Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	27097
Gene name	TATA-box binding protein associated factor 5 like
Gene symbol	TAF5L
Synonyms (NCBI Gene)	PAF65B
Chromosome	1
Chromosome location	1q42.13
Summary	The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of wh

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miRTarBase ID	miRNA	Experiments	Reference
MIRT020642	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT027492	hsa-miR-98-5p	Microarray	19088304
MIRT052518	hsa-let-7a-5p	CLASH	23622248
MIRT051804	hsa-let-7c-5p	CLASH	23622248
MIRT047279	hsa-miR-181b-5p	CLASH	23622248
MIRT037149	hsa-miR-877-3p	CLASH	23622248
MIRT439487	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439487	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1409604	hsa-miR-1183	CLIP-seq
MIRT1409605	hsa-miR-1245b-3p	CLIP-seq
MIRT1409606	hsa-miR-1257	CLIP-seq
MIRT1409607	hsa-miR-1269	CLIP-seq
MIRT1409608	hsa-miR-1269b	CLIP-seq
MIRT1409609	hsa-miR-1288	CLIP-seq
MIRT1409610	hsa-miR-1292	CLIP-seq
MIRT1409611	hsa-miR-155	CLIP-seq
MIRT1409612	hsa-miR-1825	CLIP-seq
MIRT1409613	hsa-miR-1909	CLIP-seq
MIRT1409614	hsa-miR-1914	CLIP-seq
MIRT1409615	hsa-miR-193a-3p	CLIP-seq
MIRT1409616	hsa-miR-193b	CLIP-seq
MIRT1409617	hsa-miR-199a-5p	CLIP-seq
MIRT1409618	hsa-miR-199b-5p	CLIP-seq
MIRT1409619	hsa-miR-200b	CLIP-seq
MIRT1409620	hsa-miR-200c	CLIP-seq
MIRT1409621	hsa-miR-3065-5p	CLIP-seq
MIRT1409622	hsa-miR-3128	CLIP-seq
MIRT1409623	hsa-miR-3152-3p	CLIP-seq
MIRT1409624	hsa-miR-3176	CLIP-seq
MIRT1409625	hsa-miR-3187-3p	CLIP-seq
MIRT1409626	hsa-miR-3192	CLIP-seq
MIRT1409627	hsa-miR-3201	CLIP-seq
MIRT1409628	hsa-miR-323b-3p	CLIP-seq
MIRT1409629	hsa-miR-3611	CLIP-seq
MIRT1409630	hsa-miR-361-5p	CLIP-seq
MIRT1409631	hsa-miR-3671	CLIP-seq
MIRT1409632	hsa-miR-3682-5p	CLIP-seq
MIRT1409633	hsa-miR-3691-3p	CLIP-seq
MIRT1409634	hsa-miR-3922-3p	CLIP-seq
MIRT1409635	hsa-miR-429	CLIP-seq
MIRT1409636	hsa-miR-4300	CLIP-seq
MIRT1409637	hsa-miR-4302	CLIP-seq
MIRT1409638	hsa-miR-4314	CLIP-seq
MIRT1409639	hsa-miR-4420	CLIP-seq
MIRT1409640	hsa-miR-4471	CLIP-seq
MIRT1409641	hsa-miR-4487	CLIP-seq
MIRT1409642	hsa-miR-4515	CLIP-seq
MIRT1409643	hsa-miR-452	CLIP-seq
MIRT1409644	hsa-miR-4520b-3p	CLIP-seq
MIRT1409645	hsa-miR-4529-3p	CLIP-seq
MIRT1409646	hsa-miR-4529-5p	CLIP-seq
MIRT1409647	hsa-miR-4532	CLIP-seq
MIRT1409648	hsa-miR-4646-5p	CLIP-seq
MIRT1409649	hsa-miR-4676-3p	CLIP-seq
MIRT1409650	hsa-miR-4710	CLIP-seq
MIRT1409651	hsa-miR-4723-5p	CLIP-seq
MIRT1409652	hsa-miR-4728-5p	CLIP-seq
MIRT1409653	hsa-miR-4740-5p	CLIP-seq
MIRT1409654	hsa-miR-4742-3p	CLIP-seq
MIRT1409655	hsa-miR-4757-5p	CLIP-seq
MIRT1409656	hsa-miR-4778-3p	CLIP-seq
MIRT1409657	hsa-miR-4791	CLIP-seq
MIRT1409658	hsa-miR-4792	CLIP-seq
MIRT1409659	hsa-miR-4802-3p	CLIP-seq
MIRT1409660	hsa-miR-501-3p	CLIP-seq
MIRT1409661	hsa-miR-502-3p	CLIP-seq
MIRT1409662	hsa-miR-515-5p	CLIP-seq
MIRT1409663	hsa-miR-522	CLIP-seq
MIRT1409664	hsa-miR-570	CLIP-seq
MIRT1409665	hsa-miR-607	CLIP-seq
MIRT1409666	hsa-miR-615-5p	CLIP-seq
MIRT1409667	hsa-miR-618	CLIP-seq
