Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	27076
Gene name	LY6/PLAUR domain containing 3
Gene symbol	LYPD3
Synonyms (NCBI Gene)	C4.4A
Chromosome	19
Chromosome location	19q13.31

264

Show/Hide all (264)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018038	hsa-miR-335-5p	Microarray	18185580
MIRT025845	hsa-miR-7-5p	Microarray	17612493
MIRT702191	hsa-miR-8485	HITS-CLIP	23313552
MIRT702190	hsa-miR-455-5p	HITS-CLIP	23313552
MIRT702189	hsa-miR-4461	HITS-CLIP	23313552
MIRT702188	hsa-miR-4729	HITS-CLIP	23313552
MIRT702187	hsa-miR-4738-3p	HITS-CLIP	23313552
MIRT702186	hsa-miR-1827	HITS-CLIP	23313552
MIRT702185	hsa-miR-1227-3p	HITS-CLIP	23313552
MIRT702184	hsa-miR-377-3p	HITS-CLIP	23313552
MIRT702183	hsa-miR-6765-5p	HITS-CLIP	23313552
MIRT702182	hsa-miR-1304-5p	HITS-CLIP	23313552
MIRT702191	hsa-miR-8485	HITS-CLIP	23313552
MIRT702190	hsa-miR-455-5p	HITS-CLIP	23313552
MIRT702189	hsa-miR-4461	HITS-CLIP	23313552
MIRT702188	hsa-miR-4729	HITS-CLIP	23313552
MIRT702187	hsa-miR-4738-3p	HITS-CLIP	23313552
MIRT702186	hsa-miR-1827	HITS-CLIP	23313552
MIRT702185	hsa-miR-1227-3p	HITS-CLIP	23313552
MIRT702184	hsa-miR-377-3p	HITS-CLIP	23313552
MIRT702183	hsa-miR-6765-5p	HITS-CLIP	23313552
MIRT702182	hsa-miR-1304-5p	HITS-CLIP	23313552
MIRT1123176	hsa-miR-124	CLIP-seq
MIRT1123177	hsa-miR-1253	CLIP-seq
MIRT1123178	hsa-miR-128	CLIP-seq
MIRT1123179	hsa-miR-1292	CLIP-seq
MIRT1123180	hsa-miR-151-5p	CLIP-seq
MIRT1123181	hsa-miR-151b	CLIP-seq
MIRT1123182	hsa-miR-1912	CLIP-seq
MIRT1123183	hsa-miR-1915	CLIP-seq
MIRT1123184	hsa-miR-27a	CLIP-seq
MIRT1123185	hsa-miR-27b	CLIP-seq
MIRT1123186	hsa-miR-28-5p	CLIP-seq
MIRT1123187	hsa-miR-298	CLIP-seq
MIRT1123188	hsa-miR-300	CLIP-seq
MIRT1123189	hsa-miR-3130-5p	CLIP-seq
MIRT1123190	hsa-miR-3131	CLIP-seq
MIRT1123191	hsa-miR-3139	CLIP-seq
MIRT1123192	hsa-miR-320e	CLIP-seq
MIRT1123193	hsa-miR-325	CLIP-seq
MIRT1123194	hsa-miR-3622a-5p	CLIP-seq
MIRT1123195	hsa-miR-3670	CLIP-seq
MIRT1123196	hsa-miR-3714	CLIP-seq
MIRT1123197	hsa-miR-377	CLIP-seq
MIRT1123198	hsa-miR-381	CLIP-seq
MIRT1123199	hsa-miR-3910	CLIP-seq
MIRT1123200	hsa-miR-3918	CLIP-seq
MIRT1123201	hsa-miR-3919	CLIP-seq
MIRT1123202	hsa-miR-4290	CLIP-seq
MIRT1123203	hsa-miR-4471	CLIP-seq
MIRT1123204	hsa-miR-4482	CLIP-seq
MIRT1123205	hsa-miR-4640-5p	CLIP-seq
MIRT1123206	hsa-miR-4666-3p	CLIP-seq
MIRT1123207	hsa-miR-4685-5p	CLIP-seq
MIRT1123208	hsa-miR-4726-5p	CLIP-seq
MIRT1123209	hsa-miR-4731-5p	CLIP-seq
MIRT1123210	hsa-miR-4738-5p	CLIP-seq
MIRT1123211	hsa-miR-4746-5p	CLIP-seq
