-874	CLIP-seq
MIRT956512	hsa-miR-877	CLIP-seq
MIRT956513	hsa-miR-885-3p	CLIP-seq
MIRT956514	hsa-miR-889	CLIP-seq
MIRT956515	hsa-miR-940	CLIP-seq
MIRT956365	hsa-miR-1185	CLIP-seq
MIRT956367	hsa-miR-1207-5p	CLIP-seq
MIRT956368	hsa-miR-1224-5p	CLIP-seq
MIRT956516	hsa-miR-1252	CLIP-seq
MIRT956369	hsa-miR-1254	CLIP-seq
MIRT956370	hsa-miR-1255a	CLIP-seq
MIRT956371	hsa-miR-1255b	CLIP-seq
MIRT956372	hsa-miR-1270	CLIP-seq
MIRT956517	hsa-miR-1272	CLIP-seq
MIRT956373	hsa-miR-1273g	CLIP-seq
MIRT956376	hsa-miR-1324	CLIP-seq
MIRT956380	hsa-miR-1538	CLIP-seq
MIRT956518	hsa-miR-1827	CLIP-seq
MIRT956382	hsa-miR-185	CLIP-seq
MIRT956519	hsa-miR-190	CLIP-seq
MIRT956520	hsa-miR-190b	CLIP-seq
MIRT956521	hsa-miR-203	CLIP-seq
MIRT956522	hsa-miR-205	CLIP-seq
MIRT956523	hsa-miR-2052	CLIP-seq
MIRT956390	hsa-miR-219-1-3p	CLIP-seq
MIRT956391	hsa-miR-22	CLIP-seq
MIRT956392	hsa-miR-221	CLIP-seq
MIRT956393	hsa-miR-222	CLIP-seq
MIRT956524	hsa-miR-298	CLIP-seq
MIRT956525	hsa-miR-299-5p	CLIP-seq
MIRT956396	hsa-miR-3116	CLIP-seq
MIRT956397	hsa-miR-3125	CLIP-seq
MIRT956403	hsa-miR-3173-3p	CLIP-seq
MIRT956526	hsa-miR-3182	CLIP-seq
MIRT956527	hsa-miR-3186-5p	CLIP-seq
MIRT956528	hsa-miR-3197	CLIP-seq
MIRT956408	hsa-miR-338-5p	CLIP-seq
MIRT956529	hsa-miR-342-5p	CLIP-seq
MIRT956409	hsa-miR-34a	CLIP-seq
MIRT956410	hsa-miR-34c-5p	CLIP-seq
MIRT956411	hsa-miR-3605-5p	CLIP-seq
MIRT956413	hsa-miR-3616-3p	CLIP-seq
MIRT956530	hsa-miR-3653	CLIP-seq
MIRT956531	hsa-miR-3658	CLIP-seq
MIRT956415	hsa-miR-3679-5p	CLIP-seq
MIRT956416	hsa-miR-3691-3p	CLIP-seq
MIRT956418	hsa-miR-3915	CLIP-seq
MIRT956419	hsa-miR-3916	CLIP-seq
MIRT956420	hsa-miR-3919	CLIP-seq
MIRT956421	hsa-miR-3925-5p	CLIP-seq
MIRT956423	hsa-miR-3942-3p	CLIP-seq
MIRT956424	hsa-miR-3944-5p	CLIP-seq
MIRT956425	hsa-miR-421	CLIP-seq
MIRT956426	hsa-miR-4254	CLIP-seq
MIRT956428	hsa-miR-4270	CLIP-seq
MIRT956435	hsa-miR-4306	CLIP-seq
MIRT956439	hsa-miR-4428	CLIP-seq
MIRT956440	hsa-miR-4436b-3p	CLIP-seq
MIRT956441	hsa-miR-4441	CLIP-seq
MIRT956443	hsa-miR-4455	CLIP-seq
MIRT956532	hsa-miR-4464	CLIP-seq
MIRT956533	hsa-miR-4466	CLIP-seq
MIRT956448	hsa-miR-449a	CLIP-seq
MIRT956449	hsa-miR-449b	CLIP-seq
MIRT956450	hsa-miR-450b-5p	CLIP-seq
MIRT956452	hsa-miR-455-5p	CLIP-seq
MIRT956453	hsa-miR-4644	CLIP-seq
MIRT956534	hsa-miR-4651	CLIP-seq
MIRT956457	hsa-miR-4655-5p	CLIP-seq
MIRT956535	hsa-miR-4664-5p	CLIP-seq
MIRT956536	hsa-miR-4667-5p	CLIP-seq
MIRT956458	hsa-miR-4683	CLIP-seq
MIRT956460	hsa-miR-4689	CLIP-seq
MIRT956537	hsa-miR-4700-5p	CLIP-seq
MIRT956461	hsa-miR-4708-3p	CLIP-seq
MIRT956462	hsa-miR-4709-5p	CLIP-seq
MIRT956463	hsa-miR-4724-3p	CLIP-seq
MIRT956464	hsa-miR-4734	CLIP-seq
MIRT956465	hsa-miR-4745-3p	CLIP-seq
MIRT956466	hsa-miR-4747-3p	CLIP-seq
MIRT956538	hsa-miR-4748	CLIP-seq
MIRT956467	hsa-miR-4756-3p	CLIP-seq
MIRT956468	hsa-miR-4763-3p	CLIP-seq
MIRT956470	hsa-miR-4773	CLIP-seq
MIRT956471	hsa-miR-4777-5p	CLIP-seq
MIRT956539	hsa-miR-4781-3p	CLIP-seq
MIRT956472	hsa-miR-4797-5p	CLIP-seq
MIRT956475	hsa-miR-488	CLIP-seq
MIRT956477	hsa-miR-493	CLIP-seq