MIRT1409668	hsa-miR-630	CLIP-seq
MIRT1409669	hsa-miR-873	CLIP-seq
MIRT1409670	hsa-miR-920	CLIP-seq
MIRT1409671	hsa-miR-939	CLIP-seq
MIRT1409672	hsa-miR-1206	CLIP-seq
MIRT1409673	hsa-miR-1252	CLIP-seq
MIRT1409674	hsa-miR-125a-5p	CLIP-seq
MIRT1409675	hsa-miR-125b	CLIP-seq
MIRT1409676	hsa-miR-148a	CLIP-seq
MIRT1409677	hsa-miR-148b	CLIP-seq
MIRT1409678	hsa-miR-150	CLIP-seq
MIRT1409679	hsa-miR-151-3p	CLIP-seq
MIRT1409680	hsa-miR-152	CLIP-seq
MIRT1409681	hsa-miR-190	CLIP-seq
MIRT1409682	hsa-miR-190b	CLIP-seq
MIRT1409683	hsa-miR-216a	CLIP-seq
MIRT1409684	hsa-miR-25	CLIP-seq
MIRT1409685	hsa-miR-32	CLIP-seq
MIRT1409628	hsa-miR-323b-3p	CLIP-seq
MIRT1409686	hsa-miR-363	CLIP-seq
MIRT1409687	hsa-miR-367	CLIP-seq
MIRT1409688	hsa-miR-371b-5p	CLIP-seq
MIRT1409689	hsa-miR-3921	CLIP-seq
MIRT1409690	hsa-miR-3938	CLIP-seq
MIRT1409691	hsa-miR-4255	CLIP-seq
MIRT1409692	hsa-miR-4319	CLIP-seq
MIRT1409693	hsa-miR-4427	CLIP-seq
MIRT1409694	hsa-miR-4452	CLIP-seq
MIRT1409695	hsa-miR-4463	CLIP-seq
MIRT1409696	hsa-miR-4499	CLIP-seq
MIRT1409697	hsa-miR-4653-5p	CLIP-seq
MIRT1409698	hsa-miR-4680-3p	CLIP-seq
MIRT1409699	hsa-miR-4698	CLIP-seq
MIRT1409700	hsa-miR-4713-5p	CLIP-seq
MIRT1409701	hsa-miR-4719	CLIP-seq
MIRT1409702	hsa-miR-4732-3p	CLIP-seq
MIRT1409703	hsa-miR-4774-5p	CLIP-seq
MIRT1409704	hsa-miR-513b	CLIP-seq
MIRT1409705	hsa-miR-520g	CLIP-seq
MIRT1409706	hsa-miR-520h	CLIP-seq
MIRT1409707	hsa-miR-532-3p	CLIP-seq
MIRT1409708	hsa-miR-670	CLIP-seq
MIRT1409709	hsa-miR-891b	CLIP-seq
MIRT1409710	hsa-miR-92a	CLIP-seq
MIRT1409711	hsa-miR-92b	CLIP-seq
MIRT2122787	hsa-miR-3692	CLIP-seq
MIRT1409688	hsa-miR-371b-5p	CLIP-seq
MIRT1409691	hsa-miR-4255	CLIP-seq
MIRT2122788	hsa-miR-4317	CLIP-seq
MIRT1409693	hsa-miR-4427	CLIP-seq
MIRT2122789	hsa-miR-4433	CLIP-seq
MIRT1409698	hsa-miR-4680-3p	CLIP-seq
MIRT1409699	hsa-miR-4698	CLIP-seq
MIRT1409701	hsa-miR-4719	CLIP-seq
MIRT2122790	hsa-miR-4766-5p	CLIP-seq
MIRT1409705	hsa-miR-520g	CLIP-seq
MIRT1409706	hsa-miR-520h	CLIP-seq
MIRT1409707	hsa-miR-532-3p	CLIP-seq
MIRT2122791	hsa-miR-665	CLIP-seq
MIRT1409673	hsa-miR-1252	CLIP-seq
MIRT2345191	hsa-miR-128	CLIP-seq
MIRT2345192	hsa-miR-1976	CLIP-seq
MIRT1409683	hsa-miR-216a	CLIP-seq
MIRT2345193	hsa-miR-27a	CLIP-seq
MIRT2345194	hsa-miR-27b	CLIP-seq
MIRT2345195	hsa-miR-3152-5p	CLIP-seq
MIRT2345196	hsa-miR-3183	CLIP-seq
MIRT2122788	hsa-miR-4317	CLIP-seq
MIRT2345197	hsa-miR-4723-3p	CLIP-seq
MIRT2345198	hsa-miR-513a-5p	CLIP-seq
MIRT1409643	hsa-miR-452	CLIP-seq
MIRT1409649	hsa-miR-4676-3p	CLIP-seq
MIRT2461086	hsa-miR-130a	CLIP-seq
MIRT2461087	hsa-miR-130b	CLIP-seq
MIRT2461088	hsa-miR-301a	CLIP-seq
MIRT2461089	hsa-miR-301b	CLIP-seq
MIRT2461090	hsa-miR-3666	CLIP-seq
MIRT2461091	hsa-miR-4295	CLIP-seq
MIRT2461092	hsa-miR-454	CLIP-seq
MIRT2461093	hsa-miR-4693-3p	CLIP-seq
MIRT2461086	hsa-miR-130a	CLIP-seq
MIRT2461087	hsa-miR-130b	CLIP-seq
MIRT2461088	hsa-miR-301a	CLIP-seq
MIRT2461089	hsa-miR-301b	CLIP-seq
MIRT2461090	hsa-miR-3666	CLIP-seq
MIRT2461091	hsa-miR-4295	CLIP-seq
MIRT2461092	hsa-miR-454	CLIP-seq
MIRT2461093	hsa-miR-4693-3p	CLIP-seq