MIRT1123212	hsa-miR-506	CLIP-seq
MIRT1123213	hsa-miR-541	CLIP-seq
MIRT1123214	hsa-miR-564	CLIP-seq
MIRT1123215	hsa-miR-611	CLIP-seq
MIRT1123216	hsa-miR-628-3p	CLIP-seq
MIRT1123217	hsa-miR-654-5p	CLIP-seq
MIRT1123218	hsa-miR-7	CLIP-seq
MIRT1123219	hsa-miR-708	CLIP-seq
MIRT1123220	hsa-miR-922	CLIP-seq
MIRT1123176	hsa-miR-124	CLIP-seq
MIRT1123177	hsa-miR-1253	CLIP-seq
MIRT2034760	hsa-miR-1255a	CLIP-seq
MIRT2034761	hsa-miR-1255b	CLIP-seq
MIRT1123178	hsa-miR-128	CLIP-seq
MIRT1123179	hsa-miR-1292	CLIP-seq
MIRT2034762	hsa-miR-1304	CLIP-seq
MIRT1123180	hsa-miR-151-5p	CLIP-seq
MIRT1123181	hsa-miR-151b	CLIP-seq
MIRT2034763	hsa-miR-1825	CLIP-seq
MIRT2034764	hsa-miR-185	CLIP-seq
MIRT1123182	hsa-miR-1912	CLIP-seq
MIRT1123183	hsa-miR-1915	CLIP-seq
MIRT2034765	hsa-miR-199a-5p	CLIP-seq
MIRT2034766	hsa-miR-199b-5p	CLIP-seq
MIRT2034767	hsa-miR-2110	CLIP-seq
MIRT2034768	hsa-miR-2355-5p	CLIP-seq
MIRT2034769	hsa-miR-2682	CLIP-seq
MIRT1123184	hsa-miR-27a	CLIP-seq
MIRT1123185	hsa-miR-27b	CLIP-seq
MIRT1123186	hsa-miR-28-5p	CLIP-seq
MIRT1123187	hsa-miR-298	CLIP-seq
MIRT1123188	hsa-miR-300	CLIP-seq
MIRT1123189	hsa-miR-3130-5p	CLIP-seq
MIRT1123190	hsa-miR-3131	CLIP-seq
MIRT1123191	hsa-miR-3139	CLIP-seq
MIRT2034770	hsa-miR-3174	CLIP-seq
MIRT1123192	hsa-miR-320e	CLIP-seq
MIRT1123193	hsa-miR-325	CLIP-seq
MIRT2034771	hsa-miR-331-3p	CLIP-seq
MIRT2034772	hsa-miR-3609	CLIP-seq
MIRT2034773	hsa-miR-3612	CLIP-seq
MIRT2034774	hsa-miR-3613-3p	CLIP-seq
MIRT2034775	hsa-miR-3617	CLIP-seq
MIRT1123194	hsa-miR-3622a-5p	CLIP-seq
MIRT1123195	hsa-miR-3670	CLIP-seq
MIRT2034776	hsa-miR-3675-5p	CLIP-seq
MIRT1123196	hsa-miR-3714	CLIP-seq
MIRT1123197	hsa-miR-377	CLIP-seq
MIRT1123198	hsa-miR-381	CLIP-seq
MIRT1123199	hsa-miR-3910	CLIP-seq
MIRT1123200	hsa-miR-3918	CLIP-seq
MIRT1123201	hsa-miR-3919	CLIP-seq
MIRT2034777	hsa-miR-4271	CLIP-seq
MIRT1123202	hsa-miR-4290	CLIP-seq
MIRT2034778	hsa-miR-4306	CLIP-seq
MIRT2034779	hsa-miR-4457	CLIP-seq
MIRT1123203	hsa-miR-4471	CLIP-seq
MIRT2034780	hsa-miR-4476	CLIP-seq
MIRT1123204	hsa-miR-4482	CLIP-seq
MIRT2034781	hsa-miR-449c	CLIP-seq
MIRT2034782	hsa-miR-455-3p	CLIP-seq
MIRT1123205	hsa-miR-4640-5p	CLIP-seq
MIRT2034783	hsa-miR-4644	CLIP-seq
MIRT1123206	hsa-miR-4666-3p	CLIP-seq
MIRT2034784	hsa-miR-4667-5p	CLIP-seq
MIRT1123207	hsa-miR-4685-5p	CLIP-seq
MIRT2034785	hsa-miR-4690-3p	CLIP-seq
MIRT2034786	hsa-miR-4700-5p	CLIP-seq
MIRT2034787	hsa-miR-4706	CLIP-seq
MIRT2034788	hsa-miR-4725-3p	CLIP-seq
MIRT1123208	hsa-miR-4726-5p	CLIP-seq