MIRT956478	hsa-miR-496	CLIP-seq
MIRT956479	hsa-miR-505	CLIP-seq
MIRT956480	hsa-miR-518d-5p	CLIP-seq
MIRT956481	hsa-miR-519b-5p	CLIP-seq
MIRT956482	hsa-miR-519c-5p	CLIP-seq
MIRT956483	hsa-miR-520c-5p	CLIP-seq
MIRT956540	hsa-miR-520d-5p	CLIP-seq
MIRT956541	hsa-miR-524-5p	CLIP-seq
MIRT956484	hsa-miR-526a	CLIP-seq
MIRT956485	hsa-miR-544	CLIP-seq
MIRT956497	hsa-miR-548v	CLIP-seq
MIRT956499	hsa-miR-558	CLIP-seq
MIRT956500	hsa-miR-577	CLIP-seq
MIRT956502	hsa-miR-584	CLIP-seq
MIRT956542	hsa-miR-608	CLIP-seq
MIRT956505	hsa-miR-620	CLIP-seq
MIRT956506	hsa-miR-635	CLIP-seq
MIRT956543	hsa-miR-637	CLIP-seq
MIRT956544	hsa-miR-658	CLIP-seq
MIRT956507	hsa-miR-661	CLIP-seq
MIRT956545	hsa-miR-675	CLIP-seq
MIRT956508	hsa-miR-7	CLIP-seq
MIRT956512	hsa-miR-877	CLIP-seq
MIRT956514	hsa-miR-889	CLIP-seq
MIRT956546	hsa-miR-922	CLIP-seq
MIRT1548260	hsa-miR-145	CLIP-seq
MIRT1548261	hsa-miR-181a	CLIP-seq
MIRT1548262	hsa-miR-181b	CLIP-seq
MIRT1548263	hsa-miR-181c	CLIP-seq
MIRT1548264	hsa-miR-181d	CLIP-seq
MIRT1548265	hsa-miR-4262	CLIP-seq
MIRT956429	hsa-miR-4282	CLIP-seq
MIRT1548266	hsa-miR-548c-3p	CLIP-seq
MIRT1548267	hsa-miR-548n	CLIP-seq
MIRT1548268	hsa-miR-548t	CLIP-seq
MIRT1548269	hsa-miR-606	CLIP-seq
MIRT1983245	hsa-miR-1208	CLIP-seq
MIRT956517	hsa-miR-1272	CLIP-seq
MIRT956376	hsa-miR-1324	CLIP-seq
MIRT956382	hsa-miR-185	CLIP-seq
MIRT1983246	hsa-miR-199a-3p	CLIP-seq
MIRT1983247	hsa-miR-199b-3p	CLIP-seq
MIRT956521	hsa-miR-203	CLIP-seq
MIRT956522	hsa-miR-205	CLIP-seq
MIRT956397	hsa-miR-3125	CLIP-seq
MIRT1983248	hsa-miR-3126-5p	CLIP-seq
MIRT1983249	hsa-miR-3129-5p	CLIP-seq
MIRT1983250	hsa-miR-3150a-3p	CLIP-seq
MIRT1983251	hsa-miR-3175	CLIP-seq
MIRT956527	hsa-miR-3186-5p	CLIP-seq
MIRT956528	hsa-miR-3197	CLIP-seq
MIRT1983252	hsa-miR-3652	CLIP-seq
MIRT956530	hsa-miR-3653	CLIP-seq
MIRT956531	hsa-miR-3658	CLIP-seq
MIRT956419	hsa-miR-3916	CLIP-seq
MIRT1983253	hsa-miR-3921	CLIP-seq
MIRT956421	hsa-miR-3925-5p	CLIP-seq
MIRT1983254	hsa-miR-4300	CLIP-seq
MIRT956435	hsa-miR-4306	CLIP-seq
MIRT1983255	hsa-miR-4419a	CLIP-seq
MIRT1983256	hsa-miR-4430	CLIP-seq
MIRT1983257	hsa-miR-4505	CLIP-seq
MIRT1983258	hsa-miR-4510	CLIP-seq
MIRT956453	hsa-miR-4644	CLIP-seq
MIRT1983259	hsa-miR-4649-3p	CLIP-seq
MIRT1983260	hsa-miR-4653-5p	CLIP-seq
MIRT956536	hsa-miR-4667-5p	CLIP-seq
MIRT956537	hsa-miR-4700-5p	CLIP-seq
MIRT956463	hsa-miR-4724-3p	CLIP-seq
MIRT1983261	hsa-miR-4731-5p	CLIP-seq
MIRT956464	hsa-miR-4734	CLIP-seq
MIRT956471	hsa-miR-4777-5p	CLIP-seq
MIRT956480	hsa-miR-518d-5p	CLIP-seq
MIRT956481	hsa-miR-519b-5p	CLIP-seq
MIRT956482	hsa-miR-519c-5p	CLIP-seq
MIRT956483	hsa-miR-520c-5p	CLIP-seq
MIRT956484	hsa-miR-526a	CLIP-seq
MIRT956485	hsa-miR-544	CLIP-seq
MIRT956494	hsa-miR-548g	CLIP-seq
MIRT1983262	hsa-miR-639	CLIP-seq
MIRT1983263	hsa-miR-647	CLIP-seq
MIRT956508	hsa-miR-7	CLIP-seq
MIRT956512	hsa-miR-877	CLIP-seq
MIRT1983264	hsa-miR-920	CLIP-seq
MIRT1983265	hsa-miR-936	CLIP-seq
MIRT1983266	hsa-miR-939	CLIP-seq
MIRT956368	hsa-miR-1224-5p	CLIP-seq
MIRT956418	hsa-miR-3915	CLIP-seq
MIRT956460	hsa-miR-4689	CLIP-seq
MIRT956366	hsa-miR-1207-3p	CLIP-seq