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000124	Component	SAGA complex	IBA
GO:0000124	Component	SAGA complex	IDA	11564863
GO:0000124	Component	SAGA complex	NAS	9674425, 19114550
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0003713	Function	Transcription coactivator activity	IDA	11564863
GO:0005515	Function	Protein binding	IPI	25609649, 28514442, 33961781
GO:0005634	Component	Nucleus	IDA	11564863
GO:0005634	Component	Nucleus	IEA
GO:0006282	Process	Regulation of DNA repair	NAS	11406595, 11564863
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	ISS
GO:0006355	Process	Regulation of DNA-templated transcription	NAS	17694077
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	9603525
GO:0006366	Process	Transcription by RNA polymerase II	TAS	9674425
GO:0016607	Component	Nuclear speck	IDA
GO:0033276	Component	Transcription factor TFTC complex	IBA
GO:0033276	Component	Transcription factor TFTC complex	IDA	10373431
GO:0033276	Component	Transcription factor TFTC complex	NAS	10373431
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IDA
GO:0043484	Process	Regulation of RNA splicing	NAS	11564863
GO:0045893	Process	Positive regulation of DNA-templated transcription	NAS	18206972
GO:1904672	Process	Regulation of somatic stem cell population maintenance	IEA
GO:1904672	Process	Regulation of somatic stem cell population maintenance	ISS

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

O75529

Protein name

TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (TAF5L) (PCAF-associated factor 65 beta) (PAF65-beta)

Protein function

Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, a

PDB

7KTR , 7KTS , 8H7G

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04494	TFIID_NTD2	64 → 195	WD40 associated region in TFIID subunit, NTD2 domain	Family
PF00400	WD40	332 → 370	WD domain, G-beta repeat	Repeat
PF00400	WD40	374 → 412	WD domain, G-beta repeat	Repeat
PF00400	WD40	416 → 454	WD domain, G-beta repeat	Repeat
PF00400	WD40	458 → 496	WD domain, G-beta repeat	Repeat
PF00400	WD40	500 → 538	WD domain, G-beta repeat	Repeat

Sequence

MKRVRTEQIQMAVSCYLKRRQYVDSDGPLKQGLRLSQTAEEMAANLTVQSESGCANIVSA
APCQAEPQQYEVQFGRLRNFLTDSDSQHSHEVMPLLYPLFVYLHLNLVQNSPKSTVESFY
SRFHGMFLQNASQKDVIEQLQTTQTIQDILSNFKLRAFLDNKYVVRLQEDSYNYLIRYLQ
SDNNTALCKVLTLHIHLDVQPAKRTDYQLYASGSSSRSENNGLEPPDMPSPILQNEAALE
VLQESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSK
KLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSC
SEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLR
IYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNG
KYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIR
NTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVTGITQENQEH

Sequence length

589

Interactions

View interactions

	KEGG
	Basal transcription factors

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	33991433	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	16206511		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	16206511		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	16206511	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	16206511, 18045485	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	16206511, 18045485		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	23374458		★★★★★ ★☆☆☆☆ Found in Text Mining only

TAF5L (TATA-box binding protein associated factor 5 like)