MIRT1123209	hsa-miR-4731-5p	CLIP-seq
MIRT1123210	hsa-miR-4738-5p	CLIP-seq
MIRT1123211	hsa-miR-4746-5p	CLIP-seq
MIRT2034789	hsa-miR-4749-5p	CLIP-seq
MIRT2034790	hsa-miR-4773	CLIP-seq
MIRT2034791	hsa-miR-4794	CLIP-seq
MIRT2034792	hsa-miR-499-3p	CLIP-seq
MIRT2034793	hsa-miR-499a-3p	CLIP-seq
MIRT1123212	hsa-miR-506	CLIP-seq
MIRT2034794	hsa-miR-513a-3p	CLIP-seq
MIRT2034795	hsa-miR-513b	CLIP-seq
MIRT1123213	hsa-miR-541	CLIP-seq
MIRT2034796	hsa-miR-548ah	CLIP-seq
MIRT1123214	hsa-miR-564	CLIP-seq
MIRT1123215	hsa-miR-611	CLIP-seq
MIRT1123216	hsa-miR-628-3p	CLIP-seq
MIRT2034797	hsa-miR-641	CLIP-seq
MIRT2034798	hsa-miR-650	CLIP-seq
MIRT1123217	hsa-miR-654-5p	CLIP-seq
MIRT2034799	hsa-miR-676	CLIP-seq
MIRT1123218	hsa-miR-7	CLIP-seq
MIRT1123219	hsa-miR-708	CLIP-seq
MIRT2034800	hsa-miR-744	CLIP-seq
MIRT1123220	hsa-miR-922	CLIP-seq
MIRT2265273	hsa-miR-1	CLIP-seq
MIRT2265274	hsa-miR-1227	CLIP-seq
MIRT1123176	hsa-miR-124	CLIP-seq
MIRT1123177	hsa-miR-1253	CLIP-seq
MIRT2034760	hsa-miR-1255a	CLIP-seq
MIRT2034761	hsa-miR-1255b	CLIP-seq
MIRT1123178	hsa-miR-128	CLIP-seq
MIRT1123180	hsa-miR-151-5p	CLIP-seq
MIRT1123181	hsa-miR-151b	CLIP-seq
MIRT2034764	hsa-miR-185	CLIP-seq
MIRT1123182	hsa-miR-1912	CLIP-seq
MIRT1123183	hsa-miR-1915	CLIP-seq
MIRT2265275	hsa-miR-206	CLIP-seq
MIRT2034767	hsa-miR-2110	CLIP-seq
MIRT1123184	hsa-miR-27a	CLIP-seq
MIRT1123185	hsa-miR-27b	CLIP-seq
MIRT1123186	hsa-miR-28-5p	CLIP-seq
MIRT1123187	hsa-miR-298	CLIP-seq
MIRT1123188	hsa-miR-300	CLIP-seq
MIRT1123189	hsa-miR-3130-5p	CLIP-seq
MIRT1123190	hsa-miR-3131	CLIP-seq
MIRT1123191	hsa-miR-3139	CLIP-seq
MIRT2265276	hsa-miR-3148	CLIP-seq
MIRT2265277	hsa-miR-3150a-3p	CLIP-seq
MIRT2265278	hsa-miR-3175	CLIP-seq
MIRT2265279	hsa-miR-3180-5p	CLIP-seq
MIRT1123192	hsa-miR-320e	CLIP-seq
MIRT1123193	hsa-miR-325	CLIP-seq
MIRT2034771	hsa-miR-331-3p	CLIP-seq
MIRT2034774	hsa-miR-3613-3p	CLIP-seq
MIRT2034775	hsa-miR-3617	CLIP-seq
MIRT1123194	hsa-miR-3622a-5p	CLIP-seq
MIRT2265280	hsa-miR-3664-5p	CLIP-seq
MIRT1123195	hsa-miR-3670	CLIP-seq
MIRT2034776	hsa-miR-3675-5p	CLIP-seq
MIRT1123196	hsa-miR-3714	CLIP-seq
MIRT2265281	hsa-miR-371b-5p	CLIP-seq
MIRT1123197	hsa-miR-377	CLIP-seq
MIRT1123198	hsa-miR-381	CLIP-seq
MIRT2265282	hsa-miR-3909	CLIP-seq
MIRT1123199	hsa-miR-3910	CLIP-seq
MIRT1123200	hsa-miR-3918	CLIP-seq
MIRT1123201	hsa-miR-3919	CLIP-seq
MIRT2265283	hsa-miR-3978	CLIP-seq
MIRT2265284	hsa-miR-409-3p	CLIP-seq
MIRT2034777	hsa-miR-4271	CLIP-seq
MIRT1123202	hsa-miR-4290	CLIP-seq
MIRT2034778	hsa-miR-4306	CLIP-seq