MIRT956367	hsa-miR-1207-5p	CLIP-seq
MIRT1983245	hsa-miR-1208	CLIP-seq
MIRT956369	hsa-miR-1254	CLIP-seq
MIRT2218483	hsa-miR-1264	CLIP-seq
MIRT956372	hsa-miR-1270	CLIP-seq
MIRT956517	hsa-miR-1272	CLIP-seq
MIRT2218484	hsa-miR-1295	CLIP-seq
MIRT956374	hsa-miR-132	CLIP-seq
MIRT956376	hsa-miR-1324	CLIP-seq
MIRT956377	hsa-miR-148a	CLIP-seq
MIRT956378	hsa-miR-148b	CLIP-seq
MIRT956379	hsa-miR-152	CLIP-seq
MIRT956380	hsa-miR-1538	CLIP-seq
MIRT956381	hsa-miR-1825	CLIP-seq
MIRT956383	hsa-miR-1909	CLIP-seq
MIRT2218485	hsa-miR-193a-3p	CLIP-seq
MIRT2218486	hsa-miR-193b	CLIP-seq
MIRT956384	hsa-miR-196a	CLIP-seq
MIRT956385	hsa-miR-196b	CLIP-seq
MIRT956386	hsa-miR-199a-5p	CLIP-seq
MIRT956387	hsa-miR-199b-5p	CLIP-seq
MIRT956521	hsa-miR-203	CLIP-seq
MIRT956522	hsa-miR-205	CLIP-seq
MIRT956389	hsa-miR-212	CLIP-seq
MIRT956390	hsa-miR-219-1-3p	CLIP-seq
MIRT956391	hsa-miR-22	CLIP-seq
MIRT2218487	hsa-miR-2355-5p	CLIP-seq
MIRT956394	hsa-miR-28-5p	CLIP-seq
MIRT956396	hsa-miR-3116	CLIP-seq
MIRT956397	hsa-miR-3125	CLIP-seq
MIRT1983248	hsa-miR-3126-5p	CLIP-seq
MIRT2218488	hsa-miR-3127-3p	CLIP-seq
MIRT956398	hsa-miR-3139	CLIP-seq
MIRT956399	hsa-miR-3151	CLIP-seq
MIRT956401	hsa-miR-3160-3p	CLIP-seq
MIRT956404	hsa-miR-3174	CLIP-seq
MIRT956527	hsa-miR-3186-5p	CLIP-seq
MIRT956528	hsa-miR-3197	CLIP-seq
MIRT956406	hsa-miR-3200-5p	CLIP-seq
MIRT2218489	hsa-miR-323-5p	CLIP-seq
MIRT956407	hsa-miR-331-5p	CLIP-seq
MIRT956529	hsa-miR-342-5p	CLIP-seq
MIRT956409	hsa-miR-34a	CLIP-seq
MIRT956410	hsa-miR-34c-5p	CLIP-seq
MIRT956412	hsa-miR-3613-3p	CLIP-seq
MIRT956413	hsa-miR-3616-3p	CLIP-seq
MIRT956530	hsa-miR-3653	CLIP-seq
MIRT956531	hsa-miR-3658	CLIP-seq
MIRT2218490	hsa-miR-3660	CLIP-seq
MIRT2218491	hsa-miR-3665	CLIP-seq
MIRT2218492	hsa-miR-3688-5p	CLIP-seq
MIRT956416	hsa-miR-3691-3p	CLIP-seq
MIRT956417	hsa-miR-3714	CLIP-seq
MIRT2218493	hsa-miR-3913-3p	CLIP-seq
MIRT956419	hsa-miR-3916	CLIP-seq
MIRT956420	hsa-miR-3919	CLIP-seq
MIRT1983253	hsa-miR-3921	CLIP-seq
MIRT956422	hsa-miR-3927	CLIP-seq
MIRT956423	hsa-miR-3942-3p	CLIP-seq
MIRT956424	hsa-miR-3944-5p	CLIP-seq
MIRT956425	hsa-miR-421	CLIP-seq
MIRT956426	hsa-miR-4254	CLIP-seq
MIRT956427	hsa-miR-4265	CLIP-seq
MIRT956428	hsa-miR-4270	CLIP-seq
MIRT956429	hsa-miR-4282	CLIP-seq
MIRT2218494	hsa-miR-4286	CLIP-seq
MIRT956431	hsa-miR-4291	CLIP-seq
MIRT956432	hsa-miR-4296	CLIP-seq
MIRT956433	hsa-miR-4302	CLIP-seq
MIRT956434	hsa-miR-4303	CLIP-seq
MIRT956436	hsa-miR-4311	CLIP-seq
MIRT956438	hsa-miR-4322	CLIP-seq
MIRT1983255	hsa-miR-4419a	CLIP-seq
MIRT956439	hsa-miR-4428	CLIP-seq
MIRT956440	hsa-miR-4436b-3p	CLIP-seq
MIRT956441	hsa-miR-4441	CLIP-seq
MIRT956442	hsa-miR-4447	CLIP-seq
MIRT956532	hsa-miR-4464	CLIP-seq
MIRT956533	hsa-miR-4466	CLIP-seq
MIRT956445	hsa-miR-4472	CLIP-seq
MIRT956446	hsa-miR-4487	CLIP-seq
MIRT956447	hsa-miR-4496	CLIP-seq
MIRT956448	hsa-miR-449a	CLIP-seq
MIRT956449	hsa-miR-449b	CLIP-seq
MIRT956450	hsa-miR-450b-5p	CLIP-seq
MIRT1983258	hsa-miR-4510	CLIP-seq
MIRT2218495	hsa-miR-4526	CLIP-seq
MIRT2218496	hsa-miR-4527	CLIP-seq
MIRT956451	hsa-miR-455-3p	CLIP-seq
MIRT956452	hsa-miR-455-5p	CLIP-seq
MIRT1983259	hsa-miR-4649-3p	CLIP-seq
MIRT956534	hsa-miR-4651	CLIP-seq
MIRT1983260	hsa-miR-4653-5p	CLIP-seq
MIRT956535	hsa-miR-4664-5p	CLIP-seq
MIRT956536	hsa-miR-4667-5p	CLIP-seq
MIRT956458	hsa-miR-4683	CLIP-seq
MIRT956459	hsa-miR-4688	CLIP-seq
MIRT956537	hsa-miR-4700-5p	CLIP-seq
MIRT2218497	hsa-miR-4701-5p	CLIP-seq
MIRT956461	hsa-miR-4708-3p	CLIP-seq
MIRT956462	hsa-miR-4709-5p	CLIP-seq
MIRT2218498	hsa-miR-4714-5p	CLIP-seq
MIRT2218499	hsa-miR-4717-5p	CLIP-seq
MIRT956463	hsa-miR-4724-3p	CLIP-seq
MIRT956465	hsa-miR-4745-3p	CLIP-seq
MIRT956466	hsa-miR-4747-3p	CLIP-seq
MIRT956538	hsa-miR-4748	CLIP-seq
MIRT956467	hsa-miR-4756-3p	CLIP-seq
MIRT2218500	hsa-miR-4760-3p	CLIP-seq
MIRT956468	hsa-miR-4763-3p	CLIP-seq
MIRT956471	hsa-miR-4777-5p	CLIP-seq
MIRT2218501	hsa-miR-4778-5p	CLIP-seq
MIRT956472	hsa-miR-4797-5p	CLIP-seq
MIRT956473	hsa-miR-486-3p	CLIP-seq
MIRT956474	hsa-miR-487a	CLIP-seq
MIRT956475	hsa-miR-488	CLIP-seq
MIRT2218502	hsa-miR-489	CLIP-seq
MIRT956476	hsa-miR-491-5p	CLIP-seq
MIRT956478	hsa-miR-496	CLIP-seq
MIRT956479	hsa-miR-505	CLIP-seq
MIRT956480	hsa-miR-518d-5p	CLIP-seq
MIRT956481	hsa-miR-519b-5p	CLIP-seq
MIRT956482	hsa-miR-519c-5p	CLIP-seq
MIRT956483	hsa-miR-520c-5p	CLIP-seq
MIRT956540	hsa-miR-520d-5p	CLIP-seq
MIRT956541	hsa-miR-524-5p	CLIP-seq
MIRT956484	hsa-miR-526a	CLIP-seq
MIRT956486	hsa-miR-545	CLIP-seq
MIRT956488	hsa-miR-548aa	CLIP-seq
MIRT956489	hsa-miR-548ac	CLIP-seq
MIRT956490	hsa-miR-548an	CLIP-seq
MIRT956491	hsa-miR-548d-3p	CLIP-seq
MIRT956496	hsa-miR-548p	CLIP-seq
MIRT956498	hsa-miR-548z	CLIP-seq
MIRT956499	hsa-miR-558	CLIP-seq
MIRT956502	hsa-miR-584	CLIP-seq
MIRT2218503	hsa-miR-588	CLIP-seq
MIRT956542	hsa-miR-608	CLIP-seq
MIRT956505	hsa-miR-620	CLIP-seq
MIRT956506	hsa-miR-635	CLIP-seq
MIRT956543	hsa-miR-637	CLIP-seq
MIRT1983262	hsa-miR-639	CLIP-seq
MIRT956544	hsa-miR-658	CLIP-seq
MIRT956507	hsa-miR-661	CLIP-seq
MIRT956545	hsa-miR-675	CLIP-seq
MIRT956508	hsa-miR-7	CLIP-seq
MIRT956509	hsa-miR-708	CLIP-seq
MIRT956510	hsa-miR-873	CLIP-seq
MIRT956512	hsa-miR-877	CLIP-seq
MIRT956514	hsa-miR-889	CLIP-seq
MIRT2218504	hsa-miR-892b	CLIP-seq
MIRT956515	hsa-miR-940	CLIP-seq
MIRT956367	hsa-miR-1207-5p	CLIP-seq
MIRT956377	hsa-miR-148a	CLIP-seq
MIRT956378	hsa-miR-148b	CLIP-seq
MIRT956379	hsa-miR-152	CLIP-seq
MIRT956383	hsa-miR-1909	CLIP-seq
MIRT956403	hsa-miR-3173-3p	CLIP-seq
MIRT956409	hsa-miR-34a	CLIP-seq
MIRT956410	hsa-miR-34c-5p	CLIP-seq
MIRT956413	hsa-miR-3616-3p	CLIP-seq
MIRT956417	hsa-miR-3714	CLIP-seq
MIRT956420	hsa-miR-3919	CLIP-seq
MIRT956423	hsa-miR-3942-3p	CLIP-seq
MIRT956428	hsa-miR-4270	CLIP-seq
MIRT956440	hsa-miR-4436b-3p	CLIP-seq
MIRT956441	hsa-miR-4441	CLIP-seq
MIRT956448	hsa-miR-449a	CLIP-seq
MIRT956449	hsa-miR-449b	CLIP-seq
MIRT956457	hsa-miR-4655-5p	CLIP-seq
MIRT956464	hsa-miR-4734	CLIP-seq
MIRT956467	hsa-miR-4756-3p	CLIP-seq
MIRT956468	hsa-miR-4763-3p	CLIP-seq
MIRT956485	hsa-miR-544	CLIP-seq
MIRT956490	hsa-miR-548an	CLIP-seq
MIRT956506	hsa-miR-635	CLIP-seq
MIRT956515	hsa-miR-940	CLIP-seq