MIRT2265285	hsa-miR-4434	CLIP-seq
MIRT2265286	hsa-miR-4450	CLIP-seq
MIRT2034779	hsa-miR-4457	CLIP-seq
MIRT2265287	hsa-miR-4481	CLIP-seq
MIRT1123204	hsa-miR-4482	CLIP-seq
MIRT2265288	hsa-miR-4516	CLIP-seq
MIRT2265289	hsa-miR-4531	CLIP-seq
MIRT2265290	hsa-miR-4639-3p	CLIP-seq
MIRT1123205	hsa-miR-4640-5p	CLIP-seq
MIRT2034783	hsa-miR-4644	CLIP-seq
MIRT1123206	hsa-miR-4666-3p	CLIP-seq
MIRT2034784	hsa-miR-4667-5p	CLIP-seq
MIRT1123207	hsa-miR-4685-5p	CLIP-seq
MIRT2265291	hsa-miR-4700-3p	CLIP-seq
MIRT2034786	hsa-miR-4700-5p	CLIP-seq
MIRT2034788	hsa-miR-4725-3p	CLIP-seq
MIRT1123208	hsa-miR-4726-5p	CLIP-seq
MIRT1123209	hsa-miR-4731-5p	CLIP-seq
MIRT1123210	hsa-miR-4738-5p	CLIP-seq
MIRT2265292	hsa-miR-4745-5p	CLIP-seq
MIRT1123211	hsa-miR-4746-5p	CLIP-seq
MIRT2265293	hsa-miR-4768-5p	CLIP-seq
MIRT2034790	hsa-miR-4773	CLIP-seq
MIRT2265294	hsa-miR-4781-3p	CLIP-seq
MIRT2265295	hsa-miR-491-5p	CLIP-seq
MIRT2034792	hsa-miR-499-3p	CLIP-seq
MIRT2034793	hsa-miR-499a-3p	CLIP-seq
MIRT1123212	hsa-miR-506	CLIP-seq
MIRT2034794	hsa-miR-513a-3p	CLIP-seq
MIRT2034795	hsa-miR-513b	CLIP-seq
MIRT2265296	hsa-miR-520f	CLIP-seq
MIRT1123214	hsa-miR-564	CLIP-seq
MIRT1123215	hsa-miR-611	CLIP-seq
MIRT2265297	hsa-miR-613	CLIP-seq
MIRT2265298	hsa-miR-617	CLIP-seq
MIRT1123216	hsa-miR-628-3p	CLIP-seq
MIRT2034797	hsa-miR-641	CLIP-seq
MIRT2034799	hsa-miR-676	CLIP-seq
MIRT1123218	hsa-miR-7	CLIP-seq
MIRT1123219	hsa-miR-708	CLIP-seq
MIRT1123220	hsa-miR-922	CLIP-seq
MIRT2265299	hsa-miR-939	CLIP-seq
MIRT2265300	hsa-miR-942	CLIP-seq
MIRT1123176	hsa-miR-124	CLIP-seq
MIRT1123178	hsa-miR-128	CLIP-seq
MIRT1123180	hsa-miR-151-5p	CLIP-seq
MIRT1123181	hsa-miR-151b	CLIP-seq
MIRT1123184	hsa-miR-27a	CLIP-seq
MIRT1123185	hsa-miR-27b	CLIP-seq
MIRT1123186	hsa-miR-28-5p	CLIP-seq
MIRT1123191	hsa-miR-3139	CLIP-seq
MIRT1123193	hsa-miR-325	CLIP-seq
MIRT1123194	hsa-miR-3622a-5p	CLIP-seq
MIRT1123195	hsa-miR-3670	CLIP-seq
MIRT2034779	hsa-miR-4457	CLIP-seq
MIRT2034792	hsa-miR-499-3p	CLIP-seq
MIRT2034793	hsa-miR-499a-3p	CLIP-seq
MIRT1123212	hsa-miR-506	CLIP-seq
MIRT2034795	hsa-miR-513b	CLIP-seq
MIRT1123214	hsa-miR-564	CLIP-seq
MIRT1123216	hsa-miR-628-3p	CLIP-seq
MIRT2034799	hsa-miR-676	CLIP-seq
MIRT1123219	hsa-miR-708	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	15012588
GO:0007160	Process	Cell-matrix adhesion	IEA
GO:0016020	Component	Membrane	IEA
GO:0034392	Process	Negative regulation of smooth muscle cell apoptotic process	IGI	32151690
GO:0043236	Function	Laminin binding	IEA
GO:0098552	Component	Side of membrane	IEA