MIRT956367	hsa-miR-1207-5p	CLIP-seq
MIRT1983245	hsa-miR-1208	CLIP-seq
MIRT2218483	hsa-miR-1264	CLIP-seq
MIRT956374	hsa-miR-132	CLIP-seq
MIRT956375	hsa-miR-1323	CLIP-seq
MIRT956380	hsa-miR-1538	CLIP-seq
MIRT956381	hsa-miR-1825	CLIP-seq
MIRT956518	hsa-miR-1827	CLIP-seq
MIRT956382	hsa-miR-185	CLIP-seq
MIRT956386	hsa-miR-199a-5p	CLIP-seq
MIRT956387	hsa-miR-199b-5p	CLIP-seq
MIRT956521	hsa-miR-203	CLIP-seq
MIRT956389	hsa-miR-212	CLIP-seq
MIRT956392	hsa-miR-221	CLIP-seq
MIRT956393	hsa-miR-222	CLIP-seq
MIRT956524	hsa-miR-298	CLIP-seq
MIRT1983248	hsa-miR-3126-5p	CLIP-seq
MIRT1983250	hsa-miR-3150a-3p	CLIP-seq
MIRT956401	hsa-miR-3160-3p	CLIP-seq
MIRT956403	hsa-miR-3173-3p	CLIP-seq
MIRT956404	hsa-miR-3174	CLIP-seq
MIRT1983251	hsa-miR-3175	CLIP-seq
MIRT956405	hsa-miR-3192	CLIP-seq
MIRT956408	hsa-miR-338-5p	CLIP-seq
MIRT956409	hsa-miR-34a	CLIP-seq
MIRT956410	hsa-miR-34c-5p	CLIP-seq
MIRT956412	hsa-miR-3613-3p	CLIP-seq
MIRT956413	hsa-miR-3616-3p	CLIP-seq
MIRT1983252	hsa-miR-3652	CLIP-seq
MIRT956530	hsa-miR-3653	CLIP-seq
MIRT956531	hsa-miR-3658	CLIP-seq
MIRT2218493	hsa-miR-3913-3p	CLIP-seq
MIRT1983253	hsa-miR-3921	CLIP-seq
MIRT956421	hsa-miR-3925-5p	CLIP-seq
MIRT956424	hsa-miR-3944-5p	CLIP-seq
MIRT956428	hsa-miR-4270	CLIP-seq
MIRT956429	hsa-miR-4282	CLIP-seq
MIRT1983254	hsa-miR-4300	CLIP-seq
MIRT956435	hsa-miR-4306	CLIP-seq
MIRT956437	hsa-miR-4314	CLIP-seq
MIRT1983255	hsa-miR-4419a	CLIP-seq
MIRT1983256	hsa-miR-4430	CLIP-seq
MIRT956440	hsa-miR-4436b-3p	CLIP-seq
MIRT956441	hsa-miR-4441	CLIP-seq
MIRT956532	hsa-miR-4464	CLIP-seq
MIRT2521962	hsa-miR-4484	CLIP-seq
MIRT956448	hsa-miR-449a	CLIP-seq
MIRT956449	hsa-miR-449b	CLIP-seq
MIRT1983257	hsa-miR-4505	CLIP-seq
MIRT1983258	hsa-miR-4510	CLIP-seq
MIRT956451	hsa-miR-455-3p	CLIP-seq
MIRT956452	hsa-miR-455-5p	CLIP-seq
MIRT956453	hsa-miR-4644	CLIP-seq
MIRT956454	hsa-miR-4646-5p	CLIP-seq
MIRT1983259	hsa-miR-4649-3p	CLIP-seq
MIRT1983260	hsa-miR-4653-5p	CLIP-seq
MIRT956536	hsa-miR-4667-5p	CLIP-seq
MIRT956537	hsa-miR-4700-5p	CLIP-seq
MIRT1983261	hsa-miR-4731-5p	CLIP-seq
MIRT956465	hsa-miR-4745-3p	CLIP-seq
MIRT956466	hsa-miR-4747-3p	CLIP-seq
MIRT956538	hsa-miR-4748	CLIP-seq
MIRT2218500	hsa-miR-4760-3p	CLIP-seq
MIRT956468	hsa-miR-4763-3p	CLIP-seq
MIRT956470	hsa-miR-4773	CLIP-seq
MIRT2218502	hsa-miR-489	CLIP-seq
MIRT956477	hsa-miR-493	CLIP-seq
MIRT956478	hsa-miR-496	CLIP-seq
MIRT956487	hsa-miR-548a-3p	CLIP-seq
MIRT956488	hsa-miR-548aa	CLIP-seq
MIRT956489	hsa-miR-548ac	CLIP-seq
MIRT956490	hsa-miR-548an	CLIP-seq
MIRT1548266	hsa-miR-548c-3p	CLIP-seq
MIRT956491	hsa-miR-548d-3p	CLIP-seq
MIRT956492	hsa-miR-548e	CLIP-seq
MIRT956493	hsa-miR-548f	CLIP-seq
MIRT956494	hsa-miR-548g	CLIP-seq
MIRT956495	hsa-miR-548o	CLIP-seq
MIRT956497	hsa-miR-548v	CLIP-seq
MIRT956498	hsa-miR-548z	CLIP-seq
MIRT956500	hsa-miR-577	CLIP-seq
MIRT956506	hsa-miR-635	CLIP-seq
MIRT1983262	hsa-miR-639	CLIP-seq
MIRT2521963	hsa-miR-643	CLIP-seq
MIRT1983263	hsa-miR-647	CLIP-seq
MIRT956512	hsa-miR-877	CLIP-seq
MIRT956513	hsa-miR-885-3p	CLIP-seq
MIRT1983264	hsa-miR-920	CLIP-seq
MIRT956546	hsa-miR-922	CLIP-seq
MIRT1983266	hsa-miR-939	CLIP-seq
MIRT956367	hsa-miR-1207-5p	CLIP-seq
MIRT1983245	hsa-miR-1208	CLIP-seq
MIRT2218483	hsa-miR-1264	CLIP-seq
MIRT956374	hsa-miR-132	CLIP-seq
MIRT956375	hsa-miR-1323	CLIP-seq
MIRT956380	hsa-miR-1538	CLIP-seq
MIRT956381	hsa-miR-1825	CLIP-seq
MIRT956518	hsa-miR-1827	CLIP-seq
MIRT956382	hsa-miR-185	CLIP-seq
MIRT956386	hsa-miR-199a-5p	CLIP-seq
MIRT956387	hsa-miR-199b-5p	CLIP-seq
MIRT956389	hsa-miR-212	CLIP-seq
MIRT956392	hsa-miR-221	CLIP-seq
MIRT956393	hsa-miR-222	CLIP-seq
MIRT956524	hsa-miR-298	CLIP-seq
MIRT1983248	hsa-miR-3126-5p	CLIP-seq
MIRT1983250	hsa-miR-3150a-3p	CLIP-seq
MIRT956401	hsa-miR-3160-3p	CLIP-seq
MIRT956403	hsa-miR-3173-3p	CLIP-seq
MIRT956404	hsa-miR-3174	CLIP-seq
MIRT1983251	hsa-miR-3175	CLIP-seq
MIRT956405	hsa-miR-3192	CLIP-seq
MIRT956408	hsa-miR-338-5p	CLIP-seq
MIRT956409	hsa-miR-34a	CLIP-seq
MIRT956410	hsa-miR-34c-5p	CLIP-seq
MIRT956412	hsa-miR-3613-3p	CLIP-seq
MIRT956413	hsa-miR-3616-3p	CLIP-seq
MIRT1983252	hsa-miR-3652	CLIP-seq
MIRT956530	hsa-miR-3653	CLIP-seq
MIRT956531	hsa-miR-3658	CLIP-seq
MIRT2218493	hsa-miR-3913-3p	CLIP-seq
MIRT1983253	hsa-miR-3921	CLIP-seq
MIRT956421	hsa-miR-3925-5p	CLIP-seq
MIRT956424	hsa-miR-3944-5p	CLIP-seq
MIRT956428	hsa-miR-4270	CLIP-seq
MIRT1983254	hsa-miR-4300	CLIP-seq
MIRT956435	hsa-miR-4306	CLIP-seq
MIRT956437	hsa-miR-4314	CLIP-seq
MIRT1983255	hsa-miR-4419a	CLIP-seq
MIRT1983256	hsa-miR-4430	CLIP-seq
MIRT956440	hsa-miR-4436b-3p	CLIP-seq
MIRT956441	hsa-miR-4441	CLIP-seq
MIRT956532	hsa-miR-4464	CLIP-seq
MIRT2521962	hsa-miR-4484	CLIP-seq
MIRT956448	hsa-miR-449a	CLIP-seq
MIRT956449	hsa-miR-449b	CLIP-seq
MIRT1983257	hsa-miR-4505	CLIP-seq
MIRT1983258	hsa-miR-4510	CLIP-seq
MIRT956451	hsa-miR-455-3p	CLIP-seq
MIRT956452	hsa-miR-455-5p	CLIP-seq
MIRT956453	hsa-miR-4644	CLIP-seq
MIRT956454	hsa-miR-4646-5p	CLIP-seq
MIRT1983259	hsa-miR-4649-3p	CLIP-seq
MIRT1983260	hsa-miR-4653-5p	CLIP-seq
MIRT956536	hsa-miR-4667-5p	CLIP-seq
MIRT956537	hsa-miR-4700-5p	CLIP-seq
MIRT1983261	hsa-miR-4731-5p	CLIP-seq
MIRT956465	hsa-miR-4745-3p	CLIP-seq
MIRT956466	hsa-miR-4747-3p	CLIP-seq
MIRT956538	hsa-miR-4748	CLIP-seq
MIRT2218500	hsa-miR-4760-3p	CLIP-seq
MIRT956468	hsa-miR-4763-3p	CLIP-seq
MIRT956470	hsa-miR-4773	CLIP-seq
MIRT2218502	hsa-miR-489	CLIP-seq
MIRT956477	hsa-miR-493	CLIP-seq
MIRT956478	hsa-miR-496	CLIP-seq
MIRT956487	hsa-miR-548a-3p	CLIP-seq
MIRT956488	hsa-miR-548aa	CLIP-seq
MIRT956489	hsa-miR-548ac	CLIP-seq
MIRT956490	hsa-miR-548an	CLIP-seq
MIRT956491	hsa-miR-548d-3p	CLIP-seq
MIRT956492	hsa-miR-548e	CLIP-seq
MIRT956493	hsa-miR-548f	CLIP-seq
MIRT956494	hsa-miR-548g	CLIP-seq
MIRT956495	hsa-miR-548o	CLIP-seq
MIRT956497	hsa-miR-548v	CLIP-seq
MIRT956498	hsa-miR-548z	CLIP-seq
MIRT956500	hsa-miR-577	CLIP-seq
MIRT956506	hsa-miR-635	CLIP-seq
MIRT1983262	hsa-miR-639	CLIP-seq
MIRT2521963	hsa-miR-643	CLIP-seq
MIRT1983263	hsa-miR-647	CLIP-seq
MIRT956512	hsa-miR-877	CLIP-seq
MIRT956513	hsa-miR-885-3p	CLIP-seq
MIRT1983264	hsa-miR-920	CLIP-seq
MIRT956546	hsa-miR-922	CLIP-seq
MIRT1983266	hsa-miR-939	CLIP-seq