MIM	HGNC	e!Ensembl
609484	24880	ENSG00000124466

O95274

Protein name

Ly6/PLAUR domain-containing protein 3 (GPI-anchored metastasis-associated protein C4.4A homolog) (Matrigel-induced gene C4 protein) (MIG-C4)

Protein function

Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression.

PDB

6IOM , 6ION

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00021	UPAR_LY6	33 → 114	u-PAR/Ly-6 domain	Domain
PF00021	UPAR_LY6	140 → 222	u-PAR/Ly-6 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in placenta, skin and urothelium. Found in suprabasal keratinocytes of chronic wounds. Weak expression is found in esophagus and peripheral blood mononuclear cells. Found in the majority of primary and metastatic transitional

Sequence

MDPARKAGAQAMIWTAGWLLLLLLRGGAQALECYSCVQKADDGCSPNKMKTVKCAPGVDV
CTEAVGAVETIHGQFSLAVRGCGSGLPGKNDRGLDLHGLLAFIQLQQCAQDRCNAKLNLT
SRALDPAGNESAYPPNGVECYSCVGLSREACQGTSPPVVSCYNASDHVYKGCFDGNVTLT
AANVTVSLPVRGCVQDEFCTRDGVTGPGFTLSGSCCQGSRCNSDLRNKTYFSPRIPPLVR
LPPPEPTTVASTTSVTTSTSAPVRPTSTTKPMPAPTSQTPRQGVEHEASRDEEPRLTGGA
AGHQDRSNSGQYPAKGGPQQPHNKGCVAPTAGLAALLLAVAAGVLL

Sequence length

346

Interactions

View interactions

	Reactome
			Post-translational modification: synthesis of GPI-anchored proteins

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (21)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	29048672	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	29377892	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	29048672	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	17912244	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	LHGDN	17912244		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	17912244, 20825414	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	32425885	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathies	Diabetic neuropathy	Pubtator	32425885	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Diseases	Lung disease	Pubtator	20825414	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	LHGDN	17706320		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	24935570	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28292941		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	11180013, 29377892, 37924160	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	11245483, 29377892, 31644911		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	28292941, 30274775		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	30618037	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	17912244	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Skin Diseases	Skin disease	Pubtator	25414274	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	LHGDN	17849475		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	28292941		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	24935570	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only

LYPD3 (LY6/PLAUR domain containing 3)