Show/Hide all (3)

Transcription factor	Regulation	Reference
ELK1	Activation	19133234
EP300	Activation	19133234
HDAC1	Repression	19133234

Show/Hide all (44)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000423	Process	Mitophagy	IDA	38340717
GO:0002526	Process	Acute inflammatory response	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004694	Function	Eukaryotic translation initiation factor 2alpha kinase activity	IBA
GO:0004694	Function	Eukaryotic translation initiation factor 2alpha kinase activity	IDA	11036079, 32132706, 32132707, 37550454, 38340717
GO:0005515	Function	Protein binding	IPI	22939624, 29568061, 31273097, 32132706, 32132707, 32707033
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	32132706, 32132707
GO:0005829	Component	Cytosol	TAS
GO:0006413	Process	Translational initiation	IDA	16289705
GO:0006417	Process	Regulation of translation	IEA
GO:0006417	Process	Regulation of translation	IEA
GO:0006446	Process	Regulation of translational initiation	IBA
GO:0006909	Process	Phagocytosis	IEA
GO:0006950	Process	Response to stress	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0017148	Process	Negative regulation of translation	IEA
GO:0020037	Function	Heme binding	IEA
GO:0020037	Function	Heme binding	ISS
GO:0030225	Process	Macrophage differentiation	IEA
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0045993	Process	Negative regulation of translational initiation by iron	NAS	11036079
GO:0046501	Process	Protoporphyrinogen IX metabolic process	IEA
GO:0046777	Process	Protein autophosphorylation	ISS
GO:0046984	Process	Regulation of hemoglobin biosynthetic process	IEA
GO:0046986	Process	Negative regulation of hemoglobin biosynthetic process	IEA
GO:0046986	Process	Negative regulation of hemoglobin biosynthetic process	ISS
GO:0051649	Process	Establishment of localization in cell	IEA
GO:0060586	Process	Multicellular organismal-level iron ion homeostasis	IEA
GO:0070585	Process	Protein localization to mitochondrion	IDA	38340717
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0140467	Process	Integrated stress response signaling	IDA	32132707
GO:0140468	Process	HRI-mediated signaling	IDA	32132706
GO:0140468	Process	HRI-mediated signaling	IDA	32132706, 32132707, 37550454, 38340717
GO:1901526	Process	Positive regulation of mitophagy	IDA	38340717
GO:1990641	Process	Response to iron ion starvation	IDA	11036079

MIM	HGNC	e!Ensembl
613635	24921	ENSG00000086232

Q9BQI3

Protein name

Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-controlled repressor) (HCR) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (hHRI) (Hemin-sensitive initiation factor 2-alpha kinase)

Protein function

Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:32132706, PubMed:32132707, PubMed:37327776, PubMed:

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	167 → 245	Protein kinase domain	Domain
PF00069	Pkinase	340 → 583	Protein kinase domain	Domain

Sequence

MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP
FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH
NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR
VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI
QPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ
NNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEE
SSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVAT
KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRN
GKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGL
RTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQ
EKEIAELKKQLNLLSQDKGVRDDGKDGGVG

Sequence length

630

Interactions

View interactions

	KEGG
	Hepatitis C Measles Herpes simplex virus 1 infection

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (21)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Adrenocortical carcinoma, hereditary	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANEMIA, HEMOLYTIC	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EIF2AK1-related disorder	Likely benign; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEUKODYSTROPHY, HYPOMYELINATING, 17	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Leukoencephalopathy, motor delay, spasticity, and dysarthria syndrome	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NONALCOHOLIC STEATOHEPATITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPLENOMEGALY	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (41)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia, Hemolytic	Anemia	CTD_human_DG	25411909		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anemia, Hemolytic, Acquired	Anemia	CTD_human_DG	25411909		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia, Microangiopathic	Anemia	CTD_human_DG	25411909		★★★★★ ★☆☆☆☆ Found in Text Mining only
Antisocial Personality Disorder	Antisocial Personality Disorder	BEFREE	29284378, 30967799, 31096835		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis, Psoriatic	Psoriatic Arthritis	BEFREE	17340018		★★★★★ ★☆☆☆☆ Found in Text Mining only
Beta thalassemia intermedia	beta Thalassemia	BEFREE	31554636		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	18559534	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognition disorder	Pubtator	32197074	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatologic disorders	Dermatologic Disorders	BEFREE	14675183		★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	32197074	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dyskinesias	Dyskinesia	Pubtator	32197074	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	2702567		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	27793847		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	27793847		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	23577178		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	23577178	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Failure	Heart failure	Pubtator	32197074	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemoglobinopathies	Hemoglobinopathy	BEFREE	28590739, 30026227		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemoglobinopathies	Hemoglobinopathy	Pubtator	30026227	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemophilia B	Hemophilia	BEFREE	21710610, 25295466		★★★★★ ★☆☆☆☆ Found in Text Mining only
Language Disorders	Language development disorders	Pubtator	32197074	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukodystrophy Metachromatic	Metachromatic leukodystrophy	Pubtator	32197074	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	11101152, 29063813		★★★★★ ★☆☆☆☆ Found in Text Mining only
Microangiopathic hemolytic anemia	Microangiopathic hemolytic anemia	CTD_human_DG	25411909		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial disease	Pubtator	32132707, 33483422	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	28119225	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	28501589		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	GWASDB_DG	21211798		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29063813		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-alcoholic Fatty Liver Disease	Non-Alcoholic Fatty Liver Disease	CTD_human_DG	29289645		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonalcoholic Steatohepatitis	Non-alcoholic Fatty Liver Disease	CTD_human_DG	29289645		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonorganic psychosis	Nonorganic Psychosis	BEFREE	30131743		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	29720726	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	BEFREE	10888604, 11348465, 11875053, 14675183, 15190014, 15214895, 16134125, 17340018, 19551138		★★★★★ ★☆☆☆☆ Found in Text Mining only
Psoriasis vulgaris	Psoriasis vulgaris	BEFREE	12648227, 15214895, 16141233		★★★★★ ★☆☆☆☆ Found in Text Mining only
Psychotic Disorders	Psychosis	BEFREE	30131743		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rectal Carcinoma	Rectal Carcinoma	BEFREE	9459162		★★★★★ ★☆☆☆☆ Found in Text Mining only
Respiratory Distress Syndrome, Adult	Respiratory Distress Syndrome	CTD_human_DG	25070658		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	30131743		★★★★★ ★☆☆☆☆ Found in Text Mining only
Vanishing White Matter Leukodystrophy with Ovarian Failure	Vanishing white matter disease	Pubtator	32197074	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